Applications of DNA-Based Liquid Biopsy for Central Nervous System Neoplasms.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Journal of Molecular Diagnostics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.jmoldx.2016.08.007PMID 27863260
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Do circulating tumor cells, exosomes, and circulating tumor nucleic acids have clinical utility? A report of the association for molecular pathology.

  2015cited by this paper
• Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients

  2015cited by this paper
• Circulating tumor DNA as a non‐invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types

  2015cited by this paper
• Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

  2015cited by this paper
• Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

  2015cited by this paper
• Analysis of cell-free circulating tumor DNA in patients with glioblastoma and other primary brain tumors.

  2015cited by this paper
• Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer

  2015cited by this paper
• Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility

  2015cited by this paper
• Do Circulating Tumor Cells, Exosomes, and Circulating Tumor Nucleic Acids Have Clinical Utility?: A Report of the Association for Molecular Pathology.

  2015cited by this paper
• Circulating biomarkers for gliomas

  2015cited by this paper
• Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

  2015cited by this paper
• Brain tumor mutations detected in cerebral spinal fluid.

  2015cited by this paper
• Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

  2015cited by this paper
• Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord

  2015cited by this paper
• Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay.

  2014cited by this paper
• Abstract 5606: Detection of circulating tumor DNA in early and late stage human malignancies

  2014cited by this paper
• Brain tumor cells in circulation are enriched for mesenchymal gene expression.

  2014cited by this paper
• TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients

  2014cited by this paper
• Whole exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

  2014cited by this paper
• Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes

  2014cited by this paper
• Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

  2014cited by this paper
• Double-stranded DNA in exosomes: a novel biomarker in cancer detection

  2014cited by this paper
• Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500.

  2014cited by this paper
• Liquid biopsies: genotyping circulating tumor DNA.

  2014cited by this paper
• Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer*

  2014cited by this paper
• Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer

  2014cited by this paper
• Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer

  2014cited by this paper
• Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

  2014cited by this paper
• Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

  2014cited by this paper
• Molecular profiling of single circulating tumor cells with diagnostic intention

  2014cited by this paper
• Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer.

  2014cited by this paper
• Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA

  2014cited by this paper
• Challenges in circulating tumour cell research

  2014cited by this paper
• Molecular analysis of circulating tumour cells—biology and biomarkers

  2014cited by this paper
• Hematogenous dissemination of glioblastoma multiforme

  2014cited by this paper
• Liquid biopsy of gastric cancer patients: circulating tumor cells and cell-free nucleic acids.

  2014cited by this paper
• Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients

  2013cited by this paper
• KRAS and BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue

  2013cited by this paper
• Liquid biopsy: monitoring cancer-genetics in the blood

  2013cited by this paper
• Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer.

  2013cited by this paper
• Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer.

  2013cited by this paper
• Detection and recovery of circulating colon cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs.

  2013cited by this paper
• Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

  2013cited by this paper
• Analysis of circulating tumor DNA to monitor metastatic breast cancer.

  2013cited by this paper
• Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.

  2013cited by this paper
• Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

  2013cited by this paper
• Extracellular vesicles: biology and emerging therapeutic opportunities

  2013cited by this paper
• Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing.

  2013cited by this paper
• BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles

  2013cited by this paper
• An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

  2013cited by this paper
• Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

  2013cited by this paper
• Detection of EGFRvIII mutant DNA in the peripheral blood of brain tumor patients

  2013cited by this paper
• Circulating epithelial cells in patients with benign colon diseases.

  2012cited by this paper
• Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

  2012cited by this paper
• Meta-Analysis of the Prognostic Value of Circulating Tumor Cells in Breast Cancer

  2012cited by this paper
• The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers

  2012cited by this paper
• Intratumor heterogeneity: evolution through space and time.

  2012cited by this paper
• Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

  2012cited by this paper
• Identification and proteomic profiling of exosomes in human cerebrospinal fluid

  2012cited by this paper
• Detection of IDH1 mutation in the plasma of patients with glioma

  2012cited by this paper
• Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

  2012cited by this paper
• Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

  2012cited by this paper
• Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

  2012cited by this paper
• Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

  2012cited by this paper
• Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing.

  2012cited by this paper
• Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers.

  2012cited by this paper
• Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease.

  2011cited by this paper
• Evaluation of Circulating Tumor Cells and Circulating Tumor DNA in Non–Small Cell Lung Cancer: Association with Clinical Endpoints in a Phase II Clinical Trial of Pertuzumab and Erlotinib

  2011cited by this paper
• Tumour and serum MGMT promoter methylation and protein expression in glioblastoma patients

  2011cited by this paper
• Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

  2011cited by this paper
• Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences.

  2011cited by this paper
• Quantitative Detection of EGFR Mutations in Circulating Tumor DNA Derived from Lung Adenocarcinomas

  2011cited by this paper
• NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

  2011cited by this paper
• Detection and quantification of rare mutations with massively parallel sequencing

  2011cited by this paper
• Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization.

  2011cited by this paper
• Cell-Free Nucleic Acids Circulating in the Plasma of Colorectal Cancer Patients Induce the Oncogenic Transformation of Susceptible Cultured Cells

  2010cited by this paper
• Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer

  2010cited by this paper
• Detection and HER2 Expression of Circulating Tumor Cells: Prospective Monitoring in Breast Cancer Patients Treated in the Neoadjuvant GeparQuattro Trial

  2010cited by this paper
• Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer

  2010cited by this paper
• Microfiltration isolation of human urinary exosomes for characterization by MS

  2010cited by this paper
• Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer.

  2010cited by this paper
• Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades.

  2010cited by this paper
• Microfluidic isolation and transcriptome analysis of serum microvesicles.

  2010cited by this paper
• Circulating tumour-derived microvesicles in plasma of gastric cancer patients

  2010cited by this paper
• Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer.

  2010cited by this paper
• HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial

  2010cited by this paper
• P16 PROMOTER METHYLATION IN THE SERUM AS A BASIS FOR THE MOLECULAR DIAGNOSIS OF GLIOMAS

  2009cited by this paper
• Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes1

  2009cited by this paper
• Pseudoprogression and pseudoresponse in the treatment of gliomas

  2009cited by this paper
• Circulating Tumor Cell Detection Predicts Early Metastatic Relapse After Neoadjuvant Chemotherapy in Large Operable and Locally Advanced Breast Cancer in a Phase II Randomized Trial

  2008cited by this paper
• Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer.

  2008cited by this paper
• Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

  2008cited by this paper
• Exosome-like vesicles with dipeptidyl peptidase IV in human saliva.

  2008cited by this paper
• Circulating mutant DNA to assess tumor dynamics

  2008cited by this paper
• Detection of mutations in EGFR in circulating lung-cancer cells.

  2008cited by this paper
• MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.

  2008cited by this paper
• Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers

  2008cited by this paper
• Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer

  2008cited by this paper
• Utility of Circulating B-RAF DNA Mutation in Serum for Monitoring Melanoma Patients Receiving Biochemotherapy

  2007cited by this paper
• Prognosis of women with stage IV breast cancer depends on detection of circulating tumor cells rather than disseminated tumor cells.

  2007cited by this paper

• Exploring the Diagnostic Test Accuracy of MicroRNAs as Potential Biomarkers for Glioblastoma: Systematic Review and Meta-Analysis.

  2025cites this paper
• Microfluidic approaches for liquid biopsy in glioblastoma: Insights into diagnostic and follow‐up strategies

  2025cites this paper
• Role and Potential of Artificial Intelligence in Biomarker Discovery and Development of Treatment Strategies for Amyotrophic Lateral Sclerosis

  2025cites this paper
• Causal effect between circulating metabolic markers and glioma: a bidirectional, two-sample, Bayesian weighted Mendelian randomization

  2025cites this paper
• Microfluidic biosensors and devices for brain tumor diagnosis and monitoring.

  2025cites this paper
• Modernizing Neuro-Oncology: The Impact of Imaging, Liquid Biopsies, and AI on Diagnosis and Treatment

  2025cites this paper
• Cancer neuroscience and glioma: clinical implications

  2025cites this paper
• Liquid Biopsy for Cerebral Aneurysms: Circulating RNA as Diagnostic and Prognostic Tools—A Systematic Review of Current Evidence and Perspectives

  2025cites this paper
• Prognostic value of circulating short-length DNA fragments in unresected glioblastoma patients

  2024cites this paper
• Liquid Biopsy for Glioma Using Cell-Free DNA in Cerebrospinal Fluid

  2024cites this paper
• Innovative Approaches to Brain Cancer: The Use of Magnetic Resonance-guided Focused Ultrasound in Glioma Therapy

  2024cites this paper
• Application of Circulating Tumor DNA in the Auxiliary Diagnosis and Prognosis Prediction of Glioma

  2024influential citation
• Serum CD133-Associated Proteins Identified by Machine Learning Are Connected to Neural Development, Cancer Pathways, and 12-Month Survival in Glioblastoma

  2024cites this paper
• Circulating Liquid Biopsy Biomarkers in Glioblastoma: Advances and Challenges

  2024cites this paper
• Extracellular vesicles in glioblastoma: a challenge and an opportunity

  2024cites this paper
• Diagnostic and Prognostic Value of Circulating DNA Fragments in Glioblastoma Multiforme Patients

  2024cites this paper
• Electrochemical biosensors for early diagnosis of glioblastoma.

  2024cites this paper
• Liquid biopsy: creating opportunities in brain space

  2023influential citation
• Advances in Central Nervous System Tumor Classification.

  2023cites this paper
• Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma

  2023cites this paper
• Simple and Ultrasensitive Detection of Glioma-Related ctDNAs in Mice Serum by SERS-Based Catalytic Hairpin Assembly Signal Amplification Coupled with Magnetic Aggregation

  2023cites this paper
• [Oral Squamous Cell Carcinoma-Derived Cell-Free DNA Modulates Stemness and Migration of Oral Squamous Cell Carcinoma Cell Line by Inducing M2 Macrophage Polarization].

  2023cites this paper
• Development of DNA aptamers for visualization of glial brain tumors and detection of circulating tumor cells.

  2023cites this paper
• Recent advances in label-free optical, electrochemical, and electronic biosensors for glioma biomarkers.

  2023cites this paper
• Cardiovascular Disease as a Consequence or a Cause of Cancer: Potential Role of Extracellular Vesicles

  2023cites this paper
• Immunoreactivity against SLC3A2 in high grade gliomas displays positive correlation with glioblastoma patient survival: Potential target for glioma diagnosis and therapy

  2023cites this paper
• Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas

  2023cites this paper
• Liquid biopsy of circulating tumor DNA in cerebrospinal fluid for early diagnosis of brain malignancies: A review

  2023cites this paper
• The Current Landscape of Glioblastoma Biomarkers in Body Fluids

  2023cites this paper
• An Overview of Brain Tumor

  2022cites this paper
• MicroRNAs as potential diagnostic markers of glial brain tumors

  2022cites this paper
• Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics

  2022cites this paper
• Liquid Biopsy in Glioblastoma

  2022cites this paper
• Single-Cell RNA Sequencing of Cerebrospinal Fluid as an Advanced Form of Liquid Biopsy for Neurological Disorders

  2022cites this paper
• Circulating tumor cells and extracellular vesicles as liquid biopsy markers in neuro-oncology: prospects and limitations

  2022cites this paper
• Molecular Docking and Molecular Dynamics Studies Reveal Secretory Proteins as Novel Targets of Temozolomide in Glioblastoma Multiforme

  2022cites this paper
• Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier

  2022cites this paper
• The Roles of Exosomes as Future Therapeutic Agents and Diagnostic Tools for Glioma

  2021cites this paper
• Time to focus on circulating nucleic acids for diagnosis and monitoring of gliomas: A systematic review of their role as biomarkers

  2021cites this paper
• A serum-based DNA methylation assay provides accurate detection of glioma.

  2021cites this paper
• Molecular and Circulating Biomarkers of Brain Tumors

  2021cites this paper
• Diagnostic and prognostic value of stem cell factor plasma level in glioblastoma multiforme patients

  2021cites this paper
• Biomarkers and focused ultrasound: the future of liquid biopsy for brain tumor patients

  2021cites this paper
• Evolving Landscape of Long Non-coding RNAs in Cerebrospinal Fluid: A Key Role From Diagnosis to Therapy in Brain Tumors

  2021cites this paper
• The utility of plasma circulating cell-free messenger RNA as a biomarker of glioma: a pilot study

  2021cites this paper
• Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.

  2021cites this paper
• A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer

  2021cites this paper
• Clinical Applications of Cerebrospinal Fluid Circulating Tumor DNA as a Liquid Biopsy for Central Nervous System Tumors

  2020cites this paper
• Detection of Circulating Tumor-specific DNA Methylation Markers in the Blood

  2020cites this paper
• Liquid biopsy in central nervous system tumors: the potential roles of circulating miRNA and exosomes.

  2020cites this paper
• Diffuse large B-cell lymphoma: Time to focus on circulating blood nucleic acids?

  2020cites this paper
• Leptomeningeal Spread in Glioblastoma: Diagnostic and Therapeutic Challenges.

  2020cites this paper
• Novel Molecular Markers in Glioblastoma—Benefits of Liquid Biopsy

  2020cites this paper
• Management of Diffuse Low-Grade Glioma: The Renaissance of Robust Evidence

  2020cites this paper
• Recent technologies enhancing the clinical utility of circulating tumor DNA.

  2020cites this paper
• The Role of Liquid Biopsies in Pediatric Brain Tumors.

  2020cites this paper
• Detection of Circulating Tumor-specific DNA Methylation Markers in the Blood of Patients with Pituitary Tumors.

  2020cites this paper
• Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism

  2020cites this paper
• Advances in diagnostic microfluidics.

  2020cites this paper
• Detection of Circulating Tumor-specific DNA Methylation Markers in the Blood of 1 Patients with Pituitary Tumors. 2

  2020cites this paper
• Clinical Applications of Cerebrospinal Fluid Circulating Tumor DNA as a Liquid Biopsy for Central Nervous System Tumors

  2020cites this paper
• Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases

  2019cites this paper
• Liquid biopsies in myeloid malignancies

  2019cites this paper
• Large and small extracellular vesicles released by glioma cells in vitro and in vivo

  2019cites this paper
• Development and validation of a targeted gene sequencing panel for application to disparate cancers

  2019cites this paper
• Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications

  2019cites this paper
• Circulating biomarkers in patients with glioblastoma

  2019cites this paper
• The Journal of Molecular Diagnostics: 20 Years Defining Professional Practice.

  2019cites this paper
• Translational Application of Circulating DNA in Oncology: Review of the Last Decades Achievements

  2019influential citation
• 2-1-2019 Technical and Regulatory Considerations for Taking Liquid Biopsy to the Clinic : Validation of the JAX PlasmaMonitor

  2019cites this paper
• Detection of glioma and prognostic subtypes by non-invasive circulating cell-free DNA methylation markers

  2019cites this paper
• Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis

  2019cites this paper
• Technical and Regulatory Considerations for Taking Liquid Biopsy to the Clinic: Validation of the JAX PlasmaMonitorTM Assay

  2019cites this paper
• Update on the types and usage of liquid biopsies in the clinical setting: a systematic review

  2018cites this paper
• Therapy of breast cancer brain metastases: challenges, emerging treatments and perspectives

  2018cites this paper
• Circulating Cell-Free DNA as a Prognostic and Molecular Marker for Patients with Brain Tumors under Perillyl Alcohol-Based Therapy

  2018cites this paper
• Mechanisms and Therapy for Cancer Metastasis to the Brain

  2018cites this paper
• The value of cell‐free DNA for molecular pathology

  2018influential citation
• Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models.

  2018cites this paper
• Integrating Genomics Into Neuro-Oncology Clinical Trials and Practice.

  2018cites this paper
• Circular RNAs: Promising Biomarkers for Human Diseases

  2018cites this paper
• Microfluidic based isolation of circulating tumor cells from whole blood for cancer diagnostics

  2017cites this paper
• Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring

  2017cites this paper
• Origins of cancer: tackling provocative questions

  2017cites this paper
• Review of the clinical applications and technological advances of circulating tumor DNA in cancer monitoring

  2017cites this paper