Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2012-07-23

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nrm3394PMID 22820888
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• K11-linked ubiquitin chains as novel regulators of cell division.

  2011cited by this paper
• NF-κB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-κB Activation*

  2011cited by this paper
• TRAF7 Protein Promotes Lys-29-linked Polyubiquitination of IκB Kinase (IKKγ)/NF-κB Essential Modulator (NEMO) and p65/RelA Protein and Represses NF-κB Activation

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• Constructing and decoding unconventional ubiquitin chains

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• Protein-linked Ubiquitin Chain Structure Restricts Activity of Deubiquitinating Enzymes*

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• SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

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• The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.

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• Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine.

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• The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines

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• Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

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• Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

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• Working on a chain: E3s ganging up for ubiquitylation

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• Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation.

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• K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.

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• Generation of Site‐Specific and Enzymatically Stable Conjugates of Recombinant Proteins with Ubiquitin‐Like Modifiers by the CuI‐Catalyzed Azide–Alkyne Cycloaddition

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• Nonproteolytic functions of ubiquitin in cell signaling.

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• Building ubiquitin chains: E2 enzymes at work

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• Structural basis and specificity of human otubain 1-mediated deubiquitination.

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• Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.

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• Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains

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• K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1

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• The structure and conformation of Lys63-linked tetraubiquitin.

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• Linear polyubiquitination: a new regulator of NF‐κB activation

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• Highly efficient and chemoselective peptide ubiquitylation.

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• Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

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• Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity

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