Gastrointestinal Distribution and Kinetic Characterization of the Sodium-Hydrogen Exchanger Isoform 8 (NHE8)

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cellular Physiology and Biochemistry

• Publication date

  2008-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000113752PMID 18209477
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Immunolocalization of NHE8 in rat kidney.

  2005cited by this paper
• Four Na+/H+ Exchanger Isoforms Are Distributed to Golgi and Post-Golgi Compartments and Are Involved in Organelle pH Regulation*

  2005cited by this paper
• Molecular physiology of intestinal Na+/H+ exchange.

  2005cited by this paper
• Subcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8.

  2005cited by this paper
• Renal expression of novel Na+/H+ exchanger isoform NHE8.

  2003cited by this paper
• Epidermal growth factor regulation of rat NHE2 gene expression.

  2001cited by this paper
• Molecular Cloning and Characterization of a Novel (Na+,K+)/H+ Exchanger Localized to the trans-Golgi Network*

  2001cited by this paper
• NHE6 Protein Possesses a Signal Peptide Destined for Endoplasmic Reticulum Membrane and Localizes in Secretory Organelles of the Cell*

  2001cited by this paper
• Epidermal growth factor regulation of rat NHE 2 gene expression

  2001cited by this paper
• Molecular Cloning, Genomic Organization, and Functional Expression of Na+/H+ Exchanger Isoform 5 (NHE5) from Human Brain*

  1999cited by this paper
• Molecular cloning, tissue distribution, and functional expression of the human Na+/H+exchanger NHE2.

  1999cited by this paper
• Simultaneous analysis of intracellular pH and Ca2+ from cell populations.

  1999cited by this paper
• Molecular Cloning and Functional Expression of a Rat Na+/H+ Exchanger (NHE5) Highly Expressed in Brain*

  1999cited by this paper
• S3226, a novel inhibitor of Na+/H+ exchanger subtype 3 in various cell types

  1998cited by this paper
• Immunochemical characterization of Na+/H+ exchanger isoform NHE4.

  1998cited by this paper
• Immunochemical characterization of Na+/H+exchanger isoform NHE4.

  1998cited by this paper
• Tissue distribution of Na+/H+ exchanger isoforms NHE2 and NHE4 in rat intestine and kidney.

  1997cited by this paper
• Tissue distribution of Na+/H+exchanger isoforms NHE2 and NHE4 in rat intestine and kidney.

  1997cited by this paper
• Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium.

  1997cited by this paper
• Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampus.

  1996cited by this paper
• Structure/function studies of mammalian Na‐H exchangers‐‐an update.

  1995cited by this paper
• Mammalian Na+/H+ exchanger gene family: structure and function studies.

  1995cited by this paper
• Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.

  1995cited by this paper
• Na+/H+ exchanger isoforms NHE-2 and NHE-1 in inner medullary collecting duct cells. Expression, functional localization, and differential regulation.

  1994cited by this paper
• Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells.

  1993cited by this paper
• Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.

  1993cited by this paper
• Kinetic characterization of a stably expressed novel Na+/H+ exchanger (NHE-2).

  1993cited by this paper
• Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line.

  1993cited by this paper
• Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger.

  1993cited by this paper
• Nucleotide sequence of the Chinese hamster Na+/H+ exchanger NHE1.

  1993cited by this paper
• Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2).

  1993cited by this paper
• Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C.

  1993cited by this paper
• Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

  1992cited by this paper
• Cloning and expression of a cAMP-activated Na+/H+ exchanger: evidence that the cytoplasmic domain mediates hormonal regulation.

  1992cited by this paper
• Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).

  1992cited by this paper
• Immunocytochemical characterization of Na(+)-H+ exchanger isoform NHE-1 in rabbit kidney.

  1992cited by this paper
• Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger.

  1991cited by this paper
• Kinetics and regulation of a polarized Na(+)-H+ exchanger from Caco-2 cells, a human intestinal cell line.

  1991cited by this paper
• Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

  1989cited by this paper
• A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

  1984cited by this paper

• Sodium/hydrogen exchanger 8 affects sheet migration of human intestinal epithelial cells (HT29-MTX) by influencing the actin cytoskeletal rearrangement.

  2025cites this paper
• The Expression of NHE8 in Liver and Its Role in Carbon Tetrachloride–Induced Liver Injury

  2022cites this paper
• Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders

  2022cites this paper
• The Physiological Function and Potential Role of the Ubiquitous Na+/H+ Exchanger Isoform 8 (NHE8): An Overview Data

  2022influential citation
• Determinants, Maintenance and Function of Organellar pH.

  2022cites this paper
• The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity

  2022cites this paper
• Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.

  2021cites this paper
• Na+/H+ Exchangers

  2021cites this paper
• Na+/H+-exchangers differentially contribute to midgut fluid sodium and proton concentration in the sea urchin larva.

  2021cites this paper
• Na+/H+ Exchangers in Epithelia

  2020cites this paper
• An indisputable role of NHE8 in mucosal protection.

  2020cites this paper
• Mucosal Abnormalities in Children With Congenital Chloride Diarrhea—An Underestimated Phenotypic Feature?

  2020cites this paper
• Na+/H+ exchanger (NHE) in Pacific white shrimp (Litopenaeus vannamei): Molecular cloning, transcriptional response to acidity stress, and physiological roles in pH homeostasis

  2019cites this paper
• The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology.

  2019cites this paper
• Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe

  2019cites this paper
• Pathophysiology of IBD associated diarrhea

  2018cites this paper
• Essential function of NHE8 in mouse retina demonstrated by AAV‐mediated CRISPR/Cas9 knockdown☆

  2018cites this paper
• Genome wide association analysis identifies genetic variants associated with reproductive variation across domestic dog breeds and uncovers links to domestication

  2018cites this paper
• NHE8 Deficiency Promotes Colitis-Associated Cancer in Mice via Expansion of Lgr5-Expressing Cells

  2018cites this paper
• SLC9 Gene Family: Function, Expression, and Regulation.

  2018cites this paper
• Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis.

  2018cites this paper
• Establishing the molecular mechanism of sodium/proton exchangers

  2017cites this paper
• Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer.

  2017cites this paper
• Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease.

  2016cites this paper
• Role of epithelial ion transports in inflammatory bowel disease.

  2016cites this paper
• Pathophysiology of Intestinal Na+/H+ Exchange

  2016cites this paper
• Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation.

  2016cites this paper
• 1 2 Sodium butyrate stimulates NHE 8 expression via its role on 3 activating NHE 8 basal promoter activity 4 5 6

  2015cites this paper
• Loss of NHE8 expression impairs intestinal mucosal integrity.

  2015cites this paper
• Sodium butyrate stimulates NHE8 expression via its role on activating NHE8 basal promoter activity.

  2015cites this paper
• Role of Na/H exchange in insulin secretion by islet cells

  2014cites this paper
• NHE8 plays important roles in gastric mucosal protection.

  2013cites this paper
• SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers.

  2013cites this paper
• Traditional and emerging roles for the SLC9 Na+/H+ exchangers

  2013cites this paper
• NHE8 plays an important role in mucosal protection via its effect on bacterial adhesion.

  2013influential citation
• The Regulation of Bile Acids on NHE8 Gene Expression

  2013cites this paper
• Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3.

  2012cites this paper
• Functional role of NHE4 as a pH regulator in rat and human colonic crypts.

  2012cites this paper
• Proximal tubule Na+/H+ exchanger activity in adult NHE8-/-, NHE3-/-, and NHE3-/-/NHE8-/- mice.

  2012cites this paper
• - /NHE8 - / - , and NHE3 - / - , NHE3 - / - NHE8

  2012cites this paper
• Lactobacillus acidophilus upregulates intestinal NHE3 expression and function.

  2012cites this paper
• Renal Acid-Base Physiology Proximal tubule Na / H exchanger activity in adult NHE 8 / , NHE 3 / , and NHE 3 / / NHE 8 / mice

  2012cites this paper
• Impaired mucin synthesis and bicarbonate secretion in the colon of NHE8 knockout mice.

  2012cites this paper
• CALL FOR PAPERS Renal Acid-Base Physiology

  2012cites this paper
• Molecular Physiology of Gastrointestinal Function during Development

  2012cites this paper
• Na + /H + Exchange in Mammalian Digestive Tract

  2012cites this paper
• Na+/H+ exchangers.

  2011cites this paper
• Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells

  2011cites this paper
• Nucleotide Sequence of the Na+/H+ Exchanger-8 in Patients With Congenital Sodium Diarrhea

  2011cites this paper
• NHE2X3 DKO mice exhibit gender-specific NHE8 compensation.

  2011cites this paper
• Transcriptional regulation of the intestinal luminal Na⁺ and Cl⁻ transporters.

  2011cites this paper
• Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway.

  2011cites this paper
• The Sodium/Proton Exchanger NHE8 Regulates Late Endosomal Morphology and Function

  2010cites this paper
• Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5.

  2010cites this paper
• Effect of metabolic acidosis on neonatal proximal tubule acidification.

  2010cites this paper
• Toxin Mediated Diarrhea in the 21st Century: The Pathophysiology of Intestinal Ion Transport in the Course of ETEC, V. cholerae and Rotavirus Infection

  2010cites this paper
• NHE3 regulatory complexes

  2009cites this paper
• Mechanisms of the Regulation of the Intestinal Na+/H+Exchanger NHE3

  2009cites this paper
• Tumor necrosis factor- (cid:1) downregulates intestinal NHE8 expression by reducing basal promoter activity

  2009cites this paper
• Ion transport in the intestine

  2009cites this paper
• High rates of HCO3– secretion and Cl– absorption against adverse gradients in the marine teleost intestine: the involvement of an electrogenic anion exchanger and H+-pump metabolon?

  2009cites this paper
• Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.

  2009cites this paper
• Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.

  2008cites this paper
• Human Intestinal Epithelial Cell Line Sk-co15 Is a New Model System to Study Na Cell Culture and Treatment. Sk-co15 Was a Gift From

  year unknowncites this paper