Metronomic Photodynamic Therapy as a New Paradigm for Photodynamic Therapy: Rationale and Preclinical Evaluation of Technical Feasibility for Treating Malignant Brain Tumors¶

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Photochemistry and Photobiology

• Publication date

  2004-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1562/2004-03-05-RA-100.1PMID 15339204
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rat brain tumor models in experimental neuro-oncology:The 9L, C6, T9, F98, RG2 (D74), RT-2 and CNS-1 Gliomas

  2004cited by this paper
• Metronomic photodynamic therapy (mPDT): concepts and technical feasibility in brain tumor

  2003cited by this paper
• Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo

  2003cited by this paper
• Metronomic photodynamic therapy (mPDT) for intracranial neoplasm: physiological, biological, and dosimetry considerations

  2003cited by this paper
• Transport of 5-aminolevulinic acid between blood and brain.

  2003cited by this paper
• Fluorescence-guided resection of intracranial VX2 tumor in a preclinical model using 5-aminolevulinic acid (ALA): preliminary results

  2003cited by this paper
• Bioluminescence monitoring of photodynamic therapy response of rat gliosarcoma in vitro and in vivo

  2003cited by this paper
• Continuous low-dose anti-angiogenic/ metronomic chemotherapy: from the research laboratory into the oncology clinic.

  2002cited by this paper
• PDT-induced apoptosis: investigations using two malignant brain tumor models

  2002cited by this paper
• Clinical studies of photodynamic therapy for malignant brain tumors: Karnofsky score and neurological score in patients with recurrent gloms treated with Photofrin PDT

  2002cited by this paper
• 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a (HPPH) in a nude rat glioma model: Implications for photodynamic therapy

  2001cited by this paper
• Development of a novel indwelling balloon applicator for optimizing light delivery in photodynamic therapy

  2001cited by this paper
• Fractionated Illumination for Oesophageal ALA-PDT: Effect on Blood Flow and PpIX Formation

  2001cited by this paper
• Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice.

  2000cited by this paper
• Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma.

  2000cited by this paper
• Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

  2000cited by this paper
• Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients.

  2000cited by this paper
• Photofrin photodynamic therapy can significantly deplete or preserve oxygenation in human basal cell carcinomas during treatment, depending on fluence rate.

  2000cited by this paper
• Photodynamic Therapy of Human Glioma Spheroids Using 5-Aminolevulinic Acid¶

  2000cited by this paper
• Apoptosis induced in vivo by photodynamic therapy in normal brain and intracranial tumour tissue

  2000cited by this paper
• Graphic analysis of microscopic tumor cell infiltration, proliferative potential, and vascular endothelial growth factor expression in an autopsy brain with glioblastoma.

  1999cited by this paper
• Enhanced photodynamic effects using fractionated laser light.

  1998cited by this paper
• 5-Aminolaevulinic acid-induced protoporphyrin IX accumulation in tissues: pharmacokinetics after oral or intravenous administration.

  1998cited by this paper
• Delta-aminolevulinic acid transport through blood-brain barrier.

  1998cited by this paper
• Photodynamic Therapy of Intracranial Tissues: A Preclinical Comparative Study of Four Different Photosensitizers

  1998influential reference
• δ-Aminolevulinic Acid Transport through Blood–Brain Barrier

  1998cited by this paper
• A solubilization technique for photosensitizer quantification in ex vivo tissue samples.

  1997cited by this paper
• Enhanced effectiveness of photodynamic therapy with laser light fractionation in patients with esophageal cancer.

  1997cited by this paper
• Preclinical studies of photodynamic therapy of intracranial tissues

  1997cited by this paper
• The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy.

  1996cited by this paper
• The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy

  1996influential reference
• Photodynamic therapy for recurrent supratentorial gliomas.

  1995cited by this paper
• Adjuvant intraoperative photodynamic therapy diminishes the rate of local recurrence in a rat mammary tumour model.

  1995cited by this paper
• Guide to the care and use of experimental animals

  1993cited by this paper
• Design of PDT protocols using delta-aminolevulinic acid (5ALA)

  1993cited by this paper
• The effect of light fluence rate in photodynamic therapy of normal rat brain.

  1992cited by this paper
• Sustained high plasma 5‐aminolaevulinic acid concentration in a volunteer: no porphyric symptoms

  1992cited by this paper
• Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.

  1992cited by this paper
• DEPTH MEASUREMENTS AND HISTOPATHOLOGICAL CHARACTERIZATION OF PHOTODYNAMIC THERAPY GENERATED NORMAL BRAIN NECROSIS AS A FUNCTION OF INCIDENT OPTICAL ENERGY DOSE

  1991influential reference
• In vivo TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULPHONATED PHTHALOCYANINE

  1990cited by this paper
• Adjuvant high-dose photoradiation therapy in the treatment of cerebral glioma: a phase 1-2 study.

  1987cited by this paper
• Neuropharmacology of δ-aminolaevulinic acid. II. Effect of chronic administration in mice

  1984cited by this paper
• Neuropharmacology of delta-aminolaevulinic acid. II. Effect of chronic administration in mice.

  1984cited by this paper
• Photochemistry and Photobiology

  1962cited by this paper

• Soft, Flexible, and Stretchable Platforms for Tissue‐Interfaced Bioelectronics

  2026cites this paper
• Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities

  2025cites this paper
• Synergistic Paradigms in Infection Control: A Review on Photodynamic Therapy as an Adjunctive Strategy to Antibiotics

  2025cites this paper
• Metronomic photodynamic therapy for deep organ cancer by implantable wireless OLEDs

  2025cites this paper
• Implanted Miniature Light Devices for Phototherapeutics

  2025cites this paper
• A long-term self-driven metronomic photodynamic system for cancer therapy

  2025cites this paper
• The assessment of 5-aminolevulinic acid photodynamic therapy in glioblastomas

  2024cites this paper
• Deeply Implantable, Shape‐Morphing, 3D MicroLEDs for Pancreatic Cancer Therapy

  2024cites this paper
• A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

  2024cites this paper
• A Microrobotic System Based on Engineered Bacteria for Targeted Self-Driven Photodynamic Therapy.

  2024cites this paper
• Imaging treatment efficacy of repeated photodynamic therapy in glioblastoma using chemical exchange transfer saturation MRI

  2024cites this paper
• 5-aminolevulinic acid induced photodynamic reactions in diagnosis and therapy for female lower genital tract diseases

  2024cites this paper
• Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy

  2024cites this paper
• Globus Lucidus: A porcine study of an intracranial implant designed to deliver closed, repetitive photodynamic and photochemical therapy in glioblastoma.

  2024cites this paper
• Soft Bioelectronics for Therapeutics.

  2023cites this paper
• A self-powered wireless detachable drug/light injector for metronomic photodynamic therapy in cancer treatment

  2023cites this paper
• Developmental synergism in the management of oral potentially malignant disorders.

  2023cites this paper
• 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy

  2023cites this paper
• Metronomic Photodynamic Therapy with Conjugated Polymer Nanoparticles in Glioblastoma Tumor Microenvironment

  2023cites this paper
• A Comparative Evaluation of the Photosensitizing Efficiency of Porphyrins, Chlorins and Isobacteriochlorins toward Melanoma Cancer Cells

  2023cites this paper
• Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions

  2023cites this paper
• Microneedle Device Delivering Aggregation-Induced Emission Photosensitizers for Enhanced Metronomic Photodynamic Therapy of Cancer.

  2023cites this paper
• Phonozen-mediated photodynamic therapy comparing two wavelengths in a mouse model of peritoneal carcinomatosis

  2023cites this paper
• Ru(II) CONTAINING PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY: A CRITIQUE ON REPORTING AND AN ATTEMPT TO COMPARE EFFICACY.

  2022cites this paper
• The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy

  2022cites this paper
• Photodynamic therapy with light-emitting diode arrays producing different light fields induces apoptosis and necrosis in gastrointestinal cancer

  2022cites this paper
• Light-triggered Photodynamic Nanomedicines for Overcoming Localized Therapeutic Efficacy in Cancer Treatment.

  2022cites this paper
• A Warp-Knitted Light-Emitting Fabric-Based Device for In Vitro Photodynamic Therapy: Description, Characterization, and Application on Human Cancer Cell Lines

  2021cites this paper
• Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

  2021cites this paper
• Perspectives on interstitial photodynamic therapy for malignant tumors

  2021cites this paper
• Photodynamic Therapy—Current Limitations and Novel Approaches

  2021cites this paper
• Investigation of Photodynamic Therapy on Breast Cancer Cell Lines Using LaF3:Tb Nanoparticles Conjugated with Meso-tetra(4-carboxyphenyl) Porphine

  2021cites this paper
• Optical Quality Resorbable Calcium-Phosphate Glasses for Biophotonic Applications

  2021cites this paper
• The role of photodynamic therapy in breast cancer - A review of in vitro research.

  2021cites this paper
• Deep proteome profiling of SW837 cells treated by photodynamic therapy (PDT) reveals the underlying mechanisms of metronomic and acute PDTs.

  2020cites this paper
• Photodynamic Diagnosis and Therapy for Peritoneal Carcinomatosis from Gastrointestinal Cancers: Status, Opportunities, and Challenges

  2020cites this paper
• Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid

  2020cites this paper
• Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier

  2020cites this paper
• Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy.

  2020cites this paper
• Investigation of the Mechanisms of Radio-Dynamic Therapy

  2020cites this paper
• Minimal required PDT light dosimetry for nonmuscle invasive bladder cancer

  2020cites this paper
• Quantum dot light-emitting diodes as light sources in photomedicine: photodynamic therapy and photobiomodulation

  2020cites this paper
• High-power light-emitting diode array design and assembly for practical photodynamic therapy research

  2020cites this paper
• Metronomic PDT induces innate and adaptive immune responses in murine models of skin cancer and pre-cancer

  2020cites this paper
• Clinical Trials and Basic Research in Photodynamic Diagnostics and Therapies from the Center for Laser Diagnostics and Therapy in Poland

  2020cites this paper
• Using Light for Therapy of Glioblastoma Multiforme (GBM)

  2020cites this paper
• A simple phototheranostics strategy to continuously deliver singlet oxygen in dark and hypoxic tumor microenvironment.

  2020cites this paper
• A regimen to minimize pain during blue light photodynamic therapy of actinic keratoses: Bilaterally controlled, randomized trial of simultaneous versus conventional illumination.

  2020cites this paper
• Printed nanofilms mechanically conforming to living bodies.

  2019cites this paper
• Metronomic photodynamic therapy with 5-aminolevulinic acid induces apoptosis and autophagy in human SW837 colorectal cancer cells.

  2019cites this paper
• Photodynamic therapy for solid tumors: A review of the literature

  2019cites this paper
• Comparison of different treatment schemes in 5-ALA interstitial photodynamic therapy for high-grade glioma in a preclinical model: An MRI study.

  2019cites this paper
• The effects of low irradiance long duration photochemical internalization on glioma spheroids.

  2019cites this paper
• Painless versus conventional photodynamic therapy for treatment of actinic keratosis: comparison of cell death and immune response in a murine model

  2019cites this paper
• Photosensitizer and Radio-Dynamic Therapy (RDT)

  2019cites this paper
• Photosensitizers for Glioma Therapy – A Role of 5 -Aminolevulinic Acid

  2019cites this paper
• Acridine Orange as a Novel Photosensitizer for Photodynamic Therapy in Glioblastoma.

  2018cites this paper
• A suppository kit for metronomic photodynamic therapy: The elimination of rectal cancer in situ.

  2018cites this paper
• Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: an in vivo histological study in rats

  2018cites this paper
• Innovative Strategien für die photodynamische Therapie hypoxischer Tumore

  2018cites this paper
• Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

  2018cites this paper
• Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment in vivo

  2018cites this paper
• Toward biomaterial-based implantable photonic devices

  2017cites this paper
• Curcumin uptake enhancement using low dose light illumination during incubation in Candida albicans

  2017cites this paper
• Light‐driven photosensitizer uptake increases Candida albicans photodynamic inactivation

  2017cites this paper
• Novel Osmium‐based Coordination Complexes as Photosensitizers for Panchromatic Photodynamic Therapy

  2017cites this paper
• Plant extracts as natural photosensitizers in photodynamic therapy: in vitro activity against human mammary adenocarcinoma MCF-7 cells

  2017cites this paper
• Interstitial photodynamic therapy and glioblastoma: Light fractionation in a preclinical model

  2017cites this paper
• Novel Photodynamic Cancer Therapy Agent and Biochemical Phosphate Sensor Based on Nanomaterials

  2016cites this paper
• Pulse mode of laser photodynamic treatment induced cell apoptosis.

  2016cites this paper
• Lowering photosensitizer doses and increasing fluences induce apoptosis in tumor bearing mice.

  2016cites this paper
• Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy

  2016cites this paper
• The biophysical aspects of photodynamic therapy

  2016cites this paper
• Implantable micro-optical semiconductor devices for optical theranostics in deep tissue

  2016cites this paper
• Comparison of two photosensitizers in photodynamic therapy using light pulses in femtosecond regime: an animal study

  2016cites this paper
• Physics of Photodynamic Therapy

  2016cites this paper
• Biodegradable electronic and optical devices toward temporary implants

  2016cites this paper
• Interstitial 5-ALA photodynamic therapy and glioblastoma: Preclinical model development and preliminary results.

  2016influential citation
• Spectroscopic Study of Singlet Oxygen in Cells and Model Systems

  2016cites this paper
• Photodynamic therapy in the treatment of intracranial gliomas: A review of current practice and considerations for future clinical directions

  2015cites this paper
• Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED).

  2015influential citation
• Characterizing low fluence thresholds for in vitro photodynamic therapy.

  2015cites this paper
• Medical laser application: translation into the clinics

  2015cites this paper
• Repeated sub-optimal photodynamic treatments with pheophorbide a induce an epithelial mesenchymal transition in prostate cancer cells via nitric oxide.

  2015cites this paper
• Photodynamic Diagnosis and Therapy for Brain Malignancies from the Bench to Clinical Application

  2014cites this paper
• Focal therapy for prostate cancer. Alternative treatment.

  2014cites this paper
• Lasers in Diagnostics and Treatment of Brain Diseases

  2014cites this paper
• 5.4L: Late-News Paper: ALA Mediated Metronomic Photodynamic Therapy in Mouse Gliomas Model using Organic Light Emitting Diode

  2014cites this paper
• 10.10 – Photodynamic Techniques in Medicine

  2014cites this paper
• Efficacy and safety of continuous low-irradiance photodynamic therapy in the treatment of chest wall progression of breast cancer.

  2014cites this paper
• Focal therapy for prostate cancer. Alternative treatment.

  2014cites this paper
• NAD(P)H and FAD as Biomarkers for Programmed Cell Death

  2014cites this paper
• Ultra low fluence rate photodynamic therapy: simulation of light emitted by the Cerenkov effect

  2014cites this paper
• Photodynamic therapy of malignant brain tumours: a complementary approach to conventional therapies.

  2014cites this paper
• Measurement of Intracellular Oxygen Concentration During Photodynamic Therapy in vitro

  2014cites this paper
• Experimental use of photodynamic therapy in high grade gliomas: a review focused on 5-aminolevulinic acid.

  2014cites this paper
• Photodynamic therapy potentiates the paracrine endothelial stimulation by colorectal cancer

  2014cites this paper
• Fluorescence spectroscopic measurements of absolute and relative photosensitizer concentrations in tissue for the optimization of photodynamic therapy

  2014cites this paper
• Continuous Low-Irradiation Photodynamic Therapy ( CLIPT ) for the Management of Cutaneous Metastases of Breast Cancer in Patients Failing Conventional Radiotherapy

  2014cites this paper
• Application of Two-Photon Absorbing Fluorene-Containing Compounds in Bioimaging and Photodyanimc Therapy

  2014cites this paper