Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Diabetologia

• Publication date

  1993-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF00401058PMID 8270128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacokinetics, safety and efficacy of Bumped Kinase Inhibitor (BKI) 1553 in a pregnant sheep model of neosporosis

  2017cited by this paper
• Glucose Modulates Glucose Transporter Affinity, Glucokinase Activity, and Secretory Response in Rat Pancreatic β-Cells

  1993cited by this paper
• Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines.

  1992cited by this paper
• Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

  1992cited by this paper
• Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus.

  1992cited by this paper
• Glucose as Regulator of Glucose Transport Activity and Glucose-Transporter mRNA in Hamster β-Cell Line

  1992cited by this paper
• Glucose transporter isotypes switch in T-antigen-transformed pancreatic beta cells growing in culture and in mice

  1992cited by this paper
• Expression of yeast hexokinase in pancreatic beta cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes.

  1992cited by this paper
• Replacement of intracellular C-terminal domain of GLUT1 glucose transporter with that of GLUT2 increases Vmax and Km of transport activity.

  1992cited by this paper
• Expression of GLUT1 and GLUT2 Glucose Transporter Isoforms in Rat Islets of Langerhans and Their Regulation by Glucose

  1992cited by this paper
• NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse.

  1991cited by this paper
• Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells.

  1991cited by this paper
• Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.

  1991cited by this paper
• Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells.

  1991cited by this paper
• NIT-1, a Pancreatic β-Cell Line Established From a Transgenic NOD/Lt Mouse

  1991cited by this paper
• Transport and metabolism of glucose in an insulin-secreting cell line, beta TC-1.

  1991cited by this paper
• The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence.

  1990cited by this paper
• Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells.

  1990cited by this paper
• Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms.

  1990cited by this paper
• Modulation of Glucose-Induced Insulin Secretion from a Rat Clonal β-Cell Line*

  1990cited by this paper
• Regulation of Insulin Secretion from β-Cell Lines Derived from Transgenic Mice Insulinomas Resembles that of Normal β-Cells*

  1990cited by this paper
• Modulation of glucose-induced insulin secretion from a rat clonal beta-cell line.

  1990cited by this paper
• The acute effects of glucose on the insulin biosynthetic-secretory pathway in a simian virus 40-transformed hamster pancreatic islet beta-cell line.

  1989cited by this paper
• Functional Pancreatic β-Cell Line From SV40 T-Antigen Transgenic Mouse

  1989cited by this paper
• Culture of mouse pancreatic islets in different glucose concentrations modifies B cell sensitivity to streptozotocin

  1988cited by this paper
• Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells.

  1988cited by this paper
• Control of Glucose Phosphorylation and Glucose Usage in Clonal Insulinoma Cells

  1988cited by this paper
• Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

  1988cited by this paper
• The glucose sensor in HIT cells is the glucose transporter

  1987cited by this paper
• Characterization of glucose transport in an insulin-secreting cell line.

  1987cited by this paper
• 3-O-methyl-D-glucose transport in tumoral insulin-producing cells.

  1986cited by this paper
• Glucose transport by radiation-induced insulinoma and clonal pancreatic beta-cells.

  1986cited by this paper
• Glucose Transport by Radiation-Induced Insulinoma and Clonal Pancreatic β-Cells

  1986cited by this paper
• Interplay of nutrients and hormones in the regulation of insulin release.

  1985cited by this paper
• Glucose metabolism in insulin-producing tumoral cells.

  1985cited by this paper
• All hexokinase isoenzymes coexist in rat hepatocytes.

  1984cited by this paper
• Hexose metabolism in pancreatic islets. Inhibition of hexokinase.

  1984cited by this paper
• Kinetics of 5-hydroxytryptophan potentiation of glucose-induced insulin release.

  1984cited by this paper
• Chromatographic resolution and kinetic characterization of glucokinase from islets of Langerhans.

  1983cited by this paper
• Differences in glucose handling by pancreatic A- and B-cells.

  1983cited by this paper
• Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F).

  1983cited by this paper
• Regulation of Glucose Metabolism in Pancreatic Islets

  1981influential reference
• The identification of extrahepatic "glucokinase" as N-acetylglucosamine kinase.

  1980cited by this paper
• The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function.

  1978cited by this paper
• Glucose and ATP levels in pancreatic islet tissue of normal and diabetic rats.

  1976cited by this paper
• The use of dispersed pancreatic islet cells in measurements of transmembrane transport

  1975cited by this paper
• The preparation of, and studies on, free cell suspensions from mouse pancreatic islets

  1974cited by this paper
• The pentose cycle and insulin release in mouse pancreatic islets.

  1972cited by this paper
• GLUCOKINASE OF RABBIT LIVER.

  1965cited by this paper
• EFFECTS OF CARBOHYDRATES ON SECRETION OF INSULIN FROM ISOLATED RAT PANCREAS.

  1963cited by this paper

• Differential effects of isopropyl alcohol on glucose-induced insulin secretion in INS-1 and MIN6 cells.

  2026cites this paper
• Involvement of glucagon-like peptide-1 receptor in fisetin tetramethyl ether-enhanced insulin secretion in MIN6 cells.

  2025cites this paper
• Temporal Effects of a Viral Peptide on Glucose-Stimulated Insulin Secretion.

  2025cites this paper
• HG043, a potent thienopyrimidine GPR119 agonist, demonstrates enhanced anti-diabetic and anti-obesity effects in preclinical models.

  2025cites this paper
• Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization

  2025cites this paper
• c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling.

  2025cites this paper
• Self-Adaptive Simulation Models: A Case Study in Cell Biology

  2025cites this paper
• Axonemal Dynein Visualized in Primary Cilia via Expansion Microscopy.

  2025cites this paper
• High-Yield Generation of Glucose-Responsive Pseudoislets From Murine Insulinoma Cells for In Vitro Studies and Longitudinal Monitoring of Graft Survival In Vivo

  2025influential citation
• Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in mouse pancreatic β cells

  2025cites this paper
• Liraglutide, a GLP-1 Receptor Agonist, Enhances Proliferation and Secretory Function of Pancreatic β-Cells with Activated ABCC8

  2025cites this paper
• Nobiletin Alleviates Npy1r‐Mediated Insulin Secretion Deficiency of Islet β‐Cells via the Clock‐Modulatory Signaling

  2025cites this paper
• c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signaling

  2025cites this paper
• Illuminating the Role of Asymmetric Mitochondrial Fission on Beta-Cell Health

  2025influential citation
• Pancreatic β cell models for screening insulin secretagogues and cytotoxicity

  2024cites this paper
• Ginsenoside Rk1 Ameliorates ER Stress-Induced Apoptosis through Directly Activating IGF-1R in Mouse Pancreatic [Formula: see text]-Cells and Diabetic Pancreas.

  2024cites this paper
• Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells

  2024cites this paper
• Clinical and functional characterization of a novel KCNJ11 (c.101G > A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13

  2024cites this paper
• Anti-diabetic effects of a phytomedicinal formulation in streptozotocin and high-fat diet-induced diabetic nephropathy

  2024cites this paper
• Genetically engineered long-acting Esculentin-2CHa(1-30) fusion protein with potential applicability for the treatment of NAFLD.

  2024cites this paper
• Hexokinase-linked glycolytic overload and unscheduled glycolysis in hyperglycemia-induced pathogenesis of insulin resistance, beta-cell glucotoxicity, and diabetic vascular complications

  2024cites this paper
• (Re-)Viewing Role of Intracellular Glucose Beyond Extracellular Regulation of Glucose-Stimulated Insulin Secretion by Pancreatic Cells

  2024cites this paper
• CK2 activity is crucial for proper glucagon expression

  2024influential citation
• Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

  2024influential citation
• Iterative sacrificial 3D printing and polymer casting to create complex vascular grafts and multi-compartment bioartificial organs

  2024cites this paper
• SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes

  2024cites this paper
• Microfluidic chip systems for characterizing glucose-responsive insulin-secreting cells equipped with FailSafe kill-switch

  2024cites this paper
• Extracellular metallothionein as a therapeutic target in the early progression of type 1 diabetes

  2024cites this paper
• Phytochemical Screening and Antidiabetic Efficacy of Balanites aegyptiaca Seed Extract and Their Silver Nanoparticles on Muscle and Pancreatic Cell Lines

  2024cites this paper
• Engineering pore-enriched and pre-vascularized volumetric constructs for enhanced blood glucose regulation in type 1 diabetes therapy

  2024cites this paper
• Pancreatic β cell-secreted factor FGF23 attenuates Alzheimer's disease-related amyloid β-induced neuronal death

  2024cites this paper
• Untangling the genetics of beta cell dysfunction and death in type 1 diabetes

  2024cites this paper
• Secretory Conservation in Insulin Producing Cells: Is There a System-Level Law of Mass Action in Biology?

  2023cites this paper
• The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease

  2023cites this paper
• Nrf2: Therapeutic target of islet function protection in diabetes and islet transplantation.

  2023cites this paper
• Energy status regulates levels of the RAR/RXR ligand 9-cis-retinoic acid in mammalian tissues: Glucose reduces its synthesis in β-cells

  2023cites this paper
• A large-scale functional analysis of genes expressed differentially in insulin secreting MIN6 sublines with high versus mildly reduced glucose-responsiveness

  2023cites this paper
• DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets

  2023cites this paper
• Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets

  2023cites this paper
• HCV affects KATP channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic β-cells leading to impaired insulin secretion

  2023cites this paper
• MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response

  2023cites this paper
• Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic β cells

  2023cites this paper
• The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function.

  2022cites this paper
• A novel in vitro approach to test the effectiveness of fish oil in ameliorating type 1 diabetes

  2022cites this paper
• Truncated suPAR simultaneously causes kidney disease and autoimmune diabetes mellitus

  2022cites this paper
• Growth of MIN-6 Cells on Salmon Fibrinogen Scaffold Improves Insulin Secretion

  2022cites this paper
• Physiological roles of hydrogen sulfide in mammalian cells, tissues and organs.

  2022cites this paper
• Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

  2022cites this paper
• Honey polyphenolic fraction inhibits cyclooxygenase-2 expression via upregulation of microRNA-26a-5p expression in pancreatic islets

  2022cites this paper
• Pseudoislet Aggregation of Pancreatic β-Cells Improves Glucose Stimulated Insulin Secretion by Altering Glucose Metabolism and Increasing ATP Production

  2022cites this paper
• Pharmacological Dose-Effect Profiles of Various Concentrations of Humanised Primary Bile Acid in Encapsulated Cells

  2022cites this paper
• ATP is an essential autocrine factor for pancreatic β‐cell signaling and insulin secretion

  2022cites this paper
• Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease

  2022cites this paper
• Importance of Heparan Sulfate Proteoglycans in Pancreatic Islets and β-Cells

  2022cites this paper
• Expression and Functional Role of Olfactory, Taste, and Phototransduction Signal Proteins in β Cells in Islets of Langerhans

  2022cites this paper
• G protein–coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin

  2022cites this paper
• 4-OI Protects MIN6 Cells from Oxidative Stress Injury by Reducing LDHA-Mediated ROS Generation

  2022cites this paper
• Upregulation of Nrf2 Signalling and the Inhibition of Erastin-Induced Ferroptosis by Ferulic Acid in MIN6 Cells

  2022cites this paper
• Nuclear Receptors in Energy Metabolism.

  2022cites this paper
• Development of a Platform for the Biofabrication of Endocrine Pancreatic Tissue Constructs through Co-Axial Micro-Extrusion

  2021cites this paper
• Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

  2021cites this paper
• Using recombinase‐mediated cassette exchange to engineer MIN6 insulin‐secreting cells based on a newly identified safe harbor locus

  2021cites this paper
• Optical Nanosensors for Real-time Feedback on Insulin Secretion by β-Cells

  2021cites this paper
• Tacrolimus inhibits insulin release and promotes apoptosis of Min6 cells through the inhibition of the PI3K/Akt/mTOR pathway.

  2021cites this paper
• Design and Catalyzed Activation of Mycophenolic Acid Prodrugs.

  2021cites this paper
• Analysis of miRNA and mRNA expression in the dysregulation of insulin secretion in MIN6 cells exposed to microcystin-leucine-arginine.

  2021cites this paper
• Proteoglycan profiling of human, rat and mouse insulin-secreting cells

  2021cites this paper
• Effect of anesthetics on insulin secretion and their mechanism

  2021cites this paper
• SGC-CK2-1 Is an Efficient Inducer of Insulin Production and Secretion in Pancreatic β-Cells

  2021cites this paper
• Engineering‐inspired approaches to study β‐cell function and diabetes

  2021cites this paper
• Clinical and Functional Characteristics of a Novel KLF11 Cys354Phe Variant Involved in Maturity-Onset Diabetes of the Young

  2021cites this paper
• In Vivo Bioengineering of Beta Cells with Immune Checkpoint Ligand as a Treatment for Early-Onset Type 1 Diabetes Mellitus.

  2021cites this paper
• Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells

  2021cites this paper
• Dynamic changes in β-cell [Ca2+] regulate NFAT activation, gene transcription, and islet gap junction communication

  2021cites this paper
• Intracellular ATP Signaling Contributes to FAM3A-Induced PDX1 Upregulation in Pancreatic Beta Cells

  2021cites this paper
• Unique Human and Mouse β-Cell Senescence-Associated Secretory Phenotype (SASP) Reveal Conserved Signaling Pathways and Heterogeneous Factors

  2021cites this paper
• Stem Cells from Human Exfoliated Deciduous Teeth Differentiation and Characterization in to Islet like Pancreatic Cell Lineages – An Ex-vivo and In-vitro Study

  2021cites this paper
• HSPB1 Is Essential for Inducing Resistance to Proteotoxic Stress in Beta-Cells

  2021cites this paper
• A 3D bioprinted hybrid encapsulation system for delivery of human pluripotent stem cell-derived pancreatic islet-like aggregates

  2021cites this paper
• Single-cell heterogeneity analysis and CRISPR screens in MIN6 cell line reveal transcriptional regulators of insulin

  2021cites this paper
• A therapeutic convection–enhanced macroencapsulation device for enhancing β cell viability and insulin secretion

  2021cites this paper
• Noninvasive Tracking of mPEG-poly(Ala) Hydrogel-Embedded MIN6 Cells after Subcutaneous Transplantation in Mice

  2021cites this paper
• Human embryonic stem cells as an in vitro model for studying developmental origins of type 2 diabetes

  2020cites this paper
• Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol.

  2020cites this paper
• Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3.

  2020cites this paper
• Hypoxia inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia.

  2020cites this paper
• Drug-integrating amphiphilic nanomaterial assemblies: 1. Spatiotemporal control of cyclosporine delivery and activity using nanomicelles and nanofibrils.

  2020cites this paper
• Photo-releasable derivatives of inositol pyrophosphates.

  2020cites this paper
• vH+-ATPase-induced intracellular acidification is critical to glucose-stimulated insulin secretion in beta cells

  2020cites this paper
• Characterization of a mouse model of islet transplantation using MIN-6 cells

  2020cites this paper
• Perfluoroalkyl substances stimulate insulin secretion by islet cells via G protein-coupled receptor 40

  2020cites this paper
• Dynamic changes in β-cell electrical activity and [Ca2+] regulates NFATc3 activation and downstream gene transcription

  2020cites this paper
• Optoacoustic imaging of GLP-1 Receptor with a near-infrared exendin-4 analog

  2020cites this paper
• Small-molecule GLP-1 secretagogs: challenges and recent advances.

  2020cites this paper
• Exploring G Protein-Coupled Receptor Signaling in Primary Pancreatic Islets

  2020cites this paper
• Optoacoustic Imaging of Glucagon-like Peptide-1 Receptor with a Near-Infrared Exendin-4 Analog

  2020influential citation
• Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

  2020cites this paper
• Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors.

  2020cites this paper
• Novel Mouse miRNA Chr13_novelMiR7354-5p Improves Bone-Marrow-Derived Mesenchymal Stem Cell Differentiation into Insulin-Producing Cells

  2020cites this paper
• Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes.

  2020cites this paper