S3226, a novel inhibitor of Na+/H+ exchanger subtype 3 in various cell types

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Pflügers Archiv

• Publication date

  1998-08-24

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s004240050704PMID 9716715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of Na+/H+ exchange in opossum kidney cells by parathyroid hormone, cyclic AMP and phorbol esters

  2004cited by this paper
• Activity and expression of Na(+)-H+ exchanger isoforms 1 and 3 in kidney proximal tubules of hypertensive rats.

  1997cited by this paper
• Ischemic-reperfusion injury in the kidney: overexpression of colonic H+-K+-ATPase and suppression of NHE-3.

  1997cited by this paper
• A Novel Screening Assay of the Na+-Dependent Cl-/HCO-3 Exchanger (NCBE) and Its Inhibitors

  1996cited by this paper
• Role of NHE3 in Mediating Renal Brush Border Na+-H+ Exchange

  1996cited by this paper
• Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion.

  1995cited by this paper
• Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.

  1989cited by this paper
• Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney.

  1976cited by this paper

• Renal ischemia/reperfusion injury triggers proximal tubular apoptosis and NHE3 dysfunction via p38MAPK/ezrin signaling pathway.

  2025cites this paper
• Partially differentiated ileal and distal-colonic human F508del-cystic fibrosis-enteroids secrete fluid in response to forskolin and linaclotide

  2025cites this paper
• Acidosis defense mechanisms in the preimplantation stages of embryos in BALB/c strain mice.

  2024cites this paper
• Proton-driven sodium secretion in a saline water animal

  2024cites this paper
• Ion uptake in naturally acidic water

  2024cites this paper
• The effect of claudin-15 deletion on cationic selectivity and transport in paracellular pathways of the cecum and large intestine

  2023cites this paper
• Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3

  2022cites this paper
• Contact‐dependent, polarized acidification response during neutrophil–epithelial interactions

  2022cites this paper
• The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity

  2022cites this paper
• New Insights into the Critical Importance of Intratubular Na+/H+ Exchanger 3 and Its Potential Therapeutic Implications in Hypertension

  2021cites this paper
• Na+/H+ Exchangers

  2021cites this paper
• Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.

  2021cites this paper
• Na+-Coupled Nutrient Cotransport Induced Luminal Negative Potential and Claudin-15 Play an Important Role in Paracellular Na+ Recycling in Mouse Small Intestine

  2020influential citation
• Na+/H+ Exchangers in Epithelia

  2020cites this paper
• Arsenic trioxide-increased MDCK cells proliferation requires activator protein 1-mediated increase of the sodium/proton exchanger 1 activity.

  2020cites this paper
• The SLC9A-C Mammalian Na+/H+ Exchanger Family: Molecules, Mechanisms, and Physiology.

  2019cites this paper
• Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing autosomal dominant polycystic kidney disease

  2019cites this paper
• The Mode of Action of NHE3 Inhibitors in Intestinal Na+ Absorption

  2019cites this paper
• Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane

  2018cites this paper
• Luminal Na+ homeostasis has an important role in intestinal peptide absorption in vivo.

  2018cites this paper
• Linaclotide improves gastrointestinal transit in cystic fibrosis mice by inhibiting sodium/hydrogen exchanger 3.

  2018cites this paper
• Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins

  2017cites this paper
• Molecular architecture underlying fluid absorption by the developing inner ear

  2017cites this paper
• The Myth of Water and Salt: From Aquaretics to Tenapanor.

  2017cites this paper
• The Regulation of Na+/H+ Exchanger Isoform 1 in Kidney Cells

  2016cites this paper
• A atividade do NHE3 em túbulo proximal é inibida pela sinalização enviesada do receptor de angiotensina II tipo 1/beta-arrestina

  2016cites this paper
• Acidic pH and short-chain fatty acids activate Na+ transport but differentially modulate expression of Na+/H+ exchanger isoforms 1, 2, and 3 in omasal epithelium.

  2016cites this paper
• Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.

  2016cites this paper
• An animal homolog of plant Mep/Amt transporters promotes ammonia excretion by the anal papillae of the disease vector mosquito Aedes aegypti

  2016cites this paper
• Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na+/H+ Exchanger Type 3 (NHE3).

  2016cites this paper
• Activity of NA(+)/H(+) exchangers alters aquaporin-mediated water transport in human placenta.

  2015cites this paper
• Na-H Exchanger Isoform-2 (NHE2) Mediates Butyrate-dependent Na+ Absorption in Dextran Sulfate Sodium (DSS)-induced Colitis*

  2015cites this paper
• Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.

  2015cites this paper
• Na/H Exchange

  2015cites this paper
• Renal nerve stimulation leads to the activation of the Na+/H+ exchanger isoform 3 via angiotensin II type I receptor.

  2015cites this paper
• The Molecular Mechanisms of Action of Two Drug Candidates for the Treatment of Myocardial Infarction and Sepsis

  2015influential citation
• The Molecular Mechanisms of Action of Two Drug Candidates for the Treatment of Myocardial Infarction and Sepsis

  2015cites this paper
• Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.

  2015cites this paper
• Pharmacologic inhibition of intestinal sodium uptake: a gut centric approach to sodium management

  2015cites this paper
• Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling.

  2015influential citation
• Investigation of Ammonia Transport Pathways in the Anal Papillae of Larval Aedes Aegypti Mosquito

  2014cites this paper
• Structural dynamics and regulation of the mammalian SLC9A family of Na⁺/H⁺ exchangers.

  2014cites this paper
• Functional role of glucose metabolism, osmotic stress, and sodium-glucose cotransporter isoform-mediated transport on Na+/H+ exchanger isoform 3 activity in the renal proximal tubule.

  2014cites this paper
• NHE1 Is the Sodium-Hydrogen Exchanger Active in Acute Intracellular pH Regulation in Preimplantation Mouse Embryos1

  2013influential citation
• JAK2 mediates the acute response to decreased cell volume in mouse preimplantation embryos by activating NHE1

  2013cites this paper
• Acidosis-mediated regulation of the NHE1 isoform of the Na⁺/H⁺ exchanger in renal cells.

  2013cites this paper
• Biological activities of guanidine compounds, 2008 – 2012 update

  2013cites this paper
• Elevated carbon dioxide upregulates NBCn1 Na+/HCO3(-) cotransporter in human embryonic kidney cells.

  2013cites this paper
• Renal Solute Cotransporters and Exchangers Mechanisms underlying the inhibitory effects of uroguanylin on NHE 3 transport activity in renal proximal tubule

  2012cites this paper
• The Proton-activated G Protein Coupled Receptor OGR1 Acutely Regulates the Activity of Epithelial Proton Transport Proteins

  2012cites this paper
• Lactobacillus acidophilus upregulates intestinal NHE3 expression and function.

  2012cites this paper
• OSR1-sensitive small intestinal Na+ transport.

  2012cites this paper
• Fructose Acutely Stimulates NHE3 Activity in Kidney Proximal Tubule

  2012cites this paper
• Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure.

  2012cites this paper
• renal proximal tubule of rats with heart failure Increased NHE3 abundance and transport activity in

  2012cites this paper
• Na + /H + Exchange in Mammalian Digestive Tract

  2012cites this paper
• Mechanisms underlying the inhibitory effects of uroguanylin on NHE3 transport activity in renal proximal tubule.

  2012cites this paper
• Evidence for NHE3-mediated Na transport in sheep and bovine forestomach.

  2011cites this paper
• Mitochondrial Function / Dysfunction in Health and Disease Evidence for NHE 3-mediated Na transport in sheep and bovine forestomach

  2011cites this paper
• Efeitos crônicos da Angiotensina II sobre a atividade e expressão da isoforma 3 do trocador Na + /H +

  2011cites this paper
• Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function

  2011cites this paper
• High capacity Na+/H+ exchange activity in mineralizing osteoblasts

  2011cites this paper
• The SLC36 family of proton‐coupled amino acid transporters and their potential role in drug transport

  2011cites this paper
• Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells.

  2011cites this paper
• Evidence for NHE3-mediated Na transport

  2011cites this paper
• Increased NHE 3 abundance and transport activity in renal proximal tubule of rats with heart failure

  2011cites this paper
• Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1.

  2011cites this paper
• Na+/H+ exchangers.

  2011cites this paper
• Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats

  2011cites this paper
• Loss of PDZ‐adaptor protein NHERF2 affects membrane localization and cGMP‐ and [Ca2+]‐ but not cAMP‐dependent regulation of Na+/H+ exchanger 3 in murine intestine

  2010cites this paper
• Posttranslational mechanisms associated with reduced NHE3 activity in adult vs. young prehypertensive SHR.

  2010cites this paper
• Role of colonic short-chain fatty acid transport in diarrhea.

  2010cites this paper
• The apical ( hPepT 1 ) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase

  2010cites this paper
• Modulation of Na and acetate transport by heat shock proteins (Hsp) across the rumen epithelium of sheep

  2010cites this paper
• The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase

  2010cites this paper
• A Novel Amiloride-Sensitive H+ Transport Pathway Mediates Enhanced Superoxide Production in Thick Ascending Limb of Salt-Sensitive Rats, Not Na+/H+ Exchange

  2009cites this paper
• pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats.

  2009cites this paper
• Regulation of intracellular pH during oocyte growth and maturation in mammals.

  2009cites this paper
• Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin der Freien Universität Berlin

  2009cites this paper
• Physiology of cell volume regulation in vertebrates.

  2009cites this paper
• Modulation of Na+‐H+ exchange isoforms NHE1 and NHE3 by insulin‐like growth factor‐1 in isolated bovine articular chondrocytes

  2008cites this paper
• HCO3− Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells during Ca2+-stimulated Fluid Secretion

  2008cites this paper
• Charakterisierung des Na+-Transportes am isolierten Psalterepithel des Schafes

  2008cites this paper
• NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells

  2008cites this paper
• Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells during Ca

  2008influential citation
• Gastrointestinal Distribution and Kinetic Characterization of the Sodium-Hydrogen Exchanger Isoform 8 (NHE8)

  2008cites this paper
• Granulosa cells regulate oocyte intracellular pH against acidosis in preantral follicles by multiple mechanisms

  2007influential citation
• Short-term effect on intestinal epithelial Na-/H- exchanger by Giα1,2-coupled 5-HT1A and Gq/11-coupled 5-HT2 receptors

  2007cites this paper
• Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-reperfusion injury.

  2007cites this paper
• Activity and Regulation of Na+-HCO3− Cotransporter in Immortalized Spontaneously Hypertensive Rat and Wistar–Kyoto Rat Proximal Tubular Epithelial Cells

  2007cites this paper
• Short-term effect on intestinal epithelial Na(+)/H(+) exchanger by Gi(alpha1,2)-coupled 5-HT(1A) and G(q/11)-coupled 5-HT(2) receptors.

  2007cites this paper
• Wirkungen subtyp-spezifischer Inhibitoren des Natrium-Protonen-Austauschers auf den Atemrhythmus

  2007cites this paper
• Regulatory binding partners and complexes of NHE3.

  2007cites this paper
• The Sodium-Hydrogen Exchange System

  2007cites this paper
• Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast.

  2007cites this paper
• Dexamethasone increases fluid absorption through Na + / H + exchanger 3 activation in normal human middle ear epithelial cells

  2007cites this paper
• Deciphering the mechanisms of intestinal imino (and amino) acid transport: the redemption of SLC36A1.

  2007cites this paper
• Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine.

  2006cites this paper
• CHAPTER 73 – Na+-H+ Exchange in Mammalian Digestive Tract

  2006cites this paper
• Apical NA+/H+ exchangers in the mammalian gastrointestinal tract.

  2006cites this paper