Phosphorylation network dynamics in the control of cell cycle transitions

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Cell Science

• Publication date

  2012-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.106351PMID 23223895
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2012influential reference
• An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.

  2012cited by this paper
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• Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.

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  2011cited by this paper
• Quantitative proteomics reveals the basis for the biochemical specificity of the cell-cycle machinery.

  2011cited by this paper
• A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast

  2011cited by this paper
• Protein phosphatase 2A controls the order and dynamics of cell-cycle transitions.

  2011influential reference
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• A quantitative model for ordered Cdk substrate dephosphorylation during mitotic exit.

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• Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

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• Driving the cell cycle with a minimal CDK control network

  2010influential reference
• Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis.

  2010cited by this paper
• A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.

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• Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2Α That Is Essential for Mitosis

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• Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

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  2009cited by this paper
• Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle

  2009cited by this paper
• Structural basis for recognition of 5′-phosphotyrosine adducts by TDP2

  2009cited by this paper
• Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.

  2009cited by this paper
• Greatwall maintains mitosis through regulation of PP2A

  2009influential reference
• Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

  2009influential reference
• Cyclin-dependent kinases: a family portrait

  2009cited by this paper
• Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops

  2008cited by this paper
• Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

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• Selective chemical inhibition as a tool to study Cdk1 and Cdk2 functions in the cell cycle

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• Cdk1 and Cdk2 activity levels determine the efficiency of replication origin firing in Xenopus

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• CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

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  2007cited by this paper
• Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast

  2007cited by this paper
• An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

  2007cited by this paper
• Substrate competition as a source of ultrasensitivity in the inactivation of Wee1.

  2007cited by this paper
• Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts.

  2006influential reference
• The reversibility of mitotic exit in vertebrate cells

  2006cited by this paper
• The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication

  2006cited by this paper
• A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25.

  2006cited by this paper
• Swe1 regulation and transcriptional control restrict the activity of mitotic cyclins toward replication proteins in Saccharomyces cerevisiae.

  2005cited by this paper
• Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates

  2005influential reference
• Normal Cell Cycle and Checkpoint Responses in Mice and Cells Lacking Cdc25B and Cdc25C Protein Phosphatases

  2005cited by this paper
• Multisite protein phosphorylation makes a good threshold but can be a poor switch.

  2005influential reference
• Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

  2005cited by this paper
• Recycling the cell cycle: cyclins revisited.

  2004cited by this paper
• Recycling the Cell Cycle Cyclins Revisited

  2004cited by this paper
• Living with or without cyclins and cyclin-dependent kinases.

  2004cited by this paper
• Regulation of early events in chromosome replication.

  2004cited by this paper
• Unmasking the S-Phase-Promoting Potential of Cyclin B1

  2003cited by this paper
• Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2

  2003cited by this paper
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  2003cited by this paper
• Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts

  2002cited by this paper
• Mutational Analysis of the Cy Motif from p21 Reveals Sequence Degeneracy and Specificity for Different Cyclin-Dependent Kinases

  2001cited by this paper
• Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

  2001cited by this paper
• Cell cycle regulation by the Cdc25 phosphatase family.

  2000cited by this paper
• Distinct Roles for PP1 and PP2A in Phosphorylation of the Retinoblastoma Protein

  1999cited by this paper
• Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

  1999cited by this paper
• The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.

  1998cited by this paper
• Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes *

  1998cited by this paper
• Structural basis of cyclin-dependent kinase activation by phosphorylation

  1996cited by this paper
• Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2, the Adipocyte Fatty Acid Binding Protein

  1996cited by this paper
• Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

  1996cited by this paper
• Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts.

  1996cited by this paper
• A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S‐phase and mitosis in the absence of G1 cyclins.

  1996influential reference
• Cell cycle regulation of a Xenopus Wee1-like kinase.

  1995influential reference
• Phosphorylation of dis2 protein phosphatase at the C‐terminal cdc2 consensus and its potential role in cell cycle regulation.

  1994cited by this paper
• Phosphorylation and inactivation of protein phosphatase 1 by cyclin-dependent kinases.

  1994cited by this paper
• Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos.

  1993cited by this paper
• Negative regulation of mitosis by the fission yeast protein phosphatase ppa2.

  1993cited by this paper
• Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.

  1993cited by this paper
• p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

  1992cited by this paper
• INH, a negative regulator of MPF, is a form of protein phosphatase 2A.

  1991cited by this paper
• An amplified sensitivity arising from covalent modification in biological systems.

  1981cited by this paper
• Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes.

  1971cited by this paper

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• Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair

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