Astrocytic control of neural circuit formation: highlights on TGF-beta signaling.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Neurochemistry International

• Publication date

  2014-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuint.2014.07.008PMID 25125369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

  2014cited by this paper
• Gliotransmitters travel in time and space.

  2014cited by this paper
• Astrocyte-Synapse Structural Plasticity

  2014influential reference
• Cortical maps: a role for astrocytes?

  2014cited by this paper
• Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

  2014cited by this paper
• Astrocytes Play a Key Role in Drosophila Mushroom Body Axon Pruning

  2014cited by this paper
• Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling

  2014cited by this paper
• Mechanisms of astrocyte development and their contributions to neurodevelopmental disorders.

  2014cited by this paper
• Neuronal and Astroglial TGFβ-Smad3 Signaling Pathways Differentially Regulate Dendrite Growth and Synaptogenesis

  2014cited by this paper
• Impaired glutamate recycling and GluN2B‐mediated neuronal calcium overload in mice lacking TGF‐β1 in the CNS

  2013cited by this paper
• TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement

  2013cited by this paper
• Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

  2013cited by this paper
• Amyloid-β inhibits thrombospondin 1 release from cultured astrocytes: effects on synaptic protein expression.

  2013cited by this paper
• Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.

  2013influential reference
• Differential Control of Thrombospondin over Synaptic Glycine and AMPA Receptors in Spinal Cord Neurons

  2013cited by this paper
• A Dramatic Increase of C1q Protein in the CNS during Normal Aging

  2013cited by this paper
• Thyroid hormone treated astrocytes induce maturation of cerebral cortical neurons through modulation of proteoglycan levels

  2013cited by this paper
• D-Serine: physiology and pathology

  2013cited by this paper
• Neuron–Astroglial Interactions in Cell-Fate Commitment and Maturation in the Central Nervous System

  2012cited by this paper
• Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.

  2012cited by this paper
• Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

  2012cited by this paper
• Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons*

  2012cited by this paper
• Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand.

  2012influential reference
• Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex.

  2012cited by this paper
• Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons

  2012cited by this paper
• Astrocyte‐secreted factors modulate the developmental distribution of inhibitory synapses in nucleus laminaris of the avian auditory brainstem

  2012cited by this paper
• Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology

  2011cited by this paper
• Neuron-glia signaling: Implications for astrocyte differentiation and synapse formation.

  2011cited by this paper
• Effects of low-dose d-serine on recognition and working memory in mice

  2011cited by this paper
• Astrocytes Control Glutamate Receptor Levels at Developing Synapses through SPARC–β-Integrin Interactions

  2011cited by this paper
• The role of microglia at synapses in the healthy CNS: novel insights from recent imaging studies.

  2011cited by this paper
• Specification of transplantable astroglial subtypes from human pluripotent stem cells

  2011cited by this paper
• Increased transforming growth factor-β1 modulates glutamate receptor expression in the hippocampus.

  2011cited by this paper
• Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

  2011cited by this paper
• Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

  2011cited by this paper
• Canonical TGF-β Signaling Is Required for the Balance of Excitatory/Inhibitory Transmission within the Hippocampus and Prepulse Inhibition of Acoustic Startle

  2010cited by this paper
• Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis.

  2010cited by this paper
• TGF-β2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size

  2010cited by this paper
• Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1

  2010cited by this paper
• Distinct FGFs promote differentiation of excitatory and inhibitory synapses

  2010cited by this paper
• A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

  2010cited by this paper
• Selective translocation of Ca2+/calmodulin protein kinase IIα (CaMKIIα) to inhibitory synapses

  2010cited by this paper
• Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

  2010cited by this paper
• Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression

  2010influential reference
• Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis

  2009cited by this paper
• Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.

  2009cited by this paper
• Cholesterol‐promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus

  2009cited by this paper
• Uniquely Hominid Features of Adult Human Astrocytes

  2009cited by this paper
• Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain

  2009cited by this paper
• A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

  2008cited by this paper
• Glia Are Essential for Sensory Organ Function in C. elegans

  2008cited by this paper
• Schwann Cells Promote Synaptogenesis at the Neuromuscular Junction via Transforming Growth Factor-β1

  2008cited by this paper
• Bergmann Glia and the Recognition Molecule CHL1 Organize GABAergic Axons and Direct Innervation of Purkinje Cell Dendrites

  2008cited by this paper
• TSP-1 Secreted by Bone Marrow Stromal Cells Contributes to Retinal Ganglion Cell Neurite Outgrowth and Survival

  2008cited by this paper
• Loss of transforming growth factor-beta 2 leads to impairment of central synapse function

  2008cited by this paper
• Apolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice

  2008cited by this paper
• Decreased transforming growth factor beta1 in autism: a potential link between immune dysregulation and impairment in clinical behavioral outcomes.

  2008cited by this paper
• Glutamate activates GFAP gene promoter from cultured astrocytes through TGF‐β1 pathways

  2008cited by this paper
• TGF‐β1/SMAD signaling induces astrocyte fate commitment in vitro: Implications for radial glia development

  2007cited by this paper
• The classical complement cascade mediates CNS synapse elimination.

  2007cited by this paper
• Activity-dependent release of transforming growth factor-beta in a neuronal network in vitro.

  2007cited by this paper
• Glia Promote Local Synaptogenesis Through UNC-6 (Netrin) Signaling in C. elegans

  2007cited by this paper
• Functional Neural Development from Human Embryonic Stem Cells: Accelerated Synaptic Activity via Astrocyte Coculture

  2007cited by this paper
• Transforming growth factor‐β2 modulates synaptic efficacy and plasticity and induces phosphorylation of CREB in hippocampal neurons

  2007cited by this paper
• Astrocyte-derived estrogen enhances synapse formation and synaptic transmission between cultured neonatal rat cortical neurons.

  2007cited by this paper
• TGF-beta1-induced long-term changes in neuronal excitability in aplysia sensory neurons depend on MAPK.

  2006cited by this paper
• Glia-derived D-serine controls NMDA receptor activity and synaptic memory.

  2006cited by this paper
• Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.

  2006cited by this paper
• Astrocyte dysfunction in neurological disorders: a molecular perspective

  2006cited by this paper
• Emerging roles for TGF-beta1 in nervous system development.

  2005cited by this paper
• Astrocytes Regulate Inhibitory Synapse Formation via Trk-Mediated Modulation of Postsynaptic GABAA Receptors

  2005cited by this paper
• Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha.

  2005cited by this paper
• Emerging roles for TGF‐β1 in nervous system development

  2005cited by this paper
• Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.

  2005influential reference
• Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α

  2005cited by this paper
• Development of interlaminar astroglial processes in the cerebral cortex of control and Down's syndrome human cases.

  2005cited by this paper
• Immunocytochemical localization of CR3 complement receptors with OX-42 in amoeboid microglia in postnatal rats

  2004cited by this paper
• Intracellular Astrocyte Calcium Waves In Situ Increase the Frequency of Spontaneous AMPA Receptor Currents in CA1 Pyramidal Neurons

  2004cited by this paper
• Glial fibrillary acidic protein gene promoter is differently modulated by transforming growth factor‐beta 1 in astrocytes from distinct brain regions

  2004cited by this paper
• Human brain evolution: insights from microarrays

  2004cited by this paper
• Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo.

  2004cited by this paper
• PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes.

  2004cited by this paper
• Wnts and TGFβ in synaptogenesis: old friends signalling at new places

  2003cited by this paper
• Wnts and TGF beta in synaptogenesis: old friends signalling at new places.

  2003cited by this paper
• Contribution of astrocytes to hippocampal long-term potentiation through release of d-serine

  2003influential reference
• New roles for astrocytes: redefining the functional architecture of the brain.

  2003cited by this paper
• Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures

  2003influential reference
• Differential Effects of Neurotrophins and Schwann Cell-Derived Signals on Neuronal Survival/Growth and Synaptogenesis

  2003influential reference
• Control of Synaptic Strength by Glial TNFα

  2002influential reference
• wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila.

  2002cited by this paper
• Control of synaptic strength by glial TNFalpha.

  2002cited by this paper
• Neuro–glia interaction effects on GFAP gene: a novel role for transforming growth factor‐β1

  2002cited by this paper
• Neuritogenesis Induced by Thyroid Hormone-treated Astrocytes Is Mediated by Epidermal Growth Factor/Mitogen-activated Protein Kinase-Phosphatidylinositol 3-Kinase Pathways and Involves Modulation of Extracellular Matrix Proteins*

  2002cited by this paper
• Disruption of astroglial interlaminar processes in Alzheimer's disease.

  2002cited by this paper
• Control of synapse number by glia.

  2001influential reference
• CNS synaptogenesis promoted by glia-derived cholesterol.

  2001influential reference
• Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons.

  2000cited by this paper
• Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology

  2000cited by this paper
• Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology.

  2000cited by this paper
• TGF-beta1 in Aplysia: role in long-term changes in the excitability of sensory neurons and distribution of TbetaR-II-like immunoreactivity.

  1999cited by this paper

• Tunneling Nanotubes in Astrocyte-Neuron Crosstalk: From Intercellular Communication and Pathological Spread to Mechanobiological and Bio-Inspired Approaches.

  2026cites this paper
• Attenuating α-synuclein pathology in mice with in situ engineered astrocytes

  2025cites this paper
• Histone Deacetylases in Neurodegenerative Diseases and Their Potential Role as Therapeutic Targets: Shedding Light on Astrocytes

  2025cites this paper
• Serum Aquaporin-4 Antibody Status and TGF-β in Neuromyelitis Optica Spectrum Disorder: Impact on Astrocyte Function and Correlation with Disease Activity and Severity

  2025cites this paper
• Transforming Growth Factor-β Serum Levels Associated with Social Function in Subjects at Ultra-high Risk for Psychosis: A Multicenter Study

  2025cites this paper
• Advancements in Stem Cell Therapeutics for Spinal Cord Injury: Theories and Applications

  2025cites this paper
• Astrocyte in Neurological Disease: Pathogenesis and Therapy

  2025cites this paper
• Inflammation as a Neurobiological Mechanism of Cognitive Impairment in Psychological Stress.

  2024cites this paper
• Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis

  2024cites this paper
• Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, promotes synaptic plasticity, and improves resistance to direct infection in offspring

  2024cites this paper
• The Role of Inflammatory Cascade and Reactive Astrogliosis in Glial Scar Formation Post-spinal Cord Injury

  2024cites this paper
• Astrocytic Proteostasis in the Tale of Aging and Neurodegeneration.

  2024cites this paper
• Autism spectrum disorder and various mechanisms behind it.

  2024cites this paper
• Aging Microglia and Their Impact in the Nervous System.

  2024cites this paper
• Accumulation of damaged mitochondria in aging astrocytes due to mitophagy dysfunction: Implications for susceptibility to mitochondrial stress.

  2024cites this paper
• From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury

  2024cites this paper
• The core of maintaining neuropathic pain: Crosstalk between glial cells and neurons (neural cell crosstalk at spinal cord)

  2023cites this paper
• Molecular Mechanisms of Astrocyte Involvement in Synaptogenesis and Brain Synaptic Plasticity

  2023cites this paper
• Age-Associated Upregulation of Glutamate Transporters and Glutamine Synthetase in Senescent Astrocytes In Vitro and in the Mouse and Human Hippocampus

  2023cites this paper
• The association of astrogliosis and microglial activation with aging and Alzheimer's disease pathology in the chimpanzee brain

  2023cites this paper
• Aryl Hydrocarbon Receptor in Glia Cells: A Plausible Glutamatergic Neurotransmission Orchestrator

  2023cites this paper
• Effects of electroacupuncture combined with hydrogel on the formation and changes in the glial scar in rats with spinal cord injury

  2022cites this paper
• Electrophysiological Activity of Primary Cortical Neuron-Glia Mixed Cultures

  2022cites this paper
• Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases

  2022cites this paper
• Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury

  2022cites this paper
• Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

  2022cites this paper
• Therapeutic potential of progesterone in spinal cord injury‐induced neuropathic pain: At the crossroads between neuroinflammation and N‐methyl‐D‐aspartate receptor

  2022cites this paper
• Identification of MMACHC and ZEB2 mutations causing coexistent cobalamin C disease and Mowat-Wilson syndrome in a 2-year-old girl.

  2022cites this paper
• Astrocyte polarization in glaucoma: a new opportunity

  2022cites this paper
• A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders

  2022cites this paper
• Neuronal and Astrocytic Morphological Alterations Driven by Prolonged Exposure with Δ9-Tetrahydrocannabinol but Not Cannabidiol

  2022cites this paper
• Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling

  2021cites this paper
• Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish

  2021cites this paper
• Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner

  2021cites this paper
• Astrocytes as a target for Nogo‐A and implications for synapse formation in vitro and in a model of acute demyelination

  2021cites this paper
• Role of astrocytes in synapse formation and maturation.

  2021cites this paper
• Tripartite synaptomics: Cell-surface proximity labeling in vivo.

  2021cites this paper
• Neurological Phenotype of Mowat-Wilson Syndrome

  2021cites this paper
• Astrocyte-Neuron Signaling in Synaptogenesis

  2021cites this paper
• Astrocyte-Derived Thrombospondin Induces Cortical Synaptogenesis in a Sex-Specific Manner

  2021cites this paper
• Why does anti-inflammatory cytokine levels increase during memory acquisition?

  2021cites this paper
• IPSC-derived GRN-mutant astrocytes delay excitatory electrical development of neurons in a non-cell autonomous manner

  2021cites this paper
• Pharmacological modulation of cytokines correlating neuroinflammatory cascades in epileptogenesis

  2021cites this paper
• Exposure to lead in the pre- and neonatal periods may result in brain inflammation

  2020cites this paper
• An Overview on the Differential Interplay Among Neurons–Astrocytes–Microglia in CA1 and CA3 Hippocampus in Hypoxia/Ischemia

  2020cites this paper
• Astrocytes and synaptogenesis

  2020cites this paper
• Reactive Astrogliosis: Implications in Spinal Cord Injury Progression and Therapy

  2020cites this paper
• Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice

  2020cites this paper
• Space-Dependent Glia–Neuron Interplay in the Hippocampus of Transgenic Models of β-Amyloid Deposition

  2020cites this paper
• Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes

  2020cites this paper
• Toxoplasma gondii infection impairs radial glia differentiation and its potential to modulate brain microvascular endothelial cell function in the cerebral cortex.

  2020cites this paper
• Astrocyte Heterogeneity: Impact to Brain Aging and Disease

  2019influential citation
• Selective Regulation of Neurons, Glial Cells, and Neural Stem/Precursor Cells by Poly(allylguanidine)-Coated Surfaces.

  2019cites this paper
• Microglial regional heterogeneity and its role in the brain

  2019cites this paper
• The Role of Astrocytes in the Development of the Cerebellum

  2019cites this paper
• Determination of neuroinflammatory biomarkers in autistic and neurotypical Saudi children

  2019cites this paper
• The influence of neuroinflammation in Autism Spectrum Disorder.

  2019cites this paper
• α‐synuclein oligomers enhance astrocyte‐induced synapse formation through TGF‐β1 signaling in a Parkinson's disease model

  2019cites this paper
• Effect of TGF-beta1 on long-term synaptic plasticity and distribution of AMPA receptors in the CA1 field of the hippocampus.

  2019cites this paper
• Astrocytes and the TGF-β1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword

  2018cites this paper
• Deficiency of transforming growth factor-&bgr; signaling disrupts memory processes in rats

  2018cites this paper
• TGF‐β2 and TGF‐β3 from cultured β‐amyloid‐treated or 3xTg‐AD‐derived astrocytes may mediate astrocyte–neuron communication

  2018cites this paper
• Phagocytic Roles of Glial Cells in Healthy and Diseased Brains

  2018cites this paper
• MFG‐E8 reverses microglial‐induced neurotoxic astrocyte (A1) via NF‐κB and PI3K‐Akt pathways

  2018cites this paper
• The role of TGF-&bgr; superfamily signaling in neurological disorders

  2018cites this paper
• Human Dental Pulp Stem Cells are more Effective than Human Bone Marrow-Derived Mesenchymal Stem Cells in Cerebral Ischemic Injury

  2017cites this paper
• Derivation of Functional Human Astrocytes from Cerebral Organoids

  2017cites this paper
• Age-Dependent Neurochemical Remodeling of Hypothalamic Astrocytes

  2017cites this paper
• Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model

  2017cites this paper
• Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

  2017cites this paper
• A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype.

  2016cites this paper
• The Role of Astrocyte-Derived Factors in the Regulation of Multidrug Resistance at the Developing Blood-Brain Barrier

  2016cites this paper
• The various forms of neuroplasticity: Biological bases of learning and teaching

  2016cites this paper
• The various forms of neuroplasticity: Biological bases of learning and teaching

  2016cites this paper
• Role of GABA(B) receptors in learning and memory and neurological disorders.

  2016cites this paper
• Urocortin 2 But Not Urocortin 3 Promotes the Synaptic Formation in Hipppocampal Neurons via Induction of NGF Production by Astrocytes.

  2016cites this paper
• Functions of flavonoids in the central nervous system: Astrocytes as targets for natural compounds.

  2016influential citation
• Effects of Transforming Growth Factor Beta 1 in Cerebellar Development: Role in Synapse Formation

  2016cites this paper
• Thyroid Hormone and Astroglia: Endocrine Control of the Neural Environment

  2015cites this paper
• Morphological plasticity of astroglia: Understanding synaptic microenvironment

  2015cites this paper
• Zeb2: A multifunctional regulator of nervous system development.

  2015cites this paper