The Catalytic Activity of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 3 Is Required To Sustain CD4+ CD8+ Thymocyte Survival

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Molecular and Cellular Biology

• Publication date

  2014-07-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01701-13PMID 25002529PMCID PMC4135614
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Centre National de la Recherche Scientifique

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  2009influential reference
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  1997cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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