The E3 Ligase RING1 Targets p53 for Degradation and Promotes Cancer Cell Proliferation and Survival.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cancer Research

• Publication date

  2018-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-17-1805PMID 29187402
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage

  2016cited by this paper
• EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells

  2016influential reference
• Epigenetic regulators: Polycomb-miRNA circuits in cancer.

  2016cited by this paper
• Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression

  2016cited by this paper
• RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins

  2015cited by this paper
• Mechanisms of p53 degradation.

  2015cited by this paper
• Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

  2015cited by this paper
• Overactivated neddylation pathway as a therapeutic target in lung cancer.

  2014cited by this paper
• Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage.

  2014cited by this paper
• Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.

  2014cited by this paper
• Polycomb Group Oncogene RING1 is Over-expressed in Non-Small Cell Lung Cancer

  2014cited by this paper
• Overexpression of RNF2 is positively associated with ovarian carcinoma aggressiveness and indicative of poor patient survival

  2014cited by this paper
• Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells.

  2014cited by this paper
• Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation

  2013cited by this paper
• E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation.

  2013cited by this paper
• RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development

  2013influential reference
• Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability

  2013cited by this paper
• Polycomb complexes in stem cells and embryonic development

  2013influential reference
• Role of BMI1, a Stem Cell Factor, in Cancer Recurrence and Chemoresistance: Preclinical and Clinical Evidences

  2012cited by this paper
• Purification and crystallization of mono-ubiquitylated ubiquitin receptor Rpn10.

  2012cited by this paper
• Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring

  2011cited by this paper
• Roles of the Polycomb group proteins in stem cells and cancer

  2011cited by this paper
• p53 and its mutants in tumor cell migration and invasion

  2011cited by this paper
• Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer.

  2010influential reference
• Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression.

  2009cited by this paper
• The E3 Ubiquitin-Ligase Bmi1/Ring1A Controls the Proteasomal Degradation of Top2α Cleavage Complex – A Potentially New Drug Target

  2009cited by this paper
• Polycomb group proteins: navigators of lineage pathways led astray in cancer

  2009cited by this paper
• Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity

  2008cited by this paper
• Concepts of epigenetics in prostate cancer development

  2008cited by this paper
• Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.

  2007cited by this paper
• Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

  2006cited by this paper
• Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays

  2006cited by this paper
• ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.

  2005cited by this paper
• Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas.

  2004cited by this paper
• Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFκB transcription factors

  2004cited by this paper
• The ubiquitin ligase COP1 is a critical negative regulator of p53

  2004cited by this paper
• Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation.

  2003cited by this paper
• Polycomb repression: from cellular memory to cellular proliferation and cancer.

  2002cited by this paper
• RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity

  1999cited by this paper
• p53, the Cellular Gatekeeper Review for Growth and Division

  1997cited by this paper
• RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor

  1997cited by this paper

• The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4

  2026cites this paper
• Prmt1-mediated methylation regulates Ncoa4 stability to transactivate Adamts genes and promote bone extracellular matrix degradation in chronic hematogenous osteomyelitis

  2025cites this paper
• RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

  2025cites this paper
• Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking‐Induced Lung Tumorigenesis

  2025cites this paper
• Tripartite motif-containing protein 26 promotes colorectal cancer growth by inactivating p53

  2025cites this paper
• Epigenetic Regulation of Cellular Senescence in Gastrointestinal Cancer.

  2025cites this paper
• SHARPIN is a novel gene of colorectal cancer that promotes tumor growth potentially via inhibition of p53 expression

  2024cites this paper
• Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells.

  2024cites this paper
• FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2.

  2024cites this paper
• The epigenetic landscape in intestinal stem cells and its deregulation in colorectal cancer

  2024cites this paper
• Protein Stability Regulation in Osteosarcoma: The Ubiquitin-like Modifications and Glycosylation as Mediators of Tumor Growth and as Targets for Therapy

  2024cites this paper
• Canalizing cell fate by transcriptional repression

  2024cites this paper
• Tripartite motif-containing protein 26 promotes colorectal cancer growth by inactivating p53

  2024cites this paper
• Anti-tumor potential of high salt in breast Cancer cell lines

  2024cites this paper
• The role of ubiquitin pathway‐mediated regulation of immune checkpoints in cancer immunotherapy

  2023cites this paper
• PRPF19 facilitates colorectal cancer liver metastasis through activation of the Src-YAP1 pathway via K63-linked ubiquitination of MYL9

  2023cites this paper
• RING induces cell cycle arrest and apoptosis in human breast cancer cells by regulating the HSF1/MT2A axis.

  2023cites this paper
• FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation

  2023cites this paper
• The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis

  2023cites this paper
• Targeting UBE2T potentiates gemcitabine efficacy in pancreatic cancer by regulating pyrimidine metabolism and replication stress.

  2023cites this paper
• Molecular mechanism of WWP1‐mediated ubiquitination modification affecting proliferation and invasion/migration of liver cancer cells

  2023cites this paper
• Comprehensive analysis of PRPF19 immune infiltrates, DNA methylation, senescence-associated secretory phenotype and ceRNA network in bladder cancer

  2023cites this paper
• Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity via Inhibiting USP33-Mediated ADRB2 Deubiquitination.

  2022cites this paper
• The Four Homeostasis Knights: In Balance upon Post-Translational Modifications

  2022cites this paper
• Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer

  2022cites this paper
• p53 regulation by ubiquitin and ubiquitin-like modifications

  2022cites this paper
• Identification and characterization of Bombyx mori homologs of Bonus, Mdm2, Rad6, Sce, and Synoviolin

  2021cites this paper
• Regulation of p53 stability as a therapeutic strategy for cancer.

  2021cites this paper
• Low Expression of the Polycomb Protein RING1 Predicts Poor Prognosis in Human Breast Cancer

  2021cites this paper
• Regulation of p53 by E3s

  2021cites this paper
• Construction of Gene Modules and Analysis of Prognostic Biomarkers for Cervical Cancer by Weighted Gene Co-Expression Network Analysis

  2021cites this paper
• The Role of Introns for the Development of Inflammation-Mediated Cancer Cell

  2021cites this paper
• The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression

  2021cites this paper
• Comprehensive Analysis Reveals the Potential Regulatory Mechanism Between Ub–Proteasome System and Cell Cycle in Colorectal Cancer

  2021cites this paper
• Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53

  2021cites this paper
• BAP1 loss augments sensitivity to BET inhibitors in cancer cells

  2021cites this paper
• Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

  2021cites this paper
• Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System

  2021cites this paper
• Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.

  2021cites this paper
• How to Inactivate Human Ubiquitin E3 Ligases by Mutation

  2020cites this paper
• p53 functional loss, stemness and hepatocellular carcinoma

  2020influential citation
• Neuronal Bmi-1 is critical for melatonin induced ubiquitination and proteasomal degradation of α-synuclein in experimental Parkinson's disease models.

  2020cites this paper
• Recent Advances in Liver Cancer Stem Cells: Non-coding RNAs, Oncogenes and Oncoproteins

  2020cites this paper
• Novel evidence for retinoic acid‐induced G (Rig‐G) as a tumor suppressor by activating p53 signaling pathway in lung cancer

  2020cites this paper
• An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling

  2020cites this paper
• A robust twelve-gene signature for prognosis prediction of hepatocellular carcinoma

  2020cites this paper
• Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.

  2019cites this paper
• Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway

  2019influential citation
• Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis

  2019cites this paper
• Activation of the Lysosome-Associated Membrane Protein LAMP5 by DOT1L Serves as a Bodyguard for MLL Fusion Oncoproteins to Evade Degradation in Leukemia

  2019cites this paper
• The Ibr‐7 derivative of ibrutinib exhibits enhanced cytotoxicity against non‐small cell lung cancer cells via targeting of mTORC1/S6 signaling

  2019cites this paper
• Ring1 promotes the transformation of hepatic progenitor cells into cancer stem cells through the Wnt/β‐catenin signaling pathway

  2019cites this paper
• Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells

  2019cites this paper
• p53 modifications: exquisite decorations of the powerful guardian

  2019cites this paper
• Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer.

  2019cites this paper
• Role of p53 circuitry in tumorigenesis: A brief review.

  2018cites this paper
• Ubiquitination: Friend and foe in cancer.

  2018influential citation
• Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis

  2018cites this paper