Physicochemical and physiological considerations for efficient nose-to-brain targeting

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Expert Opinion on Drug Delivery

• Publication date

  2012-01-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1517/17425247.2012.636801PMID 22171740
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intranasal drug delivery system- A glimpse to become maestro

  2011cited by this paper
• Nasal in situ gel containing hydroxy propyl β-cyclodextrin inclusion complex of artemether: development and in vitro evaluation

  2011cited by this paper
• Advances in nasal trans-mucosal drug delivery

  2011influential reference
• Neurobiological aspects of Alzheimer's disease

  2011cited by this paper
• Intranasal insulin: from nose to brain.

  2010cited by this paper
• Strategy for effective brain drug delivery.

  2010cited by this paper
• Gold nanoparticles: opportunities and challenges in nanomedicine

  2010cited by this paper
• Micellar Nanocarriers: Potential Nose-to-Brain Delivery of Zolmitriptan as Novel Migraine Therapy

  2010cited by this paper
• Intranasal Delivery—Modification of Drug Metabolism and Brain Disposition

  2010cited by this paper
• Freeze-dried chitosan/pectin nasal inserts for antipsychotic drug delivery.

  2010cited by this paper
• Formulation and characterization of nanoemulsion of olanzapine for intranasal delivery.

  2009cited by this paper
• Direct transport of VEGF from the nasal cavity to brain.

  2009cited by this paper
• A New Minimal-Stress Freely-Moving Rat Model for Preclinical Studies on Intranasal Administration of CNS Drugs

  2009cited by this paper
• Intranasal drug delivery: how, why and what for?

  2009influential reference
• Brain targeting studies on buspirone hydrochloride after intranasal administration of mucoadhesive formulation in rats

  2009cited by this paper
• Nanoparticles for direct nose-to-brain delivery of drugs.

  2009cited by this paper
• Nanoparticles for nasal vaccination.

  2009cited by this paper
• Direct nose-to-brain transfer of a growth hormone releasing neuropeptide, hexarelin after intranasal administration to rabbits.

  2009cited by this paper
• Nasal Delivery of High Molecular Weight Drugs

  2009influential reference
• New strategies to deliver anticancer drugs to brain tumors

  2009cited by this paper
• Intranasal delivery of antiepileptic medications for treatment of seizures

  2009cited by this paper
• Formulation and Characterization of Nanoemulsion-Based Drug Delivery System of Risperidone

  2009cited by this paper
• Intranasal drug delivery: a novel approach

  2009cited by this paper
• Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

  2008cited by this paper
• Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies

  2008influential reference
• Preparation of estradiol chitosan nanoparticles for improving nasal absorption and brain targeting.

  2008cited by this paper
• The nose may help the brain: intranasal drug delivery for treating neurological diseases

  2008cited by this paper
• Bioavailability of intranasal drug delivery system

  2008cited by this paper
• Mucoadhesive nanoemulsion-based intranasal drug delivery system of olanzapine for brain targeting

  2008influential reference
• Intranasal nanoemulsion based brain targeting drug delivery system of risperidone.

  2008cited by this paper
• Intranasal delivery: physicochemical and therapeutic aspects.

  2007cited by this paper
• Drug Targeting to the Brain

  2007cited by this paper
• Nasal Drug Delivery System-Factors Affecting and Applications

  2007influential reference
• Chitosan Reduced Gold Nanoparticles as Novel Carriers for Transmucosal Delivery of Insulin

  2007cited by this paper
• Distribution and clearance of bioadhesive formulations from the olfactory region in man: effect of polymer type and nasal delivery device.

  2007cited by this paper
• Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan.

  2006cited by this paper
• Spray-dried mucoadhesive microspheres: Preparation and transport through nasal cell monolayer

  2006cited by this paper
• Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting.

  2006cited by this paper
• Preliminary brain-targeting studies on intranasal mucoadhesive microemulsions of sumatriptan

  2006cited by this paper
• Formulation and in vitro, in vivo evaluation of extended- release matrix tablet of Zidovudine: Influence of combination of hydrophilic and hydrophobic matrix formers

  2006cited by this paper
• Insulin gel as an alternate to parenteral insulin: formulation, preclinical, and clinical studies.

  2005cited by this paper
• Intranasal mucoadhesive microemulsions of zolmitriptan: Preliminary studies on brain-targeting

  2005cited by this paper
• Nasal insulin gel as an alternate to parenteral insulin: Formulation, preclinical, and clinical studies

  2005cited by this paper
• Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives.

  2005cited by this paper
• Study on brain targeting of raltitrexed following intranasal administration in rats

  2005cited by this paper
• Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.

  2004cited by this paper
• Uptake of estradiol or progesterone into the CSF following intranasal and intravenous delivery in rats.

  2004cited by this paper
• Drug Metabolism in the Nasal Mucosa

  2004cited by this paper
• Intranasal delivery: An approach to bypass the blood brain barrier

  2004cited by this paper
• Nasal route and drug delivery systems

  2004cited by this paper
• Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain.

  2004cited by this paper
• Nasal drug delivery--possibilities, problems and solutions.

  2003influential reference
• The Effect of Blood Sampling Site and Physicochemical Characteristics of Drugs on Bioavailability After Nasal Administration in the Sheep Model

  2003cited by this paper
• In Vitro Polarized Transport of L-Phenylalanine in Human Nasal Epithelium and Partial Characterization of the Amino Acid Transporters Involved

  2003cited by this paper
• Permeability issues in nasal drug delivery.

  2002influential reference
• Nasal drug delivery: new developments and strategies.

  2002cited by this paper
• The nose and paranasal sinuses physiology and anatomy.

  2001cited by this paper
• Nasal absorption of ondansetron in rats: an alternative route of drug delivery

  2000cited by this paper
• Transport of drugs from the nasal cavity to the central nervous system.

  2000cited by this paper
• Intranasal drug delivery.

  1998cited by this paper
• Nasal delivery systems and their effect on deposition and absorption.

  1998cited by this paper
• Effects of physicochemical properties and other factors on systemic nasal drug delivery.

  1998cited by this paper
• Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters. III. Effects on Nasal Transport and Enzymatic Degradation of Acyclovir Prodrugs

  1994cited by this paper
• The nasal delivery of peptides and proteins.

  1991cited by this paper
• Nasal absorption of tetraethylammonium in rats.

  1989cited by this paper
• The Influence of Drugs on Nasal Ciliary Movement

  1987cited by this paper

• Silver nanoparticle microemulsion as a novel localized antimicrobial therapy: Formulation, efficacy, and safety evaluation

  2026influential citation
• mPEG-PLA micelles for nose-to-brain delivery of crizotinib-heptamethine cyanine dye conjugate for potential treatment of glioblastoma

  2025cites this paper
• Thermoresponsive engineered emulsions stabilised with branched copolymer surfactants for nasal drug delivery of molecular therapeutics.

  2025cites this paper
• Polysaccharides: New Frontiers for Nasal Administration of Medicines

  2025cites this paper
• Chitosan-Coated Liposomes for Intranasal Delivery of Ghrelin: Enhancing Bioavailability to the Central Nervous System

  2025cites this paper
• Characterization of a custom 3D-printed microfluidic aerosolizer for enhanced nose-to-brain delivery of nanoemulsion.

  2025cites this paper
• The review of nasal drug delivery system: The strategies to enhance the efficiency of intranasal drug delivery by improving drug absorption.

  2025cites this paper
• Intranasal administration of temozolomide conjugated nanoparticles with transcranial magnetic stimulation improves the survival in glioblastoma xenograft models

  2025cites this paper
• Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage.

  2024cites this paper
• In-depth Mechanism, Challenges, and Opportunities of Delivering Therapeutics in Brain Using Intranasal Route

  2024cites this paper
• Effect of Particle Size versus Surface Charge on the Brain Targeting Behaviour of Elastic Nanovesicles: In-Vitro Characterization, Comparison between I-optimal and D-optimal Statistical Optimization and In-vivo Pharmacokinetic Evaluation

  2024cites this paper
• Characterizing regional drug delivery within the nasal airways

  2024cites this paper
• Development of nanostructured environmentally responsive system containing hydroxypropyl methylcellulose for nose-to-brain administration of meloxicam.

  2024cites this paper
• Advances in Aerosol Formulation for Targeted Delivery of Therapeutic Agents from Nose to Brain.

  2024cites this paper
• Optimizing nasal drug delivery for peptides, proteins, and small molecules: strategic use of materials and techniques to target the CNS

  2024cites this paper
• Exploring the Potential of Nasal Drug Delivery for Brain Targeted Therapy: A Detailed Analysis

  2024influential citation
• Technological Strategies Applied to Pharmaceutical Systems for Intranasal Administration of Drugs Intended for Neurological Treatments: A Review

  2024influential citation
• Non-Invasive Techniques of Nose to Brain Delivery Using Nanoparticulate Carriers: Hopes and Hurdles

  2024cites this paper
• Systematic Approach in the Development of Chitosan Functionalized Iloperidone Nanoemulsions for Transnasal Delivery, In Vitro and In Vivo Studies

  2024cites this paper
• Advances in Polysaccharide-Based Formulations for Intranasal Drug Delivery: A Review

  2024cites this paper
• A Comprehensive Review on the Nanotechnology-based Intranasal Drug Delivery Systems for Brain Targeting

  2024cites this paper
• Novel therapeutic delivery for neurodegenerative diseases: Strategies to overcome CNS barriers

  2023cites this paper
• THE DEVELOPMENT OF A BRAIN TARGETED MUCOADHESIVE AMISULPRIDE LOADED NANOSTRUCTURED LIPID CARRIER

  2023cites this paper
• Nose-to-brain drug delivery for the treatment of glioblastoma multiforme: nanotechnological interventions

  2023cites this paper
• A new approach for the treatment of Alzheimer’s disease: insulin-quantum dots

  2023cites this paper
• Intranasal nanoparticulate delivery systems for neurodegenerative disorders: a review.

  2023cites this paper
• Polysaccharide-based platforms for nasal delivery: design, features, and perspectives

  2023cites this paper
• Recent update on pharmacokinetics and drug metabolism in CNS-based drug discovery.

  2023cites this paper
• In vitro and ex vivo experimental models for evaluation of intranasal systemic drug delivery as well as direct nose‐to‐brain drug delivery

  2023cites this paper
• Nasal administration of a temozolomide-loaded thermoresponsive nanoemulsion reduces tumor growth in a preclinical glioblastoma model.

  2023cites this paper
• A Comprehensive Review on Nanomedicine: Promising approach for treatment of brain tumor through intranasal administration.

  2022cites this paper
• A comprehensive review of recent advances and considerations for the selection of cell-based in-vitro techniques for the assessment of permeability.

  2022cites this paper
• The effect of inlet flow profile and nozzle diameter on drug delivery to the maxillary sinus

  2022cites this paper
• Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders

  2022influential citation
• Current Update on Transcellular Brain Drug Delivery

  2022cites this paper
• Formulation considerations for improving intranasal delivery of CNS acting therapeutics.

  2022cites this paper
• Nasal Route: A Breakthrough for Drug Delivery

  2022cites this paper
• Emerging nanoformulations for drug targeting to brain through intranasal delivery: A comprehensive review

  2022cites this paper
• Potential of naso-brain drug delivery in glioblastoma therapy

  2021cites this paper
• The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery.

  2021cites this paper
• Adenosinergic Pathway: A Hope in the Immunotherapy of Glioblastoma

  2021cites this paper
• A comparison study of Lipid and Polymeric Nanoparticles in the Nasal Delivery of Meloxicam: Formulation, Characterization, and In-Vitro Evaluation.

  2021cites this paper
• Clozapine loaded nanostructured lipid carriers engineered for brain targeting via nose-to-brain delivery: Optimization and in vivo pharmacokinetic studies

  2021cites this paper
• Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: Optimization and in vivo pharmacokinetic studies.

  2021cites this paper
• Mesenchymal Stem Cells for Neurological Disorders

  2021cites this paper
• Drug Delivery Systems and Strategies to Overcome the Barriers of Brain.

  2021cites this paper
• Intranasal Administration as a Route to Deliver Drugs to the Brain (Review)

  2021cites this paper
• Sceletium tortuosum: A review on its phytochemistry, pharmacokinetics, biological, pre-clinical and clinical activities.

  2021cites this paper
• Biomedical and biophysical limits to mathematical modeling of pulmonary system mechanics: a scoping review on aerosol and drug delivery

  2021cites this paper
• Particulate carriers for nose-to-brain delivery

  2021cites this paper
• Nose-to-brain drug delivery: Regulatory aspects, clinical trials, patents, and future perspectives

  2021cites this paper
• Physicochemical, biopharmaceutical, and practical considerations for efficient nose-to-brain drug delivery

  2021cites this paper
• Thermosensitive mucoadhesive in situ gel for intranasal delivery of Almotriptan malate: Formulation, characterization, and evaluation

  2020cites this paper
• Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in Alzheimer's disease.

  2020cites this paper
• Nanoparticlized System: Promising Approach for the Management of Alzheimer's Disease through Intranasal Delivery.

  2020cites this paper
• Nasal Bioadhesive Drug Delivery Systems and Their Applications

  2020cites this paper
• Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

  2020cites this paper
• The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems.

  2020cites this paper
• Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery.

  2020cites this paper
• Formulation and In Vitro Comparison Study between Lipid-Based and Polymeric-Based Nanoparticles for Nose-to-Brain Delivery of a Model Drug for Alzheimer’s Disease

  2020cites this paper
• Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery

  2019cites this paper
• In vitro validation of peptide-T3 conjugates as a treatment option for MCT8-deficiency via a “Trojan Horse”-like mechanism

  2019cites this paper
• Intranasal Tadalafil nanoemulsions: formulation, characterization and pharmacodynamic evaluation

  2019influential citation
• Smart thermosensitive chitosan hydrogel for nasal delivery of ibuprofen to treat neurological disorders

  2019cites this paper
• HPLC-UV method for temozolomide determination in complex biological matrices: application for in vitro, ex vivo and in vivo studies.

  2019cites this paper
• Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach

  2019cites this paper
• Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine

  2019cites this paper
• A REVIEW ON CLASSIFICATION, METHOD OF PREPARATION, CHARACTERIZATION OF SOLID LIPID NANOPARTICLES AND THEIR APPLICATION

  2019cites this paper
• Intranasal Delivering Method in the Treatment of Ischemic Stroke

  2019cites this paper
• Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650

  2019cites this paper
• A Precision Medicine Approach to Oxytocin Trials.

  2018cites this paper
• Investigation of Absorption Routes of Meloxicam and Its Salt Form from Intranasal Delivery Systems

  2018influential citation
• Regional deposition of nasal sprays in adults: A wide ranging computational study

  2018cites this paper
• Comparison of the Structural Features of Micron and Submicron Vaterite Particles and Their Efficiency for Intranasal Delivery of Anesthetic to the Brain

  2018cites this paper
• Modifying the physicochemical properties of NSAIDs for nasal and pulmonary administration.

  2018cites this paper
• Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

  2018cites this paper
• Numerical Comparison of Nasal Aerosol Administration Systems for Efficient Nose-to-Brain Drug Delivery

  2017cites this paper
• Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles.

  2017cites this paper
• Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

  2017cites this paper
• Proniosomes derived niosomes: recent advancements in drug delivery and targeting

  2017cites this paper
• Challenges in nasal drug absorption: how far have we come?

  2016cites this paper
• Targeted delivery of growth factors in ischemic stroke animal models

  2016cites this paper
• Chitosan and its derivatives-based nano-formulations in drug delivery

  2016cites this paper
• Brain Targeting of Temozolomide via the Intranasal Route Using Lipid-Based Nanoparticles: Brain Pharmacokinetic and Scintigraphic Analyses.

  2016cites this paper
• POTENTIAL APPLICATION OF DENDRIMERS IN DRUG DELIVERY: A CONCISE REVIEW AND UPDATE

  2016cites this paper
• Nasal-nanotechnology: revolution for efficient therapeutics delivery

  2016cites this paper
• Development and application of an ex vivo fosphenytoin nasal bioconversion/permeability evaluation method.

  2016influential citation
• Bioanalytical method validation of Venlafaxine and Desvenlafaxine in mouse plasma, brain and liver using a MEPS/HPLC assay: a path to study these drugs’ intranasal administration

  2015influential citation
• Formulation and evaluation of thermoreversible mucoadhesive in-situ gel for intranasal delivery of naratriptan hydrochloride

  2015cites this paper
• Advances in Neurotherapeutic Delivery Technologies

  2015cites this paper
• Is Alzheimer’s Disease Autoimmune Inflammation of the Brain That Can be Treated With Nasal Nonsteroidal Anti-Inflammatory Drugs?

  2015cites this paper
• Transport Mechanisms of Neurotherapeutics across the Blood-Brain Barrier eBooks

  2015cites this paper
• Chitosan as a suitable nanocarrier material for anti-Alzheimer drug delivery.

  2015cites this paper
• Formulation and Development of In-Situ Nasal Gel of NH Liposome based drug delivery system for brain targeting through intranasal route 147 8 FORMULATION AND DEVELOPMENT OF THERMOREVERSIBLE IN-SITU NASAL GEL OF NARATRIPTAN HYDROCHLORIDE

  2015cites this paper
• Mucoadhesive Amphiphilic Methacrylic Copolymer-Functionalized Poly(ε-caprolactone) Nanocapsules for Nose-to-Brain Delivery of Olanzapine.

  2015cites this paper
• Do delivery routes of intranasally administered oxytocin account for observed effects on social cognition and behavior? A two-level model.

  2015cites this paper
• Intranasal delivery of stem cells as therapy for central nervous system disease.

  2015cites this paper
• Brain Targeting of a Water Insoluble Antipsychotic Drug Haloperidol via the Intranasal Route Using PAMAM Dendrimer.

  2015cites this paper
• Brain Uptake of Neurotherapeutics after Intranasal versus Intraperitoneal Delivery in Mice.

  2015cites this paper
• Intranasal Oxytocin Administration is Associated With Enhanced Endogenous Pain Inhibition and Reduced Negative Mood States

  2014cites this paper