Pulmonary Hypertension in Preterm Infants With Bronchopulmonary Dysplasia

Background and Objectives With the increasing survival of preterm infants, pulmonary hypertension (PH) related to bronchopulmonary dysplasia (BPD) has become an important complication. The aim of this study was to investigate the characteristics and outcome of PH in preterm infants with BPD and to identify the risk factors for PH. Subjects and Methods We reviewed the records of 116 preterm infants with BPD cared for at a single tertiary center between 2004 and 2008. Results Twenty-nine (25%) infants had PH >2 months after birth. PH occurred initially at a median age of 65 days (range, 7-232 days). Severe BPD, a birth weight <800 g, long-term ventilator care and oxygen supplementation, a high ventilator setting, infection, and a patent ductus arteriosus (PDA) were related to PH based on univariate analysis (p<0.05). The infants who had longer oxygen supplementation were significantly more likely to have PH (odds ratio, 18.5; 95% confidence interval, 4.1-84.6; p<0.001). PH was improved in 76% of infants after a median of 85 days (range, 20-765 days). Four infants (14%) died. The death of 3 infants was attributed to PH. Conclusion BPD was frequently complicated by PH. Although PH resolved in the majority of infants, PH in preterm infants with BPD can be fatal. Regular screening for PH and adequate management are required.

• Publication year

  2010

• Venue

  Korean Circulation Journal

• Publication date

  2010-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.4070/kcj.2010.40.3.131PMID 20339498PMCID 2844979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Review article DOI: 10.3345/kjp.2010.53.6.688

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