Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Science

• Publication date

  1990-05-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1126/SCIENCE.2110384PMID 2110384
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.

  1989cited by this paper
• Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

  1989cited by this paper
• Amyloid beta protein precursor is a mitogen.

  1989cited by this paper
• Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor.

  1989cited by this paper
• Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease.

  1989cited by this paper
• The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

  1989cited by this paper
• Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

  1989cited by this paper
• Soluble derivatives of the β amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β amyloid protein

  1989cited by this paper
• Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

  1989cited by this paper
• Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

  1989cited by this paper
• beta-amyloid protein of Alzheimer's disease is found in cerebral and spinal cord vascular malformations.

  1988cited by this paper
• Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

  1988cited by this paper
• A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

  1988cited by this paper
• Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.

  1988cited by this paper
• Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.

  1987cited by this paper
• Purification of protease nexin II from human fibroblasts.

  1987cited by this paper
• Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

  1987cited by this paper
• Family study of platelet membrane fluidity in Alzheimer's disease.

  1987cited by this paper
• The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

  1987cited by this paper
• The biology of platelet-derived growth factor

  1986cited by this paper
• High molecular weight kininogen: localization in the unstimulated and activated platelet and activation by a platelet calpain(s).

  1986cited by this paper
• Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease?

  1986cited by this paper
• Senile plaque amyloid, paired helical filaments, and cerebrovascular amyloid in Alzheimer's disease are all deposits of the same protein.

  1985cited by this paper
• Platelet C1- inhibitor. A secreted alpha-granule protein.

  1985cited by this paper
• Amyloid plaque core protein in Alzheimer disease and Down syndrome.

  1985cited by this paper
• Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

  1985cited by this paper
• Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein.

  1984cited by this paper
• Epidermal growth factor carrier protein binds to cells via a complex with released carried protein nexin.

  1982cited by this paper
• Antiheparin proteins secreted by human platelets. purification, characterization, and radioimmunoassay.

  1979cited by this paper
• An improved method for the isolation of dense storage granules from human platelets

  1978cited by this paper
• Distribution of Fibrinogen, and Platelet Factors 4 and XIII in Subcellular Fractions of Human Platelets

  1975cited by this paper
• Determination of ATP and ADP in blood platelets: a modification of the firefly luciferase assay for plasma.

  1972cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

  1966cited by this paper
• Lactic Dehydrogenase Activity in Blood.∗

  1955cited by this paper
• Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

  1955cited by this paper

• Amyloid Protein-Induced Remodeling of Morphometry and Nanomechanics in Human Platelets

  2025cites this paper
• A novel APP splice variant-dependent marker system to precisely demarcate maturity in SH-SY5Y cell-derived neurons

  2024cites this paper
• Physiological Functions of the Platelets and the Importance of the Correction of Their Disorders in Acute Coronary Syndrome

  2023cites this paper
• Human platelets release amyloid peptides β1-40 and β1-42 in response to hemostatic, immune, and hypoxic stimuli

  2023cites this paper
• Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease

  2023cites this paper
• Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy

  2022cites this paper
• Platelets’ Nanomechanics and Morphology in Neurodegenerative Pathologies

  2022cites this paper
• Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity

  2022cites this paper
• Can platelet activation result in increased plasma Aβ levels and contribute to the pathogenesis of Alzheimer's disease?

  2021cites this paper
• Selection and in vitro and in vivo characterization of a Kunitz Protease Inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin.

  2021cites this paper
• Endothelium-specific deletion of amyloid-β precursor protein exacerbates endothelial dysfunction induced by aging

  2021cites this paper
• Platelet APP Processing: Is It a Tool to Explore the Pathophysiology of Alzheimer’s Disease? A Systematic Review

  2021cites this paper
• The contact activation system and vascular factors as alternative targets for Alzheimer's disease therapy

  2021cites this paper
• High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 × Tg) mouse model of Alzheimer’s disease associated with chronic platelet activation

  2021cites this paper
• Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems

  2021cites this paper
• Why do platelets express K+ channels?

  2021cites this paper
• Modulation of Immune Responses by Platelet-Derived ADAM10

  2020cites this paper
• Interplay between platelets and coagulation

  2020cites this paper
• Amyloid precursor protein 770 is specifically expressed and released from platelets

  2020cites this paper
• Depression and Cardiovascular Disease: The Viewpoint of Platelets

  2020cites this paper
• On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications

  2020cites this paper
• Platelets in Neurodegenerative Conditions—Friend or Foe?

  2020cites this paper
• Effect of a Cognitive Training Program on the Platelet APP Ratio in Patients with Alzheimer’s Disease

  2020cites this paper
• Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

  2020cites this paper
• Platelets in Healthy and Disease States: From Biomarkers Discovery to Drug Targets Identification by Proteomics

  2020cites this paper
• Interactions Between Platelets and the Coagulation System

  2019cites this paper
• Blood platelets: Circulating mirrors of neurons?

  2019cites this paper
• Accumulation of Amyloid Beta (Aβ) Peptide on Blood Vessel Walls in the Damaged Brain after Transient Middle Cerebral Artery Occlusion

  2019cites this paper
• Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma.

  2019influential citation
• Amyloid precursor protein is required for in vitro platelet adhesion to amyloid peptides and potentiation of thrombus formation.

  2018cites this paper
• Amyloid Beta Peptide Is Released during Thrombosis in the Skin

  2018cites this paper
• Fusion to Human Serum Albumin Extends the Circulatory Half-Life and Duration of Antithrombotic Action of the Kunitz Protease Inhibitor Domain of Protease Nexin 2

  2018cites this paper
• Differential expression of microRNAs and other small RNAs in muscle tissue of patients with ALS and healthy age-matched controls

  2018cites this paper
• Amyloid- (1-40) and Mortality in Patients With NonST-Segment Elevation Acute Coronary Syndrome

  2018cites this paper
• Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid β-protein precursor abolishes its anti-thrombotic properties in vivo.

  2017cites this paper
• Platelets in Neurological Disorders

  2017cites this paper
• Platelets are responsible for the accumulation of β-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis.

  2017cites this paper
• Platelets and Neurodegenerative Diseases

  2017cites this paper
• Aβ Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development

  2017cites this paper
• Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries

  2017cites this paper
• Platelet amyloid precursor protein is a modulator of venous thromboembolism in mice.

  2017cites this paper
• Physiological role of amyloid precursor protein during neural development

  2017cites this paper
• Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium.

  2017cites this paper
• Coagulation and fibrinolysis

  2016cites this paper
• Alzheimer disease is in part a thrombohemorrhagic disorder

  2016cites this paper
• Title : Platelets are responsible for the accumulation of β ‐ amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis

  2016cites this paper
• Investigating novel interaction partners of amyloid precursor protein: the mechanistic target of rapamycin and pikyve complex

  2016cites this paper
• The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis.

  2016cites this paper
• Origin(s) of Intraneuronal Amyloid

  2016cites this paper
• Plasma amyloid β-quo vadis?

  2015cites this paper
• Rôle et potentialités thérapeutiques des cellules T régulatrices dans la physiopathologie de la maladie d'Alzheimer

  2015cites this paper
• Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease

  2015cites this paper
• Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

  2014cites this paper
• Glycosylation of Amyloid β-Precursor Protein

  2014cites this paper
• Imatinib treatment and Aβ42 in humans

  2014cites this paper
• Amyloid  peptide-dependent activation of human platelets: essential role of Ca 2+ and ADP in aggregation and thrombus formation

  2014cites this paper
• 1 Amyloid  peptide-dependent activation of human platelets: essential role of Ca 2+ and ADP in aggregation and

  2014cites this paper
• Amyloid β-peptide-dependent activation of human platelets: essential role for Ca2+ and ADP in aggregation and thrombus formation.

  2014cites this paper
• Platelets Contain Tissue Factor Pathway Inhibitor-2 Derived from Megakaryocytes and Inhibits Fibrinolysis*

  2014cites this paper
• Opus: University of Bath Online Publication Store Open Peer Review

  2014cites this paper
• Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy

  2013cites this paper
• Soluble amyloid precursor protein 770 is a novel biomarker candidate for acute coronary syndrome

  2013cites this paper
• Experimental Human Endotoxemia Activation of Clotting Factor XI Without Detectable Contact Activation in

  2013cites this paper
• Abnormal Platelet Amyloid-β Protein Precursor (AβPP) Metabolism in Alzheimer's Disease: Identification and Characterization of a New AβPP Isoform as Potential Biomarker

  2013cites this paper
• Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease

  2013cites this paper
• P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitor.

  2013cites this paper
• Coagulation Factor XIa

  2013cites this paper
• Altered clot formation and anticoagulation in a familial Alzheimer's disease mouse model

  2013cites this paper
• The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis

  2012cites this paper
• Soluble Amyloid Precursor Protein 770 Is Released from Inflamed Endothelial Cells and Activated Platelets

  2012cites this paper
• Platelets and Alzheimer's disease: Potential of APP as a biomarker.

  2012cites this paper
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer ’ s disease

  2012cites this paper
• A bioenergética do músculo esquelético na Doença de Alzheimer

  2012cites this paper
• Studies on the use of glycosaminoglycans for the treatment of Alzheimer's Disease

  2012cites this paper
• Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?

  2012cites this paper
• The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis.

  2012influential citation
• Review: Sporadic cerebral amyloid angiopathy

  2011cites this paper
• Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets.

  2011cites this paper
• Complex assemblies of factors IX and X regulate the initiation, maintenance, and shutdown of blood coagulation.

  2011cites this paper
• The Role of Factor XIa (FXIa) Catalytic Domain Exosite Residues in Substrate Catalysis and Inhibition by the Kunitz Protease Inhibitor Domain of Protease Nexin 2*

  2011cites this paper
• Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor.

  2010cites this paper
• Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Aβ1-40

  2010cites this paper
• Blood cell markers in Alzheimer Disease: Amyloid Precursor Protein form ratio in platelets.

  2010cites this paper
• [The genetics of dementias. Part 2: The biology of Alzheimer's disease].

  2009cites this paper
• Bleeding in the brain: Amyloid-beta may keep clots away.

  2009cites this paper
• Bleeding in the brain: Amyloid-β may keep clots away

  2009cites this paper
• Platelet alpha-granules: basic biology and clinical correlates.

  2009cites this paper
• Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease.

  2008cites this paper
• Identification de déterminants génétiques impliqués dans la composante vasculaire de la MA, par analyses transcriptomiques, génétiques et moléculaires

  2008cites this paper
• Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease.

  2008cites this paper
• Reduced incidence of ischemic stroke in patients with severe factor XI deficiency.

  2008cites this paper
• The molecular pathology of amyloid deposition in Alzheimer's disease

  2008cites this paper
• Does Abeta 42 have a function related to blood homeostasis?

  2007cites this paper
• Increased Severity of Hemorrhage in Transgenic Mice Expressing Cerebral Protease Nexin-2/Amyloid &bgr;-Protein Precursor

  2007cites this paper
• CHAPTER 43 – Alzheimer's Disease

  2007cites this paper
• Modifications of platelet from Alzheimer disease patients: a possible relation between membrane properties and NO metabolites.

  2007cites this paper
• A catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets.

  2007cites this paper
• Structure and functions of the human amyloid precursor protein: the whole is more than the sum of its parts.

  2007cites this paper
• Does Aβ 42 Have a Function Related to Blood Homeostasis?

  2007cites this paper
• The Function of the Amyloid Precursor Protein Family

  2007cites this paper