A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Controlled Release

• Publication date

  2003-01-09

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1016/S0168-3659(02)00320-6PMID 12490371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles

  2008cited by this paper
• Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol).

  2002cited by this paper
• Preparation and characterization of sterile and freeze-dried sub-200 nm nanoparticles.

  2002cited by this paper
• Paclitaxel and its formulations.

  2002cited by this paper
• The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.

  2000cited by this paper
• Revisiting PLA/PLGA microspheres: an analysis of their potential in parenteral vaccination.

  2000cited by this paper
• Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method.

  1999cited by this paper
• Influence of the Degrees of Hydrolyzation and Polymerization of Poly(vinylalchol)on the Preparation and Properties of Poly(DL-lactide-co-glycolide)nanoparticle.

  1997cited by this paper
• Nanoparticle drug delivery system for restenosis

  1997cited by this paper
• Effects of cyclosporin and cremophor on working rat heart and incidence of myocardial lipid peroxidation.

  1996cited by this paper
• Preparation and characterization of poly(lactic-co-glycolic acid) microspheres for targeted delivery of a novel anticancer agent, taxol.

  1996cited by this paper
• Improving Protein Delivery from Microparticles Using Blends of Poly(DL lactide co-glycolide) and Poly(ethylene oxide)-poly(propylene oxide) Copolymers

  1996cited by this paper
• Encyclopedic Handbook of Biomaterials and Bioengineering

  1995cited by this paper
• Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery

  1995cited by this paper
• Peripheral Intravenous Line Survival and Phlebitis Prevention in Patients Receiving Intravenous Antibiotics: Heparin/Hydrocortisone versus In-Line Filters

  1994cited by this paper
• Enhanced cytotoxicity of doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres against multidrug-resistant tumour cells in culture.

  1994cited by this paper
• Pharmacology and Toxicology of Cremophor EL Diluent

  1994cited by this paper
• Is Cremophor EL, solvent for paclitaxel, cytotoxic?

  1993cited by this paper
• Influence of polybutylcyanoacrylate nanoparticles and liposomes on the efficacy and toxicity of the anticancer drug mitoxantrone in murine tumour models.

  1993cited by this paper
• Measurement of cremophor EL following taxol: plasma levels sufficient to reverse drug exclusion mediated by the multidrug-resistant phenotype.

  1993cited by this paper
• Advice from a seasoned congress tourist

  1993cited by this paper
• The preparation of sub-200 nm poly(lactide-co-glycolide) microspheres for site-specific drug delivery

  1993cited by this paper
• Acute effects of cyclosporin and cremophor EL on endothelial function and vascular smooth muscle in the isolated rat heart

  1992cited by this paper
• Doxorubicin-loaded nanospheres bypass tumor cell multidrug resistance.

  1992cited by this paper
• Nanoparticles as drug carriers for vinblastine. Acute toxicity of vinblastine in a free form and associated to polybutylcyanoacrylate nanoparticles.

  1991cited by this paper
• Interaction of cremophor EL with human plasma.

  1991cited by this paper
• Retention and clearance of 0.9-micron particles inhaled by hamsters during rest or exercise.

  1991cited by this paper
• The preparation and characterisation of poly(lactide-co-glycolide) microparticles. I: Oil-in-water emulsion solvent evaporation

  1991cited by this paper
• Preparation of biodegradable microspheres and microcapsules: 2. Polyactides and related polyesters

  1991cited by this paper
• Effect of nanoparticles on transdermal drug delivery.

  1991cited by this paper
• Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties.

  1990influential reference
• Enhancement of adriamycin antitumor activity by its binding with an intracellular sustained-release form, polymethacrylate nanospheres, in U-937 cells.

  1988cited by this paper
• Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles.

  1986cited by this paper
• A new long-acting injectable microcapsule system for the administration of progesterone.

  1979cited by this paper
• Nanocapsules: A new type of lysosomotropic carrier

  1977cited by this paper

• Effectiveness of drug-loaded poly(ethylene glycol) and poly(lactic-co-glycolic-acid) nanoparticles in the in vitro treatment of breast cancer: a systematic review

  2026cites this paper
• Folate-Functionalized Polymeric Nanoparticles for 5‑Fluorouracil Delivery to Prostate Cancer: Physicochemical and In Vitro/In Vivo Characterization

  2025cites this paper
• Orodispersible films prepared by hot-melt extrusion versus solvent casting.

  2025cites this paper
• Re-purposing of Linagliptin for enhanced wound healing and skin rejuvenation via chitosan- modified PLGA Nanoplatforms.

  2025cites this paper
• Bào chế hệ vi hạt PLGA chứa hoạt chất luteolin-7-O-β-D-glucopyranoside và đánh giá hoạt tính kháng ung thư của chế phẩm

  2025cites this paper
• “Nano-Paclitaxel” Unlocking Potential and Redefining Cancer Chemotherapy

  2025cites this paper
• Smart nanomaterials for multimodal theranostics and tissue regeneration

  2025cites this paper
• Future Possibilities and Challenges in Medication Delivery using Nanoparticles

  2025cites this paper
• An overview of the mechanistic approaches of antifungal nanomaterials

  2025cites this paper
• Can breakthroughs in dermal and transdermal macromolecule delivery surmount existing barriers and revolutionize future therapeutics?

  2025cites this paper
• Surface Functionalized Polyhydroxyalkanoate Nanoparticles via SpyTag–SpyCatcher System for Targeted Breast Cancer Treatment

  2025cites this paper
• Poly Lactic Co-glycolic Acid d-α-tocopheryl Polyethylene Glycol 1000 Succinate Fabricated Polyethylene Glycol Hybrid Nanoparticles of Imatinib Mesylate for the Treatment of Glioblastoma Multiforme.

  2025cites this paper
• PLGA nanoparticles provide a safe delivery system for bee venom and melittin to alleviate their hepatotoxic effects in mice.

  2025cites this paper
• Recent advancements in nanoparticle-based topical drug delivery systems for psoriasis treatment

  2025cites this paper
• Enhancing palbociclib efficacy with low toxicity in breast cancer using polycaprolactone-based nanocarriers

  2025cites this paper
• Unlocking Superior MFH Performance Below Hergt’s Biological Safety Limit: SPION-Based Magnetic Nanoplatforms Deliver High Heating Efficiency at Low AMF

  2025cites this paper
• Encapsulation-based enhancements in modern drug delivery systems.

  2025cites this paper
• PTX-RPPR, a conjugate of paclitaxel and NRP-1 peptide inhibitor to prevent tumor growth and metastasis.

  2024cites this paper
• Synthesis of silver nanoparticles from mango pulp and analysis of its antioxidant property

  2024cites this paper
• Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells

  2024cites this paper
• Impact of PEG Content on Doxorubicin Release from PLGA-co-PEG Nanoparticles

  2024influential citation
• Co-Delivery Polymeric Poly(Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles to Target Cancer Stem-Like Cells.

  2024cites this paper
• Preparation of Water-Soluble Tocopherol Compositions Based on N-Vinylpyrrolidone Polymers and Exploration of the Molecular Exchange Process in Aqueous Solutions Using High-Resolution and Pulsed Field Gradient NMR Techniques

  2024cites this paper
• Targeted thermosensitive liposomes loaded with gold nanoparticles and temozolomide hexadecanoate for the synergistic photothermal-chemotherapy treatment of glioblastoma.

  2024cites this paper
• d-α-tocopheryl polyethylene glycol 1000 succinate surface scaffold polysarcosine based polymeric nanoparticles of enzalutamide for the treatment of colorectal cancer: In vitro, in vivo characterizations

  2024cites this paper
• Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation.

  2024cites this paper
• Research on the Medicinal Chemistry and Pharmacology of Taxus × media

  2024cites this paper
• Optimizing Intranasal Amisulpride Loaded Nanostructured Lipid Carriers: Formulation, Development, and Characterization Parameters.

  2024cites this paper
• Polymeric linagliptin nanoparticles as a sustained release treatment for type 2 diabetes

  2024cites this paper
• Role of Phytoconstituents in Cancer Treatment: A Review.

  2024cites this paper
• A COMPREHENSIVE REVIEW ON NEUROTRANSMITTERS, ITS BIOLOGICAL IMPORTANCE AND METHODS OF ANALYSIS

  2023cites this paper
• Surface Modification of Poly(lactide-co-glycolide) Nanoparticles for the Sustained in vitro Release and the Enhanced Cytotoxicity of Chelidonine.

  2023cites this paper
• Development and in-vitro, in-vivo evaluation of Pioglitazone-loaded polymeric nanoparticles using central composite design surface response methodology

  2023cites this paper
• Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone

  2023cites this paper
• Biomedical Approach of Nanotechnology and Biological Risks: A Mini-Review

  2023cites this paper
• Immune cell membrane-coated nanoparticles for targeted myocardial ischemia/reperfusion injury therapy

  2023cites this paper
• Machine learning models to accelerate the design of polymeric long-acting injectables

  2023cites this paper
• Drug release using nanoparticles in the cancer cells on 2-D materials in order to target drug delivery: A numerical simulation via molecular dynamics method

  2023cites this paper
• Sensitivity analysis of the formation of hollow solid lipid micro- and nanoparticles from CO2-saturated solution of fully hydrogenated soybean oil

  2023cites this paper
• Recent developments in nanoparticles for the treatment of diabetes

  2023cites this paper
• Nanoparticle Based Targeting Approaches for Lung Cancer: A Mini Review

  2023cites this paper
• Near-Infrared Light-Activatable Melanized Paclitaxel Nano–Self-Assemblies for Synergistic Anti-tumor Therapy

  2023cites this paper
• Emerging Polymer-Based Nanosystem Strategies in the Delivery of Antifungal Drugs

  2023cites this paper
• Nanoscale drug delivery systems for cancer therapy using paclitaxel— A review of challenges and latest progressions

  2023cites this paper
• Recent advances in oral drug delivery materials for targeted diagnosis or treatment of gastrointestinal diseases

  2023cites this paper
• Rice Nutraceuticals and Bioactive Compounds: Extraction, Characterization and Antioxidant Activity: A Review.

  2023cites this paper
• Modification of α-Tocopherol Succinate with a Tumor-targeting Peptide Conjugate Enhances the Antitumor Efficacy of a Paclitaxel-loaded Lipid Aggregate.

  2022cites this paper
• Nanoparticles: As a Nano based Drug Delivery System

  2022cites this paper
• Pharmacometabolomic assessment of vitamin E loaded human serum albumin nanoparticles on HepG2 cancer cell lines

  2022cites this paper
• Development and characterization of self-assembling sirolimus-loaded micelles as a sublingual delivery system

  2022cites this paper
• Atazanavir-Loaded Crosslinked Gamma-Cyclodextrin Nanoparticles to Improve Solubility and Dissolution Characteristics.

  2022cites this paper
• Lonidamine loaded Poly(ethylene glycol)–block–poly(ε-caprolacton) nanocarriers inhibited the proliferation of colorectal cancer cells through G0/G1 cell cycle arrest

  2022cites this paper
• A review on nanoparticles categorization, characterization and applications in drug delivery systems

  2022cites this paper
• Design and Scale-Up of Amorphous Drug Nanoparticles Production via a One-Step Anhydrous Continuous Process.

  2022cites this paper
• PLGA-modified Syloid®-based microparticles for the ocular delivery of terconazole: in-vitro and in-vivo investigations

  2022cites this paper
• Novel controlled-release polylactic-co-glycolic acid (PLGA) nanoparticles for sodium thiosulphate, a hydrogen sulphide donor, retains pro-angiogenic potential of hydrogen sulphide

  2022cites this paper
• Etravirine Lipid Nanoparticles: Development and Validation Using Specific RP-HPLC Technique

  2022influential citation
• Coarse-Grained Molecular Dynamics Simulations of Paclitaxel-Loaded Polymeric Micelles.

  2022cites this paper
• Revisiting Flubendazole Through Nanocrystal Technology: Statistical Design, Characterization and Its Potential Inhibitory Effect on Xenografted Lung Tumor Progression in Mice

  2022cites this paper
• Binary polymer systems for biomedical applications

  2022cites this paper
• Development and Optimization of Hybrid Polymeric Nanoparticles of Apigenin: Physicochemical Characterization, Antioxidant Activity and Cytotoxicity Evaluation

  2022cites this paper
• In vitro biocompatibility evaluations of pH-sensitive Bi2MoO6/NH2-GO conjugated polyethylene glycol for release of daunorubicin in cancer therapy.

  2022cites this paper
• Mucoadhesive PLGA Nanospheres and Nanocapsules for Lactoferrin Controlled Ocular Delivery

  2022cites this paper
• Drug Carriers

  2022cites this paper
• Polyhydroxyalkanoate Decelerates the Release of Paclitaxel from Poly(lactic-co-glycolic acid) Nanoparticles

  2022cites this paper
• Anti-tumor pharmacology of natural products targeting mitosis

  2022cites this paper
• Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment

  2022cites this paper
• Applying quality by design approach for the determination of potent paclitaxel loaded poly(lactic acid) based implants for localized tumor drug delivery

  2022cites this paper
• Vitamin E TPGS-Poloxamer Nanoparticles Entrapping a Novel PI3Kα Inhibitor Potentiate Its Activity against Breast Cancer Cell Lines

  2022cites this paper
• Nanoparticle Drug Delivery: An Advanced Approach for Highly Competent and Multifunctional Therapeutic Treatment

  2021cites this paper
• Preparation of Silymarin–quercetin Loaded Nanoparticles by Spontaneous Emulsification Solvent Diffusion Method Using D-alpha-tocopheryl Poly (Ethylene Glycol) 1000 Succinate

  2021cites this paper
• Application of Fundamental Techniques for Physicochemical Characterizations to Understand Post-Formulation Performance of Pharmaceutical Nanocrystalline Materials

  2021cites this paper
• Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

  2021cites this paper
• Current applications and prospects of nanoparticles for antifungal drug delivery

  2021cites this paper
• Pharmacokinetic-pharmacodynamic modeling approach for dose prediction of the optimal long-acting injectable formulation of finasteride.

  2021cites this paper
• Rational nanocarrier design towards clinical translation of cancer nanotherapy

  2021cites this paper
• Opportunities and Challenges of Fatty Acid Conjugated Therapeutics.

  2021cites this paper
• Pluronic-Coated Biogenic Gold Nanoparticles for Colon Delivery of 5-Fluorouracil: In vitro and Ex vivo Studies

  2021cites this paper
• In Vivo Study of New Oral Docetaxel -Loaded Nanomicelles

  2021cites this paper
• Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines

  2021cites this paper
• Functionalizing nanoparticles with CafA protein to target BAR peptide for oral delivery applications

  2021cites this paper
• Synthesis of a Therapeutic Amphiphilic Copolymer of SN38 via RAFT Polymerization and Its Self-Assembly to Peptomicelles for Fighting against Colon Adenocarcinoma

  2021cites this paper
• Macrophage-Biomimetic Nanoparticles Ameliorate Ulcerative Colitis through Reducing Inflammatory Factors Expression

  2021cites this paper
• Facile fabrication of elongated polymer micro/nano discs and their surface adhesiveness

  2021cites this paper
• Microbiota and Nanoparticles: Description and Interactions.

  2021cites this paper
• Formulations, Characterization and Applications of Nanoparticle in Drug Delivery: Reviewc

  2021cites this paper
• Exosome-mediated bioinspired drug delivery

  2021cites this paper
• Optimization and Development of Selective Histone Deacetylase Inhibitor (MPT0B291)-Loaded Albumin Nanoparticles for Anticancer Therapy

  2021cites this paper
• Functionalized nanomaterials (FNMS) in terrestial environments: a critical review from bioavailability perspective

  2021cites this paper
• Initial Formation of the Skin Layer of PLGA Microparticles

  2021cites this paper
• Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview.

  2021cites this paper
• Functional Nanocarriers for Delivering Itraconazole Against Fungal Intracellular Infections

  2021cites this paper
• Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells

  2021cites this paper
• Current Trends of “Nanotechnology” in Pharmaceutical

  2021cites this paper
• Alginate sulfate-based hydrogel/nanofiber composite scaffold with controlled Kartogenin delivery for tissue engineering.

  2021cites this paper
• Simulation study of biopolymer microspheres shape varying behavior

  2021cites this paper
• Improving the bioavailability and bioactivity of garlic bioactive compounds via nanotechnology

  2021cites this paper
• 5-Fluorouracil-Impregnated PLGA Coated Gold Nanoparticles for Augmented Delivery to Lung Cancer: in vitro Investigations.

  2021cites this paper
• Development of 6-Thioguanine conjugated PLGA nanoparticles through thioester bond formation: Benefits of electrospray mediated drug encapsulation and sustained release in cancer therapeutic applications.

  2020cites this paper
• Morphology and microstructural analysis of bioactive-loaded micro/nanocarriers via microscopy techniques; CLSM/SEM/TEM/AFM.

  2020cites this paper