The Protein Tyrosine Kinase p56lck Is Required for Triggering NF-κB Activation upon Interaction of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein gp120 with Cell Surface CD4

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Journal of Virology

• Publication date

  1998-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.72.7.6207-6214.1998PMID 9621091PMCID PMC110439
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The lck protein tyrosine kinase is not involved in antibody‐mediated CD4 (CDR3‐loop) signal transduction that inhibits HIV‐1 transcription

  1998cited by this paper
• Involvement of extracellular signal-regulated kinase module in HIV-mediated CD4 signals controlling activation of nuclear factor-kappa B and AP-1 transcription factors.

  1998cited by this paper
• Transduction of Activation Signal That Follows HIV-1 Binding to CD4 and CD4 Dimerization Involves the Immunoglobulin CDR3-like Region in Domain 1 of CD4*

  1997cited by this paper
• Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase.

  1997influential reference
• CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.

  1997influential reference
• Baseline HIV type 1 load predicts the long-term clinical outcome of infected patients. The 'positive feedback theory'.

  1997cited by this paper
• Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5

  1997cited by this paper
• Upregulation of human immunodeficiency virus (HIV) replication by CD4 cross-linking in peripheral blood mononuclear cells of HIV-infected adults

  1997cited by this paper
• An antibody that binds domain 1 of CD4 inhibits replication of HIV-1, but not HTLV-I, in a CD4-positive/p56lck-negative HTLV-I-transformed cell line.

  1996cited by this paper
• HIV infection in vitro enhances the activity of src-family protein tyrosine kinases.

  1996cited by this paper
• HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

  1996influential reference
• HIV induces activation of phosphatidylinositol 4‐kinase and mitogen‐activated protein kinase by interacting with T cell CD4 surface molecules

  1996influential reference
• Binding of HIV-1 virions or gp120-anti-gp120 immune complexes to HIV-1-infected quiescent peripheral blood mononuclear cells reveals latent infection.

  1996influential reference
• Cyclosporin A sensitivity of the HIV‐1 long terminal repeat identifies distinct p56lck‐dependent pathways activated by CD4 triggering

  1996cited by this paper
• Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway

  1996influential reference
• The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3-like region in domain 1 of CD4

  1995influential reference
• Inhibition of CD4/p56lck signaling by a dominant negative mutant of the Shc adaptor protein.

  1995cited by this paper
• HIV-1 Envelope Glycoproteins Induce Activation of Activated Protein-1 in CD4+ T Cells (*)

  1995cited by this paper
• HIV-1 gp120/160 expressing cells upregulate HIV-1 LTR directed gene expression in a cell line transfected with HIV-1 LTR-reporter gene constructs.

  1995cited by this paper
• The CD4-associated Tyrosine Kinase p56 Is Required for Lymphocyte Chemoattractant Factor-induced T Lymphocyte Migration (*)

  1995cited by this paper
• Signals Transduced through the CD4 Molecule on T-Lymphocytes Activate NF-κB

  1994cited by this paper
• CD4-mediated enhancement or inhibition of T cell activation does not require the CD4:p56lck association

  1994cited by this paper
• Signals transduced through the CD4 molecule on T lymphocytes activate NF-kappa B.

  1994cited by this paper
• gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.

  1994cited by this paper
• The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T‐cells.

  1994influential reference
• Signal transduction by lymphocyte antigen receptors.

  1994influential reference
• Tyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation.

  1993cited by this paper
• Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

  1993cited by this paper
• Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase

  1993cited by this paper
• An antibody that binds the immunoglobulin CDR3‐like region of the CD4 molecule inhibits provirus transcription in HIV‐infected T cells.

  1993cited by this paper
• A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells

  1992cited by this paper
• Disruption of the CD4-p56lck complex is required for rapid internalization of CD4.

  1992cited by this paper
• The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

  1992cited by this paper
• Interaction of human immunodeficiency virus glycoprotein 160 with CD4 in Jurkat cells increases p56lck autophosphorylation and kinase activity.

  1992cited by this paper
• Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/murine heterokaryons

  1992cited by this paper
• Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

  1992cited by this paper
• Tyrosyl phosphorylation and activation of MAP kinases by p56lck.

  1992cited by this paper
• Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens.

  1991cited by this paper
• Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides

  1991cited by this paper
• Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

  1991cited by this paper
• Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.

  1991cited by this paper
• Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes.

  1991cited by this paper
• The HIV protein, GP120, activates nuclear protein kinase C in nuclei from lymphocytes and brain.

  1990influential reference
• Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

  1990cited by this paper
• Crystal structure of an HIV-binding recombinant fragment of human CD4

  1990cited by this paper
• Structural features of the cytoplasmic region of CD4 required for internalization.

  1990cited by this paper
• Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.

  1990cited by this paper
• Crystal structure of an HIV-binding recombinant fragment of human CD4.

  1990cited by this paper
• T-cell receptor-CD4 physical association in a murine T-cell hybridoma: induction by antigen receptor ligation.

  1989cited by this paper
• The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain.

  1989cited by this paper
• Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

  1989cited by this paper
• Human immunodeficiency virus induces phosphorylation of its cell surface receptor

  1988cited by this paper
• Lymphocyte activation by HIV-1 envelope glycoprotein

  1988influential reference
• The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

  1988cited by this paper
• HIV infection does not require endocytosis of its receptor, CD4.

  1988cited by this paper
• Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

  1987cited by this paper
• Evidence for a physical association of CD4 and the CD3:alpha:beta T-cell receptor.

  1987cited by this paper
• Cross-linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes.

  1987cited by this paper
• The structure of the CD4 and CD8 genes.

  1987cited by this paper
• Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

  1987cited by this paper
• The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.

  1986cited by this paper
• The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

  1984cited by this paper
• T-lymphocyte T4 molecule behaves as the receptor for human retrovirus  LAV

  1984cited by this paper
• Disruption of the CD 4p 56 lck complex is required for rapid internalization of CD 4 ( T-celi activation / receptor inteatio / protein-tyrosine kinae )

  year unknowncited by this paper

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