Chromatinized Protein Kinase C-θ Directly Regulates Inducible Genes in Epithelial to Mesenchymal Transition and Breast Cancer Stem Cells

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular and Cellular Biology

• Publication date

  2014-06-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01693-13PMID 24891615PMCID PMC4135602
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Using formaldehyde-assisted isolation of regulatory elements (FAIRE) to isolate active regulatory DNA

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• Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1.

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• Protein kinase C-theta inhibitors: a novel therapy for inflammatory disorders.

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• Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?

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• Chromatin-associated protein kinase C-θ regulates an inducible gene expression program and microRNAs in human T lymphocytes.

  2011cited by this paper
• SnapShot: The epithelial-mesenchymal transition.

  2011cited by this paper
• Pioneer transcription factors: establishing competence for gene expression.

  2011cited by this paper
• BayesPeak—an R package for analysing ChIP-seq data

  2011cited by this paper
• ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions

  2011influential reference
• Breast cancer stem cells: treatment resistance and therapeutic opportunities.

  2011cited by this paper
• Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

  2010cited by this paper
• ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data

  2010cited by this paper
• Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells.

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• Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways

  2010cited by this paper
• Phorbol ester phorbol‐12‐myristate‐13‐acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells

  2010cited by this paper
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  2010cited by this paper
• Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

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• Chromatin poises miRNA- and protein-coding genes for expression.

  2009cited by this paper
• GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.

  2009cited by this paper
• Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.

  2009cited by this paper
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  2009cited by this paper
• Protein Kinase C-θ Is Required for NK Cell Activation and In Vivo Control of Tumor Progression1

  2009cited by this paper
• Epithelial-mesenchymal transitions in development and disease.

  2009cited by this paper
• Dynamic Histone Variant Exchange Accompanies Gene Induction in T Cells

  2009cited by this paper
• Phosphorylation of NF‐κB p65 at Ser468 controls its COMMD1‐dependent ubiquitination and target gene‐specific proteasomal elimination

  2009cited by this paper
• An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.

  2009cited by this paper
• The epithelial-mesenchymal transition generates cells with properties of stem cells.

  2008cited by this paper
• A functional Notch–survivin gene signature in basal breast cancer

  2008cited by this paper
• IkappaBalpha kinase inhibitor IKI-1 conferred tumor necrosis factor alpha sensitivity to pancreatic cancer cells and a xenograft tumor model.

  2008cited by this paper
• Shared principles in NF-kappaB signaling.

  2008cited by this paper
• A module of negative feedback regulators defines growth factor signaling

  2007cited by this paper
• The role of chromatin during transcription.

  2007cited by this paper
• Integrative genomic approaches identify IKBKE as a breast cancer oncogene.

  2007cited by this paper
• PKCtheta promotes c-Rel-driven mammary tumorigenesis in mice and humans by repressing estrogen receptor alpha synthesis.

  2007cited by this paper
• Correction for Woodward et al., WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells

  2007cited by this paper
• PKCθ promotes c-Rel–driven mammary tumorigenesis in mice and humans by repressing estrogen receptor α synthesis

  2007cited by this paper
• Indexing Techniques for CHR based on program transformation

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• Beyond IκBs: alternative regulation of NF‐KB activity

  2007cited by this paper
• WNT/β-catenin mediates radiation resistance of mouse mammary progenitor cells

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• Inducible Phosphorylation of NF-κB p65 at Serine 468 by T Cell Costimulation Is Mediated by IKKϵ*

  2006cited by this paper
• CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis

  2006cited by this paper
• Genome-wide location analysis of the stress-activated MAP kinase Hog1 in yeast.

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• Activated Signal Transduction Kinases Frequently Occupy Target Genes

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• Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

  2006cited by this paper
• The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation.

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  2006cited by this paper
• Proteins kinases: chromatin-associated enzymes?

  2006cited by this paper
• The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.

  2006cited by this paper
• Cancer stem cells and radiotherapy: new insights into tumor radioresistance.

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• PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state.

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• LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

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• Microarray analysis of primary endothelial cells challenged with different inflammatory and immune cytokines.

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• Cancer stem cells: Implications for cancer causation and therapy resistance.

  2005cited by this paper
• Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.

  2005cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005influential reference
• NF-kappaB: a multifaceted transcription factor regulated at several levels.

  2004cited by this paper
• NF‐κB: A Multifaceted Transcription Factor Regulated at Several Levels

  2004cited by this paper
• Expression profiling of epithelial plasticity in tumor progression

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• Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

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  2001cited by this paper
• Induction and regulation of epithelial-mesenchymal transitions.

  2000cited by this paper
• Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta.

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  2000cited by this paper
• NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta.

  2000cited by this paper
• The language of covalent histone modifications

  2000cited by this paper
• Transcriptional elongation of c-myb is regulated by NF-kappaB (p50/RelB).

  1999cited by this paper
• Distinctive gene expression patterns in human mammary epithelial cells and breast cancers.

  1999cited by this paper

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  2020cites this paper
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  2016influential citation
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  2016cites this paper
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  2016cites this paper
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