Immunohistochemistry of Carbonic Anhydrase Isozyme IX (MN/CA IX) in Human Gut Reveals Polarized Expression in the Epithelial Cells with the Highest Proliferative Capacity

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Histochemistry and Cytochemistry

• Publication date

  1998-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/002215549804600409PMID 9524195
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Carbonic anhydrase isoenzymes II and I are present in the zona glomerulosa cells of the human adrenal gland

  2004cited by this paper
• Immunohistochemical demonstration of human carbonic anhydrase isoenzyme II in brain tumours

  2004cited by this paper
• Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts.

  1997cited by this paper
• Membrane‐bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium

  1996cited by this paper
• Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships.

  1996cited by this paper
• Carbonic anhydrase in the alimentary tract. Roles of the different isozymes and salivary factors in the maintenance of optimal conditions in the gastrointestinal canal.

  1996cited by this paper
• Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families.

  1996cited by this paper
• The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin.

  1995cited by this paper
• Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity.

  1995cited by this paper
• Human carbonic anhydrases and carbonic anhydrase deficiencies.

  1995cited by this paper
• Complex-type Asparagine-linked Oligosaccharides on Phosphacan and Protein-tyrosine Phosphatase-ζ/β Mediate Their Binding to Neural Cell Adhesion Molecules and Tenascin (*)

  1995cited by this paper
• Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.

  1995cited by this paper
• Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment.

  1994cited by this paper
• Receptor tyrosine phosphatase beta is expressed in the form of proteoglycan and binds to the extracellular matrix protein tenascin.

  1994cited by this paper
• Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase.

  1994cited by this paper
• High-activity carbonic anhydrase isoenzyme (CA II) in human gallbladder epithelium.

  1994cited by this paper
• Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas.

  1994cited by this paper
• A competitive dual-label time-resolved immunofluorometric assay for simultaneous detection of carbonic anhydrase I and II in cerebrospinal fluid.

  1994cited by this paper
• Brain-specific receptor-type protein-tyrosine phosphatase RPTP beta is a chondroitin sulfate proteoglycan in vivo.

  1994cited by this paper
• Distribution of the carbonic anhydrase isoenzymes I, II, and VI in the human alimentary tract.

  1994cited by this paper
• Immunohistochemistry of carbonic anhydrase in human placenta and fetal membranes

  1994cited by this paper
• Close similarity between receptor-linked tyrosine phosphatase and rat brain proteoglycan.

  1994cited by this paper
• Competitive time-resolved immunofluorometric assay for quantifying carbonic anhydrase VI in saliva.

  1993cited by this paper
• Location of a membrane-bound carbonic anhydrase isoenzyme (CA IV) in the human male reproductive tract.

  1993cited by this paper
• Expression of MaTu‐MN protein in human tumor cultures and in clinical specimens

  1993cited by this paper
• Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases

  1993cited by this paper
• The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system.

  1993cited by this paper
• A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases.

  1992influential reference
• A novel quasi-viral agent, MaTu, is a two-component system.

  1992cited by this paper
• Studies of intestinal stem cells using normal, chimeric, and transgenic mice 1

  1992cited by this paper
• Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases.

  1991cited by this paper
• Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands.

  1990cited by this paper
• Intestinal epithelial differentiation: new insights from chimeric and transgenic mice

  1989cited by this paper
• Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5

  1989cited by this paper
• Expression vector system based on the chicken beta-actin promoter directs efficient production of interleukin-5.

  1989cited by this paper
• Amount and distribution of carbonic anhydrases CA I and CA II in the gastrointestinal tract.

  1985cited by this paper
• Growth and development of gastrointestinal cells.

  1985cited by this paper
• High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment.

  1984cited by this paper
• High efficiency polyoma DNA transfection of chloroquine treated cells.

  1983cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Cleavage of structural proteins during

  1970cited by this paper

• Triazinyl-benzenesulfonamide derivatives as hCA IX inhibitors: Design, synthesis, and activity determination using an optimized stop-flow methodology.

  2026cites this paper
• Small Organic Carbonic Anhydrase IX Ligands from DNA-Encoded Chemical Libraries for Tumor-Targeted Delivery of Radionuclides.

  2025cites this paper
• Synthesis and Preclinical Evaluation of 99mTc-Labeled Benzenesulfonamides for SPECT Imaging of Carbonic Anhydrase IX Expression.

  2025cites this paper
• pH regulators and their inhibitors in tumor microenvironment.

  2024cites this paper
• IL-22 regulates MASTL expression in intestinal epithelial cells.

  2024cites this paper
• Chemically Programmed Fc Protein as Antibody Mimetic to Targeting Carbonic Anhydrase IX

  2024cites this paper
• Exploration of newly synthesized deferasirox derivatives as potential anti-cancer agents via in-vitro and in-silico approaches.

  2024cites this paper
• Design, synthesis and in vitro evaluation of novel thiazole-coumarin hybrids as selective and potent human carbonic anhydrase IX and XII inhibitors.

  2024cites this paper
• Preclinical and pilot clinical evaluation of a small-molecule carbonic anhydrase IX targeting PET tracer in clear cell renal cell carcinoma

  2023cites this paper
• Nourishing Yin and moistening dryness formula inhibits colon cell apoptosis via activating the PI3K/AKT signaling pathway to ameliorate Yin-deficiency constipation in mice

  2023cites this paper
• The relationship between carbonic anhydrase IX (CAIX) and patient survival in breast cancer: systematic review and meta-analysis

  2023cites this paper
• Carbonic Anhydrases in Metazoan Model Organisms: Molecules, Mechanisms, and Physiology.

  2022cites this paper
• General conclusions and future perspectives

  2022cites this paper
• GLUT3/SLC2A3 Is an Endogenous Marker of Hypoxia in Prostate Cancer Cell Lines and Patient-Derived Xenograft Tumors

  2022cites this paper
• OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis

  2022cites this paper
• Primary Duodenal Adenocarcinoma Expressing Carbonic Anhydrase IX

  2022cites this paper
• Carbonic Anhydrase Isozymes as Diagnostic Biomarkers and Therapeutic Targets

  2021cites this paper
• Carbonic anhydrase XII inhibition overcomes P-glycoprotein-mediated drug resistance: a potential new combination therapy in cancer

  2021cites this paper
• Carbonic anhydrase IX: a regulator of pH and participant in carcinogenesis

  2021cites this paper
• Immunohistochemical localization of carbonic anhydrase IV in the human parotid gland

  2021cites this paper
• Design, synthesis, and biological evaluation of selective hCA IX inhibitors

  2021cites this paper
• Dual-targeting vaccine of FGL1/CAIX exhibits potent anti-tumor activity by activating DC-mediated multi-functional CD8 T cell immunity

  2021cites this paper
• Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

  2021cites this paper
• The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

  2021cites this paper
• Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX

  2021cites this paper
• Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer’s Disease and Stroke

  2021cites this paper
• Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.

  2021cites this paper
• Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma

  2021cites this paper
• CA9 Silencing Promotes Mitochondrial Biogenesis, Increases Putrescine Toxicity and Decreases Cell Motility to Suppress ccRCC Progression

  2020cites this paper
• Microsecond Simulation of the Proteoglycan-like Region of Carbonic Anhydrase IX and Design of Chemical Inhibitors Targeting pH Homeostasis in Cancer Cells

  2020cites this paper
• Fundamentals of Bicarbonate Secretion in Epithelia

  2020cites this paper
• How and Why Are Cancers Acidic? Carbonic Anhydrase IX and the Homeostatic Control of Tumour Extracellular pH

  2020cites this paper
• Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness

  2020cites this paper
• Inhibitor–Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms

  2019cites this paper
• Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles

  2019cites this paper
• Function of ion transporters in maintaining acid-base homeostasis of the mammary gland and the pathophysiological role in breast cancer.

  2019cites this paper
• Comparative evaluation of affibody- and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts

  2019cites this paper
• Carbonic anhydrase IX and acid transport in cancer

  2019cites this paper
• Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one

  2018cites this paper
• Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers.

  2018cites this paper
• Carbonic anhydrase IX Carbonic anhydrase

  2018cites this paper
• Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

  2018cites this paper
• Different expression patterns of carbonic anhydrase IX in oral lichen planus and leukoplakia.

  2018cites this paper
• Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.

  2018cites this paper
• Hypoxia-targeted gold nanorods for cancer photothermal therapy

  2018cites this paper
• UFH-001 cells: A novel triple negative, CAIX-positive, human breast cancer model system

  2018cites this paper
• Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells

  2018cites this paper
• Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.

  2017cites this paper
• Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX

  2017cites this paper
• Cell-surface marker discovery for lung cancer

  2017cites this paper
• GdmCl-induced unfolding studies of human carbonic anhydrase IX: a combined spectroscopic and MD simulation approach

  2017cites this paper
• Hexokinase II expression is correlated with colorectal cancer prognosis

  2016cites this paper
• A 99mTc-Labeled Ligand of Carbonic Anhydrase IX Selectively Targets Renal Cell Carcinoma In Vivo

  2016cites this paper
• Comparative Evaluation of Affibody Molecules for Radionuclide Imaging of in Vivo Expression of Carbonic Anhydrase IX.

  2016cites this paper
• Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium.

  2016cites this paper
• Targeting tumour microenvironment : development of carbonic anhydrase IX nuclear imaging agents

  2016cites this paper
• A technetium 99 m-labeled ligand of carbonic anhydrase IX selectively targets renal cell carcinoma in vivo

  2016cites this paper
• Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer

  2016cites this paper
• Stromal Cells of Cerebellar Hemangioblastomas Express Carbonic Anhydrase IX

  2015cites this paper
• Hypoxia and Prostate Cancer Aggressiveness: A Tale With Many Endings.

  2015cites this paper
• CA9 overexpression is an independent favorable prognostic marker in intrahepatic cholangiocarcinoma.

  2015cites this paper
• Targeting Carbonic Anhydrase IX Activity and Expression

  2015cites this paper
• Next revolution in molecular theranostics: personalized medicine for urologic cancers.

  2015cites this paper
• Correlation of carbonic anhydrase IX expression with clinico-morphological parameters, hormonal receptor status and HER-2 expression in breast cancer.

  2015cites this paper
• Advances in Anti-Cancer Drug Development Targeting Carbonic Anhydrase IX and XII.

  2015cites this paper
• Tumor-Associated Carbonic Anhydrases IX and XII

  2015cites this paper
• Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo

  2015cites this paper
• An exploratory biomarker study in metastatic tumors from colorectal cancer patients treated with bevacizumab

  2015influential citation
• Trimeric Radiofluorinated Sulfonamide Derivatives to Achieve In Vivo Selectivity for Carbonic Anhydrase IX–Targeted PET Imaging

  2015cites this paper
• Biological significance of Carbonic Anhydrase IX in ovarian cancer

  2015cites this paper
• Carbonic anhydrase IX: a promising diagnostic and prognostic biomarker in breast carcinoma.

  2014cites this paper
• Expression of Carbonic Anhydrases II, IX and XII in the Normal Female Reproductive Tract, Gynecological Tumors and Lynch Syndrome

  2014cites this paper
• Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers

  2014cites this paper
• Carbonic Anhydrase IX: From Biology to Therapy

  2014cites this paper
• Carbonic anhydrase inhibitors. Synthesis, and molecular structure of novel series N-substituted N'-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)guanidines and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.

  2014cites this paper
• Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor

  2014cites this paper
• DIE EFFEKTE DER CARBOANHYDRASE IX-INHIBITION AUF DIE CHEMO- UND STRAHLENSENSIBILITÄT VON GLIOBLASTOMZELLEN

  2014cites this paper
• The Potential of Liposomes with Carbonic Anhydrase IX to Deliver Anticancer Ingredients to Cancer Cells in Vivo

  2014cites this paper
• Physiological functions of the alpha class of carbonic anhydrases.

  2014cites this paper
• Carbonic Anhydrase IX in Adult and Pediatric Brain Tumors

  2013influential citation
• Screening of a Novel Peptide Targeting the Proteoglycan-Like Region of Human Carbonic Anhydrase IX

  2013cites this paper
• miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis

  2013cites this paper
• Role of vaccine therapy for renal cell carcinoma in the era of targeted therapy

  2013cites this paper
• Expression of carbonic anhydrase in the fetal eye and extra-ocular tissues.

  2013cites this paper
• Functional Cftr in crypt epithelium of organotypic enteroid cultures from murine small intestine.

  2012cites this paper
• Chapter 48 – Gastroduodenal Bicarbonate Secretion

  2012cites this paper
• Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics

  2012cites this paper
• Carbonic anhydrase IX as a target for designing novel anticancer drugs.

  2012cites this paper
• Role of zinc in catalytic activity of carbonic anhydrase IX.

  2012cites this paper
• In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia

  2012cites this paper
• Carbonic anhydrase isozymes II, IX, and XII in uterine tumors

  2012cites this paper
• Astrocytic Tumors: Role of Carbonic Anhydrase IX

  2012cites this paper
• Therapeutic Mechanism and Efficacy of the Antibody–Drug Conjugate BAY 79-4620 Targeting Human Carbonic Anhydrase 9

  2011cites this paper
• The prognostic relevance of tumor hypoxia markers in resected carcinoma of the gallbladder.

  2011cites this paper
• Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.

  2011cites this paper
• Vaccination therapy in renal cell carcinoma: current position and future options in metastatic and localized disease

  2011cites this paper
• Nucleologenesis and Embryonic Genome Activation are Defective in Interspecies Cloned Embryos Between Bovine Ooplasm and Rhesus Monkey Somatic Cells

  2011cites this paper
• Karbonická anhydráza IX (CA IX) a její exprese u adenokarcinomu ledviny a uroteliálních nádorů močového měchýře

  2011cites this paper
• Carbonic anhydrase IX (CA IX)expression in renal cell carcinoma and transitional cell carcinoma of urinary tract

  2011cites this paper
• Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells.

  2011cites this paper