An Update on Translating Stem Cell Therapy for Stroke from Bench to Bedside

With a constellation of stem cell sources available, researchers hope to utilize their potential for cellular repair as a therapeutic target for disease. However, many lab-to-clinic translational considerations must be given in determining their efficacy, variables such as the host response, effects on native tissue, and potential for generating tumors. This review will discuss the current knowledge of stem cell research in neurological disease, mainly stroke, with a focus on the benefits, limitations, and clinical potential.

• Publication year

  2013

• Venue

  Journal of Clinical Medicine

• Publication date

  2013-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3390/jcm2040220PMID 25177494PMCID 4148819
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Analysis of cd45- [cd34+/kdr+] Endothelial Progenitor Cells as Juvenile Protective Factors in a Rat Model of Ischemic-Hemorrhagic Stroke

  2013cited by this paper
• Neuroprotective Effect of Human Placenta-Derived Cell Treatment of Stroke in Rats

  2013cited by this paper
• Effect of the Presence of Brain-Derived Neurotrophic Factor Val66Met Polymorphism on the Recovery in Patients With Acute Subcortical Stroke

  2013cited by this paper
• The battle of the sexes for stroke therapy: female- versus male-derived stem cells.

  2013cited by this paper
• The survival of engrafted neural stem cells within hyaluronic acid hydrogels.

  2013cited by this paper
• Vector-Free and Transgene-Free Human iPS Cells Differentiate into Functional Neurons and Enhance Functional Recovery after Ischemic Stroke in Mice

  2013cited by this paper
• Neural progenitor cell survival in mouse brain can be improved by co-transplantation of helper cells expressing bFGF under doxycycline control.

  2013cited by this paper
• Two cells are better than one: optimizing stem cell survival by co-grafting "helper" cells that offer regulated trophic support.

  2013cited by this paper
• Hematopoietic stem cells improve dopaminergic neuron in the MPTP-mice.

  2013cited by this paper
• Brain-derived neurotrophic factor in generalized anxiety disorder: results from a duloxetine clinical trial.

  2013cited by this paper
• The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model.

  2012cited by this paper
• When one cell is enough

  2012cited by this paper
• Nerve growth factor: from the early discoveries to the potential clinical use

  2012cited by this paper
• Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells

  2012cited by this paper
• Intra-Arterial Bone Marrow Mononuclear Cells in Ischemic Stroke: A Pilot Clinical Trial

  2012cited by this paper
• Bone marrow- and subcutaneous adipose tissue-derived mesenchymal stem cells: Differences and similarities

  2012cited by this paper
• Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells

  2012cited by this paper
• Mesenchymal stem cell‐derived interleukin‐6 and vascular endothelial growth factor promote breast cancer cell migration

  2012cited by this paper
• Amnion-Derived Mesenchymal Stromal Cells Show Angiogenic Properties but Resist Differentiation into Mature Endothelial Cells

  2012cited by this paper
• Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells.

  2012cited by this paper
• Neurological disorders and the potential role for stem cells as a therapy.

  2012cited by this paper
• The immune score as a new possible approach for the classification of cancer

  2012cited by this paper
• Intra-Arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Patients with Moderate to Severe Middle Cerebral Artery Acute Ischemic Stroke

  2012cited by this paper
• The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations

  2012cited by this paper
• Breastmilk Is a Novel Source of Stem Cells with Multilineage Differentiation Potential

  2012cited by this paper
• Immunogenicity of induced pluripotent stem cells

  2011cited by this paper
• Intravenous autologous bone marrow mononuclear cells for ischemic stroke

  2011cited by this paper
• Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury.

  2011cited by this paper
• Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage.

  2011cited by this paper
• Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic stroke.

  2011cited by this paper
• Gene expression profile in mesenchymal stem cells derived from dental tissues and bone marrow

  2011cited by this paper
• Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells

  2011cited by this paper
• The risk of putting something where it does not belong: mesenchymal stem cells produce masses in the brain.

  2011cited by this paper
• Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke

  2011cited by this paper
• Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy.

  2011cited by this paper
• Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells.

  2011influential reference
• Baby STEPS: A Giant Leap for Cell Therapy in Neonatal Brain Injury

  2011cited by this paper
• Placenta‐derived MSCs are partially immunogenic and less immunomodulatory than bone marrow‐derived MSCs

  2011cited by this paper
• Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice—novel view on Igf-1, stem cells and aging

  2011cited by this paper
• The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders.

  2011cited by this paper
• Tumorigenic Development of Induced Pluripotent Stem Cells in Ischemic Mouse Brain

  2011cited by this paper
• Immunogenicity of induced pluripotent stem cells.

  2011cited by this paper
• Cotransplantation of Mouse Neural Stem Cells (mNSCs) with Adipose Tissue-Derived Mesenchymal Stem Cells Improves mNSC Survival in a Rat Spinal Cord Injury Model

  2011cited by this paper
• Induction of pluripotent stem cells transplantation therapy for ischemic stroke

  2011cited by this paper
• Effect of human neural precursor cell transplantation on endogenous neurogenesis after focal cerebral ischemia in the rat.

  2011cited by this paper
• Safety of Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Animals and Humans

  2011cited by this paper
• Functional Differences Between Mesenchymal Stem Cell Populations Are Reflected by Their Transcriptome

  2010cited by this paper
• Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration.

  2010cited by this paper
• Tridermal Tumorigenesis of Induced Pluripotent Stem Cells Transplanted in Ischemic Brain

  2010cited by this paper
• Recent advances on the non-classical major histocompatibility complex class I HLA-G molecule.

  2010cited by this paper
• Transplantation of placenta-derived mesenchymal stromal cells upon experimental stroke in rats.

  2010cited by this paper
• Brain injury activates microglia that induce neural stem cell proliferation ex vivo and promote differentiation of neurosphere-derived cells into neurons and oligodendrocytes.

  2010cited by this paper
• Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord.

  2010cited by this paper
• Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era.

  2010cited by this paper
• Hematopoietic stem cell transplantation protects mice from lethal stroke

  2010cited by this paper
• Human Umbilical Cord Blood Cells Have Trophic Effects on Young and Aging Hippocampal Neurons in Vitro.

  2010cited by this paper
• The Efficient Generation of Induced Pluripotent Stem (iPS) Cells from Adult Mouse Adipose Tissue-Derived and Neural Stem Cells

  2010cited by this paper
• The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization.

  2010cited by this paper
• Increased Neuronal Proliferation in the Dentate Gyrus of Aged Rats Following Neural Stem Cell Implantation

  2010cited by this paper
• Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis

  2010cited by this paper
• A Long‐Term Follow‐Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke

  2010cited by this paper
• Retraction: Spontaneous human adult stem cell transformation.

  2010cited by this paper
• Functional Improvement of Focal Cerebral Ischemia Injury by Subdural Transplantation of Induced Pluripotent Stem Cells with Fibrin Glue

  2010cited by this paper
• Transplantation of Human Neural Precursor Cells in Matrigel Scaffolding Improves Outcome from Focal Cerebral Ischemia after Delayed Postischemic Treatment in Rats

  2010cited by this paper
• Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke

  2010cited by this paper
• Generation of Human Induced Pluripotent Stem Cells from Umbilical Cord Matrix and Amniotic Membrane Mesenchymal Cells*

  2010cited by this paper
• A Teratocarcinoma-Like Human Embryonic Stem Cell (hESC) Line and Four hESC Lines Reveal Potentially Oncogenic Genomic Changes

  2010cited by this paper
• Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats

  2010cited by this paper
• Menstrual Blood Cells Display Stem Cell–Like Phenotypic Markers and Exert Neuroprotection Following Transplantation in Experimental Stroke

  2010cited by this paper
• Amnion: A Potent Graft Source for Cell Therapy in Stroke

  2009cited by this paper
• Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries.

  2009cited by this paper
• Neurotrophism of Bone Marrow Stromal Cells to Embryonic Stem Cells: Noncontact Induction and Transplantation to a Mouse Ischemic Stroke Model

  2009cited by this paper
• Endothelial Cells Support Survival, Proliferation, and Neuronal Differentiation of Transplanted Adult Ischemia‐Induced Neural Stem/Progenitor Cells After Cerebral Infarction

  2009cited by this paper
• Mechanisms of Positive Effects of Transplantation of Human Placental Mesenchymal Stem Cells on Recovery of Rats after Experimental Ischemic Stroke

  2009cited by this paper
• Who's in favor of translational cell therapy for stroke: STEPS forward please?

  2009cited by this paper
• Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine

  2009cited by this paper
• Cell Therapy for Stroke: Remaining Issues to Address Before Embarking on Clinical Trials

  2009cited by this paper
• A simple and efficient method for generating Nurr1-positive neuronal stem cells from human wisdom teeth (tNSC) and the potential of tNSC for stroke therapy.

  2009cited by this paper
• Cotransplantation of Mouse Embryonic Stem Cells and Bone Marrow Stromal Cells following Spinal Cord Injury Suppresses Tumor Development

  2009cited by this paper
• Intraarterially delivered human umbilical cord blood‐derived mesenchymal stem cells in canine cerebral ischemia

  2009cited by this paper
• Therapeutic Effect of Human Umbilical Cord Multipotent Mesenchymal Stromal Cells in a Rat Model of Stroke

  2009cited by this paper
• Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system.

  2009cited by this paper
• Cotransplantation of mouse embryonic stem cells and bone marrow stromal cells following spinal cord injury suppresses tumor development.

  2009cited by this paper
• Patterns and Dynamics of Subventricular Zone Neuroblast Migration in the Ischemic Striatum of the Adult Mouse

  2009cited by this paper
• Angiopoietin 2 Mediates the Differentiation and Migration of Neural Progenitor Cells in the Subventricular Zone after Stroke*

  2009cited by this paper
• Neural progenitor NT2N cell lines from teratocarcinoma for transplantation therapy in stroke.

  2008cited by this paper
• Hematopoietic Stem Cells Reduce Postischemic Inflammation and Ameliorate Ischemic Brain Injury

  2008cited by this paper
• Stem-cell ecology and stem cells in motion.

  2008cited by this paper
• Level and Value of Circulating Endothelial Progenitor Cells in Patients After Acute Ischemic Stroke

  2008cited by this paper
• Beneficial effect of autologous transplantation of bone marrow stromal cells and endothelial progenitor cells on cerebral ischemia in rabbits.

  2008cited by this paper
• Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma

  2008cited by this paper
• Endothelial progenitor cells for cardiovascular regeneration.

  2008cited by this paper
• Comparison of Human Placenta- and Bone Marrow–Derived Multipotent Mesenchymal Stem Cells

  2008cited by this paper
• Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain

  2008cited by this paper
• In vitro hypoxic preconditioning of embryonic stem cells as a strategy of promoting cell survival and functional benefits after transplantation into the ischemic rat brain.

  2008cited by this paper
• Potential of stem/progenitor cells in treating stroke: the missing steps in translating cell therapy from laboratory to clinic.

  2008cited by this paper
• Myocyte Enhancer Factor 2C as a Neurogenic and Antiapoptotic Transcription Factor in Murine Embryonic Stem Cells

  2008cited by this paper
• Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study.

  2008cited by this paper
• The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats.

  2008cited by this paper
• Fetal stem cells from extra-embryonic tissues: do not discard

  2008cited by this paper

• The promise of stem cell therapies for cellular recovery after stroke

  2025cites this paper
• Regenerative Neurology and Regenerative Cardiology: Shared Hurdles and Achievements

  2022cites this paper
• Emerging regenerative medicine for hemorrhagic stroke: An update on stem cell therapies

  2022cites this paper
• Ischemic Brain Stroke and Mesenchymal Stem Cells: An Overview of Molecular Mechanisms and Therapeutic Potential

  2022cites this paper
• Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

  2022cites this paper
• Potential Mechanisms and Perspectives in Ischemic Stroke Treatment Using Stem Cell Therapies

  2021cites this paper
• Mesenchymal Stem Cell-Induced Anti-Neuroinflammation Against Traumatic Brain Injury

  2021cites this paper
• Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme‐2 and masR receptor‐dependent

  2021cites this paper
• Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy

  2021cites this paper
• Delayed Treatment with Human Dental Pulp Stem Cells Accelerates Functional Recovery and Modifies Responses of Peri-Infarct Astrocytes Following Photothrombotic Stroke in Rats

  2021cites this paper
• Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke

  2020cites this paper
• Metabolomic Profiling of the Synergistic Effects of Ginsenoside Rg1 in Combination with Neural Stem Cell Transplantation in Ischemic Stroke Rats.

  2020cites this paper
• Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury

  2020cites this paper
• Amniotic fluid and breast milk: a rationale for breast milk stem cell therapy in neonatal diseases

  2020cites this paper
• Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow

  2020cites this paper
• Stem cells in human breast milk

  2019cites this paper
• Trends in clinical trials for stroke by cell therapy: data mining ClinicalTrials.gov and the ICTRP portal site

  2019cites this paper
• Drug-like delivery methods of stem cells as biologics for stroke

  2019cites this paper
• Transplantation of Directly Reprogrammed Human Neural Precursor Cells Following Stroke Promotes Synaptogenesis and Functional Recovery

  2019cites this paper
• Stem Cell-Paved Biobridge: A Merger of Exogenous and Endogenous Stem Cells Toward Regenerative Medicine in Stroke

  2018cites this paper
• Wharton’s Jelly-Derived Mesenchymal Stem Cell Transplantation in a Patient with Hypoxic-Ischemic Encephalopathy

  2018cites this paper
• Stem cell‐based cell therapy for neuroprotection in stroke: A review

  2018cites this paper
• Stem cell therapy for abrogating stroke‐induced neuroinflammation and relevant secondary cell death mechanisms

  2017influential citation
• Transplantation with hypoxia‐preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest–induced global cerebral ischemia in rats

  2017influential citation
• Cell therapy for cerebral hemorrhage: Five year follow-up report

  2016cites this paper
• Translating G-CSF as an Adjunct Therapy to Stem Cell Transplantation for Stroke

  2015cites this paper
• Stem-cell therapy for neurologic diseases

  2015cites this paper
• Stem cell therapies in preclinical models of stroke associated with aging

  2014cites this paper
• Hematopoietic stem cells improve dopaminergic neuron in the MPTP-mice.

  2013cites this paper
• Digital Commons @ University of South Florida Digital Commons @ University of South Florida

  year unknowncites this paper