HuR, an RNA-binding protein, involved in the control of cellular differentiation.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  In Vivo

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 16433023
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An early event in adipogenesis, the nuclear selection of the CCAAT enhancer-binding protein {beta} (C/EBP{beta}) mRNA by HuR and its translocation to the cytosol.

  2005cited by this paper
• An Early Event in Adipogenesis, the Nuclear Selection of the CCAAT Enhancer-binding Protein β (C/EBPβ) mRNA by HuR and its Translocation to the Cytosol*

  2005cited by this paper
• Sequential phosphorylation of CCAAT enhancer-binding protein β by MAPK and glycogen synthase kinase 3β is required for adipogenesis

  2005cited by this paper
• The RNA-binding protein HuD regulates neuronal cell identity and maturation.

  2005cited by this paper
• Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis.

  2005cited by this paper
• Structural organization of mouse peroxisome proliferator-activated receptor y ( mPPARy ) gene : Alternative promoter use and different splicing yield two mPPARy isoforms ( peroxisome proliferation / nuclear receptor superfamily / fatty acid P-oxidation )

  2005cited by this paper
• Role of CREB in Transcriptional Regulation of CCAAT/Enhancer-binding Protein β Gene during Adipogenesis*

  2004cited by this paper
• Epidermal Growth Factor Receptor Stimulation Activates the RNA Binding Protein CUG-BP1 and Increases Expression of C/EBPβ-LIP in Mammary Epithelial Cells

  2004cited by this paper
• HuB localizes to polysomes and alters C/EBP-β expression in 3T3-L1 adipocytes

  2004cited by this paper
• Epidermal growth factor receptor stimulation activates the RNA binding protein CUG-BP1 and increases expression of C/EBPbeta-LIP in mammary epithelial cells.

  2004cited by this paper
• Identification of a target RNA motif for RNA-binding protein HuR.

  2004cited by this paper
• HuB localizes to polysomes and alters C/EBP-beta expression in 3T3-L1 adipocytes.

  2004cited by this paper
• Rb regulates C/EBPbeta-DNA-binding activity during 3T3-L1 adipogenesis.

  2004cited by this paper
• The 3′-Untranslated Region of p21WAF1 mRNA Is a Composite cis-Acting Sequence Bound by RNA-binding Proteins from Breast Cancer Cells, Including HuR and Poly(C)-binding Protein*

  2003cited by this paper
• Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes

  2003cited by this paper
• Increased AMP:ATP Ratio and AMP-activated Protein Kinase Activity during Cellular Senescence Linked to Reduced HuR Function*

  2003cited by this paper
• CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis.

  2003cited by this paper
• RNAi-mediated HuR Depletion Leads to the Inhibition of Muscle Cell Differentiation*

  2003cited by this paper
• CCAAT/enhancer-binding proteins: structure, function and regulation.

  2002cited by this paper
• ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

  2002cited by this paper
• Lipopolysaccharide-induced Methylation of HuR, an mRNA-stabilizing Protein, by CARM1*

  2002cited by this paper
• UBA1 and UBA2, Two Proteins That Interact with UBP1, a Multifunctional Effector of Pre-mRNA Maturation in Plants

  2002cited by this paper
• Nucleocytoplasmic transport: cargo trafficking across the border.

  2002cited by this paper
• AMP-Activated Kinase Regulates Cytoplasmic HuR

  2002cited by this paper
• A 40-bp RNA Element That Mediates Stabilization of Vascular Endothelial Growth Factor mRNA by HuR*

  2002cited by this paper
• Messenger-RNA-binding proteins and the messages they carry

  2002cited by this paper
• Calreticulin Interacts with C/EBPα and C/EBPβ mRNAs and Represses Translation of C/EBP Proteins

  2002cited by this paper
• Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins.

  2002cited by this paper
• Decreased activity and enhanced nuclear export of CCAAT-enhancer-binding protein beta during inhibition of adipogenesis by ceramide.

  2002cited by this paper
• A conserved mRNA export machinery coupled to pre-mRNA splicing.

  2002cited by this paper
• HuR binds a cyclic nucleotide‐dependent, stabilizing domain in the 3′ untranslated region of Na+/glucose cotransporter (SGLT1) mRNA

  2001cited by this paper
• The effects of AICAR on adipocyte differentiation of 3T3-L1 cells.

  2001cited by this paper
• Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells.

  2001cited by this paper
• Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

  2001cited by this paper
• The 3′ Untranslated Region of Tumor Necrosis Factor Alpha mRNA Is a Target of the mRNA-Stabilizing Factor HuR

  2001cited by this paper
• Agonist-mediated down-regulation of rat beta1-adrenergic receptor transcripts: role of potential post-transcriptional degradation factors.

  2001cited by this paper
• PPAR gamma: an essential role in metabolic control.

  2001cited by this paper
• Delineation of mRNA Export Pathways by the Use of Cell-Permeable Peptides

  2001cited by this paper
• Functional diversity of hnRNP proteins.

  2001cited by this paper
• Functional diversity of hnRNP proteins.

  2001cited by this paper
• Diabetes: Dialogue between muscle and fat

  2001cited by this paper
• Translational control of C/EBP (cid:1) and C/EBP (cid:2) isoform expression

  2000cited by this paper
• Transcriptional regulation of adipogenesis.

  2000cited by this paper
• Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

  2000cited by this paper
• HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

  2000cited by this paper
• Analysis of the 5' end of the mouse Elavl1 (mHuA) gene reveals a transcriptional regulatory element and evidence for conserved genomic organization.

  2000cited by this paper
• A U-Rich Element in the 5′ Untranslated Region Is Necessary for the Translation of p27 mRNA

  2000cited by this paper
• HuR binding to cytoplasmic mRNA is perturbed by heat shock.

  2000cited by this paper
• α1 Adrenergic Agonist Induction of p21 waf1/cip1 mRNA Stability in Transfected HepG2 Cells Correlates with the Increased Binding of an AU-rich Element Binding Factor*

  2000cited by this paper
• ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells.

  1999cited by this paper
• Why is Hu where? Shuttling of early-response-gene messenger RNA subsets.

  1999cited by this paper
• Repressive Effect of Sp1 on the C/EBPα Gene Promoter: Role in Adipocyte Differentiation

  1999cited by this paper
• Role of PPARγ in Regulating a Cascade Expression of Cyclin-dependent Kinase Inhibitors, p18(INK4c) and p21(Waf1/Cip1), during Adipogenesis*

  1999cited by this paper
• Cytoplasmic localization is required for the mammalian ELAV‐like protein HuD to induce neuronal differentiation

  1999cited by this paper
• Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems.

  1999cited by this paper
• Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation.

  1999cited by this paper
• Role of calpain in adipocyte differentiation.

  1999cited by this paper
• RNA stabilization by the AU‐rich element binding protein, HuR, an ELAV protein

  1998cited by this paper
• Overexpression of HuR, a nuclear–cytoplasmic shuttling protein, increases the in vivo stability of ARE‐containing mRNAs

  1998cited by this paper
• Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR*

  1998cited by this paper
• The Role of C/EBP Genes in Adipocyte Differentiation*

  1998cited by this paper
• HNS, a nuclear-cytoplasmic shuttling sequence in HuR.

  1998cited by this paper
• Identification of HuR as a protein implicated in AUUUA‐mediated mRNA decay

  1997cited by this paper
• CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma 2 promoter.

  1997cited by this paper
• Adipocyte differentiation and leptin expression.

  1997cited by this paper
• RNA-binding proteins as regulators of gene expression.

  1997cited by this paper
• Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes

  1997cited by this paper
• Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells.

  1996cited by this paper
• Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: Implications for nutrient partitioning

  1996cited by this paper
• Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein (*)

  1996cited by this paper
• The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolism

  1996cited by this paper
• Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

  1995cited by this paper
• Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.

  1995cited by this paper
• Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

  1993cited by this paper
• CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.

  1991cited by this paper
• The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs.

  1988cited by this paper
• A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.

  1986cited by this paper
• Mutant alleles at the locus elav in Drosophila melanogaster lead to nervous system defects. A developmental-genetic analysis.

  1985cited by this paper
• Cytological and enzymological characterization of adult human adipocyte precursors in culture.

  1976cited by this paper

• Role of DNMT3a Expression and Nuclear Translocation under ELAVL1 mediation for Dendritic Cell Function and Th17/Treg Balance in COPD.

  2025cites this paper
• SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

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• Analysis of RNA Interference Targeted Against Human Antigen R (HuR) to Reduce Vascular Endothelial Growth Factor (VEGF) Protein Expression in Human Retinal Pigment Epithelial Cells

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• Necessity of HuR/ELAVL1 for activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification.

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• Long Noncoding RNA HAFML Promotes Migration and Invasion of Rheumatoid Fibroblast-like Synoviocytes.

  2022cites this paper
• The Role of E3 Ligase Pirh2 in Disease

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• Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors

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• Long Noncoding RNA SCIRT Promotes HUVEC Angiogenesis via Stabilizing VEGFA mRNA Induced by Hypoxia

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• HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models.

  2021cites this paper
• The RNA-binding protein HuR is a negative regulator in adipogenesis

  2020cites this paper
• Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

  2017cites this paper
• Role of post‐transcriptional regulation of mRNA stability in renal pathophysiology: focus on chronic kidney disease

  2017cites this paper
• Posttranslational control of HuR function

  2017cites this paper
• A HuR/TGF-β1 feedback circuit regulates airway remodeling in airway smooth muscle cells

  2016cites this paper
• HuR and TIA1/TIAL1 Are Involved in Regulation of Alternative Splicing of SIRT1 Pre-mRNA

  2014cites this paper
• The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

  2014cites this paper
• A single element in the 3'UTR of the apical sodium-dependent bile acid transporter controls both stabilization and destabilization of mRNA.

  2014cites this paper
• HuR Function and Translational State Analysis Following Global Brain Ischemia and Reperfusion

  2013cites this paper
• Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases.

  2012cites this paper
• Insights from the HuR-interacting transcriptome: ncRNAs, ubiquitin pathways, and patterns of secondary structure dependent RNA interactions

  2012cites this paper
• RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility.

  2012cites this paper
• Post‐transcriptional regulation of the Ras‐ERK/MAPK signaling pathway

  2012cites this paper
• A conserved TGFβ1/HuR feedback circuit regulates the fibrogenic response in fibroblasts.

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• Hu antigen R and tristetraprolin: Counter‐regulators of rat apical sodium‐dependent bile acid transporter by way of effects on messenger RNA stability

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• Dephosphorylated NSSR1 Is Induced by Androgen in Mouse Epididymis and Phosphorylated NSSR1 Is Increased during Sperm Maturation

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• Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression.

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• MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease.

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• Mechanisms of persistent translation arrest following global brain ischemia & reperfusion

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• RNA-binding protein HuR regulates RGS4 mRNA stability in rabbit colonic smooth muscle cells.

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• Fragile X protein family member FXR1P is regulated by microRNAs.

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• Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members

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• RNA-binding protein HuR regulates RGS 4 mRNA stability in rabbit colonic smooth muscle cells

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• Cold‐inducible RNA‐binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer

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• MicroRNA Implication in Cancer

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• Role of the RNA-Binding Protein HuR in Apoptosis and Apoptosome Function

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• The RNA-Binding Protein Elavl1/HuR Is Essential for Placental Branching Morphogenesis and Embryonic Development

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• A Role for the RNA binding protein Sam68 in the prevention of Obesity

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• HuR expression in the nucleus correlates with high histological grade and poor disease‐free survival in ovarian cancer

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• MicroRNA-mediated regulation and the fragile X family of proteins

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• Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion.

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• Genomic RNA profiling and the programme controlling preimplantation mammalian development

  2008cites this paper
• Diverse molecular functions of Hu proteins

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• Renal response to metabolic acidosis: role of mRNA stabilization.

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• miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

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• Posttranscriptional Orchestration of an Anti-Apoptotic Program by HuR

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• HuR binds to a single site on the C/EBPbeta mRNA of 3T3-L1 adipocytes.

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• The 3′ Untranslated Region of Sindbis Virus Represses Deadenylation of Viral Transcripts in Mosquito and Mammalian Cells

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• Stabilization of Snail by HuR in the process of hydrogen peroxide induced cell migration.

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• The regulation of glucose transporter (GLUT1) expression by the RNA binding protein HuR

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