Effective Encapsulation of Proteins into Size‐Controlled Phospholipid Vesicles Using Freeze‐Thawing and Extrusion

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Biotechnology progress (Print)

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1021/bp0201004PMID 14524718
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characteristics of bovine hemoglobin as a potential source of hemoglobin-vesicles for an artificial oxygen carrier.

  2002cited by this paper
• Developments in liposomal drug delivery systems

  2001cited by this paper
• Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles.

  2000cited by this paper
• Formation of unilamellar vesicles by repetitive freeze-thaw cycles: characterization by electron microscopy and 31P-nuclear magnetic resonance

  2000cited by this paper
• Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency and permeability of vesicles.

  2000cited by this paper
• Synthesis and Assembly of Poly(ethylene glycol)−Lipids with Mono-, Di-, and Tetraacyl Chains and a Poly(ethylene glycol) Chain of Various Molecular Weights

  2000cited by this paper
• Poly(ethylene glycol)-conjugation and deoxygenation enable long-term preservation of hemoglobin-vesicles as oxygen carriers in a liquid state.

  2000cited by this paper
• Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors.

  1999cited by this paper
• Liposomal drug formulations. Rationale for development and what we can expect for the future.

  1998cited by this paper
• Surface modification of hemoglobin vesicles with poly(ethylene glycol) and effects on aggregation, viscosity, and blood flow during 90% exchange transfusion in anesthetized rats.

  1997cited by this paper
• The “Stealth” Liposome: A Prototypical Biomaterial

  1996cited by this paper
• Physical Properties of Hemoglobin Vesicles as Red Cell Substitutes

  1996cited by this paper
• Layer-controlled hemoglobin vesicles by interaction of hemoglobin with a phospholipid assembly

  1996cited by this paper
• Driven transport of fluid vesicles through narrow pores.

  1995cited by this paper
• Entrapment of haemoglobin into liposomes by the dehydration-rehydration method: vesicle characterization and in vivo behaviour.

  1994cited by this paper
• Preparation and characterization of liposome-encapsulated haemoglobin by a freeze-thaw method.

  1994cited by this paper
• Fragmentation into small vesicles of dioleoylphosphatidylcholine bilayers during freezing and thawing.

  1994cited by this paper
• Characteristics of Hb-vesicles and encapsulation procedure.

  1994cited by this paper
• Microencapsulation of hemoglobin in liposomes using a double emulsion, film dehydration/rehydration approach.

  1994cited by this paper
• Cryoprotective Mechanism of Saccharides on Freeze-Drying of Liposome

  1992cited by this paper
• Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma.

  1991cited by this paper
• Preparation of hemoglobin-containing liposomes using octyl glucoside and octyltetraoxyethylene.

  1989cited by this paper
• Interactions of sugars with membranes.

  1988cited by this paper
• Liposome-encapsulated hemoglobin as an artificial oxygen-carrying system.

  1987cited by this paper
• Liposome-encapsulated hemoglobin as a red cell surrogate. Preparation scale-up.

  1986cited by this paper
• Vesicles of variable sizes produced by a rapid extrusion procedure.

  1986cited by this paper
• Synthesis and evaluation of a prototypal artificial red cell.

  1985cited by this paper
• A novel method for encapsulation of macromolecules in liposomes.

  1985cited by this paper
• Production of large unilamellar vesicles by a rapid extrusion procedure: characterization of size distribution, trapped volume and ability to maintain a membrane potential.

  1985cited by this paper
• Structural characteristics of phospholipid multilamellar liposomes.

  1984cited by this paper
• Encapsulation of hemoglobin in phospholipid vesicles

  1983cited by this paper
• Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures.

  1981cited by this paper
• Synthetic erythrocytes from lipid encapsulated hemoglobin.

  1980cited by this paper
• Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes.

  1979cited by this paper
• Diffusion of univalent ions across the lamellae of swollen phospholipids.

  1965cited by this paper

• Microfluidic preparation of size- and lamellarity-controlled liposomes using a static mixer and the advantage of a multilamellar structure in biosensing applications

  2026cites this paper
• Exosomal lipid PI4P regulates small extracellular vesicle secretion by modulating intraluminal vesicle formation

  2023cites this paper
• Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin

  2023cites this paper
• Evaluation of a static mixer as a new microfluidic method for liposome formulation

  2023cites this paper
• Scalable production and complete biophysical characterization of poly(ethylene glycol) surface conjugated liposome encapsulated hemoglobin (PEG-LEH)

  2022influential citation
• Research of storable and ready-to-use artificial red blood cells (hemoglobin vesicles) for emergency medicine and other clinical applications

  2022cites this paper
• Utility of TPP-manufactured biophysical restrictions to probe multiscale cellular dynamics

  2021cites this paper
• Preparation of Artificial Red Blood Cells (Hemoglobin Vesicles) Using the Rotation-Revolution Mixer for High Encapsulation Efficiency.

  2021cites this paper
• Effects of Protein Source on Liposome Uptake by Cells: Corona Composition and Impact of the Excess Free Proteins

  2021cites this paper
• Protein Delivery by Peptide-Based Stealth Liposomes: A Biomolecular Insight into Enzyme Replacement Therapy.

  2020cites this paper
• Liposome interactions with biological systems: a journey into cells

  2020cites this paper
• An Assay to Evaluate the Function of Liposomal Platelet Substitutes Delivered to Platelet Aggregates

  2019cites this paper
• Controlled and Tunable Loading and Release of Vesicles by Using Gigahertz Acoustics

  2018cites this paper
• Potential New Non-Invasive Therapy Using Artificial Oxygen Carriers for Pre-Eclampsia

  2017cites this paper
• Hemoglobin Vesicles prolong the time to circulatory collapse in rats during apnea

  2017cites this paper
• Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes

  2017cites this paper
• Transmembrane Difference in Colloid Osmotic Pressure Affects the Lipid Membrane Fluidity of Liposomes Encapsulating a Concentrated Protein Solution.

  2017cites this paper
• The Use of Hemoglobin Vesicles for Delivering Medicinal Gas for the Treatment of Intractable Disorders.

  2017cites this paper
• Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier

  2016cites this paper
• Effect of Cationic Surfactant Micelles on Hydroxyapatite Nanocrystal Formation: An Investigation into the Inorganic–Organic Interfacial Interactions

  2016cites this paper
• Preparation of Phospholipid Vesicle-Templated Calcium Phosphate Nanostructures and Their Cytocompatibility

  2016cites this paper
• Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model

  2015cites this paper
• Protein-Resistant Biodegradable Amphiphilic Graft Copolymer Vesicles as Protein Carriers.

  2015cites this paper
• Lipid Matrices for Nanoencapsulation in Food: Liposomes and Lipid Nanoparticles

  2015cites this paper
• Two-Step Self-Assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release

  2014cites this paper
• Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia.

  2014cites this paper
• Primary and secondary immune responses to keyhole limpet hemocyanin in rats after infusion of hemoglobin vesicle, an artificial oxygen carrier.

  2014cites this paper
• Targeted Delivery of Gaseous Ligands (CO and NO) for the Treatment of Ischemia Reperfusion Injury

  2014influential citation
• Cellular-Type Hemoglobin-Based Oxygen Carrier as a Resuscitative Fluid for Hemorrhagic Shock: Acute and Long-Term Safety Evaluation Using Beagle Dogs

  2013cites this paper
• Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure

  2013cites this paper
• Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

  2013cites this paper
• Advanced Drug Carriers Targeting Bone Marrow

  2012cites this paper
• Fluid Resuscitation of Hemorrhagic Shock with Hemoglobin Vesicles in Beagle Dogs: Pilot Study

  2012cites this paper
• Hemoglobin-based oxygen carrier microparticles: synthesis, properties, and in vitro and in vivo investigations.

  2012cites this paper
• Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model.

  2012cites this paper
• Bone marrow-targeted liposomal carriers

  2011cites this paper
• Electrostatics of carboxylated anionic vesicles for improving entrapment capacity.

  2011cites this paper
• Phagocytosis of Liposome Particles by Rat Splenic Immature Monocytes Makes Them Transiently and Highly Immunosuppressive In Ex Vivo Culture Conditions

  2011cites this paper
• Increased viscosity of hemoglobin-based oxygen carriers retards NO-binding when perfused through narrow gas-permeable tubes.

  2011cites this paper
• Intravenous infusion of Hb-vesicles (artificial oxygen carriers) after repetitive blood exchange with a series of plasma expanders (water-soluble biopolymers) in a rat model†

  2011cites this paper
• PEGylated liposomes encapsulating human hemoglobin enhance oxygen transfer and cell proliferation while decreasing cell hypoxia in fibrin

  2011cites this paper
• Engineering Cellular Hemoglobin-Based Oxygen Carriers For Use In Transfusion Medicine

  2011influential citation
• Simple method for preparing poly(ethylene glycol)-surface-conjugated liposome-encapsulated hemoglobins: physicochemical properties, long-term storage stability, and their reactions with O2, CO, and NO.

  2011cites this paper
• Kinetic switching between two modes of bisurea surfactant self-assembly.

  2010cites this paper
• Hemoglobin encapsulation in vesicles retards NO and CO binding and O2 release when perfused through narrow gas-permeable tubes.

  2010cites this paper
• Trapping single molecules in liposomes: surface interactions and freeze-thaw effects.

  2010cites this paper
• Improved formulation of liposome-encapsulated hemoglobin with an anionic non-phospholipid.

  2010cites this paper
• Bone marrow-targeted liposomal carriers: a feasibility study in nonhuman primates.

  2010cites this paper
• Automatic labeling method for injectable 15O-oxygen using hemoglobin-containing liposome vesicles and its application for measurement of brain oxygen consumption by PET.

  2010cites this paper
• Research and development of Haemoglobin vesicle, a cellular type artificial oxygen carrier

  2009cites this paper
• Chapter 1 Current Perspectives in Liposome‐Encapsulated Hemoglobin as Oxygen Carrier

  2009cites this paper
• Undulating tubular liposomes through incorporation of a synthetic skin ceramide into phospholipid bilayers.

  2009cites this paper
• Hemoglobin-vesicles as an artificial oxygen carrier.

  2009cites this paper
• Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry.

  2009cites this paper
• Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model.

  2009cites this paper
• Biocompatibility Study of Hemoglobin Vesicles, Cellular-Type Artificial Oxygen Carriers, with Human Umbilical Cord Hematopoietic Stem/Progenitor Cells Using an In Vitro Expansion System

  2009cites this paper
• Static structures and dynamics of hemoglobin vesicle (HBV) developed as a transfusion alternative.

  2009cites this paper
• Realization, characterization and functionalization of lipidic wrapped carbon nanotubes

  2009cites this paper
• Porosity and semipermeability of hemoglobin-loaded polymeric nanoparticles as potential blood substitutes.

  2009cites this paper
• Preparation and characterisation of soluble CLIC1 and liposomes

  2009cites this paper
• Influence of hemoglobin vesicles, cellular-type artificial oxygen carriers, on human umbilical cord blood hematopoietic progenitor cells in vitro.

  2009cites this paper
• Mechanism of flocculate formation of highly concentrated phospholipid vesicles suspended in a series of water-soluble biopolymers.

  2009cites this paper
• From Outsiders to Influential Insiders: Pensioners' Organizations in the Policy Process in Sweden

  2008cites this paper
• Electrostatic interactions and complement activation on the surface of phospholipid vesicle containing acidic lipids: effect of the structure of acidic groups.

  2008cites this paper
• NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers.

  2008cites this paper
• Encapsulation of Concentrated Hemoglobin Solution in Phospholipid Vesicles Retards the Reaction with NO, but Not CO, by Intracellular Diffusion Barrier*

  2008cites this paper
• Reduction and suppression of methemoglobin loaded in the polymeric nanoparticles intended for blood substitutes.

  2008cites this paper
• Haemoglobin‐vesicles as artificial oxygen carriers: present situation and future visions

  2007cites this paper
• Solution to the problems of acellular hemoglobins by encapsulation and the intrinsic issues of hemoglobin vesicles as a molecular assembly

  2007cites this paper
• ヘモグロビン小胞体 (HbV)-リコンビナントアルブミン分散溶液による40%交換輸血 : ラット脾臓内HbV代謝と造血に関する2週間の観察

  2007cites this paper
• One-Year Observation of Wistar Rats after Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers)

  2007cites this paper
• Selective uptake of surface-modified phospholipid vesicles by bone marrow macrophages in vivo.

  2007cites this paper
• Insertion of poly (ethylene glycol)-lipid reduces the liposome-encapsulated hemoglobininduced thrombocytopenic reaction

  2007cites this paper
• Rheological properties of hemoglobin vesicles (artificial oxygen carriers) suspended in a series of plasma-substitute solutions.

  2007cites this paper
• Effects of Hemoglobin Vesicles, a Liposomal Artificial Oxygen Carrier, on Hematological Responses, Complement and Anaphylactic Reactions in Rats

  2007cites this paper
• Hemoglobin-vesicles for a Transfusion Alternative and Targeted Oxygen Delivery

  2007cites this paper
• Developing a cross-linked hyaluronic microparticle system for protein encapsulation

  2006cites this paper
• Acute 40 percent exchange‐transfusion with hemoglobin‐vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks

  2006cites this paper
• Hemoglobin vesicles as a molecular assembly. Characteristics of preparation process and performances as artificial oxygen carriers

  2006cites this paper
• Performances of PEG-modified hemoglobin-vesicles as artificial oxygen carriers in microcirculation

  2006cites this paper
• Interaction of Hemoglobin Vesicles, a Cellular-Type Artificial Oxygen Carrier, with Human Plasma: Effects on Coagulation, Kallikrein-Kinin, and Complement Systems

  2006cites this paper
• Oxygen release from low and normal P50 Hb vesicles in transiently occluded arterioles of the hamster window model.

  2005cites this paper
• Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers

  2005cites this paper
• Oxygen infusions (hemoglobin‐vesicles and albumin‐hemes) based on nano‐molecular sciences

  2005cites this paper
• Cellular Hemoglobin-Based Oxygen Carriers as Potential Artificial Blood Substitutes

  2005influential citation
• Hemostatic effects of phospholipid vesicles carrying fibrinogen gamma chain dodecapeptide in vitro and in vivo.

  2005cites this paper
• Effects of Hemoglobin Vesicles on Resting and Agonist-Stimulated Human Platelets In Vitro

  2005cites this paper
• Circulation Kinetics and Organ Distribution of Hb-Vesicles Developed as a Red Blood Cell Substitute

  2005cites this paper
• Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days

  2004cites this paper
• Detection of lipopolysaccharide in hemoglobin-vesicles by Limulus amebocyte lysate test with kinetic-turbidimetric gel clotting analysis and pretreatment of surfactant.

  2004cites this paper
• Reduction of methemoglobin via electron transfer from photoreduced flavin: restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles.

  2004cites this paper
• Safety and Efficacy of Hemoglobin-Vesicles and Albumin-Hemes

  2004cites this paper
• Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.

  2004cites this paper
• Prolonged oxygen-carrying ability of hemoglobin vesicles by coencapsulation of catalase in vivo.

  2003cites this paper
• O2 release from Hb vesicles evaluated using an artificial, narrow O2-permeable tube: comparison with RBCs and acellular Hbs.

  2003cites this paper