Ectopic Pax6 expression disturbs lens fiber cell differentiation.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2004-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/IOVS.04-0151PMID 15452066
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mafs, Prox1, and Pax6 Can Regulate Chicken βB1-Crystallin Gene Expression*

  2004cited by this paper
• Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice.

  2004cited by this paper
• Corneal abnormalities in Pax6+/- small eye mice mimic human aniridia-related keratopathy.

  2003cited by this paper
• Requirement for Pax6 in corneal morphogenesis: a role in adhesion

  2003cited by this paper
• The Stability of the Lens-specific Maf Protein is Regulated by Fibroblast Growth Factor (FGF)/ERK Signaling in Lens Fiber Differentiation*

  2003cited by this paper
• Distinct roles of SOX2, Pax6 and Maf transcription factors in the regulation of lens‐specific δ1‐crystallin enhancer

  2002cited by this paper
• Identification of Genes Downstream of Pax6 in the Mouse Lens Using cDNA Microarrays* 210

  2002cited by this paper
• Systematic analysis of E-, N- and P-cadherin expression in mouse eye development.

  2002cited by this paper
• Iris hypoplasia in mice that lack the alternatively spliced Pax6(5a) isoform

  2002cited by this paper
• General Utility of the Chicken βB1-Crystallin Promoter to Drive Protein Expression in Lens Fiber Cells of Transgenic Mice

  2002cited by this paper
• Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype

  2002cited by this paper
• Lens proteomics: the accumulation of crystallin modifications in the mouse lens with age.

  2002cited by this paper
• Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities.

  2002cited by this paper
• A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens

  2002cited by this paper
• Regulation of c-maf gene expression by Pax6 in cultured cells.

  2001cited by this paper
• Quantitation of PAX6 and PAX6(5a) transcript levels in adult human lens, cornea, and monkey retina.

  2001cited by this paper
• Early eye development in vertebrates.

  2001cited by this paper
• An immunohistochemical method for the detection of proteins in the vertebrate lens.

  2001cited by this paper
• Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye

  2001cited by this paper
• Pax6 lights-up the way for eye development.

  2001cited by this paper
• Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye.

  2000cited by this paper
• Truncated forms of Pax-6 disrupt lens morphology in transgenic mice.

  2000cited by this paper
• Dosage requirement and allelic expression of PAX6 during lens placode formation.

  2000cited by this paper
• Regulation of mouse lens fiber cell development and differentiation by the Maf gene.

  2000cited by this paper
• Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression.

  2000cited by this paper
• Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2.

  2000cited by this paper
• Pax6 induces ectopic eyes in a vertebrate.

  1999cited by this paper
• Transcription factors for lens development assessed in vivo.

  1999cited by this paper
• Regulation of Lens Fiber Cell Differentiation by Transcription Factor c-Maf*

  1999cited by this paper
• Prox1 function is crucial for mouse lens-fibre elongation

  1999cited by this paper
• Molecular regulators involved in vertebrate eye development.

  1998cited by this paper
• Dual Roles for Pax-6: a Transcriptional Repressor of Lens Fiber Cell-Specific β-Crystallin Genes

  1998cited by this paper
• Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice.

  1998cited by this paper
• The Maf transcription factors: regulators of differentiation.

  1997cited by this paper
• PAX-6 in development and evolution.

  1997cited by this paper
• Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8

  1997cited by this paper
• Alternative splicing of Pax6 in bovine eye and evolutionary conservation of intron sequences.

  1997cited by this paper
• Pax-6 and αB-crystallin/Small Heat Shock Protein Gene Regulation in the Murine Lens INTERACTION WITH THE LENS-SPECIFIC REGIONS, LSR1 AND LSR2*

  1996cited by this paper
• Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities.

  1996cited by this paper
• Cellular and molecular features of lens differentiation: a review of recent advances.

  1996cited by this paper
• Lens development and crystallin gene expression: many roles for Pax‐6

  1996cited by this paper
• The role of Pax-6 in eye and nasal development.

  1995cited by this paper
• Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site

  1995cited by this paper
• Pax-6 is essential for lens-specific expression of zeta-crystallin.

  1995cited by this paper
• TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes.

  1995cited by this paper
• Involvement of SOX proteins in lens‐specific activation of crystallin genes.

  1995cited by this paper
• Expression of a truncated FGF receptor results in defective lens development in transgenic mice.

  1995cited by this paper
• Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene.

  1995cited by this paper
• PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

  1994cited by this paper
• Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.

  1994cited by this paper
• Structural similarity of a developmentally regulated bacterial spore coat protein to beta gamma-crystallins of the vertebrate eye lens.

  1994cited by this paper
• Mouse Small eye results from mutation in a paired-like homebox-containing gene

  1992cited by this paper
• Embryonic lens induction: shedding light on vertebrate tissue determination.

  1992cited by this paper
• FVB/N: an inbred mouse strain preferable for transgenic analyses.

  1991cited by this paper
• Developmental analysis of the eye lens obsolescence (Elo) gene in the mouse: cell proliferation and Elo gene expression in the aggregation chimera.

  1991cited by this paper
• Mouse Small eye results from mutations in a paired-like homeobox-containing gene

  1991cited by this paper
• Pax-6, a murine paired box gene, is expressed in the developing CNS.

  1991cited by this paper
• Rescue of developmental lens abnormalities in chimaeras of noncataractous and congenital cataractous mice.

  1987cited by this paper
• Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse.

  1986cited by this paper
• δ- and β-crystallin mRNA levels in the embryonic and posthatched chicken lens: Temporal and spatial changes during development

  1985cited by this paper
• delta- and beta-Crystallin mRNA levels in the embryonic and posthatched chicken lens: temporal and spatial changes during development.

  1985cited by this paper
• Lens differentiation in vertebrates. A review of cellular and molecular features.

  1981cited by this paper

• ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment

  2023cites this paper
• Human brain organoids assemble functionally integrated bilateral optic vesicles

  2021cites this paper
• PAX8 Expression in the Crystalline Lens and Lens-Derived Lesions

  2021cites this paper
• Proteinaceous Transformers: Structural and Functional Variability of Human sHsps

  2020cites this paper
• The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development

  2020cites this paper
• Sall1 plays pivotal roles for lens fiber cell differentiation in mouse.

  2019cites this paper
• The Cataract‐associated RNA‐Binding Protein Celf1 Post‐transcriptionally Regulates the Key Eye Transcription Factor Pax6

  2019influential citation
• Explorer PAX 6 dosage effects on comeal development , growth , and wound healing

  2018influential citation
• PAX 6 expression and retinal cell death in a transgenic mouse model for acute angle-closure glaucoma

  2018cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2012influential citation
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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