Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Toxicology in Vitro

• Publication date

  1995-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/0887-2333(94)00187-YPMID 20650059
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cyclophosphamide-induced lung toxicity: mechanism of endothelial cell injury.

  1994cited by this paper
• Metabolism of cyclophosphamide by lipoxygenases.

  1994cited by this paper
• Acrolein-induced oxygen radical formation.

  1993cited by this paper
• Thiol status and cytopathological effects of acrolein in normal and xeroderma pigmentosum skin fibroblasts.

  1993cited by this paper
• Acrolein-induced injury to cultured pulmonary artery endothelial cells.

  1993cited by this paper
• Evidence for peroxidase-mediated metabolism of cyclophosphamide.

  1993cited by this paper
• Bioactivation mechanism of S-(3-oxopropyl)-N-acetyl-L-cysteine, the mercapturic acid of acrolein.

  1992cited by this paper
• Nephrotoxicity of the 1:1 acrolein-glutathione adduct in the rat.

  1992cited by this paper
• Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo

  1991cited by this paper
• Glutathione diminishes the anti-tumour activity of 4-hydroperoxycyclophosphamide by stabilising its spontaneous breakdown to alkylating metabolites.

  1991cited by this paper
• Cyclophosphamide toxicity. Characterising and avoiding the problem.

  1991cited by this paper
• Cooxidation of cyclophosphamide as an alternative pathway for its bioactivation and lung toxicity.

  1991cited by this paper
• Calcium chelation induced glutathione efflux from tumor cells and prevention by ruthenium red or neomycin.

  1991cited by this paper
• In vitro studies of aldehyde effects related to human respiratory carcinogenesis.

  1990cited by this paper
• Metabolism and pulmonary toxicity of cyclophosphamide.

  1990cited by this paper
• Comparative toxicity of allylamine and acrolein in cultured myocytes and fibroblasts from neonatal rat heart.

  1989cited by this paper
• Allyl alcohol- and acrolein-induced toxicity in isolated rat hepatocytes.

  1989cited by this paper
• Injurious effect of buthionine sulfoximine, an inhibitor of glutathione biosynthesis, on the lethality and urotoxicity of cyclophosphamide in mice.

  1989cited by this paper
• 3‐Hydroxypropylmercapturic acid: A biologic marker of exposure to allylic and related compounds

  1989cited by this paper
• Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture.

  1989cited by this paper
• Pathobiological effects of acrolein in cultured human bronchial epithelial cells.

  1988cited by this paper
• Metabolism of arachidonic acid in human lung cancer cell lines.

  1987cited by this paper
• Identification and quantitative determination of four different mercapturic acids formed from 1,3-dibromopropane and its 1,1,3,3-tetradeutero analogue by the rat.

  1986cited by this paper
• Formation, toxicity and inactivation of acrolein during biotransformation of cyclophosphamide as studied in freshly isolated cells from rat liver and kidney

  1985cited by this paper
• Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide.

  1981cited by this paper
• Evaluation of cytotoxicity in cultured cells by enzyme leakage

  1980cited by this paper
• Cyclophosphamide cystitis--identification of acrolein as the causative agent.

  1979cited by this paper
• Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.

  1979cited by this paper
• The biosynthesis of 3-hydroxypropylmercapturic acid from cyclophosphamide.

  1979cited by this paper
• Studies on the in vivo formation of acrolein: 3-hydroxy-propylmercapturic acid as an index of cyclophosphamide (NSC-26271) activation.

  1976cited by this paper
• Studies on the in vivo formation of acrolein: 3-hydroxy-propylmercapturic acid as an index of cyclophosphamide (NSC-26271) activation.

  1976cited by this paper
• The reaction of cysteine with α,β-unsaturated aldehydes

  1976cited by this paper
• Studies on the mechanism of action of cytoxan. Evidence of activation in vivo and in vitro.

  1961cited by this paper

• The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates

  2023cites this paper
• Acrolein measurement and degradation in Dulbecco’s Modified Eagle Medium: an examination of in-vitro exposure metrics

  2018cites this paper
• Investigation of Antigenotoxic Potential of Wheatgrass (Triticumaestivum) Powder on Cyclophosphamide Induced Genotoxicity and Oxidative Stress in Mice

  2017influential citation
• Modulator effect of watercress against cyclophosphamide-induced oxidative stress in mice.

  2017cites this paper
• Amelioration of cyclophosphamide induced myelosuppression and oxidative stress by cinnamic acid.

  2012cites this paper
• Comparación en la frecuencia espontánea e inducida de aberraciones cromosómicas en médula ósea de ratones OF-1 y C57BL/6/cenp

  2010cites this paper
• Evaluación del potencial genotóxico del D-004, para inducir aberraciones cromosómicas en médula ósea de ratones

  2010cites this paper
• Evaluación del potencial genotóxico del D-004, para inducir aberraciones cromosómicas en médula ósea de ratones. Assessment the potential genotoxic of D-004, for inducing chromosomal aberrations in bone marrow of mice.

  2010cites this paper
• Efectos del D-003, mezcla de ácidos alifáticos en el ensayo de aberraciones cromosómicas in vivo

  2010cites this paper
• Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice.

  2009cites this paper
• Protection Against Cyclophosphamide-Induced Renal Oxidative Stress by Amifostine: The Role of Antioxidative Mechanisms

  2003cites this paper
• Frecuencia espontánea e inducida de aberraciones cromosómicas en médula ósea de ratones NMRI y Balb-C de

  2003cites this paper
• Acrolein MAK value – Peak limitation – Absorption through the skin – Sensitization – Carcinogenicity

  2002cites this paper
• Acrolein causes inhibitor kappaB-independent decreases in nuclear factor kappaB activation in human lung adenocarcinoma (A549) cells.

  1999cites this paper
• Glutathione antagonized cyclophosphamide- and acrolein-induced cytotoxicity of PC3 cells and immunosuppressive actions in mice.

  1999cites this paper
• Acrolein Causes Inhibitor κB-independent Decreases in Nuclear Factor κB Activation in Human Lung Adenocarcinoma (A549) Cells*

  1999cites this paper
• Bcl-2 and Bcl-xL in peroxide-resistant A549 and U87MG cells.

  1998cites this paper
• Relationships between cell density, glutathione and proliferation of A549 human lung adenocarcinoma cells treated with acrolein.

  1997cites this paper
• 2‐Methyl‐thiazolidine‐2,4‐dicarboxylic acid as prodrug of L‐cysteine. Protection against paracetamol hepatotoxicity in mice

  1997cites this paper
• Studies on the basis for the toxicity of acrolein mercapturates.

  1996cites this paper
• Acrolein mercapturates: synthesis, characterization, and assessment of their role in the bladder toxicity of cyclophosphamide.

  1995cites this paper