Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2011-05-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1011711108PMID 21571636PMCID PMC3107274
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic dissection of axon regeneration.

  2011cited by this paper
• Genetically increased cell-intrinsic excitability enhances neuronal integration into adult brain circuits.

  2010cited by this paper
• The genetics of ageing

  2010cited by this paper
• Neuronal activity and Wnt signaling act through Gsk3-β to regulate axonal integrity in mature Drosophila olfactory sensory neurons

  2009cited by this paper
• The multipurpose 15-protofilament microtubules in C. elegans have specific roles in mechanosensation.

  2009cited by this paper
• Neurosensory mechanotransduction

  2009cited by this paper
• Oxidation of a potassium channel causes progressive sensory function loss during ageing

  2009influential reference
• The measurement and analysis of age-related changes in Caenorhabditis elegans.

  2008cited by this paper
• The aging brain.

  2008cited by this paper
• Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects Without Alzheimer Disease

  2008cited by this paper
• Non-developmentally programmed cell death in Caenorhabditis elegans.

  2007cited by this paper
• Electrical activity in early neuronal development

  2006cited by this paper
• Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner

  2005cited by this paper
• Age-related changes of nuclear architecture in Caenorhabditis elegans.

  2005cited by this paper
• Extracellular proteins organize the mechanosensory channel complex in C. elegans touch receptor neurons.

  2004cited by this paper
• Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family.

  2003cited by this paper
• A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.

  2003cited by this paper
• Developmental Genetics of the Mechanosensory Neurons of Caenorhabditis elegans

  2003influential reference
• Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

  2003cited by this paper
• Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.

  2002cited by this paper
• Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans.

  1999cited by this paper
• Extracellular proteins needed for C. elegans mechanosensation.

  1996cited by this paper
• The genetics of feeding in Caenorhabditis elegans.

  1993cited by this paper
• The aging brain

  1992cited by this paper
• The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

  1991cited by this paper
• Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons.

  1989cited by this paper
• Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans.

  1981cited by this paper

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