Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Neurochemistry

• Publication date

  1993-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.1993.tb07480.xPMID 8245987
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Pathology of Alzheimer's Disease

  2013cited by this paper
• Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

  1994cited by this paper
• Amyloidogenicity of rodent and human beta A4 sequences.

  1993cited by this paper
• β2‐Microglobulin Amyloidosis: An Overview

  1993cited by this paper
• Amyloidogenicity of rodent and human βA4 sequences

  1993cited by this paper
• Neurotoxicity of a prion protein fragment

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• Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

  1993cited by this paper
• Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

  1993cited by this paper
• Methodological variables in the assessment of beta amyloid neurotoxicity.

  1992cited by this paper
• β-amyloid peptide in vitro toxicity: Lot-to-lot variability

  1992cited by this paper
• beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

  1992cited by this paper
• Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.

  1992cited by this paper
• Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.

  1992cited by this paper
• Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.

  1992cited by this paper
• Promotion of beta-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine.

  1992cited by this paper
• Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides.

  1992cited by this paper
• Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures.

  1991cited by this paper
• The molecular pathology of Alzheimer's disease.

  1991cited by this paper
• Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4.

  1991cited by this paper
• Syntheses, structures and anorectic effects of human and rat amylin.

  1991cited by this paper
• Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis.

  1991cited by this paper
• Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

  1990influential reference
• Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.

  1990cited by this paper
• Isolation and sequence determination of rat islet amyloid polypeptide.

  1989cited by this paper
• Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

  1988cited by this paper
• Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.

  1987cited by this paper
• Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

  1987cited by this paper

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  2021cites this paper
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• Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP.

  2018cites this paper
• Familial Cardiac Amyloidoses

  2018cites this paper
• Pancreatic islet dysfunction in type 2 diabetes mellitus

  2018cites this paper
• The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins

  2017cites this paper
• Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease.

  2017cites this paper
• Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease

  2017cites this paper
• Amylin Receptor: A Potential Therapeutic Target for Alzheimer's Disease.

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• Transfection of Cultured Primary Neurons

  2017cites this paper
• Multiple target of hAmylin on rat primary hippocampal neurons

  2017cites this paper
• Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease

  2016cites this paper
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  2016cites this paper
• Investigation of strategies to ameliorate beta-amyloid mediated deficits in hippocampus-dependent synaptic plasticity

  2016cites this paper
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  2015cites this paper
• Polymorphic cross-seeding amyloid assemblies of amyloid-β and human islet amyloid polypeptide.

  2015cites this paper
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  2015cites this paper
• Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition.

  2014cites this paper
• Role of amylin and its receptors in neurodegeneration.

  2013cites this paper
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  2013cites this paper
• Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Alzheimer's Disease and Diabetes: An Integrative View of the Role of Mitochondria, Oxidative Stress, and Insulin

  2012cites this paper
• Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain

  2012cites this paper
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  2012cites this paper
• Actions of -Amyloid Protein on Human Neurons Are Expressed through the Amylin Receptor

  2010cites this paper
• Calcium dyshomeostasis and neurotoxicity of Alzheimer’s β-amyloid protein

  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2007cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
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  2000cites this paper
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• Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

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• Amyloidogenicity of recombinant human pro-islet amyloid polypeptide (ProIAPP).

  2000cites this paper
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  2000cites this paper
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• Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis.

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• A Unifying Hypothesis of Alzheimer's Disease. IV. Causation and Sequence of Events

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  1999cites this paper
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• Fibroblast growth factor-8 protects cultured rat hippocampal neurons from oxidative insult.

  1999cites this paper
• Characterization of 8-epiprostaglandin F2alpha as a marker of amyloid beta-peptide-induced oxidative damage.

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  1999cites this paper
• Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches.

  1999cites this paper
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  1998cites this paper
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  1998cites this paper
• Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide.

  1998cites this paper
• Transcription factor NF-kappaB: friend or foe of neurons?

  1998cites this paper
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  1998cites this paper
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