Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cell Cycle

• Publication date

  2010-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.9.6.11049PMID 20237432PMCID PMC3059328
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Roles of Human AND-1 in Chromosome Transactions in S Phase*

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• The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM.

  2009cited by this paper
• Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.

  2009influential reference
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  2009cited by this paper
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  2009cited by this paper
• Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae.

  2009cited by this paper
• A key role for Ctf4 in coupling the MCM2‐7 helicase to DNA polymerase α within the eukaryotic replisome

  2009cited by this paper
• Assembly of the Cdc45-Mcm2–7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

  2009cited by this paper
• MCM10 mediates RECQ4 association with MCM2‐7 helicase complex during DNA replication

  2009cited by this paper
• Replisome progression complex links DNA replication to sister chromatid cohesion in Xenopus egg extracts

  2009cited by this paper
• Studying the DNA damage response using in vitro model systems.

  2009cited by this paper
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  2009cited by this paper
• Polymerase Dynamics at the Eukaryotic DNA Replication Fork*

  2009cited by this paper
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  2009influential reference
• Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends

  2008influential reference
• Ku80 removal from DNA through double strand break–induced ubiquitylation

  2008cited by this paper
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  2008influential reference
• Dynamic Removal of Replication Protein A by Dna2 Facilitates Primer Cleavage during Okazaki Fragment Processing in Saccharomyces cerevisiae*

  2008cited by this paper
• A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.

  2008cited by this paper
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  2008cited by this paper
• Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication.

  2007cited by this paper
• Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.

  2007influential reference
• Mcm10 and And-1/CTF4 recruit DNA polymerase α to chromatin for initiation of DNA replication

  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

  2006cited by this paper
• Biochemical analysis of human Dna2

  2006cited by this paper
• Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

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• Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Mcm2 Is a Direct Substrate of ATM and ATR during DNA Damage and DNA Replication Checkpoint Responses*

  2004cited by this paper
• Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.

  2004cited by this paper
• Dna2 requirement for normal reproduction of Caenorhabditis elegans is temperature-dependent.

  2003cited by this paper
• Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

  2003cited by this paper
• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

  2003cited by this paper
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  2003cited by this paper
• Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti-PCM-1 antibodies.

  2002cited by this paper
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  2002cited by this paper
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  2002influential reference
• Nuclear retention of ATM at sites of DNA double strand breaks.

  2001cited by this paper
• Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.

  2000cited by this paper
• The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways.

  2000cited by this paper
• Identification of the Xenopus laevis Homolog ofSaccharomyces cerevisiae DNA2 and Its Role in DNA Replication*

  2000influential reference
• Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends.

  2000cited by this paper
• Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth.

  1999cited by this paper
• Role for a Xenopus Orc2-related protein in controlling DNA replication

  1996cited by this paper
• Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex

  1994cited by this paper
• Protein affinity chromatography with purified yeast DNA polymerase alpha detects proteins that bind to DNA polymerase.

  1992cited by this paper
• Cell cycle extracts.

  1991cited by this paper
• Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs.

  1986cited by this paper

• ATM promotes reversed fork processing during DNA interstrand cross-link repair

  2025cites this paper
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  2025cites this paper
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• Dna2 Responds to Endogenous and Exogenous Replication Stress in Drosophila melanogaster

  2025cites this paper
• The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5

  2024cites this paper
• Multifaceted role of the DNA replication protein MCM10 in maintaining genome stability and its implication in human diseases

  2024cites this paper
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  2024cites this paper
• MCM10: An effective treatment target and a prognostic biomarker in patients with uterine corpus endometrial carcinoma

  2023cites this paper
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  2019influential citation
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  2019cites this paper
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  2018cites this paper
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