Polycomb group proteins: navigators of lineage pathways led astray in cancer

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Nature Reviews. Cancer

• Publication date

  2009-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrc2736PMID 19851313
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multiple roles for Sox2 in the developing and adult mouse trachea

  2009cited by this paper
• Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.

  2009cited by this paper
• The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.

  2009cited by this paper
• RUNX3 Attenuates β-Catenin/T Cell Factors in Intestinal Tumorigenesis

  2009cited by this paper
• LONG NONCODING RNAs: INSIGHTS INTO FUNCTION

  2009cited by this paper
• Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

  2009cited by this paper
• Genetics and epigenetics: stability and plasticity during cellular differentiation.

  2009cited by this paper
• Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

  2009cited by this paper
• CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis.

  2009cited by this paper
• SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas

  2009cited by this paper
• Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

  2009cited by this paper
• Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

  2009cited by this paper
• Long non-coding RNAs: insights into functions

  2009cited by this paper
• Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.

  2009cited by this paper
• The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

  2009cited by this paper
• Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

  2009cited by this paper
• RNA-Seq: a revolutionary tool for transcriptomics

  2009cited by this paper
• Epigenetic reprogramming and induced pluripotency

  2009cited by this paper
• Multilayered epithelium in a rat model and human Barrett's esophagus: Similar expression patterns of transcription factors and differentiation markers

  2008cited by this paper
• Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.

  2008cited by this paper
• Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

  2008cited by this paper
• Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.

  2008cited by this paper
• BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

  2008cited by this paper
• KLF6 Induces Apoptosis in Prostate Cancer Cells through Up-regulation of ATF3*

  2008cited by this paper
• Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

  2008cited by this paper
• An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

  2008cited by this paper
• Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome

  2008cited by this paper
• Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.

  2008cited by this paper
• Structured non-coding RNAs and the RNP Renaissance.

  2008cited by this paper
• Nuclear Reprogramming in Cells

  2008cited by this paper
• MYB function in normal and cancer cells

  2008cited by this paper
• Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

  2008cited by this paper
• Genomic Profiling Identifies GATA6 as a Candidate Oncogene Amplified in Pancreatobiliary Cancer

  2008cited by this paper
• RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.

  2008cited by this paper
• Stability and Dynamics of Polycomb Target Sites in Drosophila Development

  2008cited by this paper
• Ikaros Represses the Transcriptional Response to Notch Signaling in T-Cell Development

  2008cited by this paper
• Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation.

  2008cited by this paper
• Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.

  2008cited by this paper
• Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5

  2008cited by this paper
• Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation.

  2008cited by this paper
• Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia

  2008cited by this paper
• Stem cell regulation by polycomb repressors: postponing commitment.

  2008cited by this paper
• Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis.

  2008cited by this paper
• GATA-3 and the regulation of the mammary luminal cell fate.

  2008cited by this paper
• Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding.

  2008cited by this paper
• PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale.

  2008cited by this paper
• Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

  2008cited by this paper
• In vivo reprogramming of adult pancreatic exocrine cells to β-cells

  2008cited by this paper
• Extreme makeover: converting one cell into another.

  2008cited by this paper
• Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.

  2008cited by this paper
• Faculty Opinions recommendation of In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.

  2008cited by this paper
• Stem Cell Chromatin Patterns: An Instructive Mechanism for DNA Hypermethylation?

  2007cited by this paper
• Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.

  2007cited by this paper
• High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma

  2007cited by this paper
• Characterizing the cancer genome in lung adenocarcinoma

  2007cited by this paper
• Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.

  2007cited by this paper
• Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

  2007cited by this paper
• Epigenetic stem cell signature in cancer

  2007cited by this paper
• A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

  2007cited by this paper
• Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

  2007cited by this paper
• Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A‐ARF locus

  2007cited by this paper
• FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.

  2007cited by this paper
• The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation

  2007cited by this paper
• Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.

  2007cited by this paper
• A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas

  2007cited by this paper
• Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis

  2007cited by this paper
• Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

  2007cited by this paper
• A tumor suppressor and oncogene: the WT1 story

  2007cited by this paper
• Polycomb/Trithorax response elements and epigenetic memory of cell identity

  2007cited by this paper
• A tumor suppressor and oncogene: the WT1 story

  2007cited by this paper
• The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.

  2007cited by this paper
• Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.

  2007cited by this paper
• Luminal cells GATA have it

  2007cited by this paper
• The Polycomb group protein EZH2 directly controls DNA methylation

  2007cited by this paper
• The emerging roles of forkhead box (Fox) proteins in cancer

  2007cited by this paper
• Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

  2007influential reference
• FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.

  2007cited by this paper
• The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.

  2007cited by this paper
• Brain tumour stem cells

  2006cited by this paper
• Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors.

  2006cited by this paper
• Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin

  2006cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• A PANorama of PAX genes in cancer and development

  2006cited by this paper
• Polycomb silencers control cell fate, development and cancer

  2006cited by this paper
• EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast.

  2006cited by this paper
• GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.

  2006cited by this paper
• Control of developmental regulators by Polycomb in human embryonic stem cells.

  2006cited by this paper
• Lineage dependency and lineage-survival oncogenes in human cancer

  2006cited by this paper
• The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late‐stage prostate cancer

  2006cited by this paper
• Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.

  2006cited by this paper
• The epigenetic progenitor origin of human cancer

  2006cited by this paper
• Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas

  2006cited by this paper
• Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all

  2006cited by this paper
• A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

  2006cited by this paper
• Polycomb complexes repress developmental regulators in murine embryonic stem cells

  2006cited by this paper
• Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells

  2006cited by this paper
• The Polycomb group protein EZH2 directly controls DNA methylation

  2006cited by this paper
• Regulation of Th2 Cell Development by Polycomb Group Gene bmi-1 through the Stabilization of GATA31

  2006cited by this paper
• Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.

  2005cited by this paper
• The runx genes: gain or loss of function in cancer

  2005cited by this paper

• DOT1L provides transcriptional memory through PRC1.1 antagonism

  2026cites this paper
• c-Myc: Central Regulator of Autophagy and Senescence in Cancer.

  2026cites this paper
• Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development

  2025cites this paper
• Polycomb repressive complex 2 (PRC2) pathway’s role in cancer cell plasticity and drug resistance

  2025cites this paper
• Epigenetic reader chromodomain as a potential therapeutic target

  2025cites this paper
• A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells

  2025cites this paper
• Challenges of small cell lung cancer heterogeneity and phenotypic plasticity

  2025cites this paper
• A novel amino-pyrimidine inhibitor suppresses tumor growth via microtubule destabilization and Bmi-1 down-regulation.

  2025cites this paper
• Epigenetic regulation of androgen dependent and independent prostate cancer.

  2024cites this paper
• Epigenetic toxicity of heavy metals - implications for embryonic stem cells.

  2024cites this paper
• Novel insights on the positive correlation between sense and antisense pairs on gene expression

  2024cites this paper
• Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes

  2024cites this paper
• sRNA-Effector: A tool to expedite discovery of small RNA regulators

  2024cites this paper
• Epigenetic and Oncogenic Inhibitors Cooperatively Drive Differentiation and Kill KRAS-Mutant Colorectal Cancers

  2024cites this paper
• PRC1 Protein Subcomplexes Architecture: Focus on the Interplay between Distinct PCGF Subunits in Protein Interaction Networks

  2024cites this paper
• EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas

  2024cites this paper
• The pharmacoepigenetic paradigm in cancer treatment

  2024cites this paper
• MiR-128-3p – a gray eminence of the human central nervous system

  2024cites this paper
• Age-dependent regulation of ELP1 exon 20 splicing in Familial Dysautonomia by RNA Polymerase II kinetics and chromatin structure

  2024cites this paper
• Epigenetic regulation in zebrafish development: the roles of polycomb group proteins in heart and pectoral fin development

  2024cites this paper
• Polycomb Repressive Complex 1.1 Component, BCOR, Promotes Syncytiotrophoblast Differentiation in Mice and Humans

  2024cites this paper
• Deciphering the Epigenetic Symphony of Cancer: Insights and Epigenetic Therapies Implications

  2024cites this paper
• Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

  2023cites this paper
• Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus

  2023cites this paper
• H2A ubiquitination alters H3-tail dynamics on linker-DNA to enhance H3K27 methylation.

  2023cites this paper
• Roles of Individual Protein in de novo Polycomb Protein Recruitment

  2023cites this paper
• Recent advances in chromosome capture techniques unraveling 3D genome architecture in germ cells, health, and disease

  2023cites this paper
• A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation

  2023cites this paper
• Beyond expression: role of phosphorylated residues of EZH2 in lineage plasticity in prostate cancer.

  2023cites this paper
• EZH2 inhibition promotes tumor immunogenicity in lung squamous cell carcinomas

  2023cites this paper
• Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis

  2023cites this paper
• Regulation of the somatotropic axis by MYC-mediated miRNA repression

  2023cites this paper
• Combined Inhibition of EZH2 and FGFR is Synergistic in BAP1-deficient Malignant Mesothelioma

  2023cites this paper
• PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1

  2023cites this paper
• Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors

  2023cites this paper
• Harnessing the immune system in the treatment of cutaneous T cell lymphomas

  2023cites this paper
• Early Cell Cultures from Prostate Cancer Tissue Express Tissue Specific Epithelial and Cancer Markers

  2023cites this paper
• Role of the Tumor Suppressor RB in the Development of Localized and Castration-Resistant Prostate Cancer

  2022influential citation
• CRABP2 - A novel biomarker for high-risk endometrial cancer.

  2022cites this paper
• LINC-PINT suppresses cisplatin resistance in gastric cancer by inhibiting autophagy activation via epigenetic silencing of ATG5 by EZH2

  2022cites this paper
• Polycomb Directed Cell Fate Decisions in Development and Cancer

  2022cites this paper
• The role of epigenetics in T-cell lymphoma

  2022cites this paper
• Interplay between Polycomb PCGF protein interactomes revealed by screening under endogenous conditions

  2022cites this paper
• Phenotypic Plasticity - Alternate Transcriptional Programs Driving Treatment Resistant Prostate Cancer.

  2022cites this paper
• Position Effect Variegation: Role of the Local Chromatin Context in Gene Expression Regulation

  2022cites this paper
• Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death.

  2022cites this paper
• A conserved HOTAIRM1-HOXA1 regulatory axis coordinates early neuronal differentiation

  2022cites this paper
• The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis

  2022cites this paper
• Role of p53 in regulation of hematopoiesis in health and disease

  2022cites this paper
• BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome-dependent manner

  2022cites this paper
• CBX2 in DSD: The Quirky Kid on the Block

  2022cites this paper
• Phenotypic pliancy and the breakdown of epigenetic polycomb mechanisms

  2022cites this paper
• Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics

  2022cites this paper
• The 3D enhancer network of the developing T cell genome is shaped by SATB1

  2022cites this paper
• Dysregulated Polycomb Repressive Complex 2 contributes to chronic obstructive pulmonary disease by rewiring stem cell fate

  2022cites this paper
• Tissue-wide genetic and cellular landscape shapes the execution of sequential PRC2 functions in neural stem cell lineage progression

  2022cites this paper
• Remarkable Synergy When Combining EZH2 Inhibitors with YM155 Is H3K27me3-Independent

  2022cites this paper
• The 3 D enhancer network of the developing T cell genome is controlled by 1 SATB 1 2 3

  2021cites this paper
• The 3D enhancer network of the developing T cell genome is controlled by SATB1

  2021cites this paper
• Current advances of targeting epigenetic modifications in neuroendocrine prostate cancer

  2021influential citation
• PRC2: an epigenetic multiprotein complex with a key role in the development of rhabdomyosarcoma carcinogenesis

  2021cites this paper
• Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8 **

  2021cites this paper
• CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10–ERK signaling

  2021cites this paper
• Global Chromatin Changes Resulting from Single-Gene Inactivation—The Role of SMARCB1 in Malignant Rhabdoid Tumor

  2021cites this paper
• YY1 involvement in embryonic development and cancer

  2021cites this paper
• Polycomb-group proteins in the initiation and progression of cancer.

  2021cites this paper
• The EZH2 inhibitor tazemetostat upregulates the expression of CCL17/TARC in B‐cell lymphoma and enhances T‐cell recruitment

  2021cites this paper
• Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma

  2021cites this paper
• Novel insights into the interaction between long non-coding RNAs and microRNAs in glioma

  2021cites this paper
• Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis

  2021cites this paper
• Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

  2021cites this paper
• Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.

  2021cites this paper
• Low Expression of the Polycomb Protein RING1 Predicts Poor Prognosis in Human Breast Cancer

  2021cites this paper
• Decreased Expression of CBX7 is an Independent Predictor of Poor Survival in Cervical Cancer

  2021cites this paper
• JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications

  2021cites this paper
• The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis

  2021cites this paper
• EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition.

  2021cites this paper
• Epigenetics and viral infectious diseases

  2021cites this paper
• Structural insights into the interactions of Polycomb Repressive Complex 2 with chromatin.

  2021cites this paper
• Exosome-Mediated Bmi1 Promotes Cholangiocarcinoma Growth and Metastasis Through the Differential Regulation of miR-320b and miR-27b-3p

  2021cites this paper
• Polycomb group proteins in cancer: multifaceted functions and strategies for modulation

  2021cites this paper
• Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP

  2021cites this paper
• Regulation of PPARgamma2 Gene Expression by PcG AND pRb Family Proteins in the Course of Adipogenic Differentation of Mesenchymal Stem Cells

  2021cites this paper
• RKIP Pleiotropic Activities in Cancer and Inflammatory Diseases: Role in Immunity

  2021cites this paper
• Polycomb group protein CBX7 represses cardiomyocyte proliferation via modulation of the TARDBP/Rbm38 axis

  2021cites this paper
• A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation

  2021cites this paper
• Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans

  2021cites this paper
• Bmi1 Regulates Wnt Signaling in Hematopoietic Stem and Progenitor Cells

  2021cites this paper
• The Synergistic Anti-Tumor Activity of EZH2 Inhibitor SHR2554 and HDAC Inhibitor Chidamide through ORC1 Reduction of DNA Replication Process in Diffuse Large B Cell Lymphoma

  2021cites this paper
• Histone deacetylase HDA-4-mediated epigenetic regulation in space-flown C. elegans

  2021cites this paper
• JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications

  2020influential citation
• Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

  2020cites this paper
• Monomeric targeted protein degraders.

  2020cites this paper
• The genetic basis for PRC1 complex diversity emerged early in animal evolution

  2020cites this paper
• EZH2 inhibitors restore epigenetically silenced CD58 expression in B-cell lymphomas.

  2020cites this paper
• Parallel PRC2/cPRC1 and vPRC1 pathways silence lineage-specific genes and maintain self-renewal in mouse embryonic stem cells

  2020cites this paper
• Emerging roles of HOTAIR in human cancer

  2020cites this paper
• The roles of long non-coding RNA in osteoporosis.

  2020cites this paper
• Inhibition of EZH2 by chidamide exerts antileukemia activity and increases chemosensitivity through Smo/Gli-1 pathway in acute myeloid leukemia

  2020cites this paper
• Pathogenic Impacts of Dysregulated Polycomb Repressive Complex Function in Hematological Malignancies

  2020cites this paper