Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Immunity

• Publication date

  2009-07-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.immuni.2009.06.008PMID 19604490
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008influential reference
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