Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent Clq of the first component of human complement.

No abstract is available for this paper.

• Publication year

  1976

• Venue

  Biochemical Journal

• Publication date

  1976-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1042/BJ1550005PMID 7240PMCID PMC1172796
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Subunit composition and structure of subcomponent C1q of the first component of human complement.

  1976cited by this paper
• The application of 0.1 M quadrol to the microsequence of proteins and the sequence of tryptic peptides.

  1975cited by this paper
• Chemical analysis and electron microscopy studies of human C1q prepared by different methods

  1975cited by this paper
• A collagen-like amino acid sequence in a polypeptide chain of human C1q (a subcomponent of the first component of complement).

  1974cited by this paper
• Studies on the structure and activity of rabbit Clq (a subcomponent of the first component of complement).

  1974cited by this paper
• Thin-layer chromatography of sub-nanomole amounts of phenylthiohydantoin (PTH) amino acids on polyamide sheets.

  1973cited by this paper
• Structural studies on human Clq: non-covalent and covalent subunits.

  1972cited by this paper
• Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera.

  1972cited by this paper
• Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq).

  1972cited by this paper
• C1q protein of human complement.

  1972cited by this paper
• Structural studies on cartilage collagen employing limited cleavage and solubilization with pepsin.

  1972cited by this paper
• Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.

  1971cited by this paper
• Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins.

  1971cited by this paper
• Characterization of collagen peptides by sodium dodecylsulfate-polyacrylamide electrophoresis.

  1971cited by this paper
• Evidence for procollagen, a biosynthetic precursors of collagen.

  1971cited by this paper
• The chemistry and structure of collagen.

  1971cited by this paper
• Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac.

  1971cited by this paper
• Molecular weight determination of random coil polypeptides from collagen by molecular sieve chromatography.

  1968cited by this paper
• Ascaris cuticle collagen: on the disulfide cross-linkages and the molecular properties of the subunits.

  1967cited by this paper
• The oxidation of ribonuclease with performic acid.

  1956cited by this paper

• Anti-nuclear antibody (ANA) detection in culture supernatant of cloned B cells

  2023cites this paper
• Hollow Octadecameric Self-Assembly of Collagen-like Peptides.

  2023cites this paper
• CTRP1: A novel player in cardiovascular and metabolic diseases.

  2023cites this paper
• Headless C1q: a new molecular tool to decipher its collagen‐like functions

  2020cites this paper
• Current Understanding of the Emerging Role of Prolidase in Cellular Metabolism

  2020cites this paper
• C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules

  2018cites this paper
• Complement Component C1q: Historical Perspective of a Functionally Versatile, and Structurally Unusual, Serum Protein

  2018cites this paper
• Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions

  2017cites this paper
• Adsorbents for the Treatment of Autoimmune Diseases through Hemoperfusion

  2017cites this paper
• Mechanisms responsible for differential bactericidal activities of human and rabbit complement for Neisseria meningitidis

  2016cites this paper
• Serum A08 C1q antibodies are associated with disease activity and prognosis in Chinese patients with lupus nephritis.

  2016cites this paper
• Low-molecular weight Clq-binding immunoglobulin G in Patients with Systemic Lupus Erythematosus Consists of Aptoantibodies to the Collagen-like Region of Clq

  2013cites this paper
• Inhibited by Calreticulin from Trypanosoma Human Complement System Is Specifically The Classical Activation Pathway of the

  2013cites this paper
• Anti-DNA antibodies cross-react with C1q.

  2013cites this paper
• Biochemical analysis of the epitope specificities of anti-C1q autoantibodies accompanying human lupus nephritis reveals them as a dynamic population in the course of the disease.

  2012cites this paper
• New insight into the autoimmunogenicity of the complement protein C1q.

  2011cites this paper
• Protein ultrastructure and the nanoscience of complement activation.

  2011cites this paper
• Islet Amyloid Polypeptide Triggers Limited Complement Activation and Binds Complement Inhibitor C4b-binding Protein, Which Enhances Fibril Formation*

  2011cites this paper
• Approaches to Manipulating the Dimensionality and Physicochemical Properties of Common Cellular Scaffolds

  2011cites this paper
• Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

  2011cites this paper
• C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis.

  2009cites this paper
• The Classical and Regulatory Functions of C1q in Immunity and Autoimmunity

  2008cites this paper
• Native, amyloid fibrils and beta-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly.

  2008cites this paper
• The role of collagen XIII in B-cell lymphoma development, and characterization of its biosynthesis and tissue distribution

  2008cites this paper
• Interaction of human C1q with IgG and IgM: revisited.

  2008cites this paper
• C1q- and collectin-dependent phagocytosis of apoptotic host cells by the intestinal protozoan Entamoeba histolytica.

  2008cites this paper
• Trimeric reassembly of the globular domain of human C1q.

  2008cites this paper
• Complement component C1q inhibits β‐amyloid‐ and serum amyloid P‐induced neurotoxicity via caspase‐ and calpain‐independent mechanisms

  2007cites this paper
• Evidence That Complement Protein C1q Interacts with C-Reactive Protein through Its Globular Head Region1

  2006cites this paper
• Globular Head Region Interacts with C-Reactive Protein through Its Evidence That Complement Protein C1q

  2006cites this paper
• Immune function of C1q and its modulators CD91 and CD93.

  2005cites this paper
• The Classical Activation Pathway of the Human Complement System Is Specifically Inhibited by Calreticulin from Trypanosoma cruzi1

  2004cites this paper
• Antibody formation against human collagen and C1q in response to a bovine collagen implant

  2004cites this paper
• The lupus band: do the autoantibodies target collagen VII?

  2004cites this paper
• Title Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular 'heads' of C1q

  2003cites this paper
• By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation.

  2003cites this paper
• Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex1

  2002cites this paper
• The effect of high salt concentration on detection of serum immune complexes and autoantibodies to C1q in patients with systemic lupus erythematosus.

  2002cites this paper
• Surfactant Protein A Regulates Complement Activation1

  2001cites this paper
• C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

  2001cites this paper
• Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions.

  2001cites this paper
• This information is current as Activation Surfactant Protein A Regulates Complement

  2001cites this paper
• β-Amyloid Fibrils Activate the C1 Complex of Complement Under Physiological Conditions: Evidence for a Binding Site for Aβ on the C1q Globular Regions1

  2001cites this paper
• Immunoadsorption, current status and future developments

  2000cites this paper
• Paraproteins Monomeric Complement-Activating IgG

  1999cites this paper
• Digestion of C1q collagen‐like domain with MMPs‐1, ‐2, ‐3, and ‐9 further defines the sequence involved in the stimulation of neutrophil superoxide production

  1999cites this paper
• Monomeric complement-activating IgG paraproteins.

  1999cites this paper
• Comparison of C1q-receptors on rat microglia and peritoneal macrophages.

  1999cites this paper
• Monomeric Complement-Activating IgG

  1999cites this paper
• C1q-containing immune complexes purified from sera of juvenile rheumatoid arthritis patients mediate IL-8 production by human synoviocytes: role of C1q receptors.

  1999cites this paper
• Functional Definition of a B Cell Epitope, KGEQGEPGA, on C1q the Fc‐Binding Subunit of the First Component of Complement

  1999cites this paper
• Synoviocytes : Role of C 1 q Receptors Patients Mediate IL-8 Production by Human from Sera of Juvenile Rheumatoid Arthritis C 1 q-Containing Immune Complexes Purified

  1999cites this paper
• Activation of the Complement Classical Pathway (C1q Binding) by Mesophilic Aeromonas hydrophila Outer Membrane Protein

  1998cites this paper
• C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms.

  1998cites this paper
• Serial analysis of autoantibody responses to the collagen-like region of Clq, collagen type II, and double stranded DNA in patients with systemic lupus erythematosus.

  1997cites this paper
• Release of calreticulin from neutrophils may alter C1q-mediated immune functions.

  1997cites this paper
• Deposition of antibodies to the collagen-like region of C1q in renal glomeruli of patients with proliferative lupus glomerulonephritis.

  1997cites this paper
• Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

  1997cites this paper
• The C1q and collectin binding site within C1q receptor (cell surface calreticulin).

  1997cites this paper
• Development of a monoclonal antibody to urinary degradation products from the C-terminal telopeptide alpha 1 chain of type I collagen. Application in an enzyme immunoassay and comparison to CrossLaps ELISA.

  1997cites this paper
• The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization

  1996cites this paper
• Circular Dichroism of Collagen and Related Polypeptides

  1996cites this paper
• Interaction between complement subcomponent C1q and the Klebsiella pneumoniae porin OmpK36

  1996cites this paper
• The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif.

  1996cites this paper
• Autoantibodies to the collagenous region of C1q occur in three strains of lupus‐prone mice

  1996cites this paper
• Human C1q induces eosinophil migration.

  1996cites this paper
• The collagen‐like component of the complement system, C1q, is recognized by 7 S autoantibodies and is functionally impaired in synovial fluids of patients with rheumatoid arthritis

  1996cites this paper
• Human Autoantibodies Against C1q: Lack of Cross‐Reactivity with the Collectins Mannan‐Binding Protein, Lung Surfactant Protein A and Bovine Conglutinin

  1996cites this paper
• C1q-binding immunoglobulin G in MRL/l mice consists of immune complexes containing antibodies to DNA.

  1995cites this paper
• C1q triggers neutrophil superoxide production by a unique CD18‐dependent mechanism

  1995cites this paper
• Localization of the Site on the Complement Component C1q Required for the Stimulation of Neutrophil Superoxide Production (*)

  1995cites this paper
• Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 M(r) component of the C1q receptor.

  1995cites this paper
• Murine mast cells express two types of C1q receptors that are involved in the induction of chemotaxis and chemokinesis.

  1995cites this paper
• Evidence for the presence of collagenous domains in Candida albicans cell surface proteins

  1995cites this paper
• Gonococcal infection in a nonhuman host is determined by human complement C1q

  1995cites this paper
• Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis.

  1994cites this paper
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  1994cites this paper
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  1994cites this paper
• Identification of a novel 33-kDa C1q-binding site on human blood platelets.

  1994cites this paper
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  1994cites this paper
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  1994cites this paper
• Chapter 18 – Complement as an Effector Mechanism of Antibodies in Host Defense

  1994cites this paper
• Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q.

  1993cites this paper
• Platelet activation by C1q results in the induction of alpha IIb/beta 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity

  1993cites this paper
• Thermodynamic studies of the collagen-like region of human subcomponent C1q. A water-containing structural model.

  1993cites this paper
• High molecular weight non-immunoglobulin salivary agglutinins (NIA) bind C1Q globular heads and have the potential to activate the first complement component.

  1993cites this paper
• Further characterization of the interaction between the C1q subcomponent of human C1 and the transmembrane envelope glycoprotein gp41 of HIV-1.

  1993cites this paper
• The phylogeny of rotifers: molecular, ultrastructural and behavioural data

  1993cites this paper
• Western Blot Analysis of Human IgG Reactive with the Collagenous Portion of C1q: Evidence of Distinct Binding Specificities

  1992cites this paper
• Biochemical and ultrastructural studies of the C-type lectin bovine conglutinin.

  1992cites this paper
• Platelet interactions with C1q in whole blood and in the presence of immune complexes or aggregated IgG.

  1992cites this paper
• Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways.

  1992cites this paper
• DNA binds and activates complement via residues 14-26 of the human C1q A chain.

  1992cites this paper
• The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex.

  1992cites this paper
• Paramyosin inhibits complement C1.

  1992cites this paper
• Simultaneous determination of amounts of major phospholipid classes and their fatty acid composition in erythrocyte membranes using high-performance liquid chromatography and gas chromatography.

  1992cites this paper
• Collagen in Cardiovascular Tissues

  1992cites this paper
• Smooth muscle and epithelial cells express specific binding sites for the C1q component of complement.

  1992cites this paper
• Binding and complement activation by C-reactive protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive protein and C1q.

  1991cites this paper
• Complement component C1q unaltered by ascorbate supplementation in healthy men and women

  1991cites this paper