Mitochondrial localization, ELK‐1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Cellular Physiology

• Publication date

  2009-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcp.21708PMID 19170108PMCID PMC3693557
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Emerging roles of BRCA1 alternative splicing

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• An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non‐familial breast cancers

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• BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases

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• BRCA1 is localized in cytoplasmic tube-like invaginations in the nucleus

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• Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

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• BRCA1 is a component of the RNA polymerase II holoenzyme.

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• BRCA1 is secreted and exhibits properties of a granin

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• Mechanistic Insights and Clinical Implications of ELK1 in Solid Tumors: A Narrative Review

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• The Role of Genetic Mutations in Mitochondrial-Driven Cancer Growth in Selected Tumors: Breast and Gynecological Malignancies

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• Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability

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• BRCA1 and ELK-1 regulate neural progenitor cell fate in the optic tectum in response to visual experience in Xenopus laevis tadpoles

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• The BRCA1 c.788G > T (NM_007294.4) variant in a high grade serous ovarian cancer (HGSOC) patient: foods for thought

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• BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis

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