Metagenomic biomarker discovery and explanation

This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/.

• Publication year

  2011

• Venue

  Genome Biology

• Publication date

  2011-06-24

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1186/gb-2011-12-6-r60PMID 21702898PMCID 3218848
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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