Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors.

D. Drummond,O. Meyer,K. Hong,D. Kirpotin,D. Papahadjopoulos

Published 1999 in Pharmacological Reviews

ABSTRACT

There are many potential barriers to the effective delivery of a drug in its active form to solid tumors. Most small-molecule chemotherapeutic agents have a large volume of distribution on i.v. administration ([Speth et al., 1988][1]; [Chabner and Longo, 1996][2]). The result of this is often a

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