Chargaff's legacy.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Gene

• Publication date

  2000-12-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0378-1119(00)00472-8PMID 11164044
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2000influential reference
• Thermophilic bacteria strictly obey Szybalski's transcription direction rule and politely purine-load RNAs with both adenine and guanine.

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  1999influential reference
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  1999influential reference
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  1999cited by this paper
• Asymmetric substitution patterns: a review of possible underlying mutational or selective mechanisms.

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• Accounting units in DNA.

  1999influential reference
• The effect of mismatch repair and heteroduplex formation on sexual isolation in Bacillus.

  1998cited by this paper
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• Viral escape from antisense RNA

  1998influential reference
• An alternative way of thinking about stem-loops in DNA. A case study of the human G0S2 gene.

  1998cited by this paper
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  1998cited by this paper
• Chargaff difference analysis of the bithorax complex of Drosophila melanogaster.

  1998cited by this paper
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  1997influential reference
• Stopping and starting the meiotic cell cycle.

  1997cited by this paper
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  1996cited by this paper
• Different biological species "broadcast" their DNAs at different (G+C)% "wavelengths".

  1996influential reference
• The regulation of the protein kinase PKR by RNA.

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• Conservation of Stem-Loop Potential in Introns of Snake Venom Phospholipase A2 Genes: An Application of FORS-D Analysis

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• Interactions between and along chromosomes during meiosis.

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• Universal Darwinism

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  1995influential reference
• DNA supercoiling in a thermotolerant mutant ofEscherichia coli

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  1995influential reference
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• Helix opening transitions in supercoiled DNA.

  1992cited by this paper
• Antisense RNA.

  1991cited by this paper
• Aging, sex, and DNA repair

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• Predicting optimal and suboptimal secondary structure for RNA.

  1990cited by this paper
• The biology and chemistry of polyamines

  1990cited by this paper
• Evolution of DNA Sequence Contributions of Mutational Bias and Selection to the Origin of Chromosomal Compartments

  1990cited by this paper
• A method for assessing the statistical significance of RNA folding.

  1989cited by this paper
• The guanine and cytosine content of genomic DNA and bacterial evolution.

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• Molecular evolution of viruses as seen by nucleic acid sequence study

  1985cited by this paper
• Injected anti-sense RNAs specifically block messenger RNA translation in vivo.

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• Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis.

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• The antiviral action of interferon.

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• How crowded is the cytoplasm?

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• Genes, radiation, and society: The life and work of H. J. Muller.

  1982cited by this paper
• Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region.

  1981cited by this paper
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• The Evolutionary synthesis : perspectives on the unification of biology

  1980cited by this paper
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  1980cited by this paper
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  1973cited by this paper
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  1973cited by this paper
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  1972cited by this paper
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• Separation of B. subtilis DNA into complementary strands. 3. Direct analysis.

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• Interferon induction.

  1967cited by this paper
• Pyrimidine clusters on the transcribing strand of DNA and their possible role in the initiation of RNA synthesis.

  1966cited by this paper
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  1964cited by this paper
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  1963cited by this paper
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  1961cited by this paper
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  1953cited by this paper
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  1951influential reference
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  1950cited by this paper
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  2007cites this paper
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  2006influential citation
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  2002cites this paper
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