DNA damage-induced cytotoxicity is dissociated from BRCA1's DNA repair function but is dependent on its cytosolic accumulation.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Research

• Publication date

  2010-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-09-4713PMID 20631074PMCID PMC2912952
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondrial localization, ELK‐1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins

  2009cited by this paper
• Caspase-dependent BRCA1 cleavage facilitates chemotherapy-induced apoptosis

  2008cited by this paper
• Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.

  2008cited by this paper
• A novel domain of BRCA1 interacts with p53 in breast cancer cells.

  2008cited by this paper
• Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells.

  2008cited by this paper
• Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

  2007cited by this paper
• The BRCA1 E3 Ubiquitin Ligase Controls Centrosome Dynamics

  2006cited by this paper
• An Amino-terminal Motif Functions as a Second Nuclear Export Sequence in BRCA1*

  2005cited by this paper
• Cell death: critical control points.

  2004cited by this paper
• Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain.

  2004cited by this paper
• Review Cell Death: Critical Control Points Another Line of Evidence for the Importance of Caspases in Cell Death Came From

  2004cited by this paper
• Expression of a Truncated Brca1 Protein Delays Lactational Mammary Development in Transgenic Mice

  2004cited by this paper
• BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.

  2004influential reference
• The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.

  2004cited by this paper
• Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

  2004cited by this paper
• DNA Damage Induces p53-dependent BRCA1 Nuclear Export*

  2004cited by this paper
• BRCA1 Transcriptionally Regulates Damaged DNA Binding Protein (DDB2) In the DNA Repair Response Following UV-Irradiation

  2002cited by this paper
• Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

  2002cited by this paper
• Cancer susceptibility and the functions of BRCA1 and BRCA2.

  2002cited by this paper
• BARD1 Induces BRCA1 Intranuclear Foci Formation by Increasing RING-dependent BRCA1 Nuclear Import and Inhibiting BRCA1 Nuclear Export*

  2002influential reference
• Identification of a Functional Nuclear Export Sequence in BRCA1*

  2000cited by this paper
• hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

  2000cited by this paper
• The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter

  1999cited by this paper
• Genetic analysis of BRCA1 function in a defined tumor cell line.

  1999influential reference
• Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

  1998cited by this paper
• Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.

  1998cited by this paper
• BRCA1 physically associates with p53 and stimulates its transcriptional activity

  1998cited by this paper
• The Nuclear Localization Sequences of the BRCA1 Protein Interact with the Importin-α Subunit of the Nuclear Transport Signal Receptor*

  1996cited by this paper
• Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

  1995cited by this paper
• BRCA1 mutations in primary breast and ovarian carcinomas.

  1994cited by this paper

• Unraveling the underlying mechanisms of cancer stem cells in therapeutic resistance for optimizing treatment strategies

  2025cites this paper
• Nonrepair functions of DNA mismatch repair proteins: new avenues for precision oncology.

  2024cites this paper
• Role of PRMT1 and PRMT5 in Breast Cancer

  2024cites this paper
• BRCA1 heterozygosity promotes DNA damage-induced senescence in a sex-specific manner following repeated mild traumatic brain injury

  2023cites this paper
• Spectroscopic studies on noncovalent binding of nicotinamide-modified BRCA1 (856-871) analogs to calf thymus DNA.

  2023cites this paper
• Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage

  2023cites this paper
• Overcoming therapeutic resistance in pancreatic cancer: Emerging opportunities by targeting BRCAs and p53.

  2023cites this paper
• T helper cell-mediated epitranscriptomic regulation via m6A RNA methylation bridges link between coronary artery disease and invasive ductal carcinoma

  2022cites this paper
• PARP inhibitors in metastatic prostate cancer: When, who, and how?

  2022cites this paper
• Role of PARP Inhibitors in Glioblastoma and Perceiving Challenges as Well as Strategies for Successful Clinical Development

  2022cites this paper
• BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy.

  2022cites this paper
• Design and Synthesis of BRCA1 (856-871) Analogous and their Interactions with RAD51 (158-180)

  2021cites this paper
• PARP inhibitor resistance: the underlying mechanisms and clinical implications

  2020cites this paper
• Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

  2020cites this paper
• BRCA1/P53: Two strengths in cancer chemoprevention.

  2020cites this paper
• PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation

  2020cites this paper
• Western Analysis of Breast Cancer 1 Protein (BRCA1).

  2019cites this paper
• Overcoming Resistance to PARP Inhibition

  2019cites this paper
• DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications.

  2018cites this paper
• Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent

  2018cites this paper
• Caspase‐mediated cleavage of X‐ray repair cross‐complementing group 4 promotes apoptosis by enhancing nuclear translocation of caspase‐activated DNase

  2018cites this paper
• Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines

  2017cites this paper
• Reverse the Resistance to PARP Inhibitors

  2017cites this paper
• Power of PTEN/AKT: Molecular switch between tumor suppressors and oncogenes.

  2016cites this paper
• Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

  2015cites this paper
• NRF2/miR-140 signaling confers radioprotection to human lung fibroblasts.

  2015cites this paper
• Zane Simtniece PROGNOSTIC FACTORS OF SURGICALLY TREATED PANCREATIC CANCER Summary of the Doctoral Thesis for obtaining the degree of a Doctor of Medicine Speciality – Pathology

  2015cites this paper
• Association between cytosolic expression of BRCA1 and metastatic risk in breast cancer

  2015cites this paper
• Epigenetic inactivation of DNA repair in breast cancer.

  2014cites this paper
• Epigenomics of Breast Cancer

  2014cites this paper
• Ionizing Radiation-Induced DNA Damage, Response, and Repair

  2014cites this paper
• BRCA1-Dependent Translational Regulation in Breast Cancer Cells

  2013cites this paper
• The role and clinical significance of DNA damage response and repair pathways in primary brain tumors

  2013cites this paper
• Apoptosis in Cancer: Mechanisms, Deregulation, and Therapeutic Targeting

  2013cites this paper
• Characterization and Targeting of the Aldehyde Dehydrogenase Subpopulation in Ovarian Cancer

  2013influential citation
• Staying a Step Ahead of Cancer

  2012cites this paper
• ��eptem�er� leads to a cascade of events that link the initiating stimuli to cellular death

  2012cites this paper
• Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition.

  2012influential citation
• Synthetic Lethal Interactions between EGFR and PARP Inhibition in Human Triple Negative Breast Cancer Cells

  2012influential citation
• The secret life of Bcl-2: apoptosis-independent inhibition of DNA repair by Bcl-2 family members.

  2012cites this paper
• Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53.

  2012cites this paper
• Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes.

  2012cites this paper
• Endoglin (CD105) Contributes to Platinum Resistance and Is A Target for Tumor-Specific Therapy in Epithelial Ovarian Cancer

  2012cites this paper
• Biomarkers to assess the targeting of DNA repair pathways to augment tumor response to therapy.

  2012cites this paper
• A guide for functional analysis of BRCA1 variants of uncertain significance

  2012cites this paper
• The intersection between DNA damage response and cell death pathways.

  2012influential citation
• The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations

  2012cites this paper
• Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma

  2012cites this paper
• Therapeutics , Targets , and Chemical Biology p 53-Dependent BRCA 1 Nuclear Export Controls Cellular Susceptibility to DNA Damage

  2011cites this paper
• Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes.

  2011cites this paper
• A CRM1‐dependent nuclear export pathway is involved in the regulation of MutLα subcellular localization

  2011cites this paper
• The poly(ADP-Ribose) polymerase inhibitor ABT-888 reduces radiation-induced nuclear EGFR and augments head and neck tumor response to radiotherapy.

  2011cites this paper
• Cetuximab Augments Cytotoxicity with Poly (ADP-Ribose) Polymerase Inhibition in Head and Neck Cancer

  2011cites this paper
• A review of the logistic role of l‐carnitine in the management of radiation toxicity and radiotherapy side effects

  2011cites this paper
• p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage.

  2011cites this paper