Release and Complex Formation of Soluble VEGFR-1 from Endothelial Cells and Biological Fluids

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Laboratory Investigation

• Publication date

  2000-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/labinvest.3780050PMID 10780661
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Placental angiogenesis: the role of the VEGF family of proteins

  2004cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Placenta Growth Factor

  2001cited by this paper
• Expression and localization of placenta growth factor and PlGF receptors in human meningiomas

  1999influential reference
• Vascular endothelial growth factor is bound in amniotic fluid and maternal serum.

  1999cited by this paper
• Detection and quantification of complexed and free soluble human vascular endothelial growth factor receptor-1 (sVEGFR-1) by ELISA.

  1999influential reference
• Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase.

  1999cited by this paper
• Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction up-regulates placenta growth factor expression: molecular evidence for "placental hyperoxia" in intrauterine growth restriction.

  1999cited by this paper
• Alternative splicing of vascular endothelial growth factor (VEGF)-R1 (FLT-1) pre-mRNA is important for the regulation of VEGF activity.

  1999cited by this paper
• Functions of the VEGF receptor-1 (FLT-1) in the vasculature.

  1998cited by this paper
• Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.

  1998influential reference
• Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors.

  1998cited by this paper
• Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice.

  1998influential reference
• Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2.

  1998influential reference
• Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1.

  1998cited by this paper
• Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

  1997cited by this paper
• Role of VEGF receptor-1 (Flt-1) in mediating calcium-dependent nitric oxide release and limiting DNA synthesis in human trophoblast cells.

  1997cited by this paper
• Hypoxia or hyperoxia in placental insufficiency?

  1997cited by this paper
• Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

  1997influential reference
• The biology of vascular endothelial growth factor.

  1997cited by this paper
• Molecular mechanisms of vasculogenesis and embryonic angiogenesis

  1997cited by this paper
• Variation in Detection of VEGF in Maternal Serum by Immunoassay and the Possible Influence of Binding Proteins

  1997cited by this paper
• Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1*

  1997cited by this paper
• Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

  1996cited by this paper
• Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR.

  1996influential reference
• Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

  1995influential reference
• Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

  1995cited by this paper
• A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

  1995influential reference
• Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.

  1995cited by this paper
• Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

  1994cited by this paper
• Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells

  1994influential reference
• VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor.

  1994cited by this paper
• A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta.

  1993cited by this paper
• Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells.

  1993cited by this paper
• Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

  1993cited by this paper
• AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor.

  1992cited by this paper
• Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

  1992cited by this paper
• Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.

  1992influential reference
• FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

  1992cited by this paper
• Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

  1990cited by this paper
• Factors affecting gas transfer across the placenta and the oxygen supply to the fetus.

  1989cited by this paper
• Vascular endothelial growth factor is a secreted angiogenic mitogen.

  1989cited by this paper

• Pirfenidone ameliorates dexamethasone-induced steatohepatitis and vascular resistance in rats.

  2026cites this paper
• Hypertensive disorders of pregnancy and retinopathy of prematurity in extremely preterm infants: A causal mediation analysis.

  2026cites this paper
• Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives

  2025cites this paper
• Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis

  2025cites this paper
• Gene Therapy for Wet Age-Related Macular Degeneration

  2025cites this paper
• Mechanistic computational modeling of sFLT1 secretion dynamics

  2025cites this paper
• VEGF family in cortical development

  2025cites this paper
• Soluble vascular endothelial growth factor receptor 1 (VEGFR1): A possible biomarker in BPS/IC?

  2025cites this paper
• Mechanistic computational modeling of sFLT1 secretion dynamics

  2025cites this paper
• Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer's disease: A putative biomarker of amyloid-induced vascular damage.

  2024cites this paper
• Maternal Microvascular Dysfunction During and After Preeclamptic Pregnancy.

  2024cites this paper
• Preeclampsia and the Kidney: Pathophysiology and Clinical Implications.

  2023cites this paper
• A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells

  2023cites this paper
• A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretion from endothelial cells

  2023cites this paper
• Targeting angiogenesis in oncology, ophthalmology and beyond

  2023cites this paper
• Comparison of Bevacizumab and Aflibercept for Suppression of Angiogenesis in Human Retinal Microvascular Endothelial Cells

  2023cites this paper
• Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration

  2023cites this paper
• What Went Wrong with VEGF-A in Peripheral Arterial Disease? A Systematic Review and Biological Insights on Future Therapeutics

  2022cites this paper
• To the question of the clinical predictive value of the sFlt-1:PlGF ratio is related to the placental dysfunction

  2022cites this paper
• Soluble Fms-like tyrosine kinase-1 (sFlt-1) is associated with subclinical and clinical atherosclerotic cardiovascular disease: The Dallas Heart Study.

  2022cites this paper
• Soluble Flt-1 in AMI Patients Serum Inhibits Angiogenesis of Endothelial Progenitor Cells by Suppressing Akt and Erk’s Activity

  2022cites this paper
• Peripheral vascular disease: preclinical models and emerging therapeutic targeting of the vascular endothelial growth factor ligand-receptor system

  2021cites this paper
• Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications

  2021cites this paper
• Involvement of Cytokines in the Pathogenesis of Diabetic Macular Edema

  2021cites this paper
• Predictive value of vascular endothelial growth factor and placenta growth factor for placenta accreta spectrum

  2021cites this paper
• The Placental Circulations

  2021cites this paper
• Peptide Inhibitors of Vascular Endothelial Growth Factor A: Current Situation and Perspectives

  2021cites this paper
• Extracellular Granzyme K Modulates Angiogenesis by Regulating Soluble VEGFR1 Release From Endothelial Cells

  2021cites this paper
• Biological role of postoperative low level laser therapy in preventing hydroxyapatite orbital implantation exposure: A case report

  2021cites this paper
• Resistance of melanoma cells to anticancer treatment: a role of vascular endothelial growth factor

  2020cites this paper
• Predictive value of vascular endothelial growth factor and placenta growth factor for morbidly adherent placenta among women with previous history of cesarean section

  2020cites this paper
• Ovarian Hyperstimulation Syndrome

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• Dynamics of soluble vascular endothelial growth factor receptors and their ligands in aqueous humour during ranibizumab for age-related macular degeneration

  2018cites this paper
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  2018cites this paper
• Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome.

  2018cites this paper
• The Role of Angiogenesis Inhibitors in Hypertension: Following “Ariadne’s Thread”

  2018cites this paper
• Soluble VEGFR1 signaling guides vascular patterns into dense branching morphologies.

  2018cites this paper
• Investigating the Role of the RNA Binding Protein LIN28 in the Human Placenta: Implications for Preeclampsia

  2018cites this paper
• The importance of some angiogenic markers in spontaneous abortion.

  2017cites this paper
• A Two-Pronged Approach to Preeclampsia: Understanding Gene Expression and Targeting sFlt1 using RNAi

  2017cites this paper
• Circulating free soluble fms-like tyrosine kinase-1 during late first trimester in relation with placental volume as a surrogate for trophoblastic production: a physiology study in low-risk cohort

  2017cites this paper
• The Pregnant Adolescent : General Considerations

  2017cites this paper
• A Clinical study of hemangiomas and vascular malformations.

  2017cites this paper
• Association between angiogenic factors and signs of arterial aging in women with pre‐eclampsia

  2017cites this paper
• Aqueous Humor Levels of Soluble Vascular Endothelial Growth Factor Receptor and Inflammatory Factors in Diabetic Macular Edema

  2017cites this paper
• Preterm Delivery as a Unique Pathophysiologic State Characterized by Maternal Soluble FMS-Like Tyrosine Kinase 1 and Uterine Artery Resistance During Pregnancy: A Longitudinal Cohort Study

  2017cites this paper
• Gene delivery nanoparticles to modulate angiogenesis☆

  2017cites this paper
• Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy

  2017cites this paper
• Reducible PEG-POD/DNA Nanoparticles for Gene Transfer In Vitro and In Vivo: Application in a Mouse Model of Age-Related Macular Degeneration

  2017influential citation
• High levels of soluble vascular endothelial growth factor receptor 1/sFlt1 and low levels of vascular endothelial growth factor in follicular fluid on the day of oocyte retrieval correlate with ovarian hyperstimulation syndrom regardless of the stimulation protocol.

  2017cites this paper
• Angiogenic factors and inflammation in steroid-refractory acute graft-vs-host disease.

  2016cites this paper
• Maternal cardiovascular and immune regulatory factors before the onset of pre-eclampsia

  2016cites this paper
• Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells

  2016cites this paper
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  2016cites this paper
• Sex-specific differences in fetal and infant growth patterns: a prospective population-based cohort study

  2016cites this paper
• [Pathophysiology of preeclampsia].

  2016cites this paper
• Predicting angiogenic receptor trafficking and signaling via computational systems biology

  2016cites this paper
• Role of soluble vascular endothelial growth factor receptor signaling and other factors or cytokines in central retinal vein occlusion with macular edema.

  2015influential citation
• Early pregnancy maternal and fetal angiogenic factors and fetal and childhood growth: the Generation R Study.

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• Differential Effects of Paracrine Factors on the Survival of Cells of the Neurovascular Unit during Oxygen Glucose Deprivation

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• Early pregnancy Early pregnancy maternal and fetal angiogenic factors and fetal and childhood growth : the Generation R Study

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• Preeclampsia is associated with lower production of vascular endothelial growth factor by peripheral blood mononuclear cells.

  2014cites this paper
• Design of growth factor sequestering biomaterials.

  2014cites this paper
• Role of Inflammation in Diabetic Macular Edema

  2014cites this paper
• Effect of LLLT on endothelial cells culture

  2014cites this paper
• Role of soluble vascular endothelial growth factor receptors-1 and -2, their ligands, and other factors in branch retinal vein occlusion with macular edema.

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• De novo hem- and lymphangiogenesis by endothelial progenitor and mesenchymal stem cells in immunocompetent mice

  2014cites this paper
• Fetal sex specific differences in human placentation: a prospective cohort study.

  2014cites this paper
• The protein expression of the nicotinic acetylcholine receptors in the human placenta, and effects of cigarette smoking and pre-eclampsia.

  2014cites this paper
• Serum-Dependence of Affinity-Mediated VEGF Release from Biomimetic Microspheres

  2014cites this paper
• [The role of vascular endothelial growth factor in inflammatory processes].

  2014cites this paper
• Maternal and Fetoplacental Hypoxia Do Not Alter Circulating Angiogenic Growth Effectors During Human Pregnancy1

  2014cites this paper
• Maternal/newborn VEGF-C936T interaction and its influence on the risk, severity and prognosis of preeclampsia, as well as on the maternal angiogenic profile

  2014cites this paper
• Computational Systems Biology for the VEGF Family in Angiogenesis

  2014cites this paper
• Fetal sex specifi cd ifferences in human placentation: Ap rospective cohort study

  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Expression of ATF4 and VEGF in chorionic villus tissue in early spontaneous abortion.

  2013cites this paper
• Expression of DJ-1 proteins in placentas from women with severe preeclampsia.

  2013cites this paper
• VEGFR and type-V RTK activation and signaling.

  2013cites this paper
• Letter to Editor

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Magnesium sulfate therapy of preeclampsia: an old tool with new mechanism of action and prospect in management and prophylaxis

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  2012cites this paper
• Aqueous concentrations of VEGF and soluble VEGF receptor-1 in diabetic retinopathy patients

  2012influential citation
• A Review on Angiogenesis and Its Assays

  2012influential citation