Interleukin-1 receptor associated kinase inhibitors: potential therapeutic agents for inflammatory- and immune-related disorders.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cellular Signalling

• Publication date

  2015-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.cellsig.2015.02.025PMID 25728511
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The IKK complex, a central regulator of NF-kappaB activation.

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  2010cited by this paper
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• IRAK4 Kinase Activity Is Required for Th17 Differentiation and Th17-Mediated Disease1

  2009cited by this paper
• IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.

  2008cited by this paper
• MyD88 Functions as a Negative Regulator of TLR3/TRIF-induced Corneal Inflammation by Inhibiting Activation of c-Jun N-terminal Kinase*

  2008cited by this paper
• IRAK-4 inhibitors. Part 1: a series of amides.

  2008cited by this paper
• IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

  2008cited by this paper
• Expression and distribution of Toll-like receptors 11–13 in the brain during murine neurocysticercosis

  2008cited by this paper
• IRAK‐4 kinase activity is required for IRAK‐4‐dependent innate and adaptive immune responses

  2008cited by this paper
• A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

  2007cited by this paper
• IRAK-4 Kinase Activity Is Required for Interleukin-1 (IL-1) Receptor- and Toll-like Receptor 7-mediated Signaling and Gene Expression*

  2007cited by this paper
• TLR9 Activation Induces Normal Neutrophil Responses in a Child with IRAK-4 Deficiency: Involvement of the Direct PI3K Pathway

  2007cited by this paper
• Cutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations

  2007cited by this paper
• Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

  2007cited by this paper
• Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop.

  2007cited by this paper
• Innate immunogenetics: a tool for exploring new frontiers of host defence

  2007cited by this paper
• Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

  2007cited by this paper
• Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.

  2006cited by this paper
• Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

  2006cited by this paper
• IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease

  2006cited by this paper
• IRAK-4 Mutation (Q293X): Rapid Detection and Characterization of Defective Post-Transcriptional TLR/IL-1R Responses in Human Myeloid and Non-Myeloid Cells1

  2006cited by this paper
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  2006cited by this paper
• Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

  2005cited by this paper
• The active conformation of the PAK1 kinase domain.

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  2005cited by this paper
• Rip1 Mediates the Trif-dependent Toll-like Receptor 3- and 4-induced NF-κB Activation but Does Not Contribute to Interferon Regulatory Factor 3 Activation*

  2005cited by this paper
• Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.

  2005cited by this paper
• Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

  2005cited by this paper
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  2004cited by this paper
• Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

  2004cited by this paper
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  2004cited by this paper
• Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.

  2004cited by this paper
• Toll-like receptors in innate immunity.

  2004cited by this paper
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  2004cited by this paper
• Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling*

  2004cited by this paper
• NF-kappaB functions as a tumour promoter in inflammation-associated cancer.

  2004cited by this paper
• TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

  2003cited by this paper
• Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

  2003cited by this paper
• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

  2003cited by this paper
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  2003cited by this paper
• Toll-like Receptor Signaling*

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• The conformational plasticity of protein kinases.

  2002cited by this paper
• Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling1

  2002cited by this paper
• IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
• Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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  2001cited by this paper
• Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

  2001cited by this paper
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  2001cited by this paper
• Complement. Second of two parts.

  2001cited by this paper
• Multifaceted physiological response allows yeast to adapt to the loss of the signal recognition particle-dependent protein-targeting pathway.

  2001influential reference
• Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

  2001cited by this paper
• Complement. First of two parts.

  2001cited by this paper
• The immune system. First of two parts.

  2000cited by this paper
• Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway1

  2000cited by this paper
• A Toll-like receptor recognizes bacterial DNA

  2000cited by this paper
• Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9.

  2000cited by this paper
• Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

  2000cited by this paper
• Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.

  2000cited by this paper
• Unresponsiveness of MyD88-deficient mice to endotoxin.

  1999cited by this paper
• ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.

  1999cited by this paper
• The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

  1999cited by this paper
• Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

  1999cited by this paper
• MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

  1999cited by this paper
• IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family*

  1999cited by this paper
• Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

  1999cited by this paper
• The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

  1999cited by this paper
• The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

  1999cited by this paper
• Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

  1999cited by this paper
• Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

  1998cited by this paper
• IL-1 receptor accessory protein is an essential component of the IL-1 receptor.

  1998cited by this paper
• MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.

  1998cited by this paper
• Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling*

  1998cited by this paper
• IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

  1997cited by this paper
• MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

  1997cited by this paper
• Purification and Characterization of the Human Interleukin-18 Receptor*

  1997cited by this paper
• Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice.

  1997cited by this paper
• Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.

  1997cited by this paper
• Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

  1997cited by this paper
• The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

  1997cited by this paper
• Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

  1996cited by this paper
• ImmunoBiology: The Immune System in Health and Diseases

  1996cited by this paper
• Structural basis of cyclin-dependent kinase activation by phosphorylation

  1996cited by this paper

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