Six cloned calves produced from adult fibroblast cells after long-term culture.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2000-02-01

• Fields of study

  Agricultural and Food Sciences, Medicine, Biology

• Identifiers
  DOI 10.1073/PNAS.97.3.990PMID 10655472PMCID PMC15497
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies).

  1999cited by this paper
• Lymphoid hypoplasia and somatic cloning.

  1999cited by this paper
• Production of goats by somatic cell nuclear transfer

  1999cited by this paper
• Flow cytometric cell cycle analysis of cultured porcine fetal fibroblast cells.

  1999cited by this paper
• Cloning of male mice from adult tail-tip cells

  1999cited by this paper
• Analysis of telomere lengths in cloned sheep

  1999cited by this paper
• Effects of serum starvation and re-cloning on the efficiency of nuclear transfer using bovine fetal fibroblasts.

  1999cited by this paper
• Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells.

  1999cited by this paper
• Production of calves by transfer of nuclei from cultured somatic cells obtained from Japanese black bulls.

  1999cited by this paper
• Cloned transgenic calves produced from nonquiescent fetal fibroblasts.

  1998cited by this paper
• Developmental potential of bovine embryos reconstructed from enucleated matured oocytes fused with cultured somatic cells.

  1998cited by this paper
• In vitro and in vivo survival of frozen‐thawed bovine oocytes after IVF, nuclear transfer, and parthenogenetic activation

  1998cited by this paper
• Eight calves cloned from somatic cells of a single adult.

  1998cited by this paper
• Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

  1998cited by this paper
• Viable offspring derived from fetal and adult mammalian cells

  1997cited by this paper
• Production of cloned lambs from an established embryonic cell line: a comparison between in vivo- and in vitro-matured cytoplasts.

  1997cited by this paper
• Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts.

  1997cited by this paper
• Sheep cloned by nuclear transfer from a cultured cell line

  1996cited by this paper
• Effect of 5-fluoro-2'-deoxyuridine (FdUrd) on 5-bromo-2'-deoxyuridine (BrdUrd) incorporation into DNA measured with a monoclonal BrdUrd antibody and by the BrdUrd/Hoechst quenching effect.

  1985cited by this paper
• Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.

  1982cited by this paper

• Utilization of oocytes from closely related domestic species for interspecies somatic cell nuclear transfer in gaur embryo production

  2025cites this paper
• Heterogeneity in somatic cell nuclear transfer embryo reprogramming across mammalian species†.

  2025cites this paper
• Influence of different cell passage numbers on bovine cloned embryo: A systematic review and meta-analysis.

  2025cites this paper
• The Cellular Mechanism of Aging as Programmed Epigenetic Phenomenon: From Hypothesis to Scientific Evidence

  2025cites this paper
• Optimization of donor cell production for somatic cell nuclear transfer in the critically endangered Vietnamese Ỉ pig.

  2024cites this paper
• Investigating cryopreservation techniques for maintaining morphology and in vitro viability of cartilage and skin from Spix’s yellow-toothed cavies (Galea spixii Wagler, 1831) for conservation through biobanks

  2024cites this paper
• Outlook on genome editing application to cattle

  2023cites this paper
• The combination of rolipram and cilostamide improved the developmental competence of cloned porcine embryos

  2023cites this paper
• Is Human Aging a Form of Phenoptosis?

  2022cites this paper
• Morphological, Ultrastructural, and Immunocytochemical Characterization and Assessment of Puma (Puma concolor Linnaeus, 1771) Cell Lines After Extended Culture and Cryopreservation

  2022cites this paper
• Time matters: characterization of fibroblast-like cells harvested from pig profundus tendon stored at room temperature at different postmortem time intervals

  2022cites this paper
• Is Evidence Supporting the Subtelomere–Telomere Theory of Aging?

  2021cites this paper
• Comparative study among Avicennia marina, Phragmites australis, and Moringa oleifera based ethanolic-extracts for their antimicrobial, antioxidant, and cytotoxic activities

  2021cites this paper
• Biotechnological Advancements in Livestock Production

  2021cites this paper
• Dynamics of small non-coding RNAs in bovine scNT embryos through the maternal-to-embryonic transition

  2021cites this paper
• Существуют ли доказательства в пользу субтеломерно-теломерной теории старения?

  2021cites this paper
• Subtelomere-Telomere Aging Theory

  2021cites this paper
• Linear polysaccharides reduce production of inflammatory cytokines by LPS-stimulated bovine fibroblasts.

  2021cites this paper
• Evaluation of the damage caused by in vitro culture and cryopreservation to dermal fibroblasts derived from jaguars: An approach to conservation through biobanks.

  2021cites this paper
• Nuclear Transfer and Cloning.

  2020cites this paper
• Vol-37, No. 2, december. 2020 Micro J..pmd

  2020cites this paper
• Isolation, characterization, and cryopreservation of collared peccary skin-derived fibroblast cell lines

  2020cites this paper
• Gene targeting in livestock.

  2019cites this paper
• Efficient production of GGTA1 knockout porcine embryos using a modified handmade cloning (HMC) method.

  2019cites this paper
• The Role of 5-aza-2′-Deoxycytidine on Methylation Status of Xist Gene in Different Genders of Buffalo (Bubalus bubalis) Bone Marrow Mesenchymal Stem Cells

  2019cites this paper
• Cloning in livestock agriculture.

  2019cites this paper
• Achilles tendon rupture in camel (Camelus dromedarius): Radiographic and Ultrasonographic findings

  2019cites this paper
• Reproduction Biotechnology in Cattle

  2019cites this paper
• Advances in application of dromedary camel tissue culture research

  2019cites this paper
• Introduction of a plasmid and a protein into bovine and swine cells by water-in-oil droplet electroporation

  2019cites this paper
• Cytoplast source influences development of somatic cell nuclear transfer (SCNT) embryos in vitro but not their development to term after transfer to synchronized recipients in dromedary camels (Camelus dromedarius).

  2018cites this paper
• Analysis of Endoplasmic Reticulum (ER) Stress Induced during Somatic Cell Nuclear Transfer (SCNT) Process in Porcine SCNT Embryos

  2018cites this paper
• Source, treatment and type of nuclear donor cells influences in vitro and in vivo development of embryos cloned by somatic cell nuclear transfer in camel (Camelus dromedarius).

  2018cites this paper
• Bovine Mastitis Resistance: Novel Quantitative Trait Loci and the Role of Bovine Mammary Epithelial Cells

  2018cites this paper
• Analysis of Apoptosis on the Somatic Cell Nuclear Transfer embryos in porcine

  2018cites this paper
• Choosing a culture medium for SCNT and iSCNT reconstructed embryos: from domestic to wildlife species

  2017cites this paper
• Metabolic programming of a Warburg effect-like phenotype in donor fibroblasts prior to somatic cell nuclear transfer

  2017cites this paper
• Instructions for use Title Effect of activation treatments of recipient oocytes on subsequent development of bovine nucleartransfer embryos

  2017cites this paper
• First cloned Bactrian camel (Camelus bactrianus) calf produced by interspecies somatic cell nuclear transfer: A step towards preserving the critically endangered wild Bactrian camels

  2017cites this paper
• Stem Cell Research: Hope or Hype?

  2017cites this paper
• The expression of β-galactosidase during long-term cultured goat skin fibroblasts and the effect of donor cell passage on in vitro development of nuclear transfer embryos

  2016cites this paper
• Screening somatic cell nuclear transfer parameters for generation of transgenic cloned cattle with intragenomic integration of additional gene copies that encode bovine adipocyte-type fatty acid-binding protein (A-FABP)

  2016cites this paper
• Genome Editing in Large Animals.

  2016cites this paper
• An Improved System for Generation of Diploid Cloned Porcine Embryos Using Induced Pluripotent Stem Cells Synchronized to Metaphase

  2016cites this paper
• Quiescence Loosens Epigenetic Constraints in Bovine Somatic Cells and Improves Their Reprogramming into Totipotency1

  2016cites this paper
• Production of Bovine Embryos and Calves Cloned by Nuclear Transfer Using Mesenchymal Stem Cells from Amniotic Fluid and Adipose Tissue

  2016cites this paper
• RNA-Seq Profiling of Intact and Enucleated Oocyte SCNT Embryos Reveals the Role of Pig Oocyte Nucleus in Somatic Reprogramming

  2016cites this paper
• Handmade cloning: recent advances, potential and pitfalls

  2015cites this paper
• Generation of transgenic fibroblasts producing doxycycline-inducible human interferon-α or erythropoietin for a bovine mammary bioreactor.

  2015cites this paper
• Coordenação do ciclo celular e inibição da desacetilação no desenvolvimento de embriões suínos produzidos por transferência nuclear

  2015cites this paper
• The Future of Human Cloning: can Human Embryos Resulting from Somatic Cell Nuclear Transfers (SCNT) be used to Treat Human Infertility?

  2015cites this paper
• Çiftlik hayvanlarına ait fibroblast, kıkırdak, granüloza ve kas hücrelerinde immunohistokimyasal karakterizasyon ve hücre siklus analizleri

  2015cites this paper
• elo m ere len g th Donor cell Germ cells ( telomerase on ) Somatic cells ( no telomerase ) Cell Divisions / Cloning process Cloned embryo Cloned animal Donor animal Oocytes Enucleated oocytes

  2015cites this paper
• Relationship between Nucleus Swelling and Development Competence of Bovine Cloned Embryos Reconstructed by Enucleated Oocytes with Serum-starved or Serum-fed Fetal Somatic Cells

  2015influential citation
• Knock-in fibroblasts and transgenic blastocysts for expression of human FGF2 in the bovine β-casein gene locus using CRISPR/Cas9 nuclease-mediated homologous recombination

  2015cites this paper
• Clonagem por transferência nuclear : histórico, aplicações potenciais e principais células doadoras de núcleo

  2015cites this paper
• Activation treatment of recipient oocytes affects the subsequent development and ploidy of bovine parthenogenetic and somatic cell nuclear transfer (SCNT) embryos

  2015cites this paper
• Isolation and characterization of skin-derived donor cells for nuclear transfer.

  2014cites this paper
• Assisted Reproductive Technologies and Embryo Culture Methods for Farm Animals

  2014cites this paper
• Current Research and Commercial Applications of Cloning Technology

  2014cites this paper
• Donor Cell Type and Cloning Efficiency in Mammals

  2014cites this paper
• Production of wild buffalo (Bubalus arnee) embryos by interspecies somatic cell nuclear transfer using domestic buffalo (Bubalus bubalis) oocytes.

  2014cites this paper
• Development and Gene Expression of Porcine Cloned Embryos Derived from Bone Marrow Stem Cells with Overexpressing Oct4 and Sox2

  2014cites this paper
• Cloning of Rabbits

  2014cites this paper
• ISOLAMENTO E CARACTERIZAÇÃO DE CÉLULAS DOADORAS DERIVADAS DA PELE PARA A TRANSFERÊNCIA NUCLEAR (Isolation and characterization of skin-derived donor cells for nuclear transfer)

  2014cites this paper
• Genomic imprinting in farm animals.

  2014cites this paper
• CpG methylation analysis at the putative differential methylated region of Xist gene in goats (Capra hircus) somatic cells.

  2014cites this paper
• First cloned swamp buffalo produced from adult ear fibroblast cell.

  2014cites this paper
• A Historical Perspective of the Cloning of Cattle

  2014cites this paper
• Effect of Altering Epigenetic Status of Donor Cells and Hand-Guided Cloned Buffalo Embryos on in Vitro Development and Gene Expression.

  2014cites this paper
• Development of interspecies nuclear transfer embryos reconstructed with argali (Ovis ammon) somatic cells and sheep ooplasm

  2014cites this paper
• Comparative analysis of various donor cell types for somatic cell nuclear transfer and its association with apoptosis and senescence.

  2014cites this paper
• Assessment of developmental potential of caprine cloned embryos with ooplasm replenishment under two culture media

  2014cites this paper
• Factors Affecting the Development of Somatic Cell Nuclear Transfer Embryos in Cattle

  2014cites this paper
• Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos

  2013cites this paper
• Pregnancy and Neonatal Care of SCNT Animals

  2013cites this paper
• The effects of artificial activation timing on the development of SCNT-derived embryos and newborn piglets.

  2013cites this paper
• Using somatic-cell nuclear transfer to study aging.

  2013cites this paper
• Developmental kinetics of pig embryos by parthenogenetic activation or by handmade cloning.

  2013cites this paper
• Generation of Five Human Lactoferrin Transgenic Cloned Goats Using Fibroblast Cells and Their Methylation Status of Putative Differential Methylation Regions of IGF2R and H19 Imprinted Genes

  2013cites this paper
• Breeding of transgenic cattle for human coagulation factor IX by a combination of lentiviral system and cloning.

  2013cites this paper
• Longitudinal Study of Reproductive Performance of Female Cattle Produced by Somatic Cell Nuclear Transfer

  2013cites this paper
• Aberrant placenta gene expression pattern in bovine pregnancies established after transfer of cloned or in vitro produced embryos.

  2013cites this paper
• Pure cultures and characterization of yak Sertoli cells.

  2013cites this paper
• Recent progress in bovine somatic cell nuclear transfer.

  2013cites this paper
• Horizontal gene transfer does not occur between sFat-1 transgenic pigs and nontransgenic pigs.

  2013cites this paper
• Assisted Reproductive Technologies: The Potential to Prevent the Transmission of Mutant mtDNA from One Generation to the Next

  2013cites this paper
• Culture medium composition affects the gene expression pattern and in vitro development potential of bovine somatic cell nuclear transfer (SCNT) embryos.

  2013cites this paper
• Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows

  2013cites this paper
• Changes in the expression pattern of developmentally important genes and possible relation to the low in vitro and in vivo developmental potential of transgenic nuclear transfer embryos

  2013cites this paper
• Establishment and characterization of fetal fibroblast cell lines for generating human lysozyme transgenic goats by somatic cell nuclear transfer

  2013cites this paper
• Development of intra- and interspecies somatic cell nuclear transfer protocols using ear fibroblast cells as donor karyoplasts for production of cloned caprine embryos / Kwong Phek Jin

  2012cites this paper
• Reproductive biotechnologies: a new approach for Cervids conservation

  2012cites this paper
• Somatic cell nuclear transfer cloning: practical applications and current legislation.

  2012cites this paper
• Effect of optimized treatment of donor cells on the efficiency of production of SCNT-cloned mastiffs.

  2012influential citation
• Reprogramming mammalian somatic cells

  2012cites this paper
• Chapter 12 – Somatic Cloning and Epigenetic Reprogramming in Mammals

  2012cites this paper
• Reprogramming mammalian somatic cells.

  2012cites this paper
• Effects of Various Activators on Bovine Embryonic Development Following Intracytoplasmic Sperm Injection

  2012cites this paper
• Following Intracytoplasmic Sperm Injection

  2012influential citation