Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Science

• Publication date

  2014-04-18

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1126/science.1249240PMID 24744379PMCID PMC4334447
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway

  2013cited by this paper
• The Effect of Lamotrigine on Nav1.4 Voltage-Gated Sodium Channels

  2013cited by this paper
• Effect of lamotrigine on Na(v)1.4 voltage-gated sodium channels.

  2013cited by this paper
• Synaptic plasticity: Balancing firing rates in vivo

  2013cited by this paper
• Dopamine neurons modulate neural encoding and expression of depression-related behaviour

  2012cited by this paper
• Rapid regulation of depression-related behaviors by control of midbrain dopamine neurons

  2012cited by this paper
• Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.

  2012cited by this paper
• BDNF Is a Negative Modulator of Morphine Action

  2012influential reference
• Input-specific control of reward and aversion in the ventral tegmental area

  2012cited by this paper
• The Science of Resilience: Implications for the Prevention and Treatment of Depression

  2012cited by this paper
• Neurobiology of resilience

  2012cited by this paper
• A Novel Role of the WNT-Dishevelled-GSK3β Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

  2011cited by this paper
• A standardized protocol for repeated social defeat stress in mice

  2011cited by this paper
• Exposure and reorganization: the what and how of effective psychotherapy.

  2011cited by this paper
• Clinical practice. Bipolar disorder--a focus on depression.

  2011cited by this paper
• Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement.

  2011cited by this paper
• ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

  2010cited by this paper
• Mesolimbic Dopamine Neurons in the Brain Reward Circuit Mediate Susceptibility to Social Defeat and Antidepressant Action

  2010influential reference
• CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

  2009cited by this paper
• Psychobiology and molecular genetics of resilience

  2009influential reference
• Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning

  2009cited by this paper
• Hyperpolarization-activated cation channels: from genes to function.

  2009cited by this paper
• The Schizophrenia Susceptibility Gene dysbindin Controls Synaptic Homeostasis

  2009cited by this paper
• Corticotropin‐releasing factor increases mouse ventral tegmental area dopamine neuron firing through a protein kinase C‐dependent enhancement of Ih

  2008cited by this paper
• Changes in Mindfulness and Emotion Regulation in an Exposure-Based Cognitive Therapy for Depression

  2008cited by this paper
• Responses to Positive Affect: A Self-Report Measure of Rumination and Dampening

  2008cited by this paper
• Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system.

  2008influential reference
• Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D2 Receptor Inhibition

  2008cited by this paper
• Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.

  2007influential reference
• Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

  2006cited by this paper
• Potentiation of cortical inhibition by visual deprivation

  2006cited by this paper
• The mesolimbic dopamine reward circuit in depression.

  2006cited by this paper
• Plasticity in single neuron and circuit computations

  2004cited by this paper
• Ih Channels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

  2002cited by this paper
• Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

  2002cited by this paper
• Activity-dependent changes in the intrinsic properties of cultured neurons.

  1994cited by this paper

• Genome-wide methylation patterns associated with chronic stress.

  2026cites this paper
• Dynamics of synchronous bursts in functionally coupled midbrain dopamine neurons driven by diverse excitatory inputs

  2026cites this paper
• Stress resilience is associated with transcriptional remodeling in the VTA.

  2026cites this paper
• Flaxseed Supplementation Confers Resilience to Stress-Induced Depression-Like Behaviors via GDNF Epigenetic Modulation in the Ventral Tegmental Area of Rats

  2026cites this paper
• Advances and Challenges of Single-Atom Metals-Based Materials for Sensing Applications through Structure–Function Relationships

  2026cites this paper
• Repeated adenosine A1 receptor antagonism rewires ventral hippocampus-ventral tegmental area transmission and enhances stress-coping responses.

  2026cites this paper
• In vivo tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity

  2025influential citation
• Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder

  2025cites this paper
• Disrupted Neuronal Dynamics of Reward Encoding in the Medial Prefrontal Cortex and the Ventral Tegmental Area after Episodic Social Stress

  2025cites this paper
• Calcium imaging: Unraveling the neurobiological mechanisms of depression across cellular and circuit dimensions.

  2025cites this paper
• Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders.

  2025cites this paper
• Potentiation of Nigra–Striatal Dopaminergic Projection Underpins Core Autism-Like Behaviors in Valproate-Exposed Mice

  2025cites this paper
• A Randomized, Controlled Trial of the Novel, Potent Kv7 Channel Opener Azetukalner in Individuals with Major Depressive Disorder and Anhedonia: Neural Response to Reward, Clinical Outcomes, and Safety

  2025cites this paper
• The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder

  2025influential citation
• Untangling the multifaceted VTA responses to stress.

  2025cites this paper
• Optogenetics: Pinpoint Light on Precise Neuromodulation

  2025cites this paper
• The Midbrain Dopaminergic System in Behavioral Models of Depression

  2025cites this paper
• Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors.

  2025cites this paper
• How dopamine guides our social world.

  2025cites this paper
• Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents

  2025cites this paper
• Intermittent and limited exposure to a high-fat diet prevents social defeat-induced increase in ethanol intake and neuroinflammation.

  2025cites this paper
• Stress-induced reduction of sodium leak currents causes social deficits by impairing dorsal dentate gyrus-medial septum glutamatergic projection

  2025cites this paper
• Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype

  2025cites this paper
• VTA Dopaminergic Neurons involved in Chronic Spared Nerve Injury Pain-induced Depressive-like Behavior.

  2025cites this paper
• Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety.

  2025cites this paper
• Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification

  2025cites this paper
• Ions in Motion: From Biological Channels to Engineered Transport Systems

  2025cites this paper
• Early-life stress sensitizes response to future stress: Evidence and mechanisms

  2025cites this paper
• Wireless activation of dopamine neurons for rapid regulation of depression-related behaviors by upconversion optogenetics

  2025cites this paper
• Different activation in left dorsolateral prefrontal cortex and left orbitofrontal cortex during autobiographical memory tasks is associated with depressive disorder with different levels of resilience: a functional near-infrared spectroscopy study

  2025cites this paper
• Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience

  2025cites this paper
• Noradrenergic efferent subsystems that gate traumatic social learning

  2025cites this paper
• Stress resilience is associated with transcriptional remodeling in the VTA

  2025cites this paper
• Stress History Modulates CRF Neurons to Establish Resilience

  2025cites this paper
• Projection-defined ventral tegmental area neurons exhibit fentanyl-induced molecular and functional adaptations that differentially support drug-context associations

  2025cites this paper
• New and emerging pharmacologic treatments for MDD

  2025cites this paper
• Addiction neurobiologists should study resilience

  2024cites this paper
• Male and female variability in response to chronic stress and morphine in C57BL/6J, DBA/2J, and their BXD progeny

  2024cites this paper
• Genetically encoded sensors for in vivo detection of neurochemicals relevant to depression

  2024cites this paper
• Adolescent stress differentially modifies dopamine and norepinephrine release in the medial prefrontal cortex of adult rats.

  2024cites this paper
• Systemic Tumors Can Cause Molecular Changes in the Hippocampus That May Have an Impact on Behavior after Chronic Social Stress

  2024cites this paper
• Dimethyl fumarate ameliorates chronic stress-induced anxiety-like behaviors by decreasing neuroinflammation and neuronal activity in the amygdala.

  2024cites this paper
• Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice

  2024cites this paper
• PI4KIIIβ-Mediated Phosphoinositides Metabolism Regulates Function of the VTA Dopaminergic Neurons and Depression-Like Behavior

  2024cites this paper
• A profile of azetukalner for the treatment of epilepsy: from pharmacology to potential for therapy

  2024cites this paper
• Layer-specific input to medial prefrontal cortex is linked to stress susceptibility

  2024cites this paper
• Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior

  2024cites this paper
• Early-life stress alters chromatin modifications in VTA to prime stress sensitivity

  2024cites this paper
• The role of KCNQ channel activators in management of major depressive disorder.

  2024cites this paper
• Neurobiological basis of stress resilience.

  2024cites this paper
• Convergence of Oxytocin and Dopamine Signaling in Neuronal Circuits: Insights into the Neurobiology of Social Interactions Across Species.

  2024cites this paper
• Conformal Neuromorphic Bioelectronics for Sense Digitalization

  2024cites this paper
• Hyperoside alleviates depressive-like behavior in social defeat mice by mediating microglial polarization and neuroinflammation via TRX1/NLRP1/Caspase-1 signal pathway.

  2024cites this paper
• Dopaminergic dominance in the ventral medial hypothalamus: A pivotal regulator for methamphetamine-induced pathological aggression.

  2024cites this paper
• Male and female behavioral variability and morphine response in C57BL/6J, DBA/2J, and their BXD progeny following chronic stress exposure

  2024cites this paper
• Heterogeneity of mesencephalic dopaminergic neurons: From molecular classifications, electrophysiological properties to functional connectivity

  2024cites this paper
• Identifying and modulating neural signatures of stress susceptibility and resilience enables control of anhedonia

  2024cites this paper
• Neurobiology and systems biology of stress resilience

  2024cites this paper
• Optogenetic behavioral studies in depression research: A systematic review

  2024cites this paper
• Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure

  2024cites this paper
• Secure attachment to caregiver prevents adult depressive symptoms in a sex-dependent manner: A translational study

  2024cites this paper
• Stress inoculation during adolescence attenuates social stress-induced increase in ethanol intake in adult male mice.

  2024cites this paper
• Neuronal heterogeneity in the ventral tegmental area: distinct contributions to reward circuitry and motivated behavior

  2024cites this paper
• Ventral tegmental area dopaminergic circuits participates in stress-induced chronic postsurgical pain in male mice

  2024cites this paper
• Role of the locus coeruleus-noradrenergic system in stress-related psychopathology and resilience: clinical and pre-clinical evidences.

  2024cites this paper
• Dorsal raphe dopaminergic neurons target CaMKII+ neurons in dorsal bed nucleus of the stria terminalis for mediating depression-related behaviors

  2024cites this paper
• Impact of protein fouling on electrochemistry of hyaluronic acid/curcumin/carbon nanotubes modified electrode: Toward electrochemical measurement of dopamine

  2024cites this paper
• Nighttime-specific differential gene expression in suprachiasmatic nucleus and habenula is associated with resilience to chronic social stress

  2024cites this paper
• Understanding the neural code of stress to control anhedonia

  2024cites this paper
• Research progress in inflammation and reward mechanisms and traditional Chinese medicine regulation of depression

  2024cites this paper
• Chronic Social Defeat Stress Increases Brain Permeability to Ghrelin in Male Mice

  2024cites this paper
• Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice.

  2024cites this paper
• Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure

  2024cites this paper
• Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility

  2024cites this paper
• Different effects of intra-RMTg infusions of pilocarpine or 4-DAMP on regulating depression- and anxiety-like behaviors.

  2024cites this paper
• The nucleus accumbens in reward and aversion processing: insights and implications

  2024cites this paper
• The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

  2024cites this paper
• Behavioral coping with chronic defeat stress in mice: A systematic review of current protocols

  2024cites this paper
• Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility.

  2024cites this paper
• The Formation and Function of the VTA Dopamine System

  2024cites this paper
• The design of self-healing memristive network circuit based on VTA DA neurons and its application

  2024cites this paper
• Nighttime-specific gene expression changes in suprachiasmatic nucleus and habenula are associated with resiliency to chronic social stress

  2023cites this paper
• Tonic Activation of NR2D-Containing NMDARs Exacerbates Dopaminergic Neuronal Loss in MPTP-Injected Parkinsonian Mice

  2023cites this paper
• Thyroid hormones mediate the impact of early-life stress on ventral tegmental area gene expression and behavior

  2023cites this paper
• Midbrain organoids—development and applications in Parkinson’s disease

  2023cites this paper
• Resilience to Pain-Related Depression in σ1 Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes.

  2023cites this paper
• A glutamatergic DRN–VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice

  2023cites this paper
• Chronic social stress blunts core body temperature and molecular rhythms of Cirbp and Rbm3 in mice lateral habenula

  2023cites this paper
• Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons

  2023cites this paper
• HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model

  2023cites this paper
• Retigabine promotes ketamine's antidepressant effect in the forced swim test in male and female C57BL/6J mice.

  2023cites this paper
• Stress relief as a natural resilience mechanism against depression-like behaviors.

  2023cites this paper
• Sex and cell-specific gene expression in corticolimbic brain regions associated with psychiatric disorders revealed by bulk and single-nuclei RNA sequencing

  2023cites this paper
• A thalamic-primary auditory cortex circuit mediates resilience to stress.

  2023cites this paper
• Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula

  2023cites this paper
• Resilience to depression: Implication for psychological vaccination

  2023influential citation
• The cation channel mechanisms of subthreshold inward depolarizing 1 currents in the VTA dopaminergic neurons and their roles in the 2 depression-like behavior

  2023cites this paper
• Neural and Molecular Investigation into the Paraventricular Thalamic-Nucleus Accumbens Circuit for Pain Sensation and Non-opioid Analgesia.

  2023cites this paper
• Anxiety and depression: A top-down, bottom-up model of circuit function

  2023influential citation
• Multiple integrated social stress induces depressive-like behavioral and neural adaptations in female C57BL/6J mice.

  2023cites this paper