Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Science

• Publication date

  2017-11-17

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1126/science.aam9305PMID 29025995PMCID PMC5748897
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

  2017cited by this paper
• An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues

  2017cited by this paper
• From Krebs to clinic: glutamine metabolism to cancer therapy

  2016cited by this paper
• The Emerging Hallmarks of Cancer Metabolism.

  2016cited by this paper
• Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis.

  2016cited by this paper
• Proteomic maps of breast cancer subtypes

  2016cited by this paper
• Mitochondria and Cancer.

  2016cited by this paper
• Normoxic accumulation of HIF1α is associated with glutaminolysis

  2016cited by this paper
• Ammonia toxicity: from head to toe?

  2016cited by this paper
• Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

  2016cited by this paper
• Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

  2015cited by this paper
• An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

  2015cited by this paper
• Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

  2015cited by this paper
• Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.

  2015cited by this paper
• Refining the ammonia hypothesis: a physiology-driven approach to the treatment of hepatic encephalopathy.

  2015cited by this paper
• Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites

  2014cited by this paper
• Proline metabolism and cancer: emerging links to glutamine and collagen

  2014cited by this paper
• The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases

  2013cited by this paper
• A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

  2013cited by this paper
• Ammonia toxicity to the brain

  2013cited by this paper
• Methods for long-term 17β-estradiol administration to mice.

  2012cited by this paper
• Ammonium metabolism in humans.

  2012cited by this paper
• Targeted Metabolomics

  2012cited by this paper
• Stable Isotope-Resolved Metabolomics (SIRM) in Cancer Research with Clinical Application to NonSmall Cell Lung Cancer

  2011cited by this paper
• Growth-limiting Intracellular Metabolites in Yeast Growing under Diverse Nutrient Limitations

  2010cited by this paper
• Function of human Rh based on structure of RhCG at 2.1 Å

  2010cited by this paper
• On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome.

  2010cited by this paper
• Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

  2010cited by this paper
• Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

  2010cited by this paper
• Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells

  2010cited by this paper
• Identification of small molecule inhibitors of pyruvate kinase M2.

  2010cited by this paper
• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  2009cited by this paper
• Hepatic glutamate metabolism: a tale of 2 hepatocytes.

  2009cited by this paper
• Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis.

  2008cited by this paper
• Glutamine synthetase is essential for proliferation of fetal skin fibroblasts.

  2008cited by this paper
• Ammonium-induced calcium mobilization in 1321N1 astrocytoma cells.

  2008cited by this paper
• Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

  2007cited by this paper
• Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES).

  2007cited by this paper
• Analysis of apoptosis by propidium iodide staining and flow cytometry

  2006cited by this paper
• Isolation of interstitial fluid from rat mammary tumors by a centrifugation method.

  2003cited by this paper
• Regulation of enzymes of the urea cycle and arginine metabolism.

  2002cited by this paper
• Intramitochondrial localization of alanine aminotransferase in rat-liver mitochondria: comparison with glutaminase and aspartate aminotransferase

  1995cited by this paper
• A smaller initial dose protects mice against several lethal doses of ammonium acetate.

  1990cited by this paper

• m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

  2026cites this paper
• Targeting CPS1 attenuates lung cancer metastasis by regulating EMT through an epigenetic mechanism

  2026cites this paper
• Proteomic profiling of extracellular fluids to identify secreted proteins from muscle and fat tissues.

  2026cites this paper
• Prognostic and immunological roles of ammonia-induced cell death-related genes in non-small cell lung cancer.

  2026cites this paper
• Impaired nitrogenous waste clearance promotes hepatocellular carcinoma

  2026cites this paper
• AURKA‐Driven Metabolic Rewiring in Gastric Epithelial Cells

  2026cites this paper
• Metabolic Vulnerabilities as a Therapeutic Target in Breast Cancer.

  2026cites this paper
• More than analgesia: evidence for metabolic regulation by the kappa opioid receptor in triple-negative breast cancer.

  2025cites this paper
• Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation

  2025cites this paper
• Ammonia metabolism and ammonia-induced cell death: role in cancer therapy

  2025influential citation
• Mitochondrial VHL rewires cell metabolism in hypoxia.

  2025cites this paper
• A Microalgae‐Based Dual‐Pathway Therapy for Simultaneous Ammonia Detoxification and Colorectal Cancer Suppression

  2025cites this paper
• Unveiling the role of the extracellular matrix in the osteosarcoma tumor microenvironment through integrated transcriptomics and experimental validation

  2025cites this paper
• Ammonia in cancer: dual roles and therapeutic strategies

  2025influential citation
• Ecological functions coupled with plasmid and phage-mediated dissemination drive the global prevalence of high-risk antimicrobial resistance genes in influent.

  2025cites this paper
• Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

  2025cites this paper
• A reversible smartphone-based fluorescent probe for the rapid detection of ammonia in biofluids

  2025cites this paper
• The ammonia-Slc4a11 axis in T cells alleviates LPS-induced mastitis

  2025cites this paper
• Nutrient Acquisition of Gut Microbiota: Implications for Tumor Immunity.

  2025cites this paper
• Novel roles of ammonia in physiology and cancer

  2025influential citation
• High-ammonia microenvironment promotes stemness and metastatic potential in hepatocellular carcinoma through metabolic reprogramming

  2025cites this paper
• Joint analysis of single-cell RNA sequencing and bulk transcriptome reveals the heterogeneity of the urea cycle of astrocytes in glioblastoma.

  2025cites this paper
• TCA cycle-derived oncometabolites in cancer and the immune microenvironment

  2025cites this paper
• Analysis of Metabolomic Reprogramming Induced by Infection with Kaposi’s Sarcoma-Associated Herpesvirus Using Untargeted Metabolomic Profiling

  2025cites this paper
• FOXO1-mediated argininosuccinate lyase transcription inhibits ammonia metabolism and breast cancer cell metastasis

  2025cites this paper
• Methods and Guidelines for Metabolism Studies: Applications to Cancer Research

  2025cites this paper
• Dynamic remodeling of amino acid metabolism in tumor-associated macrophages: Fueling immunosuppression, reshaping tumor niches, and unlocking metabolic checkpoints.

  2025cites this paper
• Ammonium metabolism rewiring in the prostate cancer microenvironment: Mechanisms and clinical prospects

  2025cites this paper
• Identification of SNP Markers in the Glutamate Dehydrogenase (GDH) and Aspartate Aminotransferase 2 (AST2) Associated with Ammonia Nitrogen Tolerance in Penaeus monodon

  2025influential citation
• FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancer

  2025cites this paper
• Purpurin/Indocyanine Green Nanocomposite for Restricting Glutaminolysis to Enhance Dual Phototherapy of Cancer.

  2025cites this paper
• In Situ Quantification of Ammonia in Biofluids using High-Resolution Nuclear Magnetic Resonance.

  2025cites this paper
• Consistency, distinction, and potential metabolic crosstalk of nitrogen mobilization-related genes in silk production and silk gland biology

  2025cites this paper
• ASS1 inhibits liver cancer by promoting CAD ubiquitination and reversing the urea cycle and pyrimidine synthesis imbalance

  2025cites this paper
• Amniotic membrane promotes doxorubicin potency by suppressing SH-SY5Y neuroblastoma cell angiogenesis

  2025cites this paper
• Mitochondrial proteome landscape unveils key insights into melanoma severity and treatment strategies

  2025cites this paper
• Differential aortic aneurysm formation provoked by chemogenetic oxidative stress

  2025cites this paper
• Metabolic Pathway Analysis of Tumors Using Stable Isotopes.

  2025cites this paper
• Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity.

  2025cites this paper
• Ammonia as a critical metabolic modulator of anti-tumor immunity

  2025cites this paper
• Reprogramming the breast tumor immune microenvironment: cold-to-hot transition for enhanced immunotherapy

  2025cites this paper
• Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin

  2025cites this paper
• Emerging insights into the impact of systemic metabolic changes on tumor-immune interactions.

  2025cites this paper
• Ammonia‐Induced Cell Death: A Novel Frontier to Enhance Cancer Immunotherapy

  2025cites this paper
• Arginine: at the crossroads of nitrogen metabolism

  2025cites this paper
• A Review of Metabolic Reprogramming in Cancer

  2025cites this paper
• Metabolic biomarker in oral squamous cell carcinoma – a comprehensive review

  2025cites this paper
• Ginseng Berry Concentrate Promotes a Metabolic Shift From Anaerobic Glycolysis to Aerobic Mitochondrial Metabolism in C2C12 Myocytes

  2025cites this paper
• Gut microbiota and host transcriptome interactions reveal diagnostic biomarkers in MASLD-associated hepatocellular carcinoma

  2025cites this paper
• Rhein Inhibits Microglia-Mediated Neuroinflammation and Neuronal Damage of Alzheimer’s Disease via Regulating the Glutamine–Aspartate–Arginine–NO Metabolic Pathway

  2025cites this paper
• Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies

  2025cites this paper
• The impact of p53 on the urea cycle and nitrogen metabolism enzymes: Mechanisms and implications for cancer development.

  2025cites this paper
• Cellular metabolism biosensing: From extracellular microenvironment to intracellular physiology monitoring.

  2025cites this paper
• L-5-[11C]-glutamine PET of breast cancer: Preclinical studies in mouse models.

  2025cites this paper
• Lifting the veil on tumor metabolism: A GDH1-focused perspective

  2025influential citation
• Glutamine synthetase shields triple-negative breast cancer cells from ferroptosis in metastasis triggered by glutamine deprivation

  2025cites this paper
• The differential regulation of the urea cycle in tumors goes awry.

  2025cites this paper
• Theoretical study of Cu-IIIA binary alloy catalysts for electrochemical nitrate reduction to ammonia.

  2025cites this paper
• The roles of arginases and arginine in immunity

  2024cites this paper
• KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1

  2024cites this paper
• Identifying metabolic limitations in the tumor microenvironment

  2024cites this paper
• Glutamate Transport Proteins and Metabolic Enzymes are Poor Prognostic Factors in Invasive Lobular Carcinoma

  2024cites this paper
• An SLC12A9-dependent ion transport mechanism maintains lysosomal osmolarity.

  2024cites this paper
• Metabolic ripple effects – deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment

  2024cites this paper
• Microbiota and detrimental protein derived metabolites in colorectal cancer.

  2024cites this paper
• Overexpression of SLC2A1, ALDOC, and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids

  2024cites this paper
• GDH1-catalytic glutaminolysis feedback activate EGFR/PI3K/AKT pathway and reprogram glioblastoma metabolism.

  2024cites this paper
• Low extracellular pH protects cancer cells from ammonia toxicity

  2024cites this paper
• SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma

  2024cites this paper
• Glutamine Metabolism and Prostate Cancer

  2024cites this paper
• The unique metabolome of clear cell ovarian carcinoma

  2024cites this paper
• GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.

  2024cites this paper
• Metabolomic landscape of renal cell carcinoma in von Hippel-Lindau syndrome in a Chinese cohort

  2024cites this paper
• NMR-based metabolomics analysis reveals the effect of environmental contamination exposure on fishermen living around the Mundaú lagoon in Maceió (Alagoas, Brazil).

  2024cites this paper
• The Role and Treatment Strategies of Ammonia-Related Metabolism in Tumor Microenvironment.

  2024cites this paper
• Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds

  2024cites this paper
• Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma

  2024cites this paper
• Metabolic Flexibility: Targeting Mitochondrial Dynamics in Cancer Therapy

  2024cites this paper
• Extracellular domains of CARs reprogramme T cell metabolism without antigen stimulation

  2024cites this paper
• Sirtuin 5 alleviates apoptosis and autophagy stimulated by ammonium chloride in bovine mammary epithelial cells

  2024cites this paper
• Trichinella: Becoming a parasite.

  2024cites this paper
• Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism

  2024cites this paper
• Ammonia-induced stress response in liver disease progression and hepatic encephalopathy

  2024cites this paper
• Plant ammonium sensitivity is associated with external pH adaptation, repertoire of nitrogen transporters, and nitrogen requirement

  2024cites this paper
• Reprogramming of urea cycle in cancer: Mechanism, regulation and prospective therapeutic scopes.

  2024cites this paper
• Neurotransmitters: Impressive regulators of tumor progression.

  2024cites this paper
• Oncogenic Control of Metabolism.

  2024cites this paper
• The role of microbial metabolites in endocrine tumorigenesis: From the mechanistic insights to potential therapeutic biomarkers.

  2024cites this paper
• The Story of Ammonia in Liver Disease: An Unraveling Continuum.

  2024cites this paper
• Sub-MIC antibiotics increased the fitness cost of CRISPR-Cas in Acinetobacter baumannii

  2024cites this paper
• β-catenin Activation Reprograms Ammonia Metabolism to Promote Senescence Resistance in Hepatocellular Carcinoma.

  2024cites this paper
• Overcoming Cancer Resistance: Strategies and Modalities for Effective Treatment

  2024cites this paper
• Mitochondrial targets in hyperammonemia: Addressing urea cycle function to improve drug therapies.

  2024cites this paper
• Combination of transcriptome and Mendelian inheritance reveals novel prognostic biomarker of CTLA-4-related lncRNAs and protective role of nitrogen metabolism pathway in lung adenocarcinoma development

  2024cites this paper
• TSPAN8+ myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer

  2024cites this paper
• Phosphocholine inhibits proliferation and reduces stemness of endometrial cancer cells by downregulating mTOR-c-Myc signaling

  2024cites this paper
• Immunosurveillance encounters cancer metabolism

  2024cites this paper
• A glutamine metabolic switch supports erythropoiesis.

  2024cites this paper
• Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma

  2024cites this paper
• Metabolic reprogramming, sensing, and cancer therapy.

  2024cites this paper