Long-term culture of adult rat hepatocyte spheroids.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Experimental Cell Research

• Publication date

  1992-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0014-4827(92)90179-CPMID 1572400
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response.

  1990cited by this paper
• Long-term culture of rat liver cell spheroids in hormonally defined media.

  1990cited by this paper
• Interleukin-6 and the acute phase response.

  1990cited by this paper
• Rapid decrease of cytochrome P‐450IIE1 in primary hepatocyte culture and its maintenance by added 4‐methylpyrazole

  1990cited by this paper
• Acute-phase-response induction in rat hepatocytes co-cultured with rat liver epithelial cells.

  1990cited by this paper
• Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments.

  1990cited by this paper
• Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s.

  1990cited by this paper
• Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4

  1989cited by this paper
• The Acute Phase Response in the Rodent a

  1989cited by this paper
• Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans.

  1989cited by this paper
• Long‐term culture of hepatocytes: Effect of hormones on enzyme activities and metabolic capacity

  1988cited by this paper
• Induction of rat acute‐phase proteins by interleukin 6 in vivo

  1988cited by this paper
• Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

  1988cited by this paper
• Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures.

  1988cited by this paper
• Long-term biosynthesis of complement component C3 and alpha-1 acid glycoprotein by adult rat hepatocytes in a co-culture system with an epithelial liver cell-type.

  1986cited by this paper
• Maintenance of differentiated rat hepatocytes in primary culture.

  1985cited by this paper
• Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities

  1985cited by this paper
• Long‐Term Co‐Cultures of Adult Human Hepatocytes with Rat Liver Epithelial Cells: Modulation of Albumin Secretion and Accumulation of Extracellular Material

  1984cited by this paper
• Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix.

  1984cited by this paper
• Culturing hepatocytes and other differentiated cells

  1984cited by this paper
• Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type.

  1983cited by this paper
• Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

  1982cited by this paper
• Hydrocortisone modulates the production of extracellular material and albumin in long-term cocultures of adult rat hepatocytes with other liver epithelial cells.

  1982cited by this paper
• The effect of hepatocyte culture conditions on cytochrome P-450 linked drug metabolising enzymes.

  1982cited by this paper
• Connective tissue biomatrix: its isolation and utilization for long- term cultures of normal rat hepatocytes

  1980cited by this paper
• Characteristics of microsomal enzyme controls in primary cultures of rat hepatocytes

  1979cited by this paper
• Characteristcs of microsomal enzyme controls in primary cultures of rat hepatocytes.

  1979cited by this paper
• Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase.

  1978cited by this paper
• Preparation of isolated rat liver cells.

  1976cited by this paper
• Measurement of the activity of bilirubin UDP-glucuronyl transferase: application to needle biopsy specimens.

  1971cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Mechanistic Study for Drug Induced Cholestasis Using Batch-Fabricated 3D Spheroids Developed by Agarose-Stamping Method.

  2023cites this paper
• Multicellular Liver Organoids: Generation and Importance of Diverse Specialized Cellular Components

  2023cites this paper
• Hepatic Spheroid Formation on Carbohydrate-Functionalized Supramolecular Hydrogels

  2023cites this paper
• bFGF-releasing biodegradable nanoparticles for effectively engrafting transplanted hepatocyte sheet.

  2023cites this paper
• Production technology and applications of honeycomb films

  2021cites this paper
• A new cell-sized support for 3D cell cultures based on recombinant spider silk fibers

  2021cites this paper
• 3D cell culture for pharmaceutical application

  2021cites this paper
• Multicellular tumor spheroids as in vitro models for studying tumor responses to anticancer therapies

  2020cites this paper
• Hepatic tissue engineering

  2020cites this paper
• Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

  2019cites this paper
• Application of complex in vitro models (CIVMs) in drug discovery for safety testing and disease modeling

  2019cites this paper
• Chapter 4 Complex High-Content Phenotypic Screening

  2019cites this paper
• Impact of Three-Dimentional Culture Systems on Hepatic Differentiation of Puripotent Stem Cells and Beyond.

  2018cites this paper
• Cell–cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions

  2017cites this paper
• Rapid fabrication of functionalised poly(dimethylsiloxane) microwells for cell aggregate formation.

  2017cites this paper
• Biomaterials based strategies for engineering tumor microenvironment

  2017cites this paper
• Hanging Drop, A Best Three-Dimensional (3D) Culture Method for Primary Buffalo and Sheep Hepatocytes

  2017cites this paper
• Human embryoid bodies to hepatocyte-like clusters: Preparing for translation

  2017cites this paper
• Cell–cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions

  2017cites this paper
• Fabrication of functional 3D hepatic tissues with polarized hepatocytes by stacking endothelial cell sheets in vitro

  2017cites this paper
• Cell–cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions

  2017cites this paper
• Complex High-Content Phenotypic Screening

  2016cites this paper
• An oxygen-permeable spheroid culture chip (Oxy chip) promotes osteoblastic differentiation of mesenchymal stem cells

  2016cites this paper
• Gel-fibers reeling system (Gel-FRS) with embedding biological cells for small diameter cellular vessels

  2016cites this paper
• Complex High-Content Phenotypic Screening Complex High-Content Phenotypic Screening

  2016cites this paper
• International of Advanced Research in Biological Sciences Drug Discovery and ADMET process: A Review

  2016cites this paper
• Sacrificial gelatin microspheres for tissue engineering applications

  2016cites this paper
• Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies.

  2015cites this paper
• Bone Related Cell-Stimulating Scaffold Materials and a 3D Cellular Construct for Hard Tissue Regeneration

  2015cites this paper
• Cell-Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation.

  2015cites this paper
• A microfluidically perfused three dimensional human liver model.

  2015cites this paper
• A Novel Microbial Source Tracking DNA Microarray Used for Pathogen Detection in Environmental Systems

  2015cites this paper
• Development and characterisation of a three-dimensional in vitro hepatic fish model to investigate xenobiotic metabolism

  2014influential citation
• Chapter 46 – Hepatic Tissue Engineering

  2014cites this paper
• A microphysiological system model of therapy for liver micrometastases

  2014cites this paper
• Liver Regeneration: The Bioengineering Approach

  2014cites this paper
• Micropatterned culture of HepG2 spheroids using microwell chip with honeycomb-patterned polymer film.

  2014cites this paper
• Multicellular Spheroid: 3-D Tissue Culture Model for Cancer Research

  2014cites this paper
• A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture.

  2014cites this paper
• Oxygen-permeable membrane-based direct oxygenation remarkably enhances functions and gene expressions of rat hepatocytes in both 3D and sandwich cultures

  2014cites this paper
• RTEMIS: Real-Time Tumoroid and Environment Monitoring Using Impedance Spectroscopy and pH Sensing

  2014cites this paper
• Assembly techniques for artificial small diameter blood vessel structures

  2013cites this paper
• Self-assembly of capillary network inside artificial hollow tissue

  2013cites this paper
• Characterization of a Rat Multi-Cell Type 3D-Liver Microtissue System

  2013cites this paper
• From Cellular Cultures to Cellular Spheroids: Is Impedance Spectroscopy a Viable Tool for Monitoring Multicellular Spheroid (MCS) Drug Models?

  2013cites this paper
• Effects of Culture Conditions on a Micropatterned Co-culture of Rat Hepatocytes with 3T3 cells

  2013cites this paper
• Microtechnology-based three-dimensional spheroid formation.

  2013cites this paper
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

  2013cites this paper
• Cytochrome P450 Protocols

  2013cites this paper
• A temperature-cured dissolvable gelatin microsphere-based cell carrier for chondrocyte delivery in a hydrogel scaffolding system.

  2013cites this paper
• Tethered spheroids as an in vitro hepatocyte model for drug safety screening.

  2012cites this paper
• The prediction of drug metabolism using scaffold-mediated enhancement of the induced cytochrome P450 activities in fibroblasts by hepatic transcriptional regulators.

  2012cites this paper
• A microfabricated platform to form three-dimensional toroidal multicellular aggregate

  2012cites this paper
• Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as self-assembling spheroids

  2012cites this paper
• Organotypic liver culture models: Meeting current challenges in toxicity testing

  2012cites this paper
• Prediction of cytochrome 450 mediated drug-drug interactions by three-dimensional cultured hepatocytes.

  2012cites this paper
• An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids.

  2012cites this paper
• Towards a more representative in vitro method for fish ecotoxicology: morphological and biochemical characterisation of three-dimensional spheroidal hepatocytes

  2012cites this paper
• A microfabricated platform to form three-dimensional toroidal multicellular aggregate

  2012cites this paper
• Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system.

  2011cites this paper
• Autocrine-controlled formation and function of tissue-like aggregates by hepatocytes in micropatterned hydrogel arrays

  2011cites this paper
• Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold.

  2011cites this paper
• Expression levels of drug-metabolizing enzyme, transporter, and nuclear receptor mRNAs in a novel three-dimensional culture system for human hepatocytes using micro-space plates.

  2011cites this paper
• Novel Microchip Technique for the Transfer of Spheroids as Floating Cultures to Micropatterned-Adherent Cultures

  2011cites this paper
• Autocrine-Controlled Formation and Function of Tissue-Like Aggregates by Primary Hepatocytes in Micropatterned Hydrogel Arrays

  2010cites this paper
• Secretion of albumin and induction of CYP1A2 and CYP3A4 in novel three-dimensional culture system for human hepatocytes using micro-space plate.

  2010cites this paper
• Effect of microwell chip structure on cell microsphere production of various animal cells.

  2010cites this paper
• Alkoxyresorufin O-dealkylase assay using a rat hepatocyte spheroid microarray.

  2010cites this paper
• Liver Cell Culture Devices.

  2010cites this paper
• Three-dimensional cell culture device utilizing thin membrane deformation by decompression

  2010cites this paper
• Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

  2010cites this paper
• Induced pluripotent stem cells: a new era for hepatology.

  2010cites this paper
• Tissue assembly and organization: developmental mechanisms in microfabricated tissues.

  2009cites this paper
• Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.

  2009cites this paper
• Comparative Analysis of Gene Expression in Rat Liver Tissue and Monolayer- and Spheroid-Cultured Hepatocytes

  2009cites this paper
• Morphological and functional studies of rat hepatocytes on a hydrophobic or hydrophilic polydimethylsiloxane surface.

  2009cites this paper
• Wheat Proteins Enhance Stability and Function of Adhesion Molecules in Cryopreserved Hepatocytes

  2009cites this paper
• In vitro evaluation of a multi-layer radial-flow bioreactor based on galactosylated chitosan nanofiber scaffolds.

  2009cites this paper
• Spheroid-based drug screen: considerations and practical approach

  2009cites this paper
• The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function.

  2009cites this paper
• The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell-substratum adhesivity and cell motility.

  2009cites this paper
• Formation of Keratocyte Spheroids on Chitosan-Coated Surface Can Maintain Keratocyte Phenotypes

  2009cites this paper
• Liver tissue engineering in the evaluation of drug safety

  2009influential citation
• Micropatterned organoid culture of rat hepatocytes and HepG2 cells.

  2008cites this paper
• Inhibitors of snake venoms and development of new therapeutics.

  2008cites this paper
• Inhibitors of Snake Venoms and Development of New Therapeutics

  2008cites this paper
• Two-dimensional microarray of HepG2 spheroids using collagen/polyethylene glycol micropatterned chip

  2008cites this paper
• A New Culture Technique for Hepatocyte Organoid Formation and Long-Term Maintenance of Liver-Specific Functions

  2008cites this paper
• Structural and functional features of bile canaliculi in adult rat hepatocyte spheroids.

  2008cites this paper
• Kultur und Transplantation von Rattenhepatozyten unter Verwendung eines Fibringel als Matrix

  2007cites this paper
• The restoration of the functions of serially passaged calf hepatocytes by spheroid formation

  2007cites this paper
• An in vitro model for long-term hepatotoxicity testing utilizing rat hepatocytes entrapped in micro-hollow fiber reactor

  2007cites this paper
• High Hepatic Function Was Maintained on Electrospun Nanofibrous Scaffold

  2007cites this paper
• A chip-based platform for the in vitro generation of tissues in three-dimensional organization.

  2007cites this paper
• Experimental anti-tumor therapy in 3-D: Spheroids – old hat or new challenge?

  2007influential citation
• Control of flow and oxygen in a 3-D perfused micro-environment fosters balanced survival of hepatocyte-non-parenchymal cell co-cultures

  2007cites this paper
• Technique for the control of spheroid diameter using microfabricated chips.

  2007cites this paper
• Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing.

  2006cites this paper
• Derivation and characterization of hepatocytes from embryonic stem cells in vitro.

  2006cites this paper
• Direct Self-assembly of Hepatocytes Spheroids within Hollow Fibers in Presence of Collagen

  2006cites this paper