Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Virology

• Publication date

  1997-02-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1006/VIRO.1996.8399PMID 9123823
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway

  1996cited by this paper
• Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule

  1996cited by this paper
• HIV induces activation of phosphatidylinositol 4‐kinase and mitogen‐activated protein kinase by interacting with T cell CD4 surface molecules

  1996cited by this paper
• Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines.

  1995cited by this paper
• HIV-1 Envelope Glycoproteins Induce Activation of Activated Protein-1 in CD4+ T Cells (*)

  1995cited by this paper
• Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4

  1995cited by this paper
• The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4

  1995cited by this paper
• Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein.

  1995cited by this paper
• The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.

  1994cited by this paper
• Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for ras activation in CHO cells

  1994cited by this paper
• Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.

  1994cited by this paper
• Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

  1994cited by this paper
• p56lck interacts via its src homology 2 domain with the ZAP-70 kinase

  1994cited by this paper
• Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

  1994cited by this paper
• 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

  1994cited by this paper
• Myristylation and palmitylation of Src family members: the fats of the matter.

  1994cited by this paper
• gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.

  1994cited by this paper
• Activation of p56lck by p72syk through physical association and N-terminal tyrosine phosphorylation

  1994cited by this paper
• Myristylation and palmitylation of Src family members: The fats of the matter

  1994cited by this paper
• Association of p56lck with the cytoplasmic domain of CD4 modulates HIV‐1 expression.

  1994cited by this paper
• The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T‐cells.

  1994cited by this paper
• Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins

  1993cited by this paper
• The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes

  1993cited by this paper
• Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

  1993influential reference
• Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.

  1993cited by this paper
• Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

  1993cited by this paper
• Interaction of human immunodeficiency virus glycoprotein 160 with CD4 in Jurkat cells increases p56lck autophosphorylation and kinase activity.

  1992cited by this paper
• Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck.

  1992cited by this paper
• A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells

  1992cited by this paper
• Wortmannin, a microbial product inhibitor of myosin light chain kinase.

  1992cited by this paper
• Construction of a Recombinant Bacterial Human CD4 Expression System Producing a Bioactive CD4 Molecule

  1992cited by this paper
• Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor

  1992cited by this paper
• Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways.

  1992cited by this paper
• Inhibition of virus production in peripheral blood mononuclear cells from human immunodeficiency virus (HIV) type 1-seropositive donors by treatment with recombinant HIV-like particles

  1992cited by this paper
• A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells

  1992cited by this paper
• Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

  1992cited by this paper
• Tyrosyl phosphorylation and activation of MAP kinases by p56lck.

  1992cited by this paper
• CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.

  1992cited by this paper
• GPI-anchored cell-surface molecules complexed to protein tyrosine kinases.

  1991cited by this paper
• The lymphocyte-specific tyrosine protein kinase p56lck.

  1991cited by this paper
• The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

  1991influential reference
• Characterization of a Monoclonal Antibody Directed Against the Phosphotyrosine Kinase p56lck, in Human T Cells

  1991cited by this paper
• HIV-1 Binding to CD4 T Cells Does Not Induce a Ca2+ Influx or Lead to Activation of Protein Kinases

  1991cited by this paper
• Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes.

  1991cited by this paper
• Functional consequences of CD4-TCR/CD3 interactions.

  1991cited by this paper
• The lck tyrosine protein kinase.

  1991cited by this paper
• Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

  1991cited by this paper
• Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

  1991cited by this paper
• The lck tyrosine protein kinase.

  1991cited by this paper
• Biologic activities of HIV-1 envelope glycoprotein: the effects of crosslinking.

  1990cited by this paper
• Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site

  1990influential reference
• Activation of phosphatidylinositol 3-kinase by insulin.

  1990cited by this paper
• Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.

  1990cited by this paper
• No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120

  1990influential reference
• Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

  1989influential reference
• The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain.

  1989cited by this paper
• Origin of HIV.

  1989cited by this paper
• Identification of the residues in human CD4 critical for the binding of HIV.

  1989cited by this paper
• Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes

  1989influential reference
• Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

  1989influential reference
• Origin of the HIV-Susceptible Human CD4+ Cell Line H9

  1989cited by this paper
• Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways

  1989influential reference
• The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.

  1988cited by this paper
• The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.

  1988cited by this paper
• Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C.

  1988cited by this paper
• Lymphocyte activation by HIV-1 envelope glycoprotein

  1988cited by this paper
• Cross‐linking of the T cell receptor complex with the subset‐specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells

  1987cited by this paper
• Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.

  1987cited by this paper
• Effective activation of resting mouse T lymphocytes by cross‐linking submitogenic concentrations of the T cell antigen receptor with either Lyt‐2 or L3T4

  1987cited by this paper
• Interaction between CD4 and class II MHC molecules mediates cell adhesion

  1987cited by this paper
• Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

  1986influential reference
• Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4

  1986cited by this paper
• The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.

  1986cited by this paper
• The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.

  1985cited by this paper
• Loss of envelope antigens of HTLV-III/LAV, a factor in AIDS pathogenesis?

  1985cited by this paper
• Perturbation of the T4 molecule transmits a negative signal to T cells

  1985cited by this paper
• The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

  1984cited by this paper
• Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines.

  1984cited by this paper
• T-lymphocyte T4 molecule behaves as the receptor for human retrovirus  LAV

  1984cited by this paper
• Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

  1984cited by this paper
• Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia

  1965cited by this paper

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  2014cites this paper
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