The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway1

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Immunology

• Publication date

  2009-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.0900441PMID 19812211
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

  2009cited by this paper
• Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

  2009cited by this paper
• Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

  2008cited by this paper
• The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes

  2008cited by this paper
• Autophagy fights disease through cellular self-digestion

  2008cited by this paper
• Structural Basis for Sorting Mechanism of p62 in Selective Autophagy*

  2008cited by this paper
• Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy

  2008cited by this paper
• Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases.

  2008cited by this paper
• p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*

  2007cited by this paper
• Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

  2007cited by this paper
• Cytosol to Lysosome Transport of Intracellular Antigens During Immune Surveillance

  2007cited by this paper
• Signal integration and diversification through the p62 scaffold protein.

  2007cited by this paper
• Sequestosome 1/p62 – More than just a scaffold

  2007cited by this paper
• Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole*

  2006cited by this paper
• Autophagy Recognizes Intracellular Salmonella enterica serovar Typhimurium in Damaged Vacuoles

  2006cited by this paper
• Escape of Intracellular Shigella from Autophagy

  2005cited by this paper
• p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

  2005cited by this paper
• Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation

  2004cited by this paper
• Autophagy Defends Cells Against Invading Group A Streptococcus

  2004cited by this paper
• Recognition of bacteria in the cytosol of Mammalian cells by the ubiquitin system.

  2004cited by this paper
• Cellular autophagy: surrender, avoidance and subversion by microorganisms

  2004cited by this paper
• The role of autophagy during the early neonatal starvation period

  2004cited by this paper
• Interaction Codes within the Family of Mammalian Phox and Bem1p Domain-containing Proteins*

  2003cited by this paper
• p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.

  2002cited by this paper
• Ubiquitin and proteasomes: Molecular dissection of autophagy: two ubiquitin-like systems

  2001cited by this paper
• Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

  2001cited by this paper
• LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

  2000cited by this paper
• Of Mice, Calves, and Men

  1999cited by this paper
• Controlling the maturation of pathogen-containing vacuoles: a matter of life and death

  1999cited by this paper
• Of mice, calves, and men. Comparison of the mouse typhoid model with other Salmonella infections.

  1999cited by this paper
• Biogenesis of Salmonella typhimurium‐containing vacuoles in epithelial cells involves interactions with the early endocytic pathway

  1999cited by this paper
• Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat

  1991cited by this paper

• Ubiquitination and autophagy in host-pathogen interactions: from immune surveillance to therapeutic targeting.

  2026cites this paper
• Metallic- nanoparticles mediated programmed cell death in cancer cells: mechanisms and therapeutic implications

  2026cites this paper
• p62 protein pleomorphism confers tissue-specific function

  2026cites this paper
• Editorial: The role of autophagy in infectious diseases, volume II

  2026cites this paper
• p62 limits Salmonella Typhimurium in macrophages through its role in cell signalling

  2026cites this paper
• Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity

  2025cites this paper
• Staphylococcus aureus reprograms CASP8 (caspase 8) signaling to evade cell death and Xenophagy

  2025cites this paper
• The battle between bacterial infection and autophagy in aquatic animals

  2025influential citation
• Fludarabine attenuates inflammation and dysregulated autophagy in alveolar macrophages via inhibition of STAT1/IRF1 pathway

  2025cites this paper
• Tropheryma whipplei escapes LAPosome and modulates macrophage response in a xenophagy-dependent manner

  2025cites this paper
• Autophagy, ER-phagy and ER Dynamics During Cell Differentiation

  2025cites this paper
• Rab GTPases are evolutionarily conserved signals mediating selective autophagy.

  2025cites this paper
• Autophagy and Bacterial infections

  2025cites this paper
• Post-translational weapons of microbial warfare: how bacterial effectors hijack host cell death and xenophagy

  2025cites this paper
• Identification, Expression of AaSQSTM1 in Aedes albopictus and Its Autophagic Function Analysis

  2025cites this paper
• Shigella flexneri evades LPS ubiquitylation through IpaH1.4-mediated degradation of RNF213

  2025cites this paper
• SQSTM1/p62 from Litopenaeus vannamei is involved in the immune response to Vibrio infection.

  2025cites this paper
• Salmonella-Induced Cell Death in Cancer Immunotherapy: What Lies Beneath?

  2025cites this paper
• Overview of the Autophagy Pathways Associated with Infection

  2025cites this paper
• Unc-51-like kinase 1 (ULK1) regulates bacterial ubiquitylation and p62 recruitment during xenophagic clearance of Listeria monocytogenes

  2025cites this paper
• SQSTM1/p62 Post-Translational Modifications and Reverse Processes Modulate Disease Pathogenesis via KEAP1-NRF2 Signaling and Selective Autophagy

  2025cites this paper
• Deletion of the E3 ubiquitin ligase LRSAM1 fosters intracellular Staphylococcus aureus survival

  2025cites this paper
• Autophagy across tissues of aging mice

  2025cites this paper
• Trafficking of K63-polyubiquitin–modified membrane proteins in a macroautophagy-independent pathway is linked to ATG9A

  2025influential citation
• Post-Translational Modification of p62: Roles and Regulations in Autophagy

  2025cites this paper
• Phase separation of p62: roles and regulations in autophagy.

  2025cites this paper
• The interconnective role of the UPS and autophagy in the quality control of cancer mitochondria

  2025cites this paper
• Evolutionary conservation and metabolic significance of autophagy in algae

  2024cites this paper
• Unc-51-like Kinase 1 (ULK1) Regulates Bacterial Ubiquitylation and p62 Recruitment during Xenophagic Clearance of Listeria monocytogenes

  2024cites this paper
• An Update on the Study of the Molecular Mechanisms Involved in Autophagy during Bacterial Pathogenesis

  2024cites this paper
• Breaking the cellular defense: the role of autophagy evasion in Francisella virulence

  2024cites this paper
• Complement C3 deposition restricts the proliferation of internalized Staphylococcus aureus by promoting autophagy

  2024cites this paper
• Dysregulation of autophagy in gastric carcinoma: Pathways to tumor progression and resistance to therapy.

  2024cites this paper
• Bacterial esterases reverse lipopolysaccharide ubiquitylation to block host immunity.

  2024cites this paper
• Friends and Foes: The Ambivalent Role of Autophagy in HIV-1 Infection

  2024cites this paper
• Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum

  2024cites this paper
• Identification of autophagy receptors for the Crohn’s disease-associated adherent-invasive Escherichia coli

  2024cites this paper
• Physiological functions of ULK1/2.

  2024cites this paper
• Uropathogenic Escherichia coli Subverts Host Autophagic Defenses by Stalling Preautophagosomal Structures to Escape Lysosome Exocytosis

  2024cites this paper
• TLR-mediated aggresome-like induced structures comprise antimicrobial peptides and attenuate intracellular bacterial survival

  2024cites this paper
• Selective autophagy receptor p62 promotes antibacterial and antiviral immunity in common carp (Cyprinus carpio).

  2024cites this paper
• Autophagy-Dependent Ferroptosis in Cancer

  2023cites this paper
• Septins and K63 ubiquitin chains are present in separate bacterial microdomains during autophagy of entrapped Shigella

  2023cites this paper
• A autophagy related-like protein 16-1 promotes the formation of autophagosomes and autolysosomes in antibacterial immune response of pacific oyster Crassostrea gigas.

  2023cites this paper
• Seneca Valley virus 3C protease cleaves OPTN (optineurin) to Impair selective autophagy and type I interferon signaling

  2023cites this paper
• Impaired autophagy in the lower airways and lung parenchyma in stable COPD

  2023cites this paper
• Autophagy in sepsis-induced acute lung injury: Friend or foe?

  2023cites this paper
• A selective ER-phagy exerts neuroprotective effects via modulation of α-synuclein clearance in parkinsonian models

  2023cites this paper
• Dedicated bacterial esterases reverse lipopolysaccharide ubiquitylation to block immune sensing

  2023cites this paper
• Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

  2023cites this paper
• Roles of Stress Response in Autophagy Processes and Aging-Related Diseases

  2023cites this paper
• Ubiquitination and cell-autonomous immunity.

  2023cites this paper
• Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function.

  2023cites this paper
• Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy

  2023cites this paper
• Autophagy and Its Lineage-Specific Roles in the Hematopoietic System

  2023cites this paper
• KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function

  2023cites this paper
• In situ snapshots along a mammalian selective autophagy pathway

  2023cites this paper
• Role of autophagy pathway in Parkinson's disease and related Genetic Neurological disorders.

  2023cites this paper
• The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives

  2023cites this paper
• Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

  2022cites this paper
• Mitochondrial proteotoxicity: implications and ubiquitin-dependent quality control mechanisms

  2022cites this paper
• p62 bodies: Phase separation, NRF2 activation, and selective autophagic degradation

  2022cites this paper
• The mechanisms and roles of selective autophagy in mammals

  2022cites this paper
• Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection.

  2022cites this paper
• Emerging degrader technologies engaging lysosomal pathways

  2022cites this paper
• Autophagy in adipogenesis: Molecular mechanisms and regulation by bioactive compounds.

  2022cites this paper
• Control of infection by LC3-associated phagocytosis, CASM, and detection of raised vacuolar pH by the V-ATPase-ATG16L1 axis

  2022cites this paper
• MR1 dependent MAIT cell activation is regulated by autophagy associated proteins

  2022cites this paper
• Interaction Between Autophagy and Porphyromonas gingivalis-Induced Inflammation

  2022cites this paper
• Homeostasis Maintenance in Plasmodium-Infected Placentas: Is There a Role for Placental Autophagy During Malaria in Pregnancy?

  2022cites this paper
• Measles virus-imposed remodeling of the autophagy machinery determines the outcome of bacterial coinfection

  2022cites this paper
• Life and Death Decisions—The Many Faces of Autophagy in Cell Survival and Cell Death

  2022cites this paper
• Multifaceted roles of TAX1BP1 in autophagy

  2022cites this paper
• The crosstalk between bacteria and host autophagy: host defense or bacteria offense

  2022cites this paper
• Mechanisms underlying ubiquitin-driven selective mitochondrial and bacterial autophagy.

  2022cites this paper
• Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson’s Disease

  2022cites this paper
• Leptospiral lipopolysaccharide dampens inflammation through upregulation 1 of autophagy adaptor p62 and NRF2 signaling in macrophages

  2022influential citation
• When the Phagosome Gets Leaky: Pore-Forming Toxin-Induced Non-Canonical Autophagy (PINCA)

  2022cites this paper
• Activated autophagy-lysosomal pathway in dairy cows with hyperketonemia is associated with lipolysis of adipose tissues.

  2022cites this paper
• Developmental toxicity of nanomaterials used in drug delivery: understanding molecular biomechanics and potential remedial measures

  2022cites this paper
• A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component

  2022cites this paper
• Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I

  2022cites this paper
• The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection

  2022cites this paper
• Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins

  2022cites this paper
• Adaptations of intracellular bacteria to vacuolar or cytosolic niches.

  2022cites this paper
• Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy.

  2022cites this paper
• Autophagy-Inflammation Interplay During Infection: Balancing Pathogen Clearance and Host Inflammation

  2022cites this paper
• Nanocarrier mediated autophagy: An emerging trend for cancer therapy

  2021cites this paper
• Targeting XPO1 enhances innate immune response and inhibits KSHV lytic replication during primary infection by nuclear stabilization of the p62 autophagy adaptor protein

  2021cites this paper
• Autophagy in Cellular Stress Responses

  2021cites this paper
• The ubiquitin ligation machinery in the defense against bacterial pathogens

  2021cites this paper
• Global Proximity Interactome of the Human Macroautophagy Pathway

  2021cites this paper
• Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52

  2021influential citation
• Leukocyte‐Derived High‐Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes

  2021cites this paper
• Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1

  2021cites this paper
• Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

  2021cites this paper
• The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

  2021cites this paper
• Legionella pneumophila targets autophagosomes and promotes host autophagy during late infection

  2021cites this paper
• Autophagy and ALS: mechanistic insights and therapeutic implications

  2021cites this paper
• Mechanisms of Selective Autophagy.

  2021cites this paper