Endocrine and autocrine/paracrine modulators of brown adipose tissue mass and activity as novel therapeutic strategies against obesity and type 2 diabetes

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Hormone Molecular Biology and Clinical Investigation

• Publication date

  2017-08-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1515/hmbci-2017-0043PMID 28850545
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiology and role of irisin in glucose homeostasis

  2017cited by this paper
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  2017cited by this paper
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• Thyroid hormones induce browning of white fat

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• Role of Brown Fat in Lipoprotein Metabolism and Atherosclerosis.

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• Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte.

  2016cited by this paper
• Thyroid Hormone Activates Brown Adipose Tissue and Increases Non-Shivering Thermogenesis - A Cohort Study in a Group of Thyroid Carcinoma Patients

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• The Gq signalling pathway inhibits brown and beige adipose tissue

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• Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

  2016cited by this paper
• Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.

  2015influential reference
• Serum FGF21 levels are associated with brown adipose tissue activity in humans

  2015cited by this paper
• Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

  2015cited by this paper
• Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice

  2015cited by this paper
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  2015cited by this paper
• FGF21, energy expenditure and weight loss – How much brown fat do you need?

  2015cited by this paper
• Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.

  2015cited by this paper
• Fibroblast growth factor-21, energy balance and obesity.

  2015cited by this paper
• Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice

  2015cited by this paper
• Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.

  2015cited by this paper
• Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress.

  2015cited by this paper
• Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans

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• Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue

  2014cited by this paper
• Browning of white fat: does irisin play a role in humans?

  2014cited by this paper
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  2014cited by this paper
• Glucocorticoid hormones and energy homeostasis

  2014cited by this paper
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  2014cited by this paper
• Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

  2014cited by this paper
• BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells.

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• Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.

  2014cited by this paper
• Browning of White Adipose Tissue Uncouples Glucose Uptake from Insulin Signaling

  2014cited by this paper
• Estrogen Deficiency and the Origin of Obesity during Menopause

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• Brown and beige fat: development, function and therapeutic potential

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  2013cited by this paper
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• Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

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• Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes.

  2012influential reference
• BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

  2012cited by this paper
• Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

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• A PGC1α-dependent myokine that drives browning of white fat and thermogenesis

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• A PGC1–α–dependent myokine that drives brown–fat–like development of white fat and thermogenesis

  2012cited by this paper
• 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

  2011cited by this paper
• Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue*

  2011cited by this paper
• Type 2 deiodinase at the crossroads of thyroid hormone action.

  2011cited by this paper
• Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

  2011cited by this paper
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  2011cited by this paper
• Effects of ovariectomy and 17-β estradiol replacement on rat brown adipose tissue mitochondrial function.

  2011cited by this paper
• Relation of B-type natriuretic peptide levels to body mass index after comprehensive lifestyle changes.

  2010cited by this paper
• Microparticles: Protagonists of a Novel Communication Network for Intercellular Information Exchange

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  2010cited by this paper
• Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

  2010cited by this paper
• Sympathetic and sensory innervation of brown adipose tissue

  2010cited by this paper
• Impaired Metabolic Effects of a Thyroid Hormone Receptor Beta-Selective Agonist in a Mouse Model of Diet-Induced Obesity

  2010cited by this paper
• Role of glucocorticoids and the glucocorticoid receptor in metabolism: insights from genetic manipulations.

  2010cited by this paper
• Cold-activated brown adipose tissue in healthy men.

  2009cited by this paper
• Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.

  2009influential reference
• Identification and importance of brown adipose tissue in adult humans.

  2009cited by this paper
• High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans

  2009cited by this paper
• Cortisol Release From Adipose Tissue by 11β-Hydroxysteroid Dehydrogenase Type 1 in Humans

  2009cited by this paper
• Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes

  2009cited by this paper
• Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141.

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• Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States

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• Sex Steroid Receptor Expression Profile in Brown Adipose Tissue. Effects of Hormonal Status

  2007cited by this paper
• FGF-21 as a novel metabolic regulator.

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• Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome

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• Diet induced thermogenesis

  2004cited by this paper
• Brown adipose tissue: function and physiological significance.

  2004cited by this paper
• Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytes

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• Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region

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• Effect of a 28-d treatment with L-796568, a novel beta(3)-adrenergic receptor agonist, on energy expenditure and body composition in obese men.

  2002cited by this paper
• Acute effect of L‐796568, a novel β3‐adrenergic receptor agonist, on energy expenditure in obese men

  2002cited by this paper
• β3-Adrenoceptor agonists: potential, pitfalls and progress

  2002cited by this paper
• beta(3)-Adrenoceptor agonists: potential, pitfalls and progress.

  2002cited by this paper
• Acute effect of L-796568, a novel beta 3-adrenergic receptor agonist, on energy expenditure in obese men.

  2002cited by this paper
• Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.

  2001cited by this paper
• Triiodothyronine amplifies the adrenergic stimulation of uncoupling protein expression in rat brown adipocytes.

  2000cited by this paper
• Natriuretic peptides: a new lipolytic pathway in human adipocytes

  2000cited by this paper
• Corticosterone decreases nonshivering thermogenesis and increases lipid storage in brown adipose tissue.

  1995cited by this paper
• Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats.

  1994cited by this paper
• Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure.

  1993cited by this paper
• Cold exposure increases glucose utilization and glucose transporter expression in brown adipose tissue.

  1992cited by this paper
• Gaft-versus-leukemia activity after bone marrow transplantation does not require graft-versus-host disease

  1992cited by this paper
• Graft-versus-leukemia activity after bone marrow transplantation does not require graft-versus-host disease.

  1992cited by this paper
• Brown adipose tissue in humans

  1989cited by this paper
• Thermogenic effects of the antiglucocorticoid RU-486 in the rat: involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue.

  1989cited by this paper

• Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivo

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