The global burden of urinary bladder cancer: an update

Bladder cancer is among the top ten most common cancer types in the world, with approximately 550,000 new cases annually. The highest burden of bladder cancer is currently falling on most developed communities across the globe. But with an anticipated shift in world demographics with growing and aging populations mainly on the African continent, and important shifts in exposure to different risk factors across the world, this is likely to change over the next decades. In this review, we provide an overview of the current incidence, mortality, prevalence, survival, risk factors and costs of bladder cancer worldwide.

• Publication year

  2019

• Venue

  World journal of urology

• Publication date

  2019-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1007/s00345-019-02984-4PMID 31676912PMCID 7363726
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Global Health Observatory Data Repository

  2020cited by this paper
• Non-Muscle Invasive Bladder Cancer: A Review of the Current Trend in Africa

  2019cited by this paper
• Bladder cancer survival: Women only fare worse in the first two years after diagnosis.

  2019cited by this paper
• Epidemiology, aetiology and screening of bladder cancer

  2019cited by this paper
• The impact of gender on oncologic outcomes of bladder cancer

  2019cited by this paper
• World Population Prospects, The 2019 Revision - Volume I: Comprehensive Tables

  2019cited by this paper
• Smoking and Smoking Cessation Among Persons with Tobacco- and Non-tobacco-Associated Cancers

  2019cited by this paper
• Bladder cancer survival: Women better off in the long run.

  2018cited by this paper
• Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

  2018cited by this paper
• Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

  2018cited by this paper
• The Role of Tobacco Smoke in Bladder and Kidney Carcinogenesis: A Comparison of Exposures and Meta-analysis of Incidence and Mortality Risks.

  2016cited by this paper
• Economic Burden of Bladder Cancer Across the European Union.

  2016influential reference
• Cancer Incidence in Five Continents: Inclusion criteria, highlights from Volume X and the global status of cancer registration

  2015cited by this paper
• Bladder Cancer Screening in Aluminum Smelter Workers

  2015cited by this paper
• Urinary tract cancer survival in Europe 1999-2007: Results of the population-based study EUROCARE-5.

  2015cited by this paper
• PLANNING AND DEVELOPING POPULATION-BASED CANCER REGISTRATION IN LOW-AND MIDDLE-INCOME SETTINGS

  2014cited by this paper
• The economics of bladder cancer: costs and considerations of caring for this disease.

  2014cited by this paper
• The burden of bladder cancer care: direct and indirect costs

  2014influential reference
• A composite metric for assessing data on mortality and causes of death: the vital statistics performance index

  2014cited by this paper
• Smoking cessation, anxiety, mood and quality of life: reassuring evidences.

  2014cited by this paper
• Environmental Determinants of Smoking Behaviors: The Role of Policy and Environmental Interventions in Preventing Smoking Initiation and Supporting Cessation

  2013cited by this paper
• Association between smoking and risk of bladder cancer among men and women.

  2011cited by this paper
• Working to overcome the global impact of neglected tropical diseases : first WHO report on neglected tropical diseases

  2010cited by this paper
• The present and future burden of urinary bladder cancer in the world

  2009cited by this paper
• Incidence analyses of bladder cancer in the Nile delta region of Egypt.

  2009cited by this paper
• Key concerns about the current state of bladder cancer

  2009cited by this paper
• SEER Cancer Statistics Review, 1975-2003, National Cancer Institute. Bethesda, MD,

  2006cited by this paper
• National and international variation in the registration of bladder cancer

  2003cited by this paper
• Benefits of smoking cessation for longevity.

  2002cited by this paper
• A descriptive model of the cigarette epidemic in developed countries

  1994cited by this paper

• Evolving patterns of bladder cancer mortality in US adults: a two-decade analysis reveals persistent disparities despite overall progress (1999-2020)

  2026cites this paper
• Harnessing Ubiquitin-Proteasome System-Related Genes to Identify Subtypes of Bladder Cancer and Reveal Immune Landscape

  2026cites this paper
• Insights into telomerase activity in bladder cancer pathology

  2026cites this paper
• A positive SPTBN2-FLI1 feedback axis promotes bladder cancer via PI3K/AKT activation.

  2026cites this paper
• Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives

  2026cites this paper
• Artificial intelligence in bladder cancer management: a narrative review of diagnostic and surgical advances and current limitations.

  2026cites this paper
• Oncological Outcomes of Epirubicin-based Hyperthermic Intravesical Chemotherapy in Bacillus Calmette-Guérin (BCG)-naïve Patients and Patients with BCG Failure: A Multicenter Retrospective Observational Study

  2026cites this paper
• An explainable machine learning model for predicting bladder tumor aecurrence risk

  2026cites this paper
• Enhancing Predictive Accuracy in Immunotherapy Models through Data Integration and Parameter Identifiability

  2026cites this paper
• The trends of congenital heart defects burden in BRICS-plus from 1990 to 2021 and its projection to 2035.

  2026cites this paper
• Area deprivation and cancer‐specific mortality in non‐muscle‐invasive bladder cancer: a statewide analysis

  2026cites this paper
• Unequal Progress in Early-Onset Bladder Cancer Control: Global Trends, Socioeconomic Disparities, and Policy Efficiency from 1990 to 2021

  2026cites this paper
• Comparison between cutaneous ureterostomy and the ileal conduit in patients with urothelial bladder carcinoma undergoing radical cystectomy: Expanding eligibility for the gold standard treatment.

  2026cites this paper
• Global trends in robot-assisted radical cystectomy: a bibliometric and visualization analysis

  2026cites this paper
• Effects of dutasteride with Bacillus Calmette-Guérin therapy on recurrence, progression, metastasis, and survival in non-muscle invasive bladder cancer: a retrospective single-center study

  2026cites this paper
• Toxicogenomic Characterization of Perfluorooctanoic Acid-Associated Bladder Carcinogenesis.

  2026cites this paper
• Advances and challenges of PET imaging in bladder cancer-An update and future trends.

  2026cites this paper
• The mechanistic role of Wilms tumor 1-associated protein in cancer pathogenesis, immunity, immunotherapy, and therapy resistance.

  2026cites this paper
• Toward Personalized Treatment of Urogenital Cancers: The Role of Patient-Derived Organoids.

  2026cites this paper
• CircPSMA4 as a novel circular RNA enhances the proliferation migration invasion and metabolism of bladder cancer cells through the miR-767-3p/HIF1A pathway

  2025cites this paper
• Bidirectional Crosstalk Between Bladder Cancer Cells and Normal Fibroblasts Drives Phenotypic Reprogramming and Modulates Chemosensitivity

  2025cites this paper
• Artificial Intelligence as a Tool in the Diagnosis of Bladder Cancer: A Narrative Review

  2025influential citation
• Contemporary management of metastatic urothelial carcinoma

  2025cites this paper
• Dynamic changes of urinary microbiota in patients with bladder cancer after surgery and its clinical significance

  2025cites this paper
• Urine cf-nucleosomes: A non-invasive window into human physiology and disease

  2025cites this paper
• A fully implantable sensorized artificial urinary bladder to restore continence and fullness monitoring

  2025cites this paper
• Saikosaponin D Modulates STAT3 and c-Myc Expression in MDA-MB-231 Cells: A Comprehensive In Silico and In Vitro Study

  2025cites this paper
• The bladder cancer m6A landscape is defined by methylation dilution and 3′-UTR hypermethylation

  2025cites this paper
• The staging of re-TURB is crucial in predicting the response to BCG therapy in patients with T1 high-grade bladder cancer

  2025cites this paper
• Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway

  2025cites this paper
• Prognostic Utility of Combining VI-RADS Scores and CYFRA 21-1 Levels in Bladder Cancer: A Retrospective Single-Center Study

  2025cites this paper
• Urinary bladder cancer needs more attention — recommendations for health care professionals and politicians in the European Union

  2025cites this paper
• Evaluating repeat transurethral resection after en bloc resection for non-muscle invasive bladder cancer

  2025cites this paper
• Protein kinase D2-mediated maintenance complex component 2 phosphorylation promotes bladder cancer progression

  2025cites this paper
• The role of DNA methylation and demethylation in bladder cancer: a focus on therapeutic strategies

  2025cites this paper
• Early outcome and quality of life post-Mainz Pouch II urinary diversion among bladder cancer patients treated at Kilimanjaro Christian Medical Centre: a 10-year experience

  2025cites this paper
• Disease burden and trends of bladder cancer in the world and BRICS from 1990 to 2021 and its projection until 2036: analysis based on the global burden of disease study 2021

  2025influential citation
• Intradermal priming to intravesical Bacillus Calmette-Guérin in non-muscle invasive bladder cancer: A translational research and phase I clinical trial

  2025influential citation
• The role of multiparametric MRI-based VI-RADS in predicting the need for a second TURB

  2025cites this paper
• The role of CDK8 gene polymorphisms in bladder cancer susceptibility and prognosis: a study in the Chinese Han population

  2025cites this paper
• Preclinical Efficacy and Safety of an Oncolytic Adenovirus KD01 for the Treatment of Bladder Cancer

  2025cites this paper
• Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity

  2025cites this paper
• A comprehensive risk model of disulfidoptosis-related lncRNAs predicts prognosis and therapeutic implications in bladder cancer

  2025cites this paper
• Socioeconomic disparities and MIBC survival outcome—An analysis of a statewide cohort

  2025cites this paper
• An Insight into Cancer Cells and Disease Progression Through the Lens of Mathematical Modeling

  2025cites this paper
• IoMT-Enabled Stretchable Strain Sensor for Real-Time Urinary Bladder Monitoring

  2025cites this paper
• Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

  2025cites this paper
• As a New Tumor Suppressor Gene, PID1 Activates the AMPK-mTOR Signal to Inhibit the Progression of Bladder Cancer

  2025cites this paper
• Fusobacterium nucleatum promotes bladder cancer progression and immune escape by activating the IL22/STAT3/PD-L1 signaling cascade.

  2025cites this paper
• Risk Score Model of Aging-Related Genes for Bladder Cancer and Its Application in Clinical Prognosis

  2025cites this paper
• Small cell carcinoma of the bladder: Review of pathogenesis, presentation, and management

  2025cites this paper
• Global, regional, and national burden and trends of bladder cancer in individuals aged 55 years and older from 1990 to 2021: findings from the Global Burden of Disease Study 2021

  2025cites this paper
• Evaluation of gene expression-based predictors of lymph node metastasis in bladder cancer

  2025cites this paper
• Non-invasive bladder cancer detection: Identification of a urinary volatile biomarker panel using GC-MS metabolomics and machine learning.

  2025cites this paper
• Comprehensive Assessment of Tumor Stromal Heterogeneity in Bladder Cancer by Deep Learning and Habitat Radiomics.

  2025cites this paper
• Plasma CAF22 and NfL reflect neuromuscular decline during cisplatin-based chemotherapy and radical cystectomy in muscle-invasive bladder cancer

  2025cites this paper
• Integrating urinary dual-gene methylation and VI-RADS score to predict residual tumors after TURBT in NMIBC: a nomogram-based model

  2025cites this paper
• A Robotic Urinary Bladder Enabling Volume Monitoring and Assisted Micturition

  2025cites this paper
• Evaluating diagnostic performance of urinary biomarkers in the surveillance of non-muscle invasive bladder carcinoma: A systematic review

  2025cites this paper
• Extracellular Vesicle‐Mediated Regulation of H3C14 Contributes to Gemcitabine Resistance in Bladder Cancer

  2025cites this paper
• Peiminine as an Anti-Inflammatory Agent: Mechanisms and Therapeutic Applications Across Diseases

  2025cites this paper
• Therapeutic Intensification Based on Immune Checkpoint Inhibitors in Non-Muscle Invasive Bladder Cancer: State of the Art and Future Perspectives

  2025cites this paper
• Increased expression of transglutaminase-2 is associated with invasive disease in bladder cancer.

  2025cites this paper
• Risk of upper urinary tract urothelial carcinoma after primary non‐muscle‐invasive urinary bladder cancer: A nationwide population‐based cohort study

  2025cites this paper
• Harnessing organoid technology in urological cancer: advances and applications in urinary system tumors

  2025cites this paper
• Risk Factors of the Bladder Cancer

  2025cites this paper
• Bisulfite‐free PCDHGB7 methylation in urine enables early noninvasive detection of urothelial carcinoma

  2025cites this paper
• Patients with Metastatic or Locally Advanced Bladder Cancer Not Undergoing Systemic Oncological Treatment—Characteristics and Long-Term Outcome in a Single-Center Danish Cohort

  2025cites this paper
• Genistein Exerts Anti-proliferative Effects by Regulating Apoptosis and Autophagy-Related Genes and MicroRNAs in Human Urinary Bladder Neoplasm EJ138 Cells: An Experimental and Bioinformatic Study

  2025cites this paper
• Clinical characterization and prognostic modeling of bladder cancer patients with a history of prior tumors: a SEER database analysis

  2025cites this paper
• Branched Hierarchical Porous Carbon Enables Ultrasensitive Detection of Serum Glycans for Comprehensive Assessment of Urological Cancers

  2025cites this paper
• A Study on the Current Situation of Supportive Care Needs and Influencing Factors of Postoperative Patients with Muscle-Invasive Bladder Cancer

  2025cites this paper
• Efficacy and safety of PD-1/PD-L1 inhibitor monotherapy or combination therapy versus platinum-based chemotherapy as a first-line treatment of advanced urothelial cancer: A systematic review and meta-analysis

  2025cites this paper
• BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma

  2025cites this paper
• Multiparametric MRI for Bladder Cancer: A Practical Approach to the Clinical Application of VI-RADS.

  2025cites this paper
• Trends in the global, regional, and national burden of bladder cancer from 1990 to 2021: an observational study from the global burden of disease study 2021

  2025cites this paper
• A Novel Prognostic Model Based on Cuproptosis-Related Genes and Multi-Omics Analysis for Predicting the Prognosis of Patients with Bladder Urothelial Carcinoma

  2025cites this paper
• Life Experience of Patients Living With Urostomy: A Meta‐Synthesis of Qualitative Research

  2025cites this paper
• Investigation of new autoantibodies in urothelial bladder cancer for biomarker discovery using immunoproteomics

  2025cites this paper
• Bladder Cancer in Lebanon: An Updated Epidemiological Comparison with Global Regions and a Comprehensive Review of Risk Factors

  2025cites this paper
• MIS18BP1 promotes bladder cancer cell proliferation and growth via inactivating P53 signaling pathway

  2025cites this paper
• Novel Urinary Biomarkers for the Detection of Bladder Cancer

  2025cites this paper
• Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer

  2025cites this paper
• WWP1 mediates the ubiquitination and degradation of HIPK3 in bladder cancer cells

  2025cites this paper
• Retinoic acid metabolism related gene CYP26B1 promotes tumor stemness and tumor microenvironment remodeling in bladder cancer

  2025cites this paper
• Prognostic impact of serum interleukin-6 and 17 level in patients with bladder cancer: a systematic review and meta-analysis

  2025cites this paper
• Antibody-drug conjugates as game changers in bladder cancer: current progress and future directions

  2025cites this paper
• AMIGO2 expression at the invasive front of bladder cancer predicts recurrence-free and overall survival after radical cystectomy

  2025cites this paper
• miR-944 inhibits malignant progression of bladder cancer through ATIC/AKT/FOXO3 A axis mediated by SHMT1

  2025cites this paper
• Socioeconomic disparities and bladder cancer stage at diagnosis: a statewide cohort analysis

  2025cites this paper
• Avelumab maintenance in advanced urothelial carcinoma: real-world data from Northern Spain (AVEBLADDER study)

  2025cites this paper
• The association between diet and bladder cancer risk: a two-sample mendelian randomization

  2025cites this paper
• Single‐Cell RNA Sequencing Identifies MMP11+ Cancer‐Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression

  2025cites this paper
• Exploring the molecular mechanism of Xiao Ji (Cirsium setosum) in treating bladder cancer using network pharmacology and molecular docking

  2025cites this paper
• Intravesical VSVd51-GM-CSF virotherapy is superior to BCG in treating bladder cancer in preclinical and translational models

  2025cites this paper
• Mini-Cog test predicts need for rehabilitation intervention during weaning after radical cystectomy

  2025cites this paper
• Bladder cancer microbiome and its association with chemoresponse

  2025cites this paper
• Bladder cancer prevalence and diagnostic test accuracy: French results from the IDENTIFY study.

  2025cites this paper
• Hydrogel technologies in andrology: advances in research and prospective applications

  2025cites this paper
• Comparison of Remimazolam-Based Monitored Anesthesia Care and Inhalation-Based General Anesthesia in Transurethral Resection of Bladder Tumor: A Randomized-Controlled Trial

  2025cites this paper