Role of human DNA2 (hDNA2) as a potential target for cancer and other diseases: A systematic review.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  DNA Repair

• Publication date

  2017-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.dnarep.2017.09.001PMID 28903076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin

  2017cited by this paper
• DNA2—An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?

  2017cited by this paper
• Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

  2017cited by this paper
• DNA-Damaging Anticancer Drugs - A Perspective for DNA Repair- Oriented Therapy.

  2017cited by this paper
• A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy

  2016cited by this paper
• HELB Is a Feedback Inhibitor of DNA End Resection.

  2016cited by this paper
• Human mitochondrial DNA replication machinery and disease.

  2016cited by this paper
• Mitochondrial cytopathies.

  2016cited by this paper
• A DNA2 Homolog Is Required for DNA Damage Repair, Cell Cycle Regulation, and Meristem Maintenance in Plants1[OPEN]

  2016cited by this paper
• Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

  2016cited by this paper
• Primer removal during mammalian mitochondrial DNA replication.

  2015cited by this paper
• Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2

  2015cited by this paper
• SUPPLEMENTAL INFORMATION TO : Lagging strand maturation factor Dna 2 is a component of the replication checkpoint initiation machinery

  2015cited by this paper
• DNA2 drives processing and restart of reversed replication forks in human cells

  2015cited by this paper
• Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres

  2015cited by this paper
• The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication

  2015cited by this paper
• DNA double-strand breaks with 5′ adducts are efficiently channeled to the DNA2-mediated resection pathway

  2015cited by this paper
• Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double‐strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

  2015cited by this paper
• BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

  2015cited by this paper
• Borrowing Nuclear DNA Helicases to Protect Mitochondrial DNA

  2015cited by this paper
• Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

  2015cited by this paper
• Yet another job for Dna2: Checkpoint activation.

  2015cited by this paper
• The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers

  2014cited by this paper
• Genomic analysis of primordial dwarfism reveals novel disease genes

  2014cited by this paper
• Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells

  2014cited by this paper
• DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells*

  2014cited by this paper
• Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection

  2014cited by this paper
• The N-terminal 45-kDa Domain of Dna2 Endonuclease/Helicase Targets the Enzyme to Secondary Structure DNA*

  2013cited by this paper
• Dna2 Is Involved in CA Strand Resection and Nascent Lagging Strand Completion at Native Yeast Telomeres*

  2013cited by this paper
• DNA2, a new player in telomere maintenance and tumor suppression

  2013cited by this paper
• DNA helicases involved in DNA repair and their roles in cancer

  2013cited by this paper
• Mammalian DNA2 helicase/nuclease cleaves G‐quadruplex DNA and is required for telomere integrity

  2013cited by this paper
• Distinct Gene Expression Signatures in Lynch Syndrome and Familial Colorectal Cancer Type X

  2013cited by this paper
• Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability.

  2013influential reference
• Dna2 offers support for stalled forks.

  2012cited by this paper
• More tasks for Dna2 in S-phase

  2012cited by this paper
• Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1

  2012cited by this paper
• DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

  2012cited by this paper
• Okazaki Fragment Processing-independent Role for Human Dna2 Enzyme during DNA Replication*

  2012cited by this paper
• The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing.

  2012cited by this paper
• DNA end resection--unraveling the tail.

  2011cited by this paper
• The changing view of Dna2

  2011cited by this paper
• Caenorhabditis elegans DNA-2 helicase/endonuclease plays a vital role in maintaining genome stability, morphogenesis, and life span.

  2011cited by this paper
• Characterization of the Endonuclease and ATP-dependent Flap Endo/Exonuclease of Dna2*

  2011cited by this paper
• BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

  2011cited by this paper
• Double-strand break end resection and repair pathway choice.

  2011cited by this paper
• Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

  2010cited by this paper
• Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM

  2010cited by this paper
• The human mitochondrial replication fork in health and disease.

  2010cited by this paper
• Dna2 Exhibits a Unique Strand End-dependent Helicase Function*

  2010cited by this paper
• Acetylation of Dna2 Endonuclease/Helicase and Flap Endonuclease 1 by p300 Promotes DNA Stability by Creating Long Flap Intermediates*

  2009cited by this paper
• Dna2 is a structure-specific nuclease, with affinity for 5′-flap intermediates

  2009cited by this paper
• Polymerase Dynamics at the Eukaryotic DNA Replication Fork*

  2009cited by this paper
• Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency.

  2009cited by this paper
• Significance of the Dissociation of Dna2 by Flap Endonuclease 1 to Okazaki Fragment Processing in Saccharomyces cerevisiae*

  2009cited by this paper
• Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

  2009cited by this paper
• Pif1 Helicase Lengthens Some Okazaki Fragment Flaps Necessitating Dna2 Nuclease/Helicase Action in the Two-nuclease Processing Pathway*

  2009cited by this paper
• Nucleases and helicases take center stage in homologous recombination.

  2009cited by this paper
• Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends.

  2008cited by this paper
• Dynamic Removal of Replication Protein A by Dna2 Facilitates Primer Cleavage during Okazaki Fragment Processing in Saccharomyces cerevisiae*

  2008cited by this paper
• DNA2 resolves expanding flap in mitochondrial base excision repair.

  2008influential reference
• Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition*

  2008cited by this paper
• [Flap endonuclease-1 and its role in the processes of DNA metabolism in eucaryotic cells].

  2008cited by this paper
• Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates and defective in myopathy

  2008cited by this paper
• Single Strand Annealing and ATP-independent Strand Exchange Activities of Yeast and Human DNA2

  2006cited by this paper
• Biochemical analysis of human Dna2

  2006cited by this paper
• Reconstituted Okazaki Fragment Processing Indicates Two Pathways of Primer Removal*

  2006cited by this paper
• Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

  2006cited by this paper
• A Network of Multi-Tasking Proteins at the DNA Replication Fork Preserves Genome Stability

  2005cited by this paper
• Dna2p Helicase/Nuclease Is a Tracking Protein, Like FEN1, for Flap Cleavage during Okazaki Fragment Maturation*

  2004cited by this paper
• On the Roles of Saccharomyces cerevisiae Dna2p and Flap Endonuclease 1 in Okazaki Fragment Processing*

  2004cited by this paper
• The Protein Components and Mechanism of Eukaryotic Okazaki Fragment Maturation

  2003cited by this paper
• Mutations in DNA Replication Genes Reduce Yeast Life Span

  2002cited by this paper
• Dynamic Localization of an Okazaki Fragment Processing Protein Suggests a Novel Role in Telomere Replication

  2002cited by this paper
• Identification of the Xenopus laevis Homolog ofSaccharomyces cerevisiae DNA2 and Its Role in DNA Replication*

  2000cited by this paper
• The endonuclease activity of the yeast Dna2 enzyme is essential in vivo.

  2000cited by this paper
• Characterization of the Enzymatic Properties of the Yeast Dna2 Helicase/Endonuclease Suggests a New Model for Okazaki Fragment Processing*

  2000cited by this paper
• Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1.

  1996cited by this paper
• [Mitochondrial cytopathies].

  1996cited by this paper
• DNA2 Encodes a DNA Helicase Essential for Replication of Eukaryotic Chromosomes (*)

  1995cited by this paper
• Eukaryotic DNA replication. Enzymes and proteins acting at the fork.

  1990cited by this paper
• Sequence and organization of the human mitochondrial genome

  1981cited by this paper
• Eukaryotic DNA Replication

  1973cited by this paper
• Molecular and Cellular Pathobiology Human Nuclease/helicase Dna2 Alleviates Replication Stress by Promoting Dna End Resection

  year unknowncited by this paper

• The Influence of Micronutrients and Environmental Factors on Thyroid DNA Integrity

  2025cites this paper
• Loss of Dna2 fidelity results in decreased Exo1-mediated resection at DNA double-strand breaks

  2024cites this paper
• Pan-Cancer Genetic Analysis of Mitochondrial DNA Repair Gene Set

  2024cites this paper
• Dna2 nuclease resolves RNA:DNA hybrids at double-strand breaks

  2024cites this paper
• Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma

  2023cites this paper
• Loss of Dna2 nuclease activity results in decreased Exo1-mediated resection at DNA double strand breaks

  2023cites this paper
• Nej1 interacts with Sae2 at DNA double-stranded breaks to inhibit DNA resection

  2022cites this paper
• Identification of targets and mechanisms for Eleutheroside E in the treatment of cancer

  2022cites this paper
• Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer

  2021cites this paper
• DNA2 in Chromosome Stability and Cell Survival—Is It All about Replication Forks?

  2021cites this paper
• Sgs1 BLM independent role of Dna2 DNA2 nuclease at DNA double strand break is inhibited by Nej1 XLF

  2021cites this paper
• Weighted Gene Coexpression Network Analysis of Key Genes Controlling Cancer Stem Cell Characteristics by Mrnasi in Colon Adenocarcinoma

  2021cites this paper
• Nej1XLF interacts with Sae2CTIP to inhibit Dna2 mediated resection at DNA double strand break

  2021cites this paper
• TWINKLE and Other Human Mitochondrial DNA Helicases: Structure, Function and Disease

  2020cites this paper
• Secondary Mutation-Induced Alternative Splicing Suppresses RNA Splicing Defect of the jhs1 Mutant1

  2020cites this paper
• Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in replication fork stability controlled by ATR

  2020cites this paper
• Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR

  2020cites this paper
• Multiple roles of DNA2 nuclease/helicase in DNA metabolism, genome stability and human diseases

  2019cites this paper
• The DNA Replication Machinery as Therapeutic Targets

  2019influential citation
• Targeted theranostic of cryptococcal encephalitis by a novel polypyridyl ruthenium complex.

  2019cites this paper
• Novel mutations in DNA2 associated with myopathy and mtDNA instability

  2019cites this paper
• Marek’s Disease Virus Infection Induced Mitochondria Changes in Chickens

  2019cites this paper
• Étude biochimique et biophysique de l’ARN hélicase UPF1 : un moteur moléculaire hautement régulé

  2018cites this paper
• A Critical Role for Dna2 at Unwound Telomeres

  2018cites this paper
• New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy

  2018cites this paper
• CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications

  2018cites this paper
• A Critical Role for Dna 2 at Unwound Telomeres

  2018cites this paper