Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Immunity

• Publication date

  2006-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.IMMUNI.2006.09.011PMID 17088084
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• hepcidin-deficient mice Deregulation of proteins involved in iron metabolism in

  2010cited by this paper
• E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

  2006cited by this paper
• Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

  2006cited by this paper
• Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors.

  2006cited by this paper
• 53 PU.1 Expression Delineates Heterogeneity in Primary Th2 Cells

  2006cited by this paper
• The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential.

  2005cited by this paper
• Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks β-Selection 1

  2005cited by this paper
• A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision

  2005cited by this paper
• PU.1 expression delineates heterogeneity in primary Th2 cells.

  2005cited by this paper
• Notch signaling controls the generation and differentiation of early T lineage progenitors

  2005cited by this paper
• Molecular genetics of T cell development.

  2005cited by this paper
• Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.

  2005cited by this paper
• Interaction between GATA and the C/EBP Family of Transcription Factors Is Critical in GATA-Mediated Suppression of Adipocyte Differentiation

  2005cited by this paper
• PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch

  2005cited by this paper
• Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

  2005cited by this paper
• Stepwise reprogramming of B cells into macrophages.

  2004cited by this paper
• Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages.

  2004cited by this paper
• Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions

  2004cited by this paper
• Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha.

  2004cited by this paper
• Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1

  2004cited by this paper
• Enforced Granulocyte/Macrophage Colony-stimulating Factor Signals Do Not Support Lymphopoiesis, but Instruct Lymphoid to Myelomonocytic Lineage Conversion

  2003cited by this paper
• T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic Cells1

  2003cited by this paper
• Blood monocytes consist of two principal subsets with distinct migratory properties.

  2003cited by this paper
• Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor

  2003cited by this paper
• Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential.

  2003cited by this paper
• Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.

  2002cited by this paper
• Differentiation plasticity of hematopoietic cells.

  2002cited by this paper
• Reciprocal Roles for CCAAT/Enhancer Binding Protein (C/EBP) and PU.1 Transcription Factors in Langerhans Cell Commitment

  2002cited by this paper
• Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

  2002cited by this paper
• Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo.

  2002cited by this paper
• Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene

  2002cited by this paper
• Transcriptional regulation of granulocyte and monocyte development

  2002cited by this paper
• Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.

  2002cited by this paper
• Constitutive expression of PU.1 in fetal hematopoietic progenitors blocks T cell development at the pro-T cell stage.

  2002cited by this paper
• Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

  2002cited by this paper
• A positive look at double-negative thymocytes

  2002cited by this paper
• Mouse and human dendritic cell subtypes

  2002cited by this paper
• Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment.

  2002cited by this paper
• A new mathematical model for relative quantification in real-time RT-PCR.

  2001cited by this paper
• A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

  2001cited by this paper
• Hematopoietic development: a balancing act.

  2001cited by this paper
• Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

  2001cited by this paper
• Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

  2000cited by this paper
• Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages.

  2000cited by this paper
• PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells.

  2000cited by this paper
• Transcription Factor PU.1 Is Necessary for Development of Thymic and Myeloid Progenitor-Derived Dendritic Cells1

  2000cited by this paper
• SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression

  2000cited by this paper
• Expression of the transcription factor GATA‐3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

  1999cited by this paper
• Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

  1999cited by this paper
• Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells.

  1999cited by this paper
• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• T cell development in PU.1-deficient mice.

  1999cited by this paper
• Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47

  1999cited by this paper
• PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors.

  1998cited by this paper
• A linkage between dendritic cell and T-cell development in the mouse thymus: the capacity of sequential T-cell precursors to form dendritic cells in culture.

  1998cited by this paper
• Loops, lineage, and leukemia.

  1998cited by this paper
• Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.

  1997cited by this paper
• Transcription factor GATA-3 is required for development of the T-cell lineage

  1996cited by this paper
• Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

  1996cited by this paper
• Human GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains

  1994cited by this paper
• Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

  1994cited by this paper
• Functional characterization of two stromal cell lines that support B lymphopoiesis.

  1990cited by this paper
• The evaluation of limiting dilution assays.

  1982cited by this paper
• The evaluation of limiting dilution assays

  1982cited by this paper

• Natural and Artificial Hematopoietic Cell Reprogramming.

  2026cites this paper
• The response to kidney injury is epigenetically regulated through the activation of bivalent genes.

  2026cites this paper
• Targeting Monocytes and Their Derivatives in Ovarian Cancer: Opportunities for Innovation in Prognosis and Therapy

  2026cites this paper
• Expanding the cytokine receptor alphabet reprograms T cells into diverse states

  2025cites this paper
• Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate Conversion

  2025cites this paper
• Control of myeloid lineage fidelity and response to stimuli by ISWI-enforced nucleosome phasing.

  2025cites this paper
• IL-6-C/EBPβ signaling drives monocytic differentiation of murine cultured lymphoid progenitors with immunoregulatory properties

  2025cites this paper
• Conventional and Alternative B Lymphopoiesis: Multiple Roads to Immunity

  2025cites this paper
• High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults

  2025cites this paper
• Synchronous clonally related anaplastic large cell lymphoma and malignant histiocytosis

  2025cites this paper
• Mis-expression of GATA6 re-programs cell fate during early hematopoiesis.

  2024cites this paper
• Transcriptional network dynamics in early T cell development

  2024cites this paper
• Synergy between pluripotent stem cell‐derived macrophages and self‐renewing macrophages: Envisioning a promising avenue for the modelling and cell therapy of infectious diseases

  2024cites this paper
• High exposure variance enables candidate biomarker detection in a small EWAS of methylmercury-exposed Peruvian adults

  2024cites this paper
• Transcription factor-mediated reprogramming to antigen-presenting cells.

  2024cites this paper
• Macrophage variants in laboratory research: most are well done, but some are RAW

  2024cites this paper
• Forward programming human pluripotent stem cells into microglia.

  2024cites this paper
• SifiNet: a robust and accurate method to identify feature gene sets and annotate cells

  2024cites this paper
• ETS Transcription Factors in Immune Cells and Immune-Related Diseases

  2024cites this paper
• Signaling Pathways in Trans-differentiation of Mesenchymal Stem Cells: Recent Advances.

  2023cites this paper
• Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy.

  2023cites this paper
• Multilingual translation for zero-shot biomedical classification using BioTranslator

  2023cites this paper
• Direct Reprogramming of Resident Non-Myocyte Cells and Its Potential for In Vivo Cardiac Regeneration

  2023cites this paper
• miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities

  2023cites this paper
• SifiNet: A robust and accurate method to identify feature gene sets and annotate cells

  2023cites this paper
• Multi-modular structure of the gene regulatory network for specification and commitment of murine T cells

  2023cites this paper
• Past, Present, and Future of Direct Cell Reprogramming

  2022cites this paper
• Insights into the multi-faceted role of Pioneer transcription factors in glioma formation and progression with targeting options.

  2022cites this paper
• Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

  2022cites this paper
• Maintenance of Lineage Identity: Lessons from a B Cell.

  2022cites this paper
• Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells

  2022cites this paper
• Lineage switch from lymphoma to myeloid neoplasms: First case series from a single institution

  2022cites this paper
• Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia

  2022cites this paper
• Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation

  2022cites this paper
• Transdifferentiation Meets Next-generation Biotechnologies

  2022cites this paper
• Expression of Pu.1, C/Ebp? and Bach1 Transcription Factors in Immune Cells in Patients with Cancer

  2021cites this paper
• Targeting neurotransmitter-mediated inflammatory mechanisms of psychiatric drugs to mitigate the double burden of multimorbidity and polypharmacy

  2021cites this paper
• PU.1 inhibition attenuates atrial fibrosis and atrial fibrillation vulnerability induced by angiotensin‐II by reducing TGF‐β1/Smads pathway activation

  2021cites this paper
• The transcription factor code: a beacon for histone methyltransferase docking.

  2021cites this paper
• Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells

  2021cites this paper
• Direct cell reprogramming: approaches, mechanisms and progress

  2021cites this paper
• Logic and lineage impacts on functional transcription factor deployment for T-cell fate commitment

  2021cites this paper
• Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response.

  2021cites this paper
• The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors

  2021cites this paper
• Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

  2021cites this paper
• Logical modeling of cell fate specification-Application to T cell commitment.

  2020cites this paper
• Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling

  2020cites this paper
• Novel Cell-Based Therapies in Hepatic Disorders

  2020cites this paper
• Differentiation of c‐Kit+CD24+ natural killer cells into myeloid cells in a GATA‐2‐dependent manner

  2020cites this paper
• Direct cell-fate conversion of somatic cells: Toward regenerative medicine and industries

  2020cites this paper
• How transcription factors drive choice of the T cell fate

  2020cites this paper
• Cell Reprogramming Preserving Epigenetic Age: Advantages and Limitations

  2020cites this paper
• The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy

  2020cites this paper
• Hematopoietic Reprogramming Entangles with Hematopoiesis.

  2020cites this paper
• How transcription factors drive choice of the T cell fate

  2020cites this paper
• Transcriptional Regulation of Natural Killer Cell Development and Functions

  2020cites this paper
• Lysophosphatidic Acid Receptors 2 and 3 Regulate Erythropoiesis at Different Hematopoietic Stages.

  2020cites this paper
• Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells

  2020cites this paper
• Chromatin Architecture as an Essential Determinant of Dendritic Cell Function

  2019cites this paper
• PRDM16s transforms megakaryocyte-erythroid progenitors to acute myeloid leukemia-initiating cells.

  2019cites this paper
• Stem cells in tissues, organoids, and cancers

  2019cites this paper
• The Road to Pathogenesis: Charting the Development of LSCs and Pre-LSCs

  2019cites this paper
• Targeting Notch Pathways

  2019cites this paper
• Dynamic control of the T-cell specification gene regulatory network.

  2019cites this paper
• Computational Analysis of Altering Cell Fate.

  2019cites this paper
• A case of an unusual lineage switch in late relapse ALL—is it actually a secondary leukemia?

  2019cites this paper
• Immunoregulatory Innate Immune Cells

  2019cites this paper
• Understanding and Modulating Immunity With Cell Reprogramming

  2019cites this paper
• NextPBM: a platform to study cell-specific transcription factor binding and cooperativity

  2019cites this paper
• Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC‐SCRIPT

  2019cites this paper
• Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

  2019cites this paper
• Encounters across networks: Windows into principles of genomic regulation.

  2019cites this paper
• Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice

  2019cites this paper
• The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1β eRNA and mRNA transcription in mouse melanoma and macrophage cell lines

  2019cites this paper
• Causal Gene Regulatory Network Modeling and Genomics: Second-Generation Challenges

  2019cites this paper
• Programming for T-lymphocyte fates: modularity and mechanisms

  2019cites this paper
• Macrophages: The Potent Immunoregulatory Innate Immune Cells

  2019cites this paper
• Gene Expression Profiling of NFATc1-Knockdown in RAW 264.7 Cells: An Alternative Pathway for Macrophage Differentiation

  2019cites this paper
• Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development

  2019influential citation
• promotes in

  2019cites this paper
• Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

  2018cites this paper
• Analysis of post-transcriptional and architectural regulatory mechanisms controlling complement receptor gene expression in B cells

  2018cites this paper
• PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

  2018cites this paper
• Notch1 expression is regulated at the post-transcriptional level by the 3′ untranslated region in hematopoietic stem cell development

  2018cites this paper
• C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.

  2018cites this paper
• Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

  2018cites this paper
• Temporal autoregulation during human PU.1 locus SubTAD formation.

  2018cites this paper
• Indeterminate Cell Histiocytosis and Mycosis Fungoides: A Hitherto Unreported Association.

  2018cites this paper
• Transcription Factor Theft-PU.1 Caught Red-Handed.

  2018cites this paper
• Biophysical Principles of Lineage Factor PU.1 Binding Revealed by NextPBMs

  2018cites this paper
• Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice

  2018cites this paper
• Rôles dans les lymphocytes T de la protéine Lis1, un régulateur de la dynamique des microtubules dépendante de la dynéine

  2018cites this paper
• GATA transcription factors in development and disease

  2018cites this paper
• PHF6 modulates the chromatin landscape in B-cell leukemia

  2018cites this paper
• Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1)

  2018cites this paper
• Cytokines, Transcription Factors, and the Initiation of T-Cell Development.

  2018cites this paper
• High-throughput chromatin accessibility profiling at single-cell resolution

  2018cites this paper
• Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases.

  2018cites this paper
• Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

  2018cites this paper
• Myeloid-derived NF-κB negative regulation of PU.1 and c/EBP-β-driven pro-inflammatory cytokine production restrains LPS-induced shock

  2017cites this paper