The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Metabolism: Clinical and Experimental

• Publication date

  2007-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.METABOL.2007.06.016PMID 17950100
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sirolimus Is Associated With Reduced Islet Engraftment and Impaired β-Cell Function

  2006cited by this paper
• Hypothalamic mTOR Signaling Regulates Food Intake

  2006cited by this paper
• Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation.

  2006cited by this paper
• Ras, PI(3)K and mTOR signalling controls tumour cell growth

  2006cited by this paper
• Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity.

  2006cited by this paper
• Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

  2005cited by this paper
• Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus.

  2005cited by this paper
• Assessing the relative risk of cardiovascular disease among renal transplant patients receiving tacrolimus or cyclosporine

  2005cited by this paper
• CARDIOVASCULAR RISK PROFILE AFTER CONVERSION FROM CYCLOSPORINE A TO TACROLIMUS IN STABLE RENAL TRANSPLANT RECIPIENTS

  2004cited by this paper
• mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

  2004cited by this paper
• Increased β-Oxidation in Muscle Cells Enhances Insulin-stimulated Glucose Metabolism and Protects against Fatty Acid-induced Insulin Resistance Despite Intramyocellular Lipid Accumulation*

  2004cited by this paper
• Mammalian target of rapamycin (mTOR) inhibitors

  2004cited by this paper
• Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation.

  2004cited by this paper
• regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesis.

  2004cited by this paper
• Nutrient sensor links obesity with diabetes risk

  2004cited by this paper
• Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

  2004influential reference
• Regulation of adipocyte differentiation and insulin action with rapamycin.

  2004cited by this paper
• Hyperlipidemia in pediatric kidney transplant recipients treated with cyclosporine

  2003cited by this paper
• TOR Signaling

  2003cited by this paper
• Structures of calcineurin and its complexes with immunophilins-immunosuppressants.

  2003cited by this paper
• Rapamycin eluting stent: the onset of a new era in interventional cardiology

  2002cited by this paper
• Predictors of weight gain and cardiovascular risk in a cohort of racially diverse kidney transplant recipients.

  2002cited by this paper
• Effects of Sirolimus on Lipids in Renal Allograft Recipients: An Analysis Using the Framingham Risk Model

  2002cited by this paper
• The limitations of calcineurin and mTOR inhibitors: new directions for immunosuppressive strategies.

  2002cited by this paper
• The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

  2002cited by this paper
• Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations.

  2001cited by this paper
• Long‐term management of the liver transplant patient: Diabetes, hyperlipidemia, and obesity

  2001cited by this paper
• Specificity and mechanism of action of some commonly used protein kinase inhibitors.

  2000cited by this paper
• The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

  2000cited by this paper
• Specificity and mechanism of action of some commonly used protein kinase inhibitors

  2000cited by this paper
• Synthesis and antitumor activity of an inhibitor of fatty acid synthase.

  2000cited by this paper
• Physiological and nutritional regulation of enzymes of triacylglycerol synthesis.

  2000cited by this paper
• Hypertriglyceridemia in renal transplant recipients treated with sirolimus.

  1998cited by this paper
• The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis.

  1997cited by this paper
• Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes.

  1997cited by this paper
• The side effect profile of sirolimus: a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients.

  1996cited by this paper
• The role of changes in the sensitivity of hepatic mitochondrial overt carnitine palmitoyltransferase in determining the onset of the ketosis of starvation in the rat.

  1996cited by this paper
• Expression of a cDNA Isolated from Rat Brown Adipose Tissue and Heart Identifies the Product as the Muscle Isoform of Carnitine Palmitoyltransferase I (M-CPT I)

  1996cited by this paper
• Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over beta-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states.

  1996cited by this paper
• Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism.

  1993cited by this paper
• Book Review: Computers in Biomedicine

  1993cited by this paper
• Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes.

  1989cited by this paper
• Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. II. Use of detergents and antibodies.

  1987cited by this paper
• A rapid method of total lipid extraction and purification.

  1959cited by this paper
• Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0982 Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

  year unknowncited by this paper

• Effect of a defatting pharmacologic cocktail with rapamycin during cold-to-warm ex situ perfusion of discarded human livers: A comparative study

  2026cites this paper
• The role of mTOR signaling pathway in systemic lupus erythematosus and systemic vasculitis.

  2025cites this paper
• Role and Mechanisms of the mTOR Signalling Pathway in the Synthesis of Milk Components

  2025cites this paper
• Metabolic programming of organ‐specific natural killer cell responses

  2024cites this paper
• Research Progress on the Mechanism of Milk Fat Synthesis in Cows and the Effect of Conjugated Linoleic Acid on Milk Fat Metabolism and Its Underlying Mechanism: A Review

  2024cites this paper
• Oxidative Phosphorylation and Fatty Acid Oxidation in Slow-Aging Mice.

  2024cites this paper
• NAFLD-associated Hepatocellular Carcinoma (HCC) - a compelling case for repositioning of existing mTORc1 inhibitors.

  2024cites this paper
• Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise

  2024cites this paper
• Dietary Restriction and Lipid Metabolism: Unveiling Pathways to Extended Healthspan

  2024cites this paper
• Contractile and Genetic Characterization of Cardiac Constructs Engineered from Human Induced Pluripotent Stem Cells: Modeling of Tuberous Sclerosis Complex and the Effects of Rapamycin

  2024cites this paper
• The significance of lipid metabolism reprogramming of tumor-associated macrophages in hepatocellular carcinoma

  2024cites this paper
• Sertoli cell adaptation to glucose deprivation: Potential role of AMPK in the regulation of lipid metabolism

  2023cites this paper
• Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice

  2023cites this paper
• Pharmacological effects of mTORC1/C2 inhibitor in a preclinical model of NASH progression.

  2023cites this paper
• Screening and management of metabolic complications of mTOR inhibitors in real-life settings.

  2023cites this paper
• Effects of Phosphatidic Acid on Mammalian Target of Rapamycin (mTOR) and Metabolic Pathways in Bivalve Mollusk Sinonovacula constricta

  2023cites this paper
• Metabolic regulation of forkhead box P3 alternative splicing isoforms and their impact on health and disease

  2023cites this paper
• An integrative approach to assessing effects of a short-term Western diet on gene expression in rat liver

  2022cites this paper
• Emerging role of aging in the progression of NAFLD to HCC.

  2022cites this paper
• The Effects of Synthetic SREBP-1 and PPAR-γ Decoy Oligodeoxynucleotide on Acne-like Disease In Vivo and In Vitro via Lipogenic Regulation

  2022cites this paper
• mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease

  2022cites this paper
• The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia

  2022cites this paper
• Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy

  2022cites this paper
• mTOR as an eligible molecular target for possible pharmacological treatment of nonalcoholic steatohepatitis.

  2022cites this paper
• Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases

  2022cites this paper
• Red yeast rice ameliorates non-alcoholic fatty liver disease through inhibiting lipid synthesis and NF-κB/NLRP3 inflammasome-mediated hepatic inflammation in mice

  2022cites this paper
• Lipid Metabolism in Tumor-Infiltrating T Cells.

  2021cites this paper
• Defatting strategies in the current era of liver steatosis

  2021cites this paper
• Potential mechanism of Huatan Qushi decoction on improving phlegm-dampness constitution using microRNA array and RT-qPCR targeting on hsa-miR-1237–3p

  2021cites this paper
• Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress

  2021cites this paper
• Metabolic disorders and gastroenteropancreatic-neuroendocrine tumors (GEP-NETs): How do they influence each other? An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of Pharmacology (SIF) mul

  2021cites this paper
• Regulation and metabolic functions of mTORC1 and mTORC2.

  2021cites this paper
• Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

  2021cites this paper
• Comparative metabolomics and lipidomics study to evaluate the metabolic differences between 1st - and 2nd -generation mTOR inhibitors.

  2021cites this paper
• Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts

  2021cites this paper
• Placental Compartmentalization of Lipid Metabolism: Implications for Singleton and Twin Pregnancies

  2020cites this paper
• Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes.

  2020cites this paper
• Is REDD1 a metabolic double agent? Lessons from physiology and pathology.

  2020cites this paper
• p‐Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1‐RPS6

  2020cites this paper
• Multifaceted regulation and functions of fatty acid desaturase 2 in human cancers.

  2020cites this paper
• The regulation of rapamycin on nutrient metabolism in Nile tilapia fed with high-energy diet

  2020cites this paper
• Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

  2020cites this paper
• Lipid metabolic reprogramming as an emerging mechanism of resistance to kinase inhibitors in breast cancer

  2020influential citation
• Metformin induces a fasting- and antifolate-mimicking modification of systemic host metabolism in breast cancer patients

  2019cites this paper
• Hemp seed/evening primrose oil affects expression of STAT3, IL-17, and FOXP3+ in experimental autoimmune encephalomyelitis

  2019cites this paper
• Association of Delta-6-Desaturase Expression with Aggressiveness of Cancer, Diabetes Mellitus, and Multiple Sclerosis: A Narrative Review

  2019cites this paper
• Role of mammalian target of rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin

  2019cites this paper
• Glial Cell Line–Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity

  2019cites this paper
• Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice.

  2019cites this paper
• mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment

  2018cites this paper
• The Sources of Essential Fatty Acids for Allergic and Cancer Patients; a Connection with Insight into Mammalian Target of Rapamycin: A Narrative Review

  2018cites this paper
• Excess Hydrocortisone Hampers Placental Nutrient Uptake Disrupting Cellular Metabolism

  2018cites this paper
• Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis

  2018cites this paper
• The potential effects of hemp seed/evening primrose oils on the mammalian target of rapamycin complex 1 and interferon-gamma genes expression in experimental autoimmune encephalomyelitis

  2018cites this paper
• on the metabolic complications of mTOR inhibitors Avis d ’ experts sur les complications métaboliques des inhibiteurs de mTOR

  2018cites this paper
• Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

  2018cites this paper
• Expert opinion on the metabolic complications of mTOR inhibitors.

  2018cites this paper
• Screening and Characterization of Oleaginous Yeasts and Modeling of Flocculation-based Algae Harvest

  2017cites this paper
• Longitudinal serum metabolomics evaluation of trastuzumab and everolimus combination as pre-operative treatment for HER-2 positive breast cancer patients.

  2017cites this paper
• Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice.

  2017cites this paper
• The effects of TORC signal interference on lipogenesis in the oleaginous yeast Trichosporon oleaginosus

  2017cites this paper
• Effects of Rapamycin on Clinical Manifestations and Blood Lipid Parameters in Different Preeclampsia-like Mouse Models

  2017cites this paper
• Longitudinal serum metabolomics evaluation of trastuzumab and everolimus combination as pre-operative treatment for HER-2 positive breast cancer patients

  2017cites this paper
• mTOR complex 1 signalling regulates the balance between lipid synthesis and oxidation in hypoxia lymphocytes

  2017cites this paper
• Role of mTOR Signaling in Cardioprotection

  2016cites this paper
• Is REDD1 a Metabolic Éminence Grise?

  2016cites this paper
• Rapamycin attenuates palmitate-induced lipid aggregation by up-regulating sirt-1 signaling in AML12 hepatocytes.

  2016cites this paper
• Soy Isoflavones Regulate Lipid Metabolism through an AKT/mTORC1 Pathway in Diet-Induced Obesity (DIO) Male Rats

  2016influential citation
• mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

  2016cites this paper
• Dynamic Metabolism in Immune Response

  2016cites this paper
• Memory T cells in organ transplantation: progress and challenges

  2016cites this paper
• Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

  2016cites this paper
• Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells

  2016cites this paper
• The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.

  2016cites this paper
• Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

  2016cites this paper
• Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes.

  2016cites this paper
• Risk of Metabolic Complications in Patients with Solid Tumors Treated with mTOR inhibitors: Meta-analysis.

  2016cites this paper
• Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response.

  2016cites this paper
• The Clinical Pharmacology and Toxicity Profile of Rapalogs

  2016cites this paper
• The mTOR Complexes in Cancer Cell Metabolism

  2016cites this paper
• Oncogenic Control and Metabolic Outputs of the Lipogenic Transcription Factor SREBP

  2016cites this paper
• International of Advanced Research in Biological Sciences Drug Discovery and ADMET process: A Review

  2016cites this paper
• Side Effects of Targeted Therapy

  2015cites this paper
• The Regulation of Lipid Deposition by Insulin in Goose Liver Cells Is Mediated by the PI3K-AKT-mTOR Signaling Pathway

  2015cites this paper
• Etude de l’intéraction entre les ros et la voie mtorc1 dans la régulation de la balance énergetique

  2015cites this paper
• Encapsulation of Genetically Modified Preadipocytes for Potential Treatment of Metabolic Disorders

  2015cites this paper
• Hepatocyte growth factor is elevated in amniotic fluid from obese 1 women and regulates placental glucose and fatty acid metabolism

  2015influential citation
• CHANGE OF THE MTOR PATHWAY IN TISSUES OF OVERFED GEESE

  2015cites this paper
• Flawed phospholipid formation or faulty fatty acid oxidation: Determining the cause of mitochondrial dysfunction in hearts lacking ACSL1

  2015cites this paper
• Effects of sexual maturation and feeding level on fatty acid metabolism gene expression in muscle, liver, and visceral adipose tissue of diploid and triploid rainbow trout, Oncorhynchus mykiss.

  2015cites this paper
• Loss of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation

  2015cites this paper
• Metabolic alterations in renal cell carcinoma.

  2015cites this paper
• mTOR inhibitors and dyslipidemia in transplant recipients: a cause for concern?

  2015cites this paper
• mTORC2 controls cancer cell survival by modulating gluconeogenesis

  2015cites this paper
• The impact of mTOR, TFEB and Bid on non-alcoholic fatty liver disease and metabolic syndrome

  2015cites this paper
• Cellular and molecular effects of the mTOR inhibitor everolimus.

  2015cites this paper
• Wiring the adaptive response of mitochondria to metabolic transitions : a Mitofusin-2- dependent proteolytic elimination of OPA1 accompanies cristae and mitochondria-ER contacts remodelling in the postprandial mouse liver

  2015cites this paper
• Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism.

  2015cites this paper
• Role of Protein Kinase Map4k4 in Energy Metabolism: A Dissertation

  2015cites this paper
• Expression of genes associated with fatty acid metabolism during maturation in diploid and triploid female rainbow trout

  2015cites this paper