Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Hepatology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jhep.2008.07.036PMID 19008011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice.

  2008cited by this paper
• Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.

  2008cited by this paper
• Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis.

  2007cited by this paper
• Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress

  2007cited by this paper
• Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma.

  2007cited by this paper
• Fatty acid synthase and cancer: new application of an old pathway.

  2006cited by this paper
• Nuclear factor-κB and liver carcinogenesis

  2005cited by this paper
• Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.

  2005cited by this paper
• Steatosis: Co‐factor in other liver diseases

  2005cited by this paper
• Hepatitis B virus pre‐S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes

  2005cited by this paper
• Differential gene alteration among hepatoma cell lines demonstrated by cDNA microarray-based comparative genomic hybridization.

  2005cited by this paper
• Nuclear factor-kappaB and liver carcinogenesis.

  2005cited by this paper
• Molecular Mechanisms of Hepatocarcinogenesis in Transgenic Mouse Models of Liver Cancer

  2005cited by this paper
• Primary liver cancer: worldwide incidence and trends.

  2004cited by this paper
• Genome-scale profiling of gene expression in hepatocellular carcinoma: classification, survival prediction, and identification of therapeutic targets.

  2004cited by this paper
• Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma.

  2004cited by this paper
• Steatosis and liver cell apoptosis in chronic hepatitis C: A mechanism for increased liver injury

  2004cited by this paper
• An update on the molecular genetics of hepatocellular carcinoma.

  2004cited by this paper
• Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP‐1 suppression

  2003cited by this paper
• Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53.

  2003cited by this paper
• Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.

  2003cited by this paper
• Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection

  2003cited by this paper
• SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

  2002cited by this paper
• Molecular pathogenesis of human hepatocellular carcinoma

  2002cited by this paper
• Ethanol Induces Fatty Acid Synthesis Pathways by Activation of Sterol Regulatory Element-binding Protein (SREBP)*

  2002cited by this paper
• NAFLD may be a common underlying liver disease in patients with hepatocellular Carcinoma in the United States

  2002cited by this paper
• Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.

  2002cited by this paper
• Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus

  2002cited by this paper
• Molecular pathogenesis of human hepatocellular carcinoma.

  2002cited by this paper
• Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.

  2002cited by this paper
• SREBP‐1: Gene Regulatory Key to Syndrome X?

  2002cited by this paper
• Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method.

  2002cited by this paper
• [Serial analysis of gene expression].

  2002cited by this paper
• Serial analysis of gene expression in chronic hepatitis C and hepatocellular carcinoma.

  2001cited by this paper
• Expression profiling suggested a regulatory role of liver-enriched transcription factors in human hepatocellular carcinoma.

  2001cited by this paper
• Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression.

  2001cited by this paper
• Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver

  2001cited by this paper
• Comprehensive gene expression profile of a normal human liver.

  2000cited by this paper
• Rising incidence of hepatocellular carcinoma in the United States.

  1999cited by this paper
• Hepatocellular carcinoma: surgical treatment and prognostic variables in 56 patients.

  1999cited by this paper
• Rising Incidence of Hepatocellular Carcinoma in the United States

  1999cited by this paper
• A model for p53-induced apoptosis

  1997cited by this paper
• Serial Analysis of Gene Expression

  1995cited by this paper
• Classification of chronic hepatitis: Diagnosis, grading and staging

  1994influential reference
• SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.

  1993influential reference
• Identification of Differentially Expressed Genes in Hepatocellular Carcinoma With cDNA Microarrays

  year unknowncited by this paper

• Validation of signature molecular profiles of advanced HCV liver disease in hepatocellular carcinoma patients

  2025cites this paper
• MARCH8 suppresses hepatocellular carcinoma by promoting SREBP1 degradation and modulating fatty acid de novo synthesis

  2025cites this paper
• Lipogenesis and MASLD: re-thinking the role of SREBPs

  2025cites this paper
• Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

  2025cites this paper
• Enhancing doxorubicin’s anticancer impact in colorectal cancer by targeting the Akt/Gsk3β/mTOR-SREBP1 signaling axis with an HDAC inhibitor

  2025cites this paper
• Hepatic Deletion of Carbohydrate Response Element Binding Protein Impairs Hepatocarcinogenesis in a High-Fat Diet-Induced Mouse Model

  2025cites this paper
• Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications

  2025cites this paper
• Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers

  2025cites this paper
• The impact of exercise on the role of lipid droplets in maintaining health: a narrative review

  2025cites this paper
• MicroRNA-Mediated Metabolic Control in HCC: From Molecular Networks to Therapy.

  2025cites this paper
• Role of lipid metabolism in hepatocellular carcinoma

  2024cites this paper
• Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin

  2024cites this paper
• Molecular Genealogy of Metabolic-associated Hepatocellular Carcinoma

  2024influential citation
• Apigenin Suppresses MED28-Mediated Cell Growth in Human Liver Cancer Cells.

  2024cites this paper
• Sirt6 ablation in the liver causes fatty liver that increases cancer risk by upregulating Serpina12

  2024cites this paper
• Histone Lactylation-Driven YTHDC1 Promotes Hepatocellular Carcinoma Progression via Lipid Metabolism Remodeling.

  2024cites this paper
• Maternal infection with SARS‐CoV‐2 during early pregnancy induces hypoxia at the maternal–fetal interface

  2024cites this paper
• Application of galactosylated albumin for targeted delivery of triptolide to suppress hepatocellular carcinoma progression through inhibiting de novo lipogenesis.

  2024cites this paper
• Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model

  2024cites this paper
• Clinical pathological significance and biological function of PLIN1 in hepatocellular carcinoma: bioinformatics analysis and in vitro experiments

  2024cites this paper
• Aurantio-obtusin regulates lipogenesis and ferroptosis of liver cancer cells through inhibiting SCD1 and sensitizing RSL3

  2024cites this paper
• Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27KIP1 Regulation

  2024cites this paper
• Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response.

  2024cites this paper
• Hypoxia-induced SKA3 promoted cholangiocarcinoma progression and chemoresistance by enhancing fatty acid synthesis via the regulation of PAR-dependent HIF-1a deubiquitylation

  2023cites this paper
• Preoperative prediction of Ki-67 expression in hepatocellular carcinoma by spectral imaging on dual-energy computed tomography (DECT)

  2023cites this paper
• Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation

  2023cites this paper
• Regulation and targeting of SREBP-1 in hepatocellular carcinoma

  2023cites this paper
• Meeting at the Crossroad between Obesity and Hepatic Carcinogenesis: Unique Pathophysiological Pathways Raise Expectations for Innovative Therapeutic Approaches

  2023cites this paper
• Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development

  2023cites this paper
• Therapeutically targeting essential metabolites to improve immunometabolism manipulation after liver transplantation for hepatocellular carcinoma

  2023cites this paper
• Metabolic Reprogramming of HCC: A New Microenvironment for Immune Responses

  2023cites this paper
• Location matters: Cellular heterogeneity in the hepatic lobule and hepatocellular carcinoma.

  2023cites this paper
• Bufalin Inhibits Tumorigenesis and SREBP-1-Mediated Lipogenesis in Hepatocellular Carcinoma via Modulating the ATP1A1/CA2 Axis.

  2023cites this paper
• Metabolic reprogramming and its clinical implication for liver cancer

  2023cites this paper
• Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma

  2022cites this paper
• The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation

  2022influential citation
• Metabolomics profiling of AKT/c-Met-induced hepatocellular carcinogenesis and the inhibitory effect of Cucurbitacin B in mice

  2022cites this paper
• A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression

  2022cites this paper
• Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation

  2022cites this paper
• Integrated analysis to study the interplay between post-translational modifications (PTM) in hepatitis C virus proteins and hepatocellular carcinoma (HCC) development

  2022cites this paper
• Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner

  2022cites this paper
• Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers

  2022cites this paper
• Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways

  2021cites this paper
• The immunological and metabolic landscape in primary and metastatic liver cancer

  2021cites this paper
• Role of Lipogenesis Rewiring in Hepatocellular Carcinoma

  2021cites this paper
• Lipid metabolism in cancer: A systematic review

  2021influential citation
• EXPLORING THE ROLE OF LIPID METABOLISM IN HEPATOCELLULAR CARCINOMA

  2021cites this paper
• Understanding the Role of Perilipin 5 in Non-Alcoholic Fatty Liver Disease and Its Role in Hepatocellular Carcinoma: A Review of Novel Insights

  2021cites this paper
• Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC

  2021cites this paper
• Genetic variants associated with expression of TCF19 contribute to the risk of head and neck cancer in Chinese population

  2021cites this paper
• Liver cancer stem cells: Recent progress in basic and clinical research

  2021cites this paper
• SPARC inhibition accelerates NAFLD‐associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism

  2021cites this paper
• Lipid Droplets and Their Interactions with Other Organelles in Liver Diseases.

  2021cites this paper
• inhibition accelerates NAFLD-associated

  2021cites this paper
• Novel Insight Into the Association Between Obesity and Hepatocellular Carcinoma Occurrence and Recurrence: High-Throughput Microarray Data Set Analysis of Differentially Expressed Genes.

  2021cites this paper
• Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing Nonalcoholic Fatty Liver Disease in Diabetes Mellitus

  2021cites this paper
• BNIP3 attenuates hepatocellular carcinoma by promoting lipid droplet turnover at the lysosome.

  2021cites this paper
• Hormonally Induced Hepatocellular Carcinoma in Diabetic Wild Type and Carbohydrate Responsive Element Binding Protein Knockout Mice

  2021influential citation
• Hepatocellular carcinoma in the context of non-alcoholic steatohepatitis (NASH): recent advances in the pathogenic mechanisms

  2020cites this paper
• Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: A review

  2020cites this paper
• Dietary cholesterol promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice

  2020cites this paper
• BMP9‐ID1 signaling promotes EpCAM‐positive cancer stem cell properties in hepatocellular carcinoma

  2020cites this paper
• ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway.

  2020cites this paper
• Epidemiology, Pathogenesis, Diagnosis and Emerging Treatment of Nonalcoholic Fatty Liver Disease.

  2020cites this paper
• Clinicopathological features of hepatocellular carcinoma with fatty change: Tumors with macrovesicular steatosis have better prognosis and aberrant expression patterns of perilipin and adipophilin

  2020cites this paper
• Effects of LRP1B Regulated by HSF1 on Lipid Metabolism in Hepatocellular Carcinoma

  2020cites this paper
• Identification of diagnostic and prognostic biomarkers, and candidate targeted agents for hepatitis B virus-associated early stage hepatocellular carcinoma based on RNA-sequencing data

  2020cites this paper
• Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma

  2020cites this paper
• The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer

  2020influential citation
• Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish

  2020cites this paper
• Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview

  2019cites this paper
• Perilipin 5 and Lipocalin 2 Expression in Hepatocellular Carcinoma

  2019cites this paper
• Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression

  2019cites this paper
• A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice

  2019cites this paper
• Decreased expression of ApoF associates with poor prognosis in human hepatocellular carcinoma

  2019cites this paper
• Mito-Nuclear Communication in Hepatocellular Carcinoma Metabolic Rewiring

  2019cites this paper
• Differentiation of hepatocellular carcinoma from non-hepatocellular malignant tumours of liver by chemical-shift MRI at 3 T.

  2019cites this paper
• Hepatocellular Carcinoma: Translational Precision Medicine Approaches

  2019cites this paper
• mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma

  2019cites this paper
• Prevention Strategies for Hepatocellular Carcinoma

  2019cites this paper
• Specific diacylglycerols generated by hepatic lipogenesis stimulate the oncogenic androgen receptor activity in male hepatocytes

  2019cites this paper
• mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico

  2019cites this paper
• Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation

  2019cites this paper
• Progressive and Prognosis Role of Lipogenic Pathway in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

  2019cites this paper
• Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma

  2019cites this paper
• SREBF1 (sterol regulatory element binding transcription factor 1)

  2019cites this paper
• Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities

  2018cites this paper
• Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression

  2018cites this paper
• Lipid Metabolic Reprogramming in Hepatocellular Carcinoma

  2018cites this paper
• Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

  2018influential citation
• Novel Mechanism of Nonalcoholic Lipid Accumulation Promoting Malignant Transformation of Hepatocytes

  2018cites this paper
• Pyruvate kinase M2 interacts with nuclear sterol regulatory element–binding protein 1a and thereby activates lipogenesis and cell proliferation in hepatocellular carcinoma

  2018cites this paper
• Ganoderma tsugae Inhibits the SREBP-1/AR Axis Leading to Suppression of Cell Growth and Activation of Apoptosis in Prostate Cancer Cells

  2018cites this paper
• Narrower insight to SIRT1 role in cancer: A potential therapeutic target to control epithelial–mesenchymal transition in cancer cells

  2018cites this paper
• Molecular Mechanisms of Hepatocarcinogenesis Following Sustained Virological Response in Patients with Chronic Hepatitis C Virus Infection

  2018cites this paper
• Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma

  2018cites this paper
• Development of hepatocellular cancer induced by long term low fat-high carbohydrate diet in a nafld/nash mouse model.

  2017cites this paper
• TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway

  2017cites this paper
• Roles of Perilipins in Diseases and Cancers

  2017cites this paper
• Molecular basis of hepatocellular carcinoma induced by hepatitis C virus infection

  2017cites this paper