Pax6 induces ectopic eyes in a vertebrate.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Development

• Publication date

  1999-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10477290
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Six3 overexpression initiates the formation of ectopic retina.

  1999cited by this paper
• Role of Xrx1 in Xenopus eye and anterior brain development.

  1999cited by this paper
• twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development.

  1999cited by this paper
• Truncation Mutations in the Transactivation Region of PAX6 Result in Dominant-Negative Mutants*

  1998influential reference
• Dissection of the Transactivation Function of the Transcription Factor Encoded by the Eye Developmental Gene PAX6 *

  1998cited by this paper
• Six3, a medaka homologue of the Drosophila homeobox gene sine oculis is expressed in the anterior embryonic shield and the developing eye.

  1998cited by this paper
• Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development.

  1998cited by this paper
• Gene expression pattern Six3, a medaka homologue of the Drosophila homeobox gene sine oculis is expressed in the anterior embryonic shield and the developing eye

  1998cited by this paper
• Lens induction by Pax-6 in Xenopus laevis.

  1997influential reference
• PAX-6 in development and evolution.

  1997cited by this paper
• Xrxl, a novel Xenopus homeobox gene expressed during eye and pineal gland development

  1997cited by this paper
• A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate.

  1997cited by this paper
• Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila.

  1997cited by this paper
• Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

  1997cited by this paper
• The Rx homeobox gene is essential for vertebrate eye development

  1997influential reference
• Basic fibroblast growth factor (FGF‐2) induced transdifferentiation of retinal pigment epithelium: Generation of retinal neurons and glia

  1997cited by this paper
• The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development.

  1997cited by this paper
• Xenopus Pax-6 and retinal development.

  1997cited by this paper
• Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas.

  1997cited by this paper
• The master control gene for morphogenesis and evolution of the eye

  1996cited by this paper
• Pax2 contributes to inner ear patterning and optic nerve trajectory.

  1996cited by this paper
• Ectopic lens induction in fish in response to the murine homeobox gene Six3.

  1996cited by this paper
• Multiple functions for Pax6 in mouse eye and nasal development.

  1996cited by this paper
• Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities.

  1996cited by this paper
• New perspectives on embryonic lens induction

  1996cited by this paper
• Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.

  1995cited by this paper
• Normal table of Xenopus laevis (Daudin)

  1995cited by this paper
• Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern.

  1995influential reference
• Midline signalling is required for Pax gene regulation and patterning of the eyes.

  1995cited by this paper
• Patterning activities of vertebrate hedgehog proteins in the developing eye and brain.

  1995cited by this paper
• The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.

  1995cited by this paper
• Mouse Otx2 functions in the formation and patterning of rostral head.

  1995cited by this paper
• Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation.

  1995cited by this paper
• Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila.

  1995cited by this paper
• Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans.

  1994cited by this paper
• Uchida rat (rSey): a new mutant rat with craniofacial abnormalities resembling those of the mouse Sey mutant.

  1994cited by this paper
• Inhibition of activin receptor signaling promotes neuralization in Xenopus.

  1994cited by this paper
• Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity.

  1994cited by this paper
• The human PAX6 gene is mutated in two patients with aniridia

  1992cited by this paper
• Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

  1992cited by this paper
• Mouse Small eye results from mutations in a paired-like homeobox-containing gene

  1991cited by this paper
• Pax-6, a murine paired box gene, is expressed in the developing CNS.

  1991cited by this paper
• Cephalic expression and molecular characterization of Xenopus En-2.

  1991cited by this paper
• Assays for gene function in developing Xenopus embryos.

  1991cited by this paper
• Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center.

  1991influential reference
• Expression of v-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase

  1991cited by this paper
• A mouse model of the aniridia-Wilms tumor deletion syndrome.

  1990cited by this paper
• Multipotent precursors can give rise to all major cell types of the frog retina.

  1988cited by this paper
• Axolotl retina and lens development: mutual tissue stimulation and autonomous failure in the eyeless mutant retina.

  1986cited by this paper
• Differential immunogold-dextran labeling of bovine and frog rod and cone cells using monoclonal antibodies against bovine rhodopsin.

  1986cited by this paper
• Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse.

  1986cited by this paper
• Crystallin genes: templates for lens transparency.

  1984cited by this paper
• A comparative study of beta-crystallin from six mammals.

  1976cited by this paper
• Vital dye mapping of the gastrula and neurula of Xenopus laevis: I. Prospective areas and morphogenetic movements of the superficial layer

  1976cited by this paper
• Vital dye mapping of the gastrula and neurula of Xenopus laevis. II. Prospective areas and morphogenetic movements of the deep layer.

  1976cited by this paper
• A comparative study of β-crystallin from six mammals

  1976cited by this paper
• Vital Dye Mapping of the Gastrula and Neurula of Xenopus Laevis

  1975cited by this paper
• EXPERIMENTAL STUDIES ON THE DEVELOPMENT OF THE THYMUS

  1967cited by this paper
• Normal Table of Xenopus Laevis (Daudin)

  1958cited by this paper
• The roles of neural and non‐neural tissues in lens induction

  1958cited by this paper
• Embryonic development and induction

  1938cited by this paper
• The Problem of Cyclopia. Part I

  1936cited by this paper
• Experimental studies on the development of the eye. II. The eye‐forming potencies of the median portions of the urodelan neural plate (Triton teniatus and Amblystoma punctatum)

  1929cited by this paper

• ANOFTALMIA EN ANUROS DE LATINOAMÉRICA: NUEVO CASO EN COLOMBIA, ESTADO DEL CONOCIMIENTO Y PERSPECTIVAS PARA LA CONSERVACIÓN

  2025cites this paper
• Variant-specific disruption to notch signalling in PAX6 microphthalmia and aniridia patient-derived hiPSC optic cup-like organoids.

  2025cites this paper
• Modulating the levels and activity of the retinal determination network Is sufficient to induce the specification of distinct tissue fates in Drosophila.

  2025cites this paper
• Parallel sensory compensation following independent subterranean colonization by groundwater salamanders (Eurycea)

  2025cites this paper
• Sonic Hedgehog Determines Early Retinal Development and Adjusts Eyeball Architecture

  2025cites this paper
• Chlorpyrifos and cypermethrin combination disrupts Sonic hedgehog signaling and associated regulatory molecules, leading to congenital eye defects in chick embryos

  2024cites this paper
• Generation of Anterior Segment of the Eye Cells from hiPSCs in Microfluidic Platforms

  2024cites this paper
• Through the Cat-Map Gateway: A Brief History of Cataract Genetics

  2024cites this paper
• The Multiscale Wisdom of the Body: Collective Intelligence as a Tractable Interface for Next‐Generation Biomedicine

  2024cites this paper
• Extrinsic electric field modulates neuronal development and increases photoreceptor population in retinal organoids

  2024cites this paper
• Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex.

  2023cites this paper
• Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex

  2023cites this paper
• Deep mutational scanning quantifies DNA binding and predicts clinical outcomes of PAX6 variants

  2023cites this paper
• The identification of downstream effectors of the Rx gene and its proposed role in anophthalmia/microphthalmia

  2023influential citation
• Making a head: Neural crest and ectodermal placodes in cranial sensory development.

  2022cites this paper
• Zebrafish cornea formation and homeostasis reveal a slow maturation process, similarly to terrestrial vertebrates’ corneas

  2022cites this paper
• Self-Organization of the Retina during Eye Development, Retinal Regeneration In Vivo, and in Retinal 3D Organoids In Vitro

  2022cites this paper
• Retinal Organoids and Retinal Prostheses: An Overview

  2022cites this paper
• PAX6 disease models for aniridia

  2022cites this paper
• Functions of block of proliferation 1 during anterior development in Xenopus laevis

  2022cites this paper
• Sox8 remodels the cranial ectoderm to generate the ear

  2022cites this paper
• Genetics of Atavism

  2022cites this paper
• Hagfish to Illuminate the Developmental and Evolutionary Origins of the Vertebrate Retina

  2022cites this paper
• A single-cell atlas of bobtail squid visual and nervous system highlights molecular principles of convergent evolution

  2022influential citation
• Genetics of Atavism

  2022cites this paper
• A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

  2021cites this paper
• A single-plasmid approach for genome editing coupled with long-term lineage analysis in chick embryos

  2021cites this paper
• Induced pluripotent stem-cell-derived corneal grafts and organoids

  2021cites this paper
• Exploring the human lacrimal gland using organoids and single-cell sequencing.

  2021cites this paper
• PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids

  2021cites this paper
• Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer.

  2021cites this paper
• Comparative development and ocular histology between epigean and subterranean salamanders (Eurycea) from central Texas

  2021cites this paper
• MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode

  2021cites this paper
• Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions.

  2021cites this paper
• Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

  2021cites this paper
• The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation

  2020cites this paper
• Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancer

  2020cites this paper
• miR-183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids

  2020cites this paper
• Regulation of development by Rx genes

  2020cites this paper
• miR‐183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids

  2020cites this paper
• The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network

  2020cites this paper
• Early Eye Development: Specification and Determination

  2020cites this paper
• The rax homeobox gene is mutated in the eyeless axolotl, Ambystoma mexicanum

  2020cites this paper
• Positive selection and fast turnover rate in tumor suppressor genes reveal how cetaceans resist cancer

  2020cites this paper
• Myogenesis control by SIX transcriptional complexes.

  2020cites this paper
• Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia

  2020cites this paper
• CRISPR-Cas, a novel tool for unraveling the mechanisms of eye-related diseases

  2020cites this paper
• An endogenous scaling mechanism in zebrafish appendages that controls two-pore potassium-leak channel activity to regulate morphogen and growth factor transcription

  2020cites this paper
• Modeling ocular lens disease in Xenopus

  2019cites this paper
• The Spectrum of PAX6 Mutations and Genotype-Phenotype Correlations in the Eye

  2019cites this paper
• RECAPITULATING DEVELOPMENTAL MECHANISMS FOR RETINAL REGENERATION.

  2019cites this paper
• The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network

  2019cites this paper
• Polarity and Regional Identity

  2019cites this paper
• Functional role of pax6 during eye and nervous system development in the annelid Capitella teleta.

  2019cites this paper
• Jmjd6a regulates GSK3β RNA splicing in Xenopus laevis eye development

  2019cites this paper
• Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation

  2019cites this paper
• Development of Neurogenic Placodes in Vertebrates

  2019cites this paper
• The Molecular Basis of Human Anophthalmia and Microphthalmia

  2019cites this paper
• Differentiation of human pluripotent stem cells into corneal epithelial like cells

  2018cites this paper
• Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans

  2018cites this paper
• Expression of genes and proteins of the pax‐six‐eya‐dach network in the metamorphic sea urchin: Insights into development of the enigmatic echinoderm body plan and sensory structures

  2018cites this paper
• The role of pparγ in embryonic development of Xenopus tropicalis under triphenyltin-induced teratogenicity.

  2018cites this paper
• Eyeless/Pax6 initiates eye formation non-autonomously from the peripodial epithelium

  2018cites this paper
• Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens.

  2018cites this paper
• Functional role of pax6 in eye and central nervous system development in the annelid Capitella teleta

  2018cites this paper
• Dedifferentiation and Vision System

  2018cites this paper
• Cellular Dedifferentiation and Regenerative Medicine

  2018cites this paper
• Photoreceptor Cell Replacement Therapy from Stem Cells

  2018cites this paper
• Methylation status of the putative Pax6 promoter in olive ridley sea turtle embryos with eye defects: An initial approach.

  2018cites this paper
• Histone deacetylase 1 (HDAC1) regulates retinal development through a PAX6-dependent pathway.

  2017cites this paper
• A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye.

  2017cites this paper
• Analysis of expression of transcription factors in early human retina

  2017cites this paper
• Funktionelle Analyse der Histondeacetylase 6 sowie experimentelle Modellierung von Lateralitätsdefekten während der Links-Rechts-Achsenentwicklung von Xenopus laevis und Paracentrotus lividus

  2017cites this paper
• Signaling and Gene Regulatory Networks in Mammalian Lens Development.

  2017cites this paper
• Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease.

  2017cites this paper
• Advances in the use of Xenopus for successful drug screening

  2017cites this paper
• Deep Homology?: Uncanny Similarities of Humans and Flies Uncovered by Evo-Devo

  2017cites this paper
• Development of functional ectopic compound eyes in scarabaeid beetles by knockdown of orthodenticle

  2017cites this paper
• Lateral thinking – interocular symmetry in neurovascular patterning, in health and disease

  2017cites this paper
• Cell Replacement Therapy for Optic Nerve Disorders

  2017cites this paper
• Human Retinal Pigment Epithelium Stem Cell (RPESC).

  2016cites this paper
• RBPJ-dependent and -independent Notch2 Signaling Regulates Ciliary Body Development in the Mouse Eye

  2016cites this paper
• PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina

  2016cites this paper
• Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors

  2016cites this paper
• Stem Cell Therapy for Treatment of Ocular Disorders

  2016cites this paper
• Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development

  2016cites this paper
• The role of small leucine-rich repeat proteoglycan Asporin in early eye development

  2016cites this paper
• Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development

  2016cites this paper
• The transcription factor Glass links eye field specification with photoreceptor differentiation in Drosophila

  2016cites this paper
• The eye development of Astyanax cavefish

  2016cites this paper
• Pax6 in Collembola: Adaptive Evolution of Eye Regression

  2016cites this paper
• Reprogramming to Kidney

  2016cites this paper
• Tbx3 represses bmp4 expression and, with Pax6, is required and sufficient for retina formation

  2016cites this paper
• Cloning and Functional Analysis of Pax6 from the Hydrothermal Vent Tubeworm Ridgeia piscesae

  2016cites this paper
• Evolutionary Genetics of the Cavefish Astyanax mexicanus.

  2016cites this paper
• Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development

  2016cites this paper
• Vertebrate Eye Gene Regulatory Networks

  2016cites this paper
• A novel PAX6 deletion in a Chinese family with congenital aniridia.

  2015cites this paper
• FGF signaling in Xenopus laevis lens regeneration

  2015cites this paper
• Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor

  2015cites this paper