Neurometabolism in human epilepsy

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Epilepsia

• Publication date

  2008-02-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1528-1167.2008.01508.xPMID 18304254PMCID PMC3657747
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T

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• Lateralization of temporal lobe epilepsy based on regional metabolic abnormalities in proton magnetic resonance spectroscopic images

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• Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain.

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• Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport.

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