Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Chemico-Biological Interactions

• Publication date

  2009-08-14

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.cbi.2009.03.017PMID 19539803
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs vol. 1 to 42. Supplement 7. 440 Seiten. International Agency for Research on Cancer, Lyon 1987. Preis: 65, – s.Fr

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  1951cited by this paper

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